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Protein
Submitted name:

Fibulin-like extracellular matrix protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Fibulin-like extracellular matrix proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500432793528 – 443Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi207 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ9H3D5.
PeptideAtlasiQ9H3D5.
PRIDEiQ9H3D5.

Expressioni

Gene expression databases

GenevisibleiQ9H3D5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309953.

Structurei

3D structure databases

ProteinModelPortaliQ9H3D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 163EGF-likeInterPro annotationAdd BLAST41
Domaini164 – 202EGF-likeInterPro annotationAdd BLAST39
Domaini203 – 238EGF-likeInterPro annotationAdd BLAST36
Domaini243 – 282EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6U. Eukaryota.
ENOG410ZNNG. LUCA.
HOVERGENiHBG051560.
KOiK19866.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR026824. Efemp2.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PANTHERiPTHR24044:SF379. PTHR24044:SF379. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 6 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9H3D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPCASCLPG SLLLWALLLL LLGSASPQDS EEPDSYTECT DGYEWDPDSQ
60 70 80 90 100
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVIND LHGEGPPPPV
110 120 130 140 150
PPAQHPNPCP PGYEPDDQDS CVDVDECAQA LHDRRPSQDC HNLSGSYQCT
160 170 180 190 200
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS
210 220 230 240 250
CVDVNECDMG APCEQRCFNS YGTFLCRCHQ GYELHRDGFS CSDIDECSYS
260 270 280 290 300
SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECESG AHQCSEAQTC
310 320 330 340 350
VNFHGGYRCV DTNRCVEPYI QVSENRCLCP ASNPLCREQP SSIVHRYMTI
360 370 380 390 400
TSERMRPADV FQIQATSVYP GAYNAFQIRA GNSQGDFYIR QINNVSAMLV
410 420 430 440
LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF
Length:443
Mass (Da):49,536
Last modified:March 1, 2001 - v1
Checksum:iD91784BF36A8A060
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124486 mRNA. Translation: AAG45245.1.
RefSeqiNP_058634.4. NM_016938.4.
UniGeneiHs.731454.

Genome annotation databases

GeneIDi30008.
KEGGihsa:30008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124486 mRNA. Translation: AAG45245.1.
RefSeqiNP_058634.4. NM_016938.4.
UniGeneiHs.731454.

3D structure databases

ProteinModelPortaliQ9H3D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309953.

Proteomic databases

PaxDbiQ9H3D5.
PeptideAtlasiQ9H3D5.
PRIDEiQ9H3D5.

Protocols and materials databases

DNASUi30008.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30008.
KEGGihsa:30008.

Organism-specific databases

CTDi30008.

Phylogenomic databases

eggNOGiENOG410IR6U. Eukaryota.
ENOG410ZNNG. LUCA.
HOVERGENiHBG051560.
KOiK19866.

Miscellaneous databases

GenomeRNAii30008.

Gene expression databases

GenevisibleiQ9H3D5. HS.

Family and domain databases

InterProiView protein in InterPro
IPR026823. cEGF.
IPR026824. Efemp2.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
PANTHERiPTHR24044:SF379. PTHR24044:SF379. 1 hit.
PfamiView protein in Pfam
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 3 hits.
SMARTiView protein in SMART
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 6 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9H3D5_HUMAN
AccessioniPrimary (citable) accession number: Q9H3D5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: April 12, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.