Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041PROSITE-ProRule annotation
Active sitei388 – 3881PROSITE-ProRule annotation
Active sitei448 – 4481PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Alternative name(s):
Carboxypeptidase, vitellogenic-like
Vitellogenic carboxypeptidase-like protein
Short name:
VCP-like protein
Short name:
hVLP
Gene namesi
Name:CPVL
Synonyms:VLP
ORF Names:PSEC0124, UNQ197/PRO223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:14399. CPVL.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 476Probable serine carboxypeptidase CPVLPRO_0000004281
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – ?Sequence AnalysisPRO_0000004280

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)1 Publication
Glycosylationi132 – 1321N-linked (GlcNAc...)1 Publication
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi346 – 3461N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9H3G5.
PaxDbiQ9H3G5.
PeptideAtlasiQ9H3G5.
PRIDEiQ9H3G5.

PTM databases

PhosphoSiteiQ9H3G5.

Expressioni

Tissue specificityi

Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.

Gene expression databases

BgeeiQ9H3G5.
CleanExiHS_CPVL.
ExpressionAtlasiQ9H3G5. baseline and differential.
GenevestigatoriQ9H3G5.

Organism-specific databases

HPAiCAB003697.
HPA045715.
HPA056466.

Interactioni

Protein-protein interaction databases

BioGridi120000. 24 interactions.
IntActiQ9H3G5. 8 interactions.
MINTiMINT-1162149.
STRINGi9606.ENSP00000265394.

Structurei

3D structure databases

ProteinModelPortaliQ9H3G5.
SMRiQ9H3G5. Positions 66-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
GeneTreeiENSGT00770000120552.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ9H3G5.
KOiK09645.
OMAiVSMPPKG.
OrthoDBiEOG74XS6J.
PhylomeDBiQ9H3G5.
TreeFamiTF354323.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H3G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAMWKVIV SLVLLMPGPC DGLFRSLYRS VSMPPKGDSG QPLFLTPYIE
60 70 80 90 100
AGKIQKGREL SLVGPFPGLN MKSYAGFLTV NKTYNSNLFF WFFPAQIQPE
110 120 130 140 150
DAPVVLWLQG GPGGSSMFGL FVEHGPYVVT SNMTLRDRDF PWTTTLSMLY
160 170 180 190 200
IDNPVGTGFS FTDDTHGYAV NEDDVARDLY SALIQFFQIF PEYKNNDFYV
210 220 230 240 250
TGESYAGKYV PAIAHLIHSL NPVREVKINL NGIAIGDGYS DPESIIGGYA
260 270 280 290 300
EFLYQIGLLD EKQKKYFQKQ CHECIEHIRK QNWFEAFEIL DKLLDGDLTS
310 320 330 340 350
DPSYFQNVTG CSNYYNFLRC TEPEDQLYYV KFLSLPEVRQ AIHVGNQTFN
360 370 380 390 400
DGTIVEKYLR EDTVQSVKPW LTEIMNNYKV LIYNGQLDII VAAALTERSL
410 420 430 440 450
MGMDWKGSQE YKKAEKKVWK IFKSDSEVAG YIRQAGDFHQ VIIRGGGHIL
460 470
PYDQPLRAFD MINRFIYGKG WDPYVG
Length:476
Mass (Da):54,164
Last modified:June 7, 2005 - v2
Checksum:i33AA4A7360BF01E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti284 – 2841F → L in AAG37991 (PubMed:11401439).Curated
Sequence conflicti284 – 2841F → L in AAG14348 (Ref. 2) Curated
Sequence conflicti287 – 2871F → L in BAC11618 (PubMed:16303743).Curated
Sequence conflicti422 – 4221F → L in AAG14348 (Ref. 2) Curated
Sequence conflicti438 – 4381F → S in AAG14348 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111S → L.
Corresponds to variant rs36074676 [ dbSNP | Ensembl ].
VAR_048681
Natural varianti25 – 251R → H.1 Publication
Corresponds to variant rs34219043 [ dbSNP | Ensembl ].
VAR_048682
Natural varianti398 – 3981R → H.2 Publications
Corresponds to variant rs1052200 [ dbSNP | Ensembl ].
VAR_048683
Natural varianti435 – 4351A → V.2 Publications
Corresponds to variant rs7313 [ dbSNP | Ensembl ].
VAR_022612

