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Q9H361 (PABP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Polyadenylate-binding protein 3

Short name=PABP-3
Short name=Poly(A)-binding protein 3
Alternative name(s):
Testis-specific poly(A)-binding protein
Gene names
Name:PABPC3
Synonyms:PABP3, PABPL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length631 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Testis specific. Ref.1

Sequence similarities

Belongs to the polyadenylate-binding protein type-1 family.

Contains 1 PABC domain.

Contains 4 RRM (RNA recognition motif) domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandRNA-binding
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA metabolic process

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

poly(A) binding

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 631631Polyadenylate-binding protein 3
PRO_0000081702

Regions

Domain11 – 8979RRM 1
Domain99 – 17577RRM 2
Domain191 – 26878RRM 3
Domain294 – 37077RRM 4
Domain537 – 61478PABC

Experimental info

Sequence conflict221 – 2222KV → EL in CAB66834. Ref.2
Sequence conflict4921A → R in AAG38953. Ref.1

Secondary structure

............ 631
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9H361 [UniParc].

Last modified February 1, 2003. Version 2.
Checksum: 2F8C5BF6F508AAEF

FASTA63170,031
        10         20         30         40         50         60 
MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG SSNYAYVNFQ 

        70         80         90        100        110        120 
HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFVKNLDKSI NNKALYDTVS 

       130        140        150        160        170        180 
AFGNILSCNV VCDENGSKGY GFVHFETHEA AERAIKKMNG MLLNGRKVFV GQFKSRKERE 

       190        200        210        220        230        240 
AELGARAKEF PNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER 

       250        260        270        280        290        300 
HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN 

       310        320        330        340        350        360 
LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT 

       370        380        390        400        410        420 
KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS GYFMTAVPQT QNHAAYYPPS 

       430        440        450        460        470        480 
QIARLRPSPR WTAQGARPHP FQNKPSAIRP GAPRVPFSTM RPASSQVPRV MSTQRVANTS 

       490        500        510        520        530        540 
TQTVGPRPAA AAAAAATPAV RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL 

       550        560        570        580        590        600 
TASRLASAPP QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS 

       610        620        630 
KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V 

« Hide

References

« Hide 'large scale' references
[1]"Human testis expresses a specific poly(A)-binding protein."
Feral C., Guellaen G., Pawlak A.
Nucleic Acids Res. 29:1872-1883(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Solution structure of RNA binding domain 4 in polyadenylation binding protein 3."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 286-376.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132026 mRNA. Translation: AAG38953.1.
AL136900 mRNA. Translation: CAB66834.2.
BC027617 mRNA. Translation: AAH27617.1.
RefSeqNP_112241.2. NM_030979.2.
UniGeneHs.458280.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2D9PNMR-A286-375[»]
4IVEX-ray2.30A/B/C/D535-631[»]
ProteinModelPortalQ9H361.
SMRQ9H361. Positions 1-376, 491-631.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111079. 6 interactions.
IntActQ9H361. 4 interactions.
MINTMINT-3067051.
STRING9606.ENSP00000281589.

PTM databases

PhosphoSiteQ9H361.

Polymorphism databases

DMDM28201852.

Proteomic databases

PaxDbQ9H361.
PRIDEQ9H361.

Protocols and materials databases

DNASU5042.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281589; ENSP00000281589; ENSG00000151846.
GeneID5042.
KEGGhsa:5042.
UCSCuc001upy.3. human.

Organism-specific databases

CTD5042.
GeneCardsGC13P025670.
HGNCHGNC:8556. PABPC3.
HPAHPA045423.
MIM604680. gene.
neXtProtNX_Q9H361.
PharmGKBPA32882.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0724.
HOGENOMHOG000217922.
HOVERGENHBG002295.
InParanoidQ9H361.
KOK13126.
OMARTVPRYK.
OrthoDBEOG7RV9FP.
PhylomeDBQ9H361.
TreeFamTF300458.

Gene expression databases

ArrayExpressQ9H361.
BgeeQ9H361.
CleanExHS_PABPC3.
GenevestigatorQ9H361.

Family and domain databases

Gene3D1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view]
SMARTSM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
[Graphical view]
SUPFAMSSF63570. SSF63570. 1 hit.
TIGRFAMsTIGR01628. PABP-1234. 1 hit.
PROSITEPS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9H361.
GeneWikiPABPC3.
GenomeRNAi5042.
NextBio19414.
PROQ9H361.
SOURCESearch...

Entry information

Entry namePABP3_HUMAN
AccessionPrimary (citable) accession number: Q9H361
Secondary accession number(s): Q8NHV0, Q9H086
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM