SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H3G5

- CPVL_HUMAN

UniProt

Q9H3G5 - CPVL_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable serine carboxypeptidase CPVL
Gene
CPVL, VLP, PSEC0124, UNQ197/PRO223
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041 By similarity
Active sitei388 – 3881 By similarity
Active sitei448 – 4481 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
    Alternative name(s):
    Carboxypeptidase, vitellogenic-like
    Vitellogenic carboxypeptidase-like protein
    Short name:
    VCP-like protein
    Short name:
    hVLP
    Gene namesi
    Name:CPVL
    Synonyms:VLP
    ORF Names:PSEC0124, UNQ197/PRO223
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14399. CPVL.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    Complete GO annotation...

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26850.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 476Probable serine carboxypeptidase CPVLPRO_0000004281
    Signal peptidei1 – 2222 Reviewed prediction
    Add
    BLAST
    Propeptidei23 – ? Reviewed predictionPRO_0000004280

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)1 Publication
    Glycosylationi132 – 1321N-linked (GlcNAc...)1 Publication
    Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi346 – 3461N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiQ9H3G5.
    PaxDbiQ9H3G5.
    PeptideAtlasiQ9H3G5.
    PRIDEiQ9H3G5.

    PTM databases

    PhosphoSiteiQ9H3G5.

    Expressioni

    Tissue specificityi

    Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

    Gene expression databases

    ArrayExpressiQ9H3G5.
    BgeeiQ9H3G5.
    CleanExiHS_CPVL.
    GenevestigatoriQ9H3G5.

    Organism-specific databases

    HPAiCAB003697.

    Interactioni

    Protein-protein interaction databases

    BioGridi120000. 7 interactions.
    IntActiQ9H3G5. 8 interactions.
    MINTiMINT-1162149.
    STRINGi9606.ENSP00000265394.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H3G5.
    SMRiQ9H3G5. Positions 57-466.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000252949.
    HOVERGENiHBG010805.
    InParanoidiQ9H3G5.
    KOiK09645.
    OMAiVSMPPKG.
    OrthoDBiEOG74XS6J.
    PhylomeDBiQ9H3G5.
    TreeFamiTF354323.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H3G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE    50
    AGKIQKGREL SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE 100
    DAPVVLWLQG GPGGSSMFGL FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY 150
    IDNPVGTGFS FTDDTHGYAV NEDDVARDLY SALIQFFQIF PEYKNNDFYV 200
    TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS DPESIIGGYA 250
    EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS 300
    DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN 350
    DGTIVEKYLR EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL 400
    MGMDWKGSQE YKKAEKKVWK IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL 450
    PYDQPLRAFD MINRFIYGKG WDPYVG 476
    Length:476
    Mass (Da):54,164
    Last modified:June 7, 2005 - v2
    Checksum:i33AA4A7360BF01E1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111S → L.
    Corresponds to variant rs36074676 [ dbSNP | Ensembl ].
    VAR_048681
    Natural varianti25 – 251R → H.1 Publication
    Corresponds to variant rs34219043 [ dbSNP | Ensembl ].
    VAR_048682
    Natural varianti398 – 3981R → H.2 Publications
    Corresponds to variant rs1052200 [ dbSNP | Ensembl ].
    VAR_048683
    Natural varianti435 – 4351A → V.2 Publications
    Corresponds to variant rs7313 [ dbSNP | Ensembl ].
    VAR_022612

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti284 – 2841F → L in AAG37991. 1 Publication
    Sequence conflicti284 – 2841F → L in AAG14348. 1 Publication
    Sequence conflicti287 – 2871F → L in BAC11618. 1 Publication
    Sequence conflicti422 – 4221F → L in AAG14348. 1 Publication
    Sequence conflicti438 – 4381F → S in AAG14348. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF106704 mRNA. Translation: AAG37991.2.
    AF282617 mRNA. Translation: AAG14348.1.
    AY358549 mRNA. Translation: AAQ88913.1.
    AK075433 mRNA. Translation: BAC11618.1.
    CH236948 Genomic DNA. Translation: EAL24207.1.
    CH471073 Genomic DNA. Translation: EAW93914.1.
    BC016838 mRNA. Translation: AAH16838.1.
    CCDSiCCDS5419.1.
    RefSeqiNP_061902.2. NM_019029.2.
    NP_112601.3. NM_031311.3.
    XP_005249843.1. XM_005249786.1.
    UniGeneiHs.233389.

