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Q9H3G5 (CPVL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable serine carboxypeptidase CPVL

EC=3.4.16.-
Alternative name(s):
Carboxypeptidase, vitellogenic-like
Vitellogenic carboxypeptidase-like protein
Short name=VCP-like protein
Short name=hVLP
Gene names
Name:CPVL
Synonyms:VLP
ORF Names:PSEC0124, UNQ197/PRO223
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Tissue specificity

Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – ? PotentialPRO_0000004280
Chain? – 476Probable serine carboxypeptidase CPVLPRO_0000004281

Sites

Active site2041 By similarity
Active site3881 By similarity
Active site4481 By similarity

Amino acid modifications

Glycosylation811N-linked (GlcNAc...) Ref.8
Glycosylation1321N-linked (GlcNAc...) Ref.8
Glycosylation3071N-linked (GlcNAc...) Potential
Glycosylation3461N-linked (GlcNAc...) Ref.8

Natural variations

Natural variant111S → L.
Corresponds to variant rs36074676 [ dbSNP | Ensembl ].
VAR_048681
Natural variant251R → H. Ref.2
Corresponds to variant rs34219043 [ dbSNP | Ensembl ].
VAR_048682
Natural variant3981R → H. Ref.1 Ref.2
Corresponds to variant rs1052200 [ dbSNP | Ensembl ].
VAR_048683
Natural variant4351A → V. Ref.4 Ref.7
Corresponds to variant rs7313 [ dbSNP | Ensembl ].
VAR_022612

Experimental info

Sequence conflict2841F → L in AAG37991. Ref.1
Sequence conflict2841F → L in AAG14348. Ref.2
Sequence conflict2871F → L in BAC11618. Ref.4
Sequence conflict4221F → L in AAG14348. Ref.2
Sequence conflict4381F → S in AAG14348. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9H3G5 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: 33AA4A7360BF01E1

FASTA47654,164
        10         20         30         40         50         60 
MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE AGKIQKGREL 

        70         80         90        100        110        120 
SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE DAPVVLWLQG GPGGSSMFGL 

       130        140        150        160        170        180 
FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY IDNPVGTGFS FTDDTHGYAV NEDDVARDLY 

       190        200        210        220        230        240 
SALIQFFQIF PEYKNNDFYV TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS 

       250        260        270        280        290        300 
DPESIIGGYA EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS 

       310        320        330        340        350        360 
DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN DGTIVEKYLR 

       370        380        390        400        410        420 
EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL MGMDWKGSQE YKKAEKKVWK 

       430        440        450        460        470 
IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL PYDQPLRAFD MINRFIYGKG WDPYVG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages."
Mahoney J.A., Ntolosi B., DaSilva R.P., Gordon S., McKnight A.J.
Genomics 72:243-251(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-398.
[2]"Cloning of VCP-like protein expressed in human heart and placenta."
Cho J.-J., Baik H.-H.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-25 AND HIS-398.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435.
Tissue: Placenta.
[5]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435.
Tissue: Lung.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-132 AND ASN-346.
Tissue: Liver.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF106704 mRNA. Translation: AAG37991.2.
AF282617 mRNA. Translation: AAG14348.1.
AY358549 mRNA. Translation: AAQ88913.1.
AK075433 mRNA. Translation: BAC11618.1.
CH236948 Genomic DNA. Translation: EAL24207.1.
CH471073 Genomic DNA. Translation: EAW93914.1.
BC016838 mRNA. Translation: AAH16838.1.
CCDSCCDS5419.1.
RefSeqNP_061902.2. NM_019029.2.
NP_112601.3. NM_031311.3.
XP_005249843.1. XM_005249786.1.
UniGeneHs.233389.

3D structure databases

ProteinModelPortalQ9H3G5.
SMRQ9H3G5. Positions 57-466.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120000. 8 interactions.
IntActQ9H3G5. 8 interactions.
MINTMINT-1162149.
STRING9606.ENSP00000265394.

Protein family/group databases

MEROPSS10.003.

PTM databases

PhosphoSiteQ9H3G5.

Polymorphism databases

DMDM67476930.

Proteomic databases

MaxQBQ9H3G5.
PaxDbQ9H3G5.
PeptideAtlasQ9H3G5.
PRIDEQ9H3G5.

Protocols and materials databases

DNASU54504.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265394; ENSP00000265394; ENSG00000106066.
ENST00000396276; ENSP00000379572; ENSG00000106066.
ENST00000409850; ENSP00000387164; ENSG00000106066.
GeneID54504.
KEGGhsa:54504.
UCSCuc003szv.3. human.

Organism-specific databases

CTD54504.
GeneCardsGC07M029001.
HGNCHGNC:14399. CPVL.
HPACAB003697.
MIM609780. gene.
neXtProtNX_Q9H3G5.
PharmGKBPA26850.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000252949.
HOVERGENHBG010805.
InParanoidQ9H3G5.
KOK09645.
OMAVSMPPKG.
OrthoDBEOG74XS6J.
PhylomeDBQ9H3G5.
TreeFamTF354323.

Gene expression databases

ArrayExpressQ9H3G5.
BgeeQ9H3G5.
CleanExHS_CPVL.
GenevestigatorQ9H3G5.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCPVL.
GenomeRNAi54504.
NextBio56863.
PROQ9H3G5.
SOURCESearch...

Entry information

Entry nameCPVL_HUMAN
AccessionPrimary (citable) accession number: Q9H3G5
Secondary accession number(s): A4D1A4 expand/collapse secondary AC list , Q6UX20, Q8NBL7, Q96AR7, Q9HB41
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM