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Q9H361

- PABP3_HUMAN

UniProt

Q9H361 - PABP3_HUMAN

Protein

Polyadenylate-binding protein 3

Gene

PABPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Feb 2003)
      Previous versions | rss
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    Functioni

    Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) binding Source: UniProtKB

    GO - Biological processi

    1. mRNA metabolic process Source: UniProtKB

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyadenylate-binding protein 3
    Short name:
    PABP-3
    Short name:
    Poly(A)-binding protein 3
    Alternative name(s):
    Testis-specific poly(A)-binding protein
    Gene namesi
    Name:PABPC3
    Synonyms:PABP3, PABPL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:8556. PABPC3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32882.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 631631Polyadenylate-binding protein 3PRO_0000081702Add
    BLAST

    Proteomic databases

    MaxQBiQ9H361.
    PaxDbiQ9H361.
    PRIDEiQ9H361.

    PTM databases

    PhosphoSiteiQ9H361.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Gene expression databases

    ArrayExpressiQ9H361.
    BgeeiQ9H361.
    CleanExiHS_PABPC3.
    GenevestigatoriQ9H361.

    Organism-specific databases

    HPAiHPA045423.

    Interactioni

    Protein-protein interaction databases

    BioGridi111079. 7 interactions.
    IntActiQ9H361. 4 interactions.
    MINTiMINT-3067051.
    STRINGi9606.ENSP00000281589.

    Structurei

    Secondary structure

    1
    631
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi542 – 5465
    Helixi550 – 56819
    Turni570 – 5723
    Helixi573 – 5808
    Helixi585 – 5928
    Helixi595 – 60915

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D9PNMR-A286-375[»]
    4IVEX-ray2.30A/B/C/D535-631[»]
    ProteinModelPortaliQ9H361.
    SMRiQ9H361. Positions 11-376, 491-631.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9H361.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 8979RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini99 – 17577RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 26878RRM 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 37077RRM 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini537 – 61478PABCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PABC domain.PROSITE-ProRule annotation
    Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000217922.
    HOVERGENiHBG002295.
    InParanoidiQ9H361.
    KOiK13126.
    OMAiMELFSEF.
    OrthoDBiEOG7RV9FP.
    PhylomeDBiQ9H361.
    TreeFamiTF300458.

    Family and domain databases

    Gene3Di1.10.1900.10. 1 hit.
    3.30.70.330. 4 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR006515. PABP_1234.
    IPR002004. PABP_HYD.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00658. PABP. 1 hit.
    PF00076. RRM_1. 4 hits.
    [Graphical view]
    SMARTiSM00517. PolyA. 1 hit.
    SM00360. RRM. 4 hits.
    [Graphical view]
    SUPFAMiSSF63570. SSF63570. 1 hit.
    TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
    PROSITEiPS51309. PABC. 1 hit.
    PS50102. RRM. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H361-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG    50
    SSNYAYVNFQ HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN 100
    IFVKNLDKSI NNKALYDTVS AFGNILSCNV VCDENGSKGY GFVHFETHEA 150
    AERAIKKMNG MLLNGRKVFV GQFKSRKERE AELGARAKEF PNVYIKNFGE 200
    DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE 250
    MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN 300
    LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV 350
    TEMNGRIVAT KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS 400
    GYFMTAVPQT QNHAAYYPPS QIARLRPSPR WTAQGARPHP FQNKPSAIRP 450
    GAPRVPFSTM RPASSQVPRV MSTQRVANTS TQTVGPRPAA AAAAAATPAV 500
    RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL TASRLASAPP 550
    QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS 600
    KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V 631
    Length:631
    Mass (Da):70,031
    Last modified:February 1, 2003 - v2
    Checksum:i2F8C5BF6F508AAEF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2222KV → EL in CAB66834. (PubMed:11230166)Curated
    Sequence conflicti492 – 4921A → R in AAG38953. (PubMed:11328870)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132026 mRNA. Translation: AAG38953.1.
    AL136900 mRNA. Translation: CAB66834.2.
    BC027617 mRNA. Translation: AAH27617.1.
    CCDSiCCDS9311.1.
    RefSeqiNP_112241.2. NM_030979.2.
    UniGeneiHs.458280.

    Genome annotation databases

    EnsembliENST00000281589; ENSP00000281589; ENSG00000151846.
    GeneIDi5042.
    KEGGihsa:5042.
    UCSCiuc001upy.3. human.

    Polymorphism databases

    DMDMi28201852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132026 mRNA. Translation: AAG38953.1 .
    AL136900 mRNA. Translation: CAB66834.2 .
    BC027617 mRNA. Translation: AAH27617.1 .
    CCDSi CCDS9311.1.
    RefSeqi NP_112241.2. NM_030979.2.
    UniGenei Hs.458280.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D9P NMR - A 286-375 [» ]
    4IVE X-ray 2.30 A/B/C/D 535-631 [» ]
    ProteinModelPortali Q9H361.
    SMRi Q9H361. Positions 11-376, 491-631.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111079. 7 interactions.
    IntActi Q9H361. 4 interactions.
    MINTi MINT-3067051.
    STRINGi 9606.ENSP00000281589.

    PTM databases

    PhosphoSitei Q9H361.

    Polymorphism databases

    DMDMi 28201852.

    Proteomic databases

    MaxQBi Q9H361.
    PaxDbi Q9H361.
    PRIDEi Q9H361.

    Protocols and materials databases

    DNASUi 5042.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281589 ; ENSP00000281589 ; ENSG00000151846 .
    GeneIDi 5042.
    KEGGi hsa:5042.
    UCSCi uc001upy.3. human.

    Organism-specific databases

    CTDi 5042.
    GeneCardsi GC13P025670.
    HGNCi HGNC:8556. PABPC3.
    HPAi HPA045423.
    MIMi 604680. gene.
    neXtProti NX_Q9H361.
    PharmGKBi PA32882.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000217922.
    HOVERGENi HBG002295.
    InParanoidi Q9H361.
    KOi K13126.
    OMAi MELFSEF.
    OrthoDBi EOG7RV9FP.
    PhylomeDBi Q9H361.
    TreeFami TF300458.

    Miscellaneous databases

    EvolutionaryTracei Q9H361.
    GeneWikii PABPC3.
    GenomeRNAii 5042.
    NextBioi 19414.
    PROi Q9H361.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H361.
    Bgeei Q9H361.
    CleanExi HS_PABPC3.
    Genevestigatori Q9H361.

    Family and domain databases

    Gene3Di 1.10.1900.10. 1 hit.
    3.30.70.330. 4 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR006515. PABP_1234.
    IPR002004. PABP_HYD.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00658. PABP. 1 hit.
    PF00076. RRM_1. 4 hits.
    [Graphical view ]
    SMARTi SM00517. PolyA. 1 hit.
    SM00360. RRM. 4 hits.
    [Graphical view ]
    SUPFAMi SSF63570. SSF63570. 1 hit.
    TIGRFAMsi TIGR01628. PABP-1234. 1 hit.
    PROSITEi PS51309. PABC. 1 hit.
    PS50102. RRM. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human testis expresses a specific poly(A)-binding protein."
      Feral C., Guellaen G., Pawlak A.
      Nucleic Acids Res. 29:1872-1883(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Solution structure of RNA binding domain 4 in polyadenylation binding protein 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 286-376.

    Entry informationi

    Entry nameiPABP3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H361
    Secondary accession number(s): Q8NHV0, Q9H086
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: February 1, 2003
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3