Q9H3G5 (CPVL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine carboxypeptidase CPVL
EC=3.4.16.-

Alternative name(s):
Carboxypeptidase, vitellogenic-like
Vitellogenic carboxypeptidase-like protein
Short name=VCP-like protein
Short name=hVLP

Gene names

Name:	CPVL
Synonyms:	VLP
ORF Names:	PSEC0124, UNQ197/PRO223

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
Tissue specificity	Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.
Sequence similarities	Belongs to the peptidase S10 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Carboxypeptidase Hydrolase Protease
PTM	Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	serine-type carboxypeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – ?		Potential		PRO_0000004280
	Chain	? – 476		Probable serine carboxypeptidase CPVL		PRO_0000004281
Sites
	Active site	204	1	By similarity
	Active site	388	1	By similarity
	Active site	448	1	By similarity
Amino acid modifications
	Glycosylation	81	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	132	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Glycosylation	346	1	N-linked (GlcNAc...) Ref.8
Natural variations
	Natural variant	11	1	S → L. Corresponds to variant rs36074676 [ dbSNP | Ensembl ].		VAR_048681
	Natural variant	25	1	R → H. Ref.2 Corresponds to variant rs34219043 [ dbSNP | Ensembl ].		VAR_048682
	Natural variant	398	1	R → H. Ref.1 Ref.2 Corresponds to variant rs1052200 [ dbSNP | Ensembl ].		VAR_048683
	Natural variant	435	1	A → V. Ref.4 Ref.7 Corresponds to variant rs7313 [ dbSNP | Ensembl ].		VAR_022612
Experimental info
	Sequence conflict	284	1	F → L in AAG37991. Ref.1
	Sequence conflict	284	1	F → L in AAG14348. Ref.2
	Sequence conflict	287	1	F → L in BAC11618. Ref.4
	Sequence conflict	422	1	F → L in AAG14348. Ref.2
	Sequence conflict	438	1	F → S in AAG14348. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H3G5 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: 33AA4A7360BF01E1	FASTA	476	54,164
	10 20 30 40 50 60 MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE AGKIQKGREL 70 80 90 100 110 120 SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE DAPVVLWLQG GPGGSSMFGL 130 140 150 160 170 180 FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY IDNPVGTGFS FTDDTHGYAV NEDDVARDLY 190 200 210 220 230 240 SALIQFFQIF PEYKNNDFYV TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS 250 260 270 280 290 300 DPESIIGGYA EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS 310 320 330 340 350 360 DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN DGTIVEKYLR 370 380 390 400 410 420 EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL MGMDWKGSQE YKKAEKKVWK 430 440 450 460 470 IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL PYDQPLRAFD MINRFIYGKG WDPYVG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages." Mahoney J.A., Ntolosi B., DaSilva R.P., Gordon S., McKnight A.J. Genomics 72:243-251(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-398.
[2]	"Cloning of VCP-like protein expressed in human heart and placenta." Cho J.-J., Baik H.-H. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-25 AND HIS-398.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435. Tissue: Placenta.
[5]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435. Tissue: Lung.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-132 AND ASN-346, MASS SPECTROMETRY. Tissue: Liver.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF106704 mRNA. Translation: AAG37991.2. AF282617 mRNA. Translation: AAG14348.1. AY358549 mRNA. Translation: AAQ88913.1. AK075433 mRNA. Translation: BAC11618.1. CH236948 Genomic DNA. Translation: EAL24207.1. CH471073 Genomic DNA. Translation: EAW93914.1. BC016838 mRNA. Translation: AAH16838.1.
IPI	IPI00301395.
RefSeq	NP_061902.2. NM_019029.2. NP_112601.3. NM_031311.3.
UniGene	Hs.233389.
3D structure databases
ProteinModelPortal	Q9H3G5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H3G5. 3 interactions.
MINT	MINT-1162149.
STRING	9606.ENSP00000265394.
Protein family/group databases
MEROPS	S10.003.
PTM databases
PhosphoSite	Q9H3G5.
Polymorphism databases
DMDM	67476930.
Proteomic databases
PaxDb	Q9H3G5.
PeptideAtlas	Q9H3G5.
PRIDE	Q9H3G5.
Protocols and materials databases
DNASU	54504.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265394; ENSP00000265394; ENSG00000106066. ENST00000396276; ENSP00000379572; ENSG00000106066. ENST00000409850; ENSP00000387164; ENSG00000106066.
GeneID	54504.
KEGG	hsa:54504.
UCSC	uc003szv.3. human.
Organism-specific databases
CTD	54504.
GeneCards	GC07M029001.
HGNC	HGNC:14399. CPVL.
HPA	CAB003697.
MIM	609780. gene.
neXtProt	NX_Q9H3G5.
PharmGKB	PA26850.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2939.
HOGENOM	HOG000252949.
HOVERGEN	HBG010805.
InParanoid	Q9H3G5.
KO	K09645.
OMA	MDWKGSQ.
OrthoDB	EOG4RFKSB.
PhylomeDB	Q9H3G5.
Gene expression databases
ArrayExpress	Q9H3G5.
Bgee	Q9H3G5.
CleanEx	HS_CPVL.
Genevestigator	Q9H3G5.
GermOnline	ENSG00000106066. Homo sapiens.
Family and domain databases
InterPro	IPR001563. Peptidase_S10. IPR018202. Peptidase_S10_AS. [Graphical view]
PANTHER	PTHR11802. PTHR11802. 1 hit.
Pfam	PF00450. Peptidase_S10. 1 hit. [Graphical view]
PRINTS	PR00724. CRBOXYPTASEC.
PROSITE	PS00560. CARBOXYPEPT_SER_HIS. False negative. PS00131. CARBOXYPEPT_SER_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54504.
NextBio	56863.
SOURCE	Search...

Entry information

Entry name

CPVL_HUMAN

Accession

Primary (citable) accession number: Q9H3G5
Secondary accession number(s): A4D1A4 , Q6UX20, Q8NBL7, Q96AR7, Q9HB41

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.