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Protein

Sorting nexin-25

Gene

SNX25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • receptor catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-25
Gene namesi
Name:SNX25
ORF Names:MSTP043
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:21883. SNX25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988505.

Polymorphism and mutation databases

BioMutaiSNX25.
DMDMi212276473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Sorting nexin-25PRO_0000213875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei665 – 6651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H3E2.
MaxQBiQ9H3E2.
PaxDbiQ9H3E2.
PeptideAtlasiQ9H3E2.
PRIDEiQ9H3E2.

PTM databases

iPTMnetiQ9H3E2.

Expressioni

Gene expression databases

BgeeiQ9H3E2.
CleanExiHS_SNX25.
ExpressionAtlasiQ9H3E2. baseline and differential.
GenevisibleiQ9H3E2. HS.

Organism-specific databases

HPAiHPA036928.

Interactioni

Protein-protein interaction databases

BioGridi123802. 5 interactions.
IntActiQ9H3E2. 1 interaction.
STRINGi9606.ENSP00000264694.

Structurei

3D structure databases

ProteinModelPortaliQ9H3E2.
SMRiQ9H3E2. Positions 289-401, 506-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 164164PXAPROSITE-ProRule annotationAdd
BLAST
Domaini287 – 401115RGSPROSITE-ProRule annotationAdd
BLAST
Domaini508 – 628121PXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili434 – 49966Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 PXA domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2101. Eukaryota.
ENOG410XQM8. LUCA.
GeneTreeiENSGT00800000124081.
HOGENOMiHOG000047059.
HOVERGENiHBG066560.
InParanoidiQ9H3E2.
KOiK17887.
OMAiYNKQLFY.
OrthoDBiEOG7B8S39.
PhylomeDBiQ9H3E2.
TreeFamiTF324055.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR016137. RGS.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKALKEVFD YSYRDYILSW YGNLSRDEGQ LYHLLLEDFW EIARQLHHRL
60 70 80 90 100
SHVDVVKVVC NDVVRTLLTH FCDLKAANAR HEEQPRPFVL HACLRNSDDE
110 120 130 140 150
VRFLQTCSRV LVFCLLPSKD VQSLSLRIML AEILTTKVLK PVVELLSNPD
160 170 180 190 200
YINQMLLAQL AYREQMNEHH KRAYTYAPSY EDFIKLINSN SDVEFLKQLR
210 220 230 240 250
YQIVVEIIQA TTISSFPQLK RHKGKETAAM KADLLRARNM KRYINQLTVA
260 270 280 290 300
KKQCEKRIRI LGGPAYDQQE DGALDEGEGP QSQKILQFED ILANTFYREH
310 320 330 340 350
FGMYMERMDK RALISFWESV EHLKNANKNE IPQLVGEIYQ NFFVESKEIS
360 370 380 390 400
VEKSLYKEIQ QCLVGNKGIE VFYKIQEDVY ETLKDRYYPS FIVSDLYEKL
410 420 430 440 450
LIKEEEKHAS QMISNKDEMG PRDEAGEEAV DDGTNQINEQ ASFAVNKLRE
460 470 480 490 500
LNEKLEYKRQ ALNSIQNAPK PDKKIVSKLK DEIILIEKER TDLQLHMART
510 520 530 540 550
DWWCENLGMW KASITSGEVT EENGEQLPCY FVMVSLQEVG GVETKNWTVP
560 570 580 590 600
RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDQKF MEKSKNQLNK
610 620 630 640 650
FLQNLLSDER LCQSEALYAF LSPSPDYLKV IDVQGKKNSF SLSSFLERLP
660 670 680 690 700
RDFFSHQEEE TEEDSDLSDY GDDVDGRKDA LAEPCFMLIG EIFELRGMFK
710 720 730 740 750
WVRRTLIALV QVTFGRTINK QIRDTVSWIF SEQMLVYYIN IFRDAFWPNG
760 770 780 790 800
KLAPPTTIRS KEQSQETKQR AQQKLLENIP DMLQSLVGQQ NARHGIIKIF
810 820 830 840
NALQETRANK HLLYALMELL LIELCPELRV HLDQLKAGQV
Length:840
Mass (Da):97,945
Last modified:November 4, 2008 - v2
Checksum:iD75682A660DEF124
GO
Isoform 2 (identifier: Q9H3E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     604-658: Missing.

