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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei204PROSITE-ProRule annotation1
Active sitei388PROSITE-ProRule annotation1
Active sitei448PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERihuman-CPVL. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Alternative name(s):
Carboxypeptidase, vitellogenic-like
Vitellogenic carboxypeptidase-like protein
Short name:
VCP-like protein
Short name:
hVLP
Gene namesi
Name:CPVL
Synonyms:VLP
ORF Names:PSEC0124, UNQ197/PRO223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14399. CPVL.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54504.
OpenTargetsiENSG00000106066.
PharmGKBiPA26850.

Polymorphism and mutation databases

BioMutaiCPVL.
DMDMi67476930.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004281? – 476Probable serine carboxypeptidase CPVL
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000428023 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)1 Publication1
Glycosylationi132N-linked (GlcNAc...)1 Publication1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi346N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

EPDiQ9H3G5.
MaxQBiQ9H3G5.
PaxDbiQ9H3G5.
PeptideAtlasiQ9H3G5.
PRIDEiQ9H3G5.

PTM databases

iPTMnetiQ9H3G5.
PhosphoSitePlusiQ9H3G5.

Expressioni

Tissue specificityi

Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Gene expression databases

BgeeiENSG00000106066.
CleanExiHS_CPVL.
ExpressionAtlasiQ9H3G5. baseline and differential.
GenevisibleiQ9H3G5. HS.

Organism-specific databases

HPAiCAB003697.
HPA045715.
HPA056466.

Interactioni

Protein-protein interaction databases

BioGridi120000. 42 interactors.
IntActiQ9H3G5. 18 interactors.
MINTiMINT-1162149.
STRINGi9606.ENSP00000265394.

Structurei

3D structure databases

ProteinModelPortaliQ9H3G5.
SMRiQ9H3G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ9H3G5.
KOiK09645.
OMAiMVGAMWK.
OrthoDBiEOG091G08SS.
PhylomeDBiQ9H3G5.
TreeFamiTF354323.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE
60 70 80 90 100
AGKIQKGREL SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE
110 120 130 140 150
DAPVVLWLQG GPGGSSMFGL FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY
160 170 180 190 200
IDNPVGTGFS FTDDTHGYAV NEDDVARDLY SALIQFFQIF PEYKNNDFYV
210 220 230 240 250
TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS DPESIIGGYA
260 270 280 290 300
EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS
310 320 330 340 350
DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN
360 370 380 390 400
DGTIVEKYLR EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL
410 420 430 440 450
MGMDWKGSQE YKKAEKKVWK IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL
460 470
PYDQPLRAFD MINRFIYGKG WDPYVG
Length:476
Mass (Da):54,164
Last modified:June 7, 2005 - v2
Checksum:i33AA4A7360BF01E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284F → L in AAG37991 (PubMed:11401439).Curated1
Sequence conflicti284F → L in AAG14348 (Ref. 2) Curated1
Sequence conflicti287F → L in BAC11618 (PubMed:16303743).Curated1
Sequence conflicti422F → L in AAG14348 (Ref. 2) Curated1
Sequence conflicti438F → S in AAG14348 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04868111S → L.Corresponds to variant rs36074676dbSNPEnsembl.1
Natural variantiVAR_04868225R → H.1 PublicationCorresponds to variant rs34219043dbSNPEnsembl.1
Natural variantiVAR_048683398R → H.2 PublicationsCorresponds to variant rs1052200dbSNPEnsembl.1
Natural variantiVAR_022612435A → V.2 PublicationsCorresponds to variant rs7313dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA. Translation: AAG37991.2.
AF282617 mRNA. Translation: AAG14348.1.
AY358549 mRNA. Translation: AAQ88913.1.
AK075433 mRNA. Translation: BAC11618.1.
CH236948 Genomic DNA. Translation: EAL24207.1.
CH471073 Genomic DNA. Translation: EAW93914.1.
BC016838 mRNA. Translation: AAH16838.1.
CCDSiCCDS5419.1.
RefSeqiNP_061902.2. NM_019029.2.
NP_112601.3. NM_031311.3.
XP_011513739.1. XM_011515437.1.
UniGeneiHs.233389.

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066.
ENST00000396276; ENSP00000379572; ENSG00000106066.
ENST00000409850; ENSP00000387164; ENSG00000106066.
GeneIDi54504.
KEGGihsa:54504.
UCSCiuc003szv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA. Translation: AAG37991.2.
AF282617 mRNA. Translation: AAG14348.1.
AY358549 mRNA. Translation: AAQ88913.1.
AK075433 mRNA. Translation: BAC11618.1.
CH236948 Genomic DNA. Translation: EAL24207.1.
CH471073 Genomic DNA. Translation: EAW93914.1.
BC016838 mRNA. Translation: AAH16838.1.
CCDSiCCDS5419.1.
RefSeqiNP_061902.2. NM_019029.2.
NP_112601.3. NM_031311.3.
XP_011513739.1. XM_011515437.1.
UniGeneiHs.233389.

3D structure databases

ProteinModelPortaliQ9H3G5.
SMRiQ9H3G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120000. 42 interactors.
IntActiQ9H3G5. 18 interactors.
MINTiMINT-1162149.
STRINGi9606.ENSP00000265394.

Protein family/group databases

ESTHERihuman-CPVL. Carboxypeptidase_S10.
MEROPSiS10.003.

PTM databases

iPTMnetiQ9H3G5.
PhosphoSitePlusiQ9H3G5.

Polymorphism and mutation databases

BioMutaiCPVL.
DMDMi67476930.

Proteomic databases

EPDiQ9H3G5.
MaxQBiQ9H3G5.
PaxDbiQ9H3G5.
PeptideAtlasiQ9H3G5.
PRIDEiQ9H3G5.

Protocols and materials databases

DNASUi54504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066.
ENST00000396276; ENSP00000379572; ENSG00000106066.
ENST00000409850; ENSP00000387164; ENSG00000106066.
GeneIDi54504.
KEGGihsa:54504.
UCSCiuc003szv.4. human.

Organism-specific databases

CTDi54504.
DisGeNETi54504.
GeneCardsiCPVL.
HGNCiHGNC:14399. CPVL.
HPAiCAB003697.
HPA045715.
HPA056466.
MIMi609780. gene.
neXtProtiNX_Q9H3G5.
OpenTargetsiENSG00000106066.
PharmGKBiPA26850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ9H3G5.
KOiK09645.
OMAiMVGAMWK.
OrthoDBiEOG091G08SS.
PhylomeDBiQ9H3G5.
TreeFamiTF354323.

Miscellaneous databases

ChiTaRSiCPVL. human.
GeneWikiiCPVL.
GenomeRNAii54504.
PROiQ9H3G5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106066.
CleanExiHS_CPVL.
ExpressionAtlasiQ9H3G5. baseline and differential.
GenevisibleiQ9H3G5. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPVL_HUMAN
AccessioniPrimary (citable) accession number: Q9H3G5
Secondary accession number(s): A4D1A4
, Q6UX20, Q8NBL7, Q96AR7, Q9HB41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.