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Protein

Gametogenetin-binding protein 2

Gene

GGNBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Gametogenetin-binding protein 2
Alternative name(s):
Laryngeal carcinoma-related protein 1
Protein ZNF403
Gene namesi
Name:GGNBP2
Synonyms:LCRG1, LZK1, ZNF403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19357. GGNBP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389409.

Polymorphism and mutation databases

DMDMi74718217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Gametogenetin-binding protein 2PRO_0000239348Add
BLAST

Proteomic databases

EPDiQ9H3C7.
MaxQBiQ9H3C7.
PaxDbiQ9H3C7.
PRIDEiQ9H3C7.

PTM databases

iPTMnetiQ9H3C7.
PhosphoSiteiQ9H3C7.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9H3C7.
CleanExiHS_GGNBP2.
ExpressionAtlasiQ9H3C7. baseline and differential.
GenevisibleiQ9H3C7. HS.

Organism-specific databases

HPAiHPA018914.
HPA057187.

Interactioni

Subunit structurei

Interacts with GGN.By similarity

Protein-protein interaction databases

BioGridi122977. 5 interactions.
STRINGi9606.ENSP00000307617.

Structurei

3D structure databases

ProteinModelPortaliQ9H3C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEAD. Eukaryota.
ENOG410XRSX. LUCA.
GeneTreeiENSGT00390000009552.
HOGENOMiHOG000264258.
HOVERGENiHBG082524.
InParanoidiQ9H3C7.
OMAiHSMLKQQ.
PhylomeDBiQ9H3C7.
TreeFamiTF323487.

Family and domain databases

InterProiIPR026073. GGNBP2.
[Graphical view]
PANTHERiPTHR13601. PTHR13601. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H3C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLVAVCRD GEEEFPFERR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG
60 70 80 90 100
AQLKQFIQRH GMLKQQDLSI AMVVTSREVL SALSQLVPCV GCRRSVERLF
110 120 130 140 150
SQLVESGNPA LEPLTVGPKG VLSVTRSCMT DAKKLYTLFY VHGSKLNDMI
160 170 180 190 200
DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM DVWELMSQEC RDEVVLIDSS
210 220 230 240 250
CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK GYCAALYEGL
260 270 280 290 300
RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT
310 320 330 340 350
CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MTVEKVQGIS
360 370 380 390 400
RLEQLCEEFS EEERVRELKQ EKKRQKRKNR RKNKCVCDIP TPLQTADEKE
410 420 430 440 450
VSQEKETDFI ENSSCKACGS TEDGNTCVEV IVTNENTSCT CPSSGNLLGS
460 470 480 490 500
PKIKKGLSPH CNGSDCGYSS SMEGSETGSR EGSDVACTEG ICNHDEHGDD
510 520 530 540 550
SCVHHCEDKE DDGDSCVECW ANSEENDTKG KNKKKKKKSK ILKCDEHIQK
560 570 580 590 600
LGSCITDPGN RETSGNTMHT VFHRDKTKDT HPESCCSSEK GGQPLPWFEH
610 620 630 640 650
RKNVPQFAEP TETLFGPDSG KGAKSLVELL DESECTSDEE IFISQDEIQS
660 670 680 690
FMANNQSFYS NREQYRQHLK EKFNKYCRLN DHKRPICSGW LTTAGAN
Length:697
Mass (Da):79,086
Last modified:March 1, 2001 - v1
Checksum:iFA57264D37BF7E5D
GO
Isoform 2 (identifier: Q9H3C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-288: RRERHA → YEYVIC
     289-697: Missing.

Show »
Length:288
Mass (Da):32,735
Checksum:i7925D6A6FE796730
GO
Isoform 3 (identifier: Q9H3C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-457: L → K
     458-697: Missing.

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):52,253
Checksum:i0FCC22CAD00378D1
GO

Sequence cautioni

The sequence BAB15031.1 differs from that shown. Reason: Frameshift at position 387. Curated
The sequence BAB15397.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC18878.1 differs from that shown. Reason: Frameshift at position 433. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti415 – 4151C → Y in BAB15031 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei283 – 2886RRERHA → YEYVIC in isoform 2. 1 PublicationVSP_019175
Alternative sequencei289 – 697409Missing in isoform 2. 1 PublicationVSP_019176Add
BLAST
Alternative sequencei457 – 4571L → K in isoform 3. 1 PublicationVSP_019177
Alternative sequencei458 – 697240Missing in isoform 3. 1 PublicationVSP_019178Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268387 mRNA. Translation: AAK38614.1.
AF126964 mRNA. Translation: AAG43247.1.
AK024883 mRNA. Translation: BAB15031.1. Frameshift.
AK026214 mRNA. Translation: BAB15397.1. Different initiation.
CH471199 Genomic DNA. Translation: EAW57566.1.
BC137491 mRNA. Translation: AAI37492.1.
AJ404670 mRNA. Translation: CAC18878.1. Frameshift.
CCDSiCCDS11314.1. [Q9H3C7-1]
RefSeqiNP_079111.1. NM_024835.4. [Q9H3C7-1]
UniGeneiHs.514116.

Genome annotation databases

EnsembliENST00000613102; ENSP00000478220; ENSG00000278311. [Q9H3C7-1]
ENST00000621686; ENSP00000478954; ENSG00000275099. [Q9H3C7-1]
GeneIDi79893.
KEGGihsa:79893.
UCSCiuc002hnb.4. human. [Q9H3C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268387 mRNA. Translation: AAK38614.1.
AF126964 mRNA. Translation: AAG43247.1.
AK024883 mRNA. Translation: BAB15031.1. Frameshift.
AK026214 mRNA. Translation: BAB15397.1. Different initiation.
CH471199 Genomic DNA. Translation: EAW57566.1.
BC137491 mRNA. Translation: AAI37492.1.
AJ404670 mRNA. Translation: CAC18878.1. Frameshift.
CCDSiCCDS11314.1. [Q9H3C7-1]
RefSeqiNP_079111.1. NM_024835.4. [Q9H3C7-1]
UniGeneiHs.514116.

3D structure databases

ProteinModelPortaliQ9H3C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122977. 5 interactions.
STRINGi9606.ENSP00000307617.

PTM databases

iPTMnetiQ9H3C7.
PhosphoSiteiQ9H3C7.

Polymorphism and mutation databases

DMDMi74718217.

Proteomic databases

EPDiQ9H3C7.
MaxQBiQ9H3C7.
PaxDbiQ9H3C7.
PRIDEiQ9H3C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000613102; ENSP00000478220; ENSG00000278311. [Q9H3C7-1]
ENST00000621686; ENSP00000478954; ENSG00000275099. [Q9H3C7-1]
GeneIDi79893.
KEGGihsa:79893.
UCSCiuc002hnb.4. human. [Q9H3C7-1]

Organism-specific databases

CTDi79893.
GeneCardsiGGNBP2.
HGNCiHGNC:19357. GGNBP2.
HPAiHPA018914.
HPA057187.
MIMi612275. gene.
neXtProtiNX_Q9H3C7.
PharmGKBiPA162389409.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAD. Eukaryota.
ENOG410XRSX. LUCA.
GeneTreeiENSGT00390000009552.
HOGENOMiHOG000264258.
HOVERGENiHBG082524.
InParanoidiQ9H3C7.
OMAiHSMLKQQ.
PhylomeDBiQ9H3C7.
TreeFamiTF323487.

Miscellaneous databases

ChiTaRSiGGNBP2. human.
GenomeRNAii79893.
NextBioi69718.
PROiQ9H3C7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H3C7.
CleanExiHS_GGNBP2.
ExpressionAtlasiQ9H3C7. baseline and differential.
GenevisibleiQ9H3C7. HS.

Family and domain databases

InterProiIPR026073. GGNBP2.
[Graphical view]
PANTHERiPTHR13601. PTHR13601. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930."
    Li Y., Chen Z.
    Cancer Lett. 209:75-85(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Cloning of a novel gene of a zinc finger protein."
    Li Z.K., Ling Z.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 351-697.
    Tissue: Small intestine.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Differential gene expression in HTLV-1-infected adult T cell leukemia cell line."
    Ruckes T.M., Saul D., Romaker D., Grassmann R.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 377-697.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGGNB2_HUMAN
AccessioniPrimary (citable) accession number: Q9H3C7
Secondary accession number(s): B2RPK7
, Q96T90, Q9GZR8, Q9H767
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.