Note: No experimental confirmation available.
Show »
Length:556
Mass (Da):64,759
Checksum:iC9676ACAC559E122
GO

Sequence cautioni

The sequence AAG39294.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti318 – 3181E → K.
Corresponds to variant rs35700132 [ dbSNP | Ensembl ].
VAR_047057
Natural varianti586 – 5861I → V.
Corresponds to variant rs3756275 [ dbSNP | Ensembl ].
VAR_047058
Natural varianti725 – 7251T → I.
Corresponds to variant rs34120554 [ dbSNP | Ensembl ].
VAR_047059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 229229Missing in isoform 2. 1 PublicationVSP_057156Add
BLAST
Alternative sequencei604 – 65855Missing in isoform 2. 1 PublicationVSP_057157Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601647 mRNA. Translation: AAT98627.1.
BC029868 mRNA. Translation: AAH29868.2.
AF113223 mRNA. Translation: AAG39294.1. Different initiation.
AY044656 mRNA. Translation: AAK98770.1.
CCDSiCCDS34116.1. [Q9H3E2-1]
RefSeqiNP_001304710.1. NM_001317781.1. [Q9H3E2-1]
UniGeneiHs.369091.

Genome annotation databases

EnsembliENST00000264694; ENSP00000264694; ENSG00000109762. [Q9H3E2-1]
ENST00000504273; ENSP00000426255; ENSG00000109762. [Q9H3E2-1]
ENST00000618785; ENSP00000483653; ENSG00000109762. [Q9H3E2-2]
GeneIDi83891.
KEGGihsa:83891.
UCSCiuc003ixh.4. human. [Q9H3E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601647 mRNA. Translation: AAT98627.1.
BC029868 mRNA. Translation: AAH29868.2.
AF113223 mRNA. Translation: AAG39294.1. Different initiation.
AY044656 mRNA. Translation: AAK98770.1.
CCDSiCCDS34116.1. [Q9H3E2-1]
RefSeqiNP_001304710.1. NM_001317781.1. [Q9H3E2-1]
UniGeneiHs.369091.

3D structure databases

ProteinModelPortaliQ9H3E2.
SMRiQ9H3E2. Positions 289-401, 506-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123802. 5 interactions.
IntActiQ9H3E2. 1 interaction.
STRINGi9606.ENSP00000264694.

PTM databases

iPTMnetiQ9H3E2.

Polymorphism and mutation databases

BioMutaiSNX25.
DMDMi212276473.

Proteomic databases

EPDiQ9H3E2.
MaxQBiQ9H3E2.
PaxDbiQ9H3E2.
PeptideAtlasiQ9H3E2.
PRIDEiQ9H3E2.

Protocols and materials databases

DNASUi83891.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264694; ENSP00000264694; ENSG00000109762. [Q9H3E2-1]
ENST00000504273; ENSP00000426255; ENSG00000109762. [Q9H3E2-1]
ENST00000618785; ENSP00000483653; ENSG00000109762. [Q9H3E2-2]
GeneIDi83891.
KEGGihsa:83891.
UCSCiuc003ixh.4. human. [Q9H3E2-1]

Organism-specific databases

CTDi83891.
GeneCardsiSNX25.
HGNCiHGNC:21883. SNX25.
HPAiHPA036928.
neXtProtiNX_Q9H3E2.
PharmGKBiPA134988505.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2101. Eukaryota.
ENOG410XQM8. LUCA.
GeneTreeiENSGT00800000124081.
HOGENOMiHOG000047059.
HOVERGENiHBG066560.
InParanoidiQ9H3E2.
KOiK17887.
OMAiYNKQLFY.
OrthoDBiEOG7B8S39.
PhylomeDBiQ9H3E2.
TreeFamiTF324055.

Miscellaneous databases

GenomeRNAii83891.
PROiQ9H3E2.

Gene expression databases

BgeeiQ9H3E2.
CleanExiHS_SNX25.
ExpressionAtlasiQ9H3E2. baseline and differential.
GenevisibleiQ9H3E2. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR016137. RGS.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hao X., Chang Z., Zhu S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 275-840 (ISOFORM 1).
    Tissue: Heart.
  4. "MSTP043 as a new member (SNX25) of the sorting nexin family."
    Hong W.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 303-840 (ISOFORM 1).
  5. Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSNX25_HUMAN
AccessioniPrimary (citable) accession number: Q9H3E2
Secondary accession number(s): Q3ZT30, Q8N6K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 4, 2008
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.