    Genome annotation databases

    EnsembliENST00000265394; ENSP00000265394; ENSG00000106066.
    ENST00000396276; ENSP00000379572; ENSG00000106066.
    ENST00000409850; ENSP00000387164; ENSG00000106066.
    GeneIDi54504.
    KEGGihsa:54504.
    UCSCiuc003szv.3. human.

    Polymorphism databases

    DMDMi67476930.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF106704 mRNA. Translation: AAG37991.2 .
    AF282617 mRNA. Translation: AAG14348.1 .
    AY358549 mRNA. Translation: AAQ88913.1 .
    AK075433 mRNA. Translation: BAC11618.1 .
    CH236948 Genomic DNA. Translation: EAL24207.1 .
    CH471073 Genomic DNA. Translation: EAW93914.1 .
    BC016838 mRNA. Translation: AAH16838.1 .
    CCDSi CCDS5419.1.
    RefSeqi NP_061902.2. NM_019029.2.
    NP_112601.3. NM_031311.3.
    XP_005249843.1. XM_005249786.1.
    UniGenei Hs.233389.

    3D structure databases

    ProteinModelPortali Q9H3G5.
    SMRi Q9H3G5. Positions 57-466.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 120000. 7 interactions.
    IntActi Q9H3G5. 8 interactions.
    MINTi MINT-1162149.
    STRINGi 9606.ENSP00000265394.

    Protein family/group databases

    MEROPSi S10.003.

    PTM databases

    PhosphoSitei Q9H3G5.

    Polymorphism databases

    DMDMi 67476930.

    Proteomic databases

    MaxQBi Q9H3G5.
    PaxDbi Q9H3G5.
    PeptideAtlasi Q9H3G5.
    PRIDEi Q9H3G5.

    Protocols and materials databases

    DNASUi 54504.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265394 ; ENSP00000265394 ; ENSG00000106066 .
    ENST00000396276 ; ENSP00000379572 ; ENSG00000106066 .
    ENST00000409850 ; ENSP00000387164 ; ENSG00000106066 .
    GeneIDi 54504.
    KEGGi hsa:54504.
    UCSCi uc003szv.3. human.

    Organism-specific databases

    CTDi 54504.
    GeneCardsi GC07M029001.
    HGNCi HGNC:14399. CPVL.
    HPAi CAB003697.
    MIMi 609780. gene.
    neXtProti NX_Q9H3G5.
    PharmGKBi PA26850.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000252949.
    HOVERGENi HBG010805.
    InParanoidi Q9H3G5.
    KOi K09645.
    OMAi VSMPPKG.
    OrthoDBi EOG74XS6J.
    PhylomeDBi Q9H3G5.
    TreeFami TF354323.

    Miscellaneous databases

    GeneWikii CPVL.
    GenomeRNAii 54504.
    NextBioi 56863.
    PROi Q9H3G5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H3G5.
    Bgeei Q9H3G5.
    CleanExi HS_CPVL.
    Genevestigatori Q9H3G5.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages."
      Mahoney J.A., Ntolosi B., DaSilva R.P., Gordon S., McKnight A.J.
      Genomics 72:243-251(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-398.
    2. "Cloning of VCP-like protein expressed in human heart and placenta."
      Cho J.-J., Baik H.-H.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-25 AND HIS-398.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435.
      Tissue: Placenta.
    5. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435.
      Tissue: Lung.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-132 AND ASN-346.
      Tissue: Liver.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCPVL_HUMAN
    AccessioniPrimary (citable) accession number: Q9H3G5
    Secondary accession number(s): A4D1A4
    , Q6UX20, Q8NBL7, Q96AR7, Q9HB41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: June 7, 2005
    Last modified: September 3, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi