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Protein

Polyadenylate-binding protein 3

Gene

PABPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

GO - Molecular functioni

  • poly(A) binding Source: UniProtKB

GO - Biological processi

  • mRNA metabolic process Source: UniProtKB

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 3
Short name:
PABP-3
Short name:
Poly(A)-binding protein 3
Alternative name(s):
Testis-specific poly(A)-binding protein
Gene namesi
Name:PABPC3
Synonyms:PABP3, PABPL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000151846.8.
HGNCiHGNC:8556. PABPC3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151846.
PharmGKBiPA32882.

Polymorphism and mutation databases

BioMutaiPABPC3.
DMDMi28201852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817021 – 631Polyadenylate-binding protein 3Add BLAST631

Proteomic databases

EPDiQ9H361.
MaxQBiQ9H361.
PaxDbiQ9H361.
PeptideAtlasiQ9H361.
PRIDEiQ9H361.

PTM databases

iPTMnetiQ9H361.
PhosphoSitePlusiQ9H361.
SwissPalmiQ9H361.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000151846.
CleanExiHS_PABPC3.
ExpressionAtlasiQ9H361. baseline and differential.
GenevisibleiQ9H361. HS.

Organism-specific databases

HPAiHPA045423.
HPA067156.

Interactioni

Protein-protein interaction databases

BioGridi111079. 25 interactors.
IntActiQ9H361. 7 interactors.
MINTiMINT-3067051.
STRINGi9606.ENSP00000281589.

Structurei

Secondary structure

1631
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi542 – 546Combined sources5
Helixi550 – 568Combined sources19
Turni570 – 572Combined sources3
Helixi573 – 580Combined sources8
Helixi585 – 592Combined sources8
Helixi595 – 609Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9PNMR-A286-375[»]
4IVEX-ray2.30A/B/C/D535-631[»]
ProteinModelPortaliQ9H361.
SMRiQ9H361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H361.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini537 – 614PABCPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123. Eukaryota.
ENOG410XR5X. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ9H361.
KOiK13126.
OrthoDBiEOG091G03ZE.
PhylomeDBiQ9H361.
TreeFamiTF300458.

Family and domain databases

InterProiView protein in InterPro
IPR036053. PABP-dom.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
PfamiView protein in Pfam
PF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
SMARTiView protein in SMART
SM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SM00361. RRM_1. 3 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiView protein in PROSITE
PS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9H361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG
60 70 80 90 100
SSNYAYVNFQ HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN
110 120 130 140 150
IFVKNLDKSI NNKALYDTVS AFGNILSCNV VCDENGSKGY GFVHFETHEA
160 170 180 190 200
AERAIKKMNG MLLNGRKVFV GQFKSRKERE AELGARAKEF PNVYIKNFGE
210 220 230 240 250
DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE
260 270 280 290 300
MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN
310 320 330 340 350
LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVAT KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS
410 420 430 440 450
GYFMTAVPQT QNHAAYYPPS QIARLRPSPR WTAQGARPHP FQNKPSAIRP
460 470 480 490 500
GAPRVPFSTM RPASSQVPRV MSTQRVANTS TQTVGPRPAA AAAAAATPAV
510 520 530 540 550
RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL TASRLASAPP
560 570 580 590 600
QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS
610 620 630
KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V
Length:631
Mass (Da):70,031
Last modified:February 1, 2003 - v2
Checksum:i2F8C5BF6F508AAEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221 – 222KV → EL in CAB66834 (PubMed:11230166).Curated2
Sequence conflicti492A → R in AAG38953 (PubMed:11328870).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132026 mRNA. Translation: AAG38953.1.
AL136900 mRNA. Translation: CAB66834.2.
BC027617 mRNA. Translation: AAH27617.1.
CCDSiCCDS9311.1.
RefSeqiNP_112241.2. NM_030979.2.
UniGeneiHs.458280.

Genome annotation databases

EnsembliENST00000281589; ENSP00000281589; ENSG00000151846.
GeneIDi5042.
KEGGihsa:5042.
UCSCiuc001upy.4. human.

Similar proteinsi

Entry informationi

Entry nameiPABP3_HUMAN
AccessioniPrimary (citable) accession number: Q9H361
Secondary accession number(s): Q8NHV0, Q9H086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: October 25, 2017
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families