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Protein

Tumor protein 63

Gene

TP63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.7 Publications

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi244ZincBy similarity1
Metal bindingi247ZincBy similarity1
Metal bindingi308ZincBy similarity1
Metal bindingi312ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi170 – 362Add BLAST193

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Apoptosis, Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-139915. Activation of PUMA and translocation to mitochondria.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
R-HSA-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
R-HSA-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.
R-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
R-HSA-6804759. Regulation of TP53 Activity through Association with Co-factors.
SignaLinkiQ9H3D4.
SIGNORiQ9H3D4.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein 63
Short name:
p63
Alternative name(s):
Chronic ulcerative stomatitis protein
Short name:
CUSP
Keratinocyte transcription factor KET
Transformation-related protein 63
Short name:
TP63
Tumor protein p73-like
Short name:
p73L
p40
p51
Gene namesi
Name:TP63
Synonyms:KET, P63, P73H, P73L, TP73L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:15979. TP63.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: GO_Central
  • dendrite Source: GO_Central
  • mitochondrion Source: GOC
  • nuclear chromatin Source: BHF-UCL
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • rough endoplasmic reticulum Source: Ensembl
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting.
See also OMIM:103285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020875337R → Q in ADULT syndrome; confers novel transcription activation capacity on isoform 6. 1 PublicationCorresponds to variant rs113993967dbSNPEnsembl.1
Isoform 2 (identifier: Q9H3D4-2)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 4 (identifier: Q9H3D4-4)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 6 (identifier: Q9H3D4-6)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 8 (identifier: Q9H3D4-8)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 10 (identifier: Q9H3D4-10)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 12 (identifier: Q9H3D4-12)
Natural varianti6N → H in ADULT syndrome. 1
Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate.
See also OMIM:106260
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020879553L → F in AEC. 1 PublicationCorresponds to variant rs121908842dbSNPEnsembl.1
Natural variantiVAR_020881561C → G in AEC. 1 PublicationCorresponds to variant rs121908843dbSNPEnsembl.1
Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting.
See also OMIM:604292
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020870243R → Q in EEC3. 2 PublicationsCorresponds to variant rs121908836dbSNPEnsembl.1
Natural variantiVAR_020871243R → W in EEC3. 2 PublicationsCorresponds to variant rs121908835dbSNPEnsembl.1
Natural variantiVAR_032738266R → Q in EEC3. 1 PublicationCorresponds to variant rs121908849dbSNPEnsembl.1
Natural variantiVAR_032739308C → Y in EEC3. 1 Publication1
Natural variantiVAR_032740311S → N in EEC3. 1 Publication1
Natural variantiVAR_032741318R → C in EEC3. 1 Publication1
Natural variantiVAR_020873318R → H in EEC3 and EDRH; does not decrease the transcriptional activity of the isoform 5 on a TP53 reporter system but disrupts the dominant-negative activity of isoform 2 and isoform 5 on the transcriptional activity of TP53. 3 PublicationsCorresponds to variant rs121908840dbSNPEnsembl.1
Natural variantiVAR_032742318R → Q in EEC3. 1 Publication1
Natural variantiVAR_020874319R → C in EEC3. 2 PublicationsCorresponds to variant rs121908839dbSNPEnsembl.1
Natural variantiVAR_032743319R → H in EEC3 and SHFM4. 1 Publication1
Natural variantiVAR_032744319R → S in EEC3. 1 Publication1
Natural variantiVAR_020876343R → Q in EEC3. 2 PublicationsCorresponds to variant rs121908841dbSNPEnsembl.1
Natural variantiVAR_032745343R → W in EEC3. 1 Publication1
Natural variantiVAR_020877345C → R in EEC3; abolishes transcription activation. 2 PublicationsCorresponds to variant rs121908837dbSNPEnsembl.1
Natural variantiVAR_032746347C → S in EEC3. 1 Publication1
Natural variantiVAR_032747348P → S in EEC3. 1 Publication1
Natural variantiVAR_020878351D → G in EEC3. 1 PublicationCorresponds to variant rs121908844dbSNPEnsembl.1
Natural variantiVAR_032748351D → H in EEC3. 1 Publication1
Split-hand/foot malformation 4 (SHFM4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.
See also OMIM:605289
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032736193T → TP in SHFM4. 1 Publication1
Natural variantiVAR_032737232K → E in SHFM4. 1 Publication1
Natural variantiVAR_020869233K → E in SHFM4. 1 PublicationCorresponds to variant rs121908838dbSNPEnsembl.1
Natural variantiVAR_032743319R → H in EEC3 and SHFM4. 1 Publication1
Limb-mammary syndrome (LMS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by ectrodactyly, cleft palate and mammary-gland abnormalities.
See also OMIM:603543

Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers.

Ectodermal dysplasia, Rapp-Hodgkin type (EDRH)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate.
See also OMIM:129400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020873318R → H in EEC3 and EDRH; does not decrease the transcriptional activity of the isoform 5 on a TP53 reporter system but disrupts the dominant-negative activity of isoform 2 and isoform 5 on the transcriptional activity of TP53. 3 PublicationsCorresponds to variant rs121908840dbSNPEnsembl.1
Natural variantiVAR_035127352R → G in EDRH and OFC8. 1 PublicationCorresponds to variant rs121908847dbSNPEnsembl.1
Natural variantiVAR_035128549I → T in EDRH. 1 PublicationCorresponds to variant rs121908845dbSNPEnsembl.1
Natural variantiVAR_035129580S → P in EDRH. 1 PublicationCorresponds to variant rs121908846dbSNPEnsembl.1
Non-syndromic orofacial cleft 8 (OFC8)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
See also OMIM:129400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035127352R → G in EDRH and OFC8. 1 PublicationCorresponds to variant rs121908847dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi55F → A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-59 and A-62. 1 Publication1
Mutagenesisi59W → A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-55 and A-62. 1 Publication1
Mutagenesisi62L → A: Abrogates transcriptional activity and interaction with transactivation inhibition domain; when associated with A-55 and A-59. 1 Publication1
Mutagenesisi543Y → F: Abolishes ubiquitination. 1 Publication1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia

Organism-specific databases

DisGeNETi8626.
MalaCardsiTP63.
MIMi103285. phenotype.
106260. phenotype.
129400. phenotype.
603543. phenotype.
604292. phenotype.
605289. phenotype.
OpenTargetsiENSG00000073282.
Orphaneti978. ADULT syndrome.
1071. Ankyloblepharon - ectodermal defects - cleft lip/palate.
93930. Bladder exstrophy.
1991. Cleft lip with or without cleft palate.
1896. EEC syndrome.
69085. Limb-mammary syndrome.
2440. Split hand-split foot malformation.
PharmGKBiPA162406776.

Polymorphism and mutation databases

BioMutaiTP63.
DMDMi57013009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857291 – 680Tumor protein 63Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

May be sumoylated.By similarity
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9H3D4.
PaxDbiQ9H3D4.
PeptideAtlasiQ9H3D4.
PRIDEiQ9H3D4.

PTM databases

iPTMnetiQ9H3D4.
PhosphoSitePlusiQ9H3D4.

Expressioni

Tissue specificityi

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.2 Publications

Gene expression databases

BgeeiENSG00000073282.
ExpressionAtlasiQ9H3D4. baseline and differential.
GenevisibleiQ9H3D4. HS.

Organism-specific databases

HPAiCAB000083.
HPA006288.
HPA007010.

Interactioni

Subunit structurei

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CABLES1Q8TDN47EBI-2400586,EBI-604615
FUSP356372EBI-2337775,EBI-400434
HNRNPKP619782EBI-2337775,EBI-304185
NIPSNAP3AQ9UFN02EBI-2337775,EBI-716291
PRKCDQ056552EBI-2337775,EBI-704279
SATB2Q9UPW65EBI-6481107,EBI-8298169
SMAD2Q157963EBI-2337775,EBI-1040141
TP53P046375EBI-2337775,EBI-366083

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • p53 binding Source: GO_Central
  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114181. 127 interactors.
DIPiDIP-29588N.
IntActiQ9H3D4. 70 interactors.
MINTiMINT-190238.
STRINGi9606.ENSP00000264731.

Structurei

Secondary structure

1680
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi156 – 161Combined sources6
Helixi173 – 175Combined sources3
Beta strandi178 – 180Combined sources3
Beta strandi187 – 189Combined sources3
Beta strandi191 – 195Combined sources5
Turni196 – 199Combined sources4
Beta strandi200 – 203Combined sources4
Beta strandi209 – 214Combined sources6
Beta strandi224 – 233Combined sources10
Turni234 – 238Combined sources5
Helixi245 – 249Combined sources5
Turni252 – 256Combined sources5
Beta strandi263 – 269Combined sources7
Beta strandi274 – 277Combined sources4
Turni279 – 281Combined sources3
Beta strandi284 – 289Combined sources6
Beta strandi300 – 306Combined sources7
Turni313 – 318Combined sources6
Beta strandi321 – 328Combined sources8
Beta strandi330 – 332Combined sources3
Beta strandi334 – 343Combined sources10
Helixi348 – 355Combined sources8
Beta strandi369 – 372Combined sources4
Beta strandi401 – 407Combined sources7
Helixi408 – 426Combined sources19
Helixi429 – 436Combined sources8
Helixi444 – 449Combined sources6
Beta strandi546 – 548Combined sources3
Helixi549 – 554Combined sources6
Turni555 – 557Combined sources3
Helixi559 – 561Combined sources3
Helixi562 – 566Combined sources5
Turni567 – 569Combined sources3
Helixi573 – 576Combined sources4
Helixi581 – 586Combined sources6
Helixi591 – 609Combined sources19
Beta strandi613 – 615Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RG6NMR-A540-614[»]
2RMNNMR-A153-388[»]
2Y9TNMR-A543-622[»]
2Y9UX-ray1.60A545-611[»]
3QYMX-ray3.20A/B/C/D/E/F/G/H166-362[»]
3QYNX-ray2.50A/B/C/D166-362[»]
3US0X-ray2.50A/B/C/D166-362[»]
3US1X-ray2.80A/D166-362[»]
3US2X-ray4.20A/B/C/D/G/H/I/J166-362[»]
3ZY0X-ray1.90A/B/C/D398-427[»]
3ZY1X-ray2.15A398-441[»]
4A9ZX-ray2.29A/B/C/D397-455[»]
ProteinModelPortaliQ9H3D4.
SMRiQ9H3D4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H3D4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini541 – 607SAMAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 107Transcription activationAdd BLAST107
Regioni352 – 388Interaction with HIPK21 PublicationAdd BLAST37
Regioni394 – 443OligomerizationAdd BLAST50
Regioni610 – 680Transactivation inhibitionAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi437 – 444Poly-Gln8

Domaini

The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.2 Publications

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiQ9H3D4.
KOiK10149.
OMAiVPSSHCT.
OrthoDBiEOG091G0XY5.
PhylomeDBiQ9H3D4.
TreeFamiTF106101.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR032645. Tp63.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 2 hits.
PTHR11447:SF8. PTHR11447:SF8. 2 hits.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3D4-1) [UniParc]FASTAAdd to basket
Also known as: TA*-alpha, TAp63alpha, P51B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL
60 70 80 90 100
SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD
110 120 130 140 150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA
160 170 180 190 200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK
210 220 230 240 250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS
260 270 280 290 300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT
310 320 330 340 350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR
360 370 380 390 400
DRKADEDSIR KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL
410 420 430 440 450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ
460 470 480 490 500
TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTIPDGMG
510 520 530 540 550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV
560 570 580 590 600
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG
610 620 630 640 650
ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI
660 670 680
SFPPRDEWND FNFDMDARRN KQQRIKEEGE
Note: Produced by alternative promoter usage.
Length:680
Mass (Da):76,785
Last modified:March 1, 2001 - v1
Checksum:iF66ECD45E87D9799
GO
Isoform 2 (identifier: Q9H3D4-2) [UniParc]FASTAAdd to basket
Also known as: DeltaN-alpha, DeltaNp63 alpha, P51delNalpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE

Note: Produced by alternative promoter usage.
Show »
Length:586
Mass (Da):65,756
Checksum:i2E2F92ABF1AF8629
GO
Isoform 3 (identifier: Q9H3D4-3) [UniParc]FASTAAdd to basket
Also known as: TA*-beta, TAp63beta

The sequence of this isoform differs from the canonical sequence as follows:
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 1.
Show »
Length:555
Mass (Da):62,433
Checksum:iE22874BE7DBABCBE
GO
Isoform 4 (identifier: Q9H3D4-4) [UniParc]FASTAAdd to basket
Also known as: DeltaN-beta, DeltaNp63 beta, P51delNbeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 2.
Show »
Length:461
Mass (Da):51,404
Checksum:i68B63547A46C1B05
GO
Isoform 5 (identifier: Q9H3D4-5) [UniParc]FASTAAdd to basket
Also known as: TA*-gamma, TAp63gamma, P51A

The sequence of this isoform differs from the canonical sequence as follows:
     450-680: QTSIQSPSSY...KQQRIKEEGE → HLLSACFRNE...SKPPNRSVYP

Note: Produced by alternative splicing of isoform 1.
Show »
Length:487
Mass (Da):55,688
Checksum:i86CC865BDF2643DD
GO
Isoform 6 (identifier: Q9H3D4-6) [UniParc]FASTAAdd to basket
Also known as: DeltaN-gamma, DeltaNp63gamma, P51delNgamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     450-680: QTSIQSPSSY...KQQRIKEEGE → HLLSACFRNE...SKPPNRSVYP

Note: Produced by alternative splicing of isoform 2.
Show »
Length:393
Mass (Da):44,658
Checksum:iC6689B83FD701610
GO
Isoform 7 (identifier: Q9H3D4-7) [UniParc]FASTAAdd to basket
Also known as: TA*-delta, TAp63delta, P51delta

The sequence of this isoform differs from the canonical sequence as follows:
     503-680: IPMMGTHMPM...KQQRIKEEGE → RSGKSENP

Note: Produced by alternative splicing of isoform 1.
Show »
Length:510
Mass (Da):57,619
Checksum:i3539D81485635FF0
GO
Isoform 8 (identifier: Q9H3D4-8) [UniParc]FASTAAdd to basket
Also known as: DeltaN-delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     503-680: IPMMGTHMPM...KQQRIKEEGE → RSGKSENP

Note: Produced by alternative splicing of isoform 2. No experimental confirmation available.
Show »
Length:416
Mass (Da):46,589
Checksum:iA5974A14B25E3118
GO
Isoform 9 (identifier: Q9H3D4-9) [UniParc]FASTAAdd to basket
Also known as: TA*-epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     109-193: Missing.

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Show »
Length:595
Mass (Da):67,779
Checksum:iF07014CB9FEF1FF2
GO
Isoform 10 (identifier: Q9H3D4-10) [UniParc]FASTAAdd to basket
Also known as: DeltaN-epsilon, DeltaNp73L

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     109-193: Missing.

Note: Produced by alternative splicing of isoform 2.
Show »
Length:501
Mass (Da):56,750
Checksum:i31E1BEA3CA305B88
GO
Isoform 11 (identifier: Q9H3D4-11) [UniParc]FASTAAdd to basket
Also known as: P63 delta

The sequence of this isoform differs from the canonical sequence as follows:
     373-377: GTKRP → A

Note: Produced by alternative splicing of isoform 1.
Show »
Length:676
Mass (Da):76,317
Checksum:iEB0E2C9E93C6D34A
GO
Isoform 12 (identifier: Q9H3D4-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     373-377: GTKRP → A

Note: Produced by alternative splicing of isoform 2. No experimental confirmation available.
Show »
Length:582
Mass (Da):65,288
Checksum:iA2DC3D2E13B6B531
GO

Sequence cautioni

The sequence AAF43486 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF43487 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF43488 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF43489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAF61624 differs from that shown. Reason: Frameshift at position 26.Curated
The sequence BAA32592 differs from that shown. Reason: Frameshift at position 26.Curated
The sequence BAA32593 differs from that shown. Reason: Frameshift at position 26.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125Q → R in BAA32433 (PubMed:9703973).Curated1
Sequence conflicti154S → P in BAA32433 (PubMed:9703973).Curated1
Sequence conflicti177F → S in BAA32433 (PubMed:9703973).Curated1
Sequence conflicti378F → S in AAC24830 (PubMed:9662346).Curated1
Sequence conflicti536H → Q in CAA76562 (PubMed:9799841).Curated1
Sequence conflicti551S → G in BAA32593 (PubMed:9662378).Curated1
Sequence conflicti551S → G in AAF43487 (PubMed:10935472).Curated1
Sequence conflicti551S → G in AAF43491 (PubMed:10935472).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035126129S → L.1 PublicationCorresponds to variant rs193287780dbSNPEnsembl.1
Natural variantiVAR_020866184S → L in head and neck cancer. 1 Publication1
Natural variantiVAR_020867187A → P in lung carcinoma; somatic mutation. 1 Publication1
Natural variantiVAR_032736193T → TP in SHFM4. 1 Publication1
Natural variantiVAR_020868204Q → L in cervical cancer. 1 Publication1
Natural variantiVAR_032737232K → E in SHFM4. 1 Publication1
Natural variantiVAR_020869233K → E in SHFM4. 1 PublicationCorresponds to variant rs121908838dbSNPEnsembl.1
Natural variantiVAR_020870243R → Q in EEC3. 2 PublicationsCorresponds to variant rs121908836dbSNPEnsembl.1
Natural variantiVAR_020871243R → W in EEC3. 2 PublicationsCorresponds to variant rs121908835dbSNPEnsembl.1
Natural variantiVAR_032738266R → Q in EEC3. 1 PublicationCorresponds to variant rs121908849dbSNPEnsembl.1
Natural variantiVAR_020872279P → H in colon cancer. 1 Publication1
Natural variantiVAR_032739308C → Y in EEC3. 1 Publication1
Natural variantiVAR_032740311S → N in EEC3. 1 Publication1
Natural variantiVAR_032741318R → C in EEC3. 1 Publication1
Natural variantiVAR_020873318R → H in EEC3 and EDRH; does not decrease the transcriptional activity of the isoform 5 on a TP53 reporter system but disrupts the dominant-negative activity of isoform 2 and isoform 5 on the transcriptional activity of TP53. 3 PublicationsCorresponds to variant rs121908840dbSNPEnsembl.1
Natural variantiVAR_032742318R → Q in EEC3. 1 Publication1
Natural variantiVAR_020874319R → C in EEC3. 2 PublicationsCorresponds to variant rs121908839dbSNPEnsembl.1
Natural variantiVAR_032743319R → H in EEC3 and SHFM4. 1 Publication1
Natural variantiVAR_032744319R → S in EEC3. 1 Publication1
Natural variantiVAR_020875337R → Q in ADULT syndrome; confers novel transcription activation capacity on isoform 6. 1 PublicationCorresponds to variant rs113993967dbSNPEnsembl.1
Natural variantiVAR_020876343R → Q in EEC3. 2 PublicationsCorresponds to variant rs121908841dbSNPEnsembl.1
Natural variantiVAR_032745343R → W in EEC3. 1 Publication1
Natural variantiVAR_020877345C → R in EEC3; abolishes transcription activation. 2 PublicationsCorresponds to variant rs121908837dbSNPEnsembl.1
Natural variantiVAR_032746347C → S in EEC3. 1 Publication1
Natural variantiVAR_032747348P → S in EEC3. 1 Publication1
Natural variantiVAR_020878351D → G in EEC3. 1 PublicationCorresponds to variant rs121908844dbSNPEnsembl.1
Natural variantiVAR_032748351D → H in EEC3. 1 Publication1
Natural variantiVAR_035127352R → G in EDRH and OFC8. 1 PublicationCorresponds to variant rs121908847dbSNPEnsembl.1
Natural variantiVAR_035128549I → T in EDRH. 1 PublicationCorresponds to variant rs121908845dbSNPEnsembl.1
Natural variantiVAR_020879553L → F in AEC. 1 PublicationCorresponds to variant rs121908842dbSNPEnsembl.1
Natural variantiVAR_020880560S → A in ovarian cancer. 1 Publication1
Natural variantiVAR_020881561C → G in AEC. 1 PublicationCorresponds to variant rs121908843dbSNPEnsembl.1
Natural variantiVAR_035129580S → P in EDRH. 1 PublicationCorresponds to variant rs121908846dbSNPEnsembl.1
Natural variantiVAR_035130603D → H.1 PublicationCorresponds to variant rs767906723dbSNPEnsembl.1
Isoform 2 (identifier: Q9H3D4-2)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 4 (identifier: Q9H3D4-4)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 6 (identifier: Q9H3D4-6)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 8 (identifier: Q9H3D4-8)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 10 (identifier: Q9H3D4-10)
Natural varianti6N → H in ADULT syndrome. 1
Isoform 12 (identifier: Q9H3D4-12)
Natural varianti6N → H in ADULT syndrome. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124651 – 108MNFET…SDPMW → MLYLENNAQTQFSE in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12. 4 PublicationsAdd BLAST108
Alternative sequenceiVSP_012466109 – 193Missing in isoform 9 and isoform 10. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_012467373 – 377GTKRP → A in isoform 11 and isoform 12. 1 Publication5
Alternative sequenceiVSP_012468450 – 680QTSIQ…KEEGE → HLLSACFRNELVEPRRETPK QSDVFFRHSKPPNRSVYP in isoform 5 and isoform 6. 2 PublicationsAdd BLAST231
Alternative sequenceiVSP_012469503 – 680IPMMG…KEEGE → RSGKSENP in isoform 7 and isoform 8. 1 PublicationAdd BLAST178
Alternative sequenceiVSP_012470551 – 680SFLAR…KEEGE → RIWQV in isoform 3 and isoform 4. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010153 mRNA. Translation: BAA32433.1.
Y16961 mRNA. Translation: CAA76562.1.
AF075428 mRNA. Translation: AAC62633.1.
AF075429 mRNA. Translation: AAC62634.1.
AF075430 mRNA. Translation: AAC62635.1.
AF075431 mRNA. Translation: AAC62636.1.
AF075432 mRNA. Translation: AAC62637.1.
AF075433 mRNA. Translation: AAC62638.1.
AF124539
, AF124528, AF124529, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537, AF124538 Genomic DNA. Translation: AAG45607.1.
AF124539
, AF124528, AF124529, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537 Genomic DNA. Translation: AAG45608.1.
AF124540
, AF124528, AF124529, AF124531, AF124532, AF124533, AF124534, AF124535 Genomic DNA. Translation: AAG45609.1.
AF124539
, AF124530, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537, AF124538 Genomic DNA. Translation: AAG45610.1.
AF124539
, AF124530, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537 Genomic DNA. Translation: AAG45611.1.
AF124540
, AF124531, AF124533, AF124535, AF124534, AF124532, AF124530 Genomic DNA. Translation: AAG45612.1.
AB016072 mRNA. Translation: BAA32592.1. Frameshift.
AB016073 mRNA. Translation: BAA32593.1. Frameshift.
AF091627 mRNA. Translation: AAC43038.1.
AF116770
, AF116756, AF116757, AF116759, AF116760, AF116761, AF116762, AF116763, AF116764, AF116765 Genomic DNA. Translation: AAF43486.1. Different initiation.
AF116769
, AF116756, AF116757, AF116759, AF116760, AF116761, AF116762, AF116763, AF116764, AF116765, AF116766, AF116767, AF116768 Genomic DNA. Translation: AAF43487.1. Different initiation.
AF116769
, AF116756, AF116759, AF116757, AF116762, AF116764, AF116766, AF116767, AF116765, AF116763, AF116761, AF116760 Genomic DNA. Translation: AAF43488.1. Different initiation.
AF116769
, AF116756, AF116757, AF116759, AF116760, AF116761, AF116762, AF116763, AF116764, AF116765, AF116766 Genomic DNA. Translation: AAF43489.1. Different initiation.
AF116770
, AF116758, AF116760, AF116762, AF116764, AF116765, AF116763, AF116761, AF116759 Genomic DNA. Translation: AAF43490.1.
AF116769
, AF116758, AF116759, AF116760, AF116764, AF116766, AF116768, AF116767, AF116765, AF116763, AF116762, AF116761 Genomic DNA. Translation: AAF43491.1.
AF116769
, AF116758, AF116760, AF116759, AF116761, AF116763, AF116765, AF116767, AF116766, AF116764, AF116762 Genomic DNA. Translation: AAF43492.1.
AF116769
, AF116758, AF116760, AF116759, AF116761, AF116763, AF116765, AF116766, AF116764, AF116762 Genomic DNA. Translation: AAF43493.1.
AF116771 mRNA. Translation: AAF61624.1. Frameshift.
AB042841 mRNA. Translation: BAB20591.1.
BC039815 mRNA. Translation: AAH39815.1.
AF061512 mRNA. Translation: AAC24830.1.
AY342152, AY341145 Genomic DNA. Translation: AAQ63448.1.
AY339663 Genomic DNA. Translation: AAQ63449.1.
AY341143, AY339664, AY341142 Genomic DNA. Translation: AAQ63450.1.
AY341143, AY341142 Genomic DNA. Translation: AAQ63451.1.
AY341144 Genomic DNA. Translation: AAQ63452.1.
AY342153 Genomic DNA. Translation: AAQ63453.1.
AY342154 Genomic DNA. Translation: AAQ63454.1.
AJ315499 mRNA. Translation: CAC48053.1.
CCDSiCCDS3293.1. [Q9H3D4-1]
CCDS46976.1. [Q9H3D4-3]
CCDS46977.1. [Q9H3D4-5]
CCDS46978.1. [Q9H3D4-2]
CCDS46979.1. [Q9H3D4-4]
CCDS46980.1. [Q9H3D4-6]
CCDS82887.1. [Q9H3D4-11]
RefSeqiNP_001108450.1. NM_001114978.1. [Q9H3D4-3]
NP_001108451.1. NM_001114979.1. [Q9H3D4-5]
NP_001108452.1. NM_001114980.1. [Q9H3D4-2]
NP_001108453.1. NM_001114981.1. [Q9H3D4-4]
NP_001108454.1. NM_001114982.1. [Q9H3D4-6]
NP_001316073.1. NM_001329144.1. [Q9H3D4-7]
NP_001316074.1. NM_001329145.1. [Q9H3D4-8]
NP_001316075.1. NM_001329146.1. [Q9H3D4-10]
NP_001316077.1. NM_001329148.1. [Q9H3D4-11]
NP_003713.3. NM_003722.4. [Q9H3D4-1]
XP_016862876.1. XM_017007387.1. [Q9H3D4-12]
UniGeneiHs.137569.

Genome annotation databases

EnsembliENST00000264731; ENSP00000264731; ENSG00000073282. [Q9H3D4-1]
ENST00000320472; ENSP00000317510; ENSG00000073282. [Q9H3D4-7]
ENST00000354600; ENSP00000346614; ENSG00000073282. [Q9H3D4-2]
ENST00000392460; ENSP00000376253; ENSG00000073282. [Q9H3D4-3]
ENST00000392461; ENSP00000376254; ENSG00000073282. [Q9H3D4-8]
ENST00000392463; ENSP00000376256; ENSG00000073282. [Q9H3D4-4]
ENST00000418709; ENSP00000407144; ENSG00000073282. [Q9H3D4-5]
ENST00000437221; ENSP00000392488; ENSG00000073282. [Q9H3D4-6]
ENST00000440651; ENSP00000394337; ENSG00000073282. [Q9H3D4-11]
ENST00000449992; ENSP00000387839; ENSG00000073282. [Q9H3D4-10]
ENST00000456148; ENSP00000389485; ENSG00000073282. [Q9H3D4-12]
GeneIDi8626.
KEGGihsa:8626.
UCSCiuc003frx.3. human. [Q9H3D4-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010153 mRNA. Translation: BAA32433.1.
Y16961 mRNA. Translation: CAA76562.1.
AF075428 mRNA. Translation: AAC62633.1.
AF075429 mRNA. Translation: AAC62634.1.
AF075430 mRNA. Translation: AAC62635.1.
AF075431 mRNA. Translation: AAC62636.1.
AF075432 mRNA. Translation: AAC62637.1.
AF075433 mRNA. Translation: AAC62638.1.
AF124539
, AF124528, AF124529, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537, AF124538 Genomic DNA. Translation: AAG45607.1.
AF124539
, AF124528, AF124529, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537 Genomic DNA. Translation: AAG45608.1.
AF124540
, AF124528, AF124529, AF124531, AF124532, AF124533, AF124534, AF124535 Genomic DNA. Translation: AAG45609.1.
AF124539
, AF124530, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537, AF124538 Genomic DNA. Translation: AAG45610.1.
AF124539
, AF124530, AF124531, AF124532, AF124533, AF124534, AF124535, AF124536, AF124537 Genomic DNA. Translation: AAG45611.1.
AF124540
, AF124531, AF124533, AF124535, AF124534, AF124532, AF124530 Genomic DNA. Translation: AAG45612.1.
AB016072 mRNA. Translation: BAA32592.1. Frameshift.
AB016073 mRNA. Translation: BAA32593.1. Frameshift.
AF091627 mRNA. Translation: AAC43038.1.
AF116770
, AF116756, AF116757, AF116759, AF116760, AF116761, AF116762, AF116763, AF116764, AF116765 Genomic DNA. Translation: AAF43486.1. Different initiation.
AF116769
, AF116756, AF116757, AF116759, AF116760, AF116761, AF116762, AF116763, AF116764, AF116765, AF116766, AF116767, AF116768 Genomic DNA. Translation: AAF43487.1. Different initiation.
AF116769
, AF116756, AF116759, AF116757, AF116762, AF116764, AF116766, AF116767, AF116765, AF116763, AF116761, AF116760 Genomic DNA. Translation: AAF43488.1. Different initiation.
AF116769
, AF116756, AF116757, AF116759, AF116760, AF116761, AF116762, AF116763, AF116764, AF116765, AF116766 Genomic DNA. Translation: AAF43489.1. Different initiation.
AF116770
, AF116758, AF116760, AF116762, AF116764, AF116765, AF116763, AF116761, AF116759 Genomic DNA. Translation: AAF43490.1.
AF116769
, AF116758, AF116759, AF116760, AF116764, AF116766, AF116768, AF116767, AF116765, AF116763, AF116762, AF116761 Genomic DNA. Translation: AAF43491.1.
AF116769
, AF116758, AF116760, AF116759, AF116761, AF116763, AF116765, AF116767, AF116766, AF116764, AF116762 Genomic DNA. Translation: AAF43492.1.
AF116769
, AF116758, AF116760, AF116759, AF116761, AF116763, AF116765, AF116766, AF116764, AF116762 Genomic DNA. Translation: AAF43493.1.
AF116771 mRNA. Translation: AAF61624.1. Frameshift.
AB042841 mRNA. Translation: BAB20591.1.
BC039815 mRNA. Translation: AAH39815.1.
AF061512 mRNA. Translation: AAC24830.1.
AY342152, AY341145 Genomic DNA. Translation: AAQ63448.1.
AY339663 Genomic DNA. Translation: AAQ63449.1.
AY341143, AY339664, AY341142 Genomic DNA. Translation: AAQ63450.1.
AY341143, AY341142 Genomic DNA. Translation: AAQ63451.1.
AY341144 Genomic DNA. Translation: AAQ63452.1.
AY342153 Genomic DNA. Translation: AAQ63453.1.
AY342154 Genomic DNA. Translation: AAQ63454.1.
AJ315499 mRNA. Translation: CAC48053.1.
CCDSiCCDS3293.1. [Q9H3D4-1]
CCDS46976.1. [Q9H3D4-3]
CCDS46977.1. [Q9H3D4-5]
CCDS46978.1. [Q9H3D4-2]
CCDS46979.1. [Q9H3D4-4]
CCDS46980.1. [Q9H3D4-6]
CCDS82887.1. [Q9H3D4-11]
RefSeqiNP_001108450.1. NM_001114978.1. [Q9H3D4-3]
NP_001108451.1. NM_001114979.1. [Q9H3D4-5]
NP_001108452.1. NM_001114980.1. [Q9H3D4-2]
NP_001108453.1. NM_001114981.1. [Q9H3D4-4]
NP_001108454.1. NM_001114982.1. [Q9H3D4-6]
NP_001316073.1. NM_001329144.1. [Q9H3D4-7]
NP_001316074.1. NM_001329145.1. [Q9H3D4-8]
NP_001316075.1. NM_001329146.1. [Q9H3D4-10]
NP_001316077.1. NM_001329148.1. [Q9H3D4-11]
NP_003713.3. NM_003722.4. [Q9H3D4-1]
XP_016862876.1. XM_017007387.1. [Q9H3D4-12]
UniGeneiHs.137569.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RG6NMR-A540-614[»]
2RMNNMR-A153-388[»]
2Y9TNMR-A543-622[»]
2Y9UX-ray1.60A545-611[»]
3QYMX-ray3.20A/B/C/D/E/F/G/H166-362[»]
3QYNX-ray2.50A/B/C/D166-362[»]
3US0X-ray2.50A/B/C/D166-362[»]
3US1X-ray2.80A/D166-362[»]
3US2X-ray4.20A/B/C/D/G/H/I/J166-362[»]
3ZY0X-ray1.90A/B/C/D398-427[»]
3ZY1X-ray2.15A398-441[»]
4A9ZX-ray2.29A/B/C/D397-455[»]
ProteinModelPortaliQ9H3D4.
SMRiQ9H3D4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114181. 127 interactors.
DIPiDIP-29588N.
IntActiQ9H3D4. 70 interactors.
MINTiMINT-190238.
STRINGi9606.ENSP00000264731.

PTM databases

iPTMnetiQ9H3D4.
PhosphoSitePlusiQ9H3D4.

Polymorphism and mutation databases

BioMutaiTP63.
DMDMi57013009.

Proteomic databases

MaxQBiQ9H3D4.
PaxDbiQ9H3D4.
PeptideAtlasiQ9H3D4.
PRIDEiQ9H3D4.

Protocols and materials databases

DNASUi8626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264731; ENSP00000264731; ENSG00000073282. [Q9H3D4-1]
ENST00000320472; ENSP00000317510; ENSG00000073282. [Q9H3D4-7]
ENST00000354600; ENSP00000346614; ENSG00000073282. [Q9H3D4-2]
ENST00000392460; ENSP00000376253; ENSG00000073282. [Q9H3D4-3]
ENST00000392461; ENSP00000376254; ENSG00000073282. [Q9H3D4-8]
ENST00000392463; ENSP00000376256; ENSG00000073282. [Q9H3D4-4]
ENST00000418709; ENSP00000407144; ENSG00000073282. [Q9H3D4-5]
ENST00000437221; ENSP00000392488; ENSG00000073282. [Q9H3D4-6]
ENST00000440651; ENSP00000394337; ENSG00000073282. [Q9H3D4-11]
ENST00000449992; ENSP00000387839; ENSG00000073282. [Q9H3D4-10]
ENST00000456148; ENSP00000389485; ENSG00000073282. [Q9H3D4-12]
GeneIDi8626.
KEGGihsa:8626.
UCSCiuc003frx.3. human. [Q9H3D4-1]

Organism-specific databases

CTDi8626.
DisGeNETi8626.
GeneCardsiTP63.
GeneReviewsiTP63.
HGNCiHGNC:15979. TP63.
HPAiCAB000083.
HPA006288.
HPA007010.
MalaCardsiTP63.
MIMi103285. phenotype.
106260. phenotype.
129400. phenotype.
603273. gene.
603543. phenotype.
604292. phenotype.
605289. phenotype.
neXtProtiNX_Q9H3D4.
OpenTargetsiENSG00000073282.
Orphaneti978. ADULT syndrome.
1071. Ankyloblepharon - ectodermal defects - cleft lip/palate.
93930. Bladder exstrophy.
1991. Cleft lip with or without cleft palate.
1896. EEC syndrome.
69085. Limb-mammary syndrome.
2440. Split hand-split foot malformation.
PharmGKBiPA162406776.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiQ9H3D4.
KOiK10149.
OMAiVPSSHCT.
OrthoDBiEOG091G0XY5.
PhylomeDBiQ9H3D4.
TreeFamiTF106101.

Enzyme and pathway databases

ReactomeiR-HSA-139915. Activation of PUMA and translocation to mitochondria.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
R-HSA-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
R-HSA-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.
R-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
R-HSA-6804759. Regulation of TP53 Activity through Association with Co-factors.
SignaLinkiQ9H3D4.
SIGNORiQ9H3D4.

Miscellaneous databases

ChiTaRSiTP63. human.
EvolutionaryTraceiQ9H3D4.
GeneWikiiTP63.
GenomeRNAii8626.
PROiQ9H3D4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073282.
ExpressionAtlasiQ9H3D4. baseline and differential.
GenevisibleiQ9H3D4. HS.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR032645. Tp63.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 2 hits.
PTHR11447:SF8. PTHR11447:SF8. 2 hits.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP63_HUMAN
AccessioniPrimary (citable) accession number: Q9H3D4
Secondary accession number(s): O75080
, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.