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA. Translation: AAG37991.2.
AF282617 mRNA. Translation: AAG14348.1.
AY358549 mRNA. Translation: AAQ88913.1.
AK075433 mRNA. Translation: BAC11618.1.
CH236948 Genomic DNA. Translation: EAL24207.1.
CH471073 Genomic DNA. Translation: EAW93914.1.
BC016838 mRNA. Translation: AAH16838.1.
CCDSiCCDS5419.1.
RefSeqiNP_061902.2. NM_019029.2.
NP_112601.3. NM_031311.3.
XP_005249843.1. XM_005249786.1.
UniGeneiHs.233389.

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066.
ENST00000396276; ENSP00000379572; ENSG00000106066.
ENST00000409850; ENSP00000387164; ENSG00000106066.
GeneIDi54504.
KEGGihsa:54504.
UCSCiuc003szv.3. human.

Polymorphism databases

DMDMi67476930.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106704 mRNA. Translation: AAG37991.2.
AF282617 mRNA. Translation: AAG14348.1.
AY358549 mRNA. Translation: AAQ88913.1.
AK075433 mRNA. Translation: BAC11618.1.
CH236948 Genomic DNA. Translation: EAL24207.1.
CH471073 Genomic DNA. Translation: EAW93914.1.
BC016838 mRNA. Translation: AAH16838.1.
CCDSiCCDS5419.1.
RefSeqiNP_061902.2. NM_019029.2.
NP_112601.3. NM_031311.3.
XP_005249843.1. XM_005249786.1.
UniGeneiHs.233389.

3D structure databases

ProteinModelPortaliQ9H3G5.
SMRiQ9H3G5. Positions 66-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120000. 24 interactions.
IntActiQ9H3G5. 8 interactions.
MINTiMINT-1162149.
STRINGi9606.ENSP00000265394.

Protein family/group databases

MEROPSiS10.003.

PTM databases

PhosphoSiteiQ9H3G5.

Polymorphism databases

DMDMi67476930.

Proteomic databases

MaxQBiQ9H3G5.
PaxDbiQ9H3G5.
PeptideAtlasiQ9H3G5.
PRIDEiQ9H3G5.

Protocols and materials databases

DNASUi54504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265394; ENSP00000265394; ENSG00000106066.
ENST00000396276; ENSP00000379572; ENSG00000106066.
ENST00000409850; ENSP00000387164; ENSG00000106066.
GeneIDi54504.
KEGGihsa:54504.
UCSCiuc003szv.3. human.

Organism-specific databases

CTDi54504.
GeneCardsiGC07M029001.
HGNCiHGNC:14399. CPVL.
HPAiCAB003697.
HPA045715.
HPA056466.
MIMi609780. gene.
neXtProtiNX_Q9H3G5.
PharmGKBiPA26850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2939.
GeneTreeiENSGT00770000120552.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ9H3G5.
KOiK09645.
OMAiVSMPPKG.
OrthoDBiEOG74XS6J.
PhylomeDBiQ9H3G5.
TreeFamiTF354323.

Miscellaneous databases

ChiTaRSiCPVL. human.
GeneWikiiCPVL.
GenomeRNAii54504.
NextBioi56863.
PROiQ9H3G5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H3G5.
CleanExiHS_CPVL.
ExpressionAtlasiQ9H3G5. baseline and differential.
GenevestigatoriQ9H3G5.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages."
    Mahoney J.A., Ntolosi B., DaSilva R.P., Gordon S., McKnight A.J.
    Genomics 72:243-251(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-398.
  2. "Cloning of VCP-like protein expressed in human heart and placenta."
    Cho J.-J., Baik H.-H.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-25 AND HIS-398.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435.
    Tissue: Placenta.
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-435.
    Tissue: Lung.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-132 AND ASN-346.
    Tissue: Liver.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCPVL_HUMAN
AccessioniPrimary (citable) accession number: Q9H3G5
Secondary accession number(s): A4D1A4
, Q6UX20, Q8NBL7, Q96AR7, Q9HB41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 7, 2005
Last modified: March 4, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.