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Q9H361

- PABP3_HUMAN

UniProt

Q9H361 - PABP3_HUMAN

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Protein

Polyadenylate-binding protein 3

Gene

PABPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) binding Source: UniProtKB

GO - Biological processi

  1. mRNA metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 3
Short name:
PABP-3
Short name:
Poly(A)-binding protein 3
Alternative name(s):
Testis-specific poly(A)-binding protein
Gene namesi
Name:PABPC3
Synonyms:PABP3, PABPL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:8556. PABPC3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Polyadenylate-binding protein 3PRO_0000081702Add
BLAST

Proteomic databases

MaxQBiQ9H361.
PaxDbiQ9H361.
PRIDEiQ9H361.

PTM databases

PhosphoSiteiQ9H361.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ9H361.
CleanExiHS_PABPC3.
ExpressionAtlasiQ9H361. baseline and differential.
GenevestigatoriQ9H361.

Organism-specific databases

HPAiHPA045423.

Interactioni

Protein-protein interaction databases

BioGridi111079. 8 interactions.
IntActiQ9H361. 4 interactions.
MINTiMINT-3067051.
STRINGi9606.ENSP00000281589.

Structurei

Secondary structure

1
631
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi542 – 5465Combined sources
Helixi550 – 56819Combined sources
Turni570 – 5723Combined sources
Helixi573 – 5808Combined sources
Helixi585 – 5928Combined sources
Helixi595 – 60915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D9PNMR-A286-375[»]
4IVEX-ray2.30A/B/C/D535-631[»]
ProteinModelPortaliQ9H361.
SMRiQ9H361. Positions 11-429, 491-631.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H361.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8979RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini99 – 17577RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini191 – 26878RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 37077RRM 4PROSITE-ProRule annotationAdd
BLAST
Domaini537 – 61478PABCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PABC domain.PROSITE-ProRule annotation
Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ9H361.
KOiK13126.
OMAiMELFSEF.
OrthoDBiEOG7RV9FP.
PhylomeDBiQ9H361.
TreeFamiTF300458.

Family and domain databases

Gene3Di1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiPS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H361-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG
60 70 80 90 100
SSNYAYVNFQ HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN
110 120 130 140 150
IFVKNLDKSI NNKALYDTVS AFGNILSCNV VCDENGSKGY GFVHFETHEA
160 170 180 190 200
AERAIKKMNG MLLNGRKVFV GQFKSRKERE AELGARAKEF PNVYIKNFGE
210 220 230 240 250
DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE
260 270 280 290 300
MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN
310 320 330 340 350
LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVAT KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS
410 420 430 440 450
GYFMTAVPQT QNHAAYYPPS QIARLRPSPR WTAQGARPHP FQNKPSAIRP
460 470 480 490 500
GAPRVPFSTM RPASSQVPRV MSTQRVANTS TQTVGPRPAA AAAAAATPAV
510 520 530 540 550
RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL TASRLASAPP
560 570 580 590 600
QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS
610 620 630
KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V
Length:631
Mass (Da):70,031
Last modified:February 1, 2003 - v2
Checksum:i2F8C5BF6F508AAEF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2222KV → EL in CAB66834. (PubMed:11230166)Curated
Sequence conflicti492 – 4921A → R in AAG38953. (PubMed:11328870)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132026 mRNA. Translation: AAG38953.1.
AL136900 mRNA. Translation: CAB66834.2.
BC027617 mRNA. Translation: AAH27617.1.
CCDSiCCDS9311.1.
RefSeqiNP_112241.2. NM_030979.2.
UniGeneiHs.458280.

Genome annotation databases

EnsembliENST00000281589; ENSP00000281589; ENSG00000151846.
GeneIDi5042.
KEGGihsa:5042.
UCSCiuc001upy.3. human.

Polymorphism databases

DMDMi28201852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132026 mRNA. Translation: AAG38953.1 .
AL136900 mRNA. Translation: CAB66834.2 .
BC027617 mRNA. Translation: AAH27617.1 .
CCDSi CCDS9311.1.
RefSeqi NP_112241.2. NM_030979.2.
UniGenei Hs.458280.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D9P NMR - A 286-375 [» ]
4IVE X-ray 2.30 A/B/C/D 535-631 [» ]
ProteinModelPortali Q9H361.
SMRi Q9H361. Positions 11-429, 491-631.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111079. 8 interactions.
IntActi Q9H361. 4 interactions.
MINTi MINT-3067051.
STRINGi 9606.ENSP00000281589.

PTM databases

PhosphoSitei Q9H361.

Polymorphism databases

DMDMi 28201852.

Proteomic databases

MaxQBi Q9H361.
PaxDbi Q9H361.
PRIDEi Q9H361.

Protocols and materials databases

DNASUi 5042.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281589 ; ENSP00000281589 ; ENSG00000151846 .
GeneIDi 5042.
KEGGi hsa:5042.
UCSCi uc001upy.3. human.

Organism-specific databases

CTDi 5042.
GeneCardsi GC13P025670.
HGNCi HGNC:8556. PABPC3.
HPAi HPA045423.
MIMi 604680. gene.
neXtProti NX_Q9H361.
PharmGKBi PA32882.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00760000118913.
HOGENOMi HOG000217922.
HOVERGENi HBG002295.
InParanoidi Q9H361.
KOi K13126.
OMAi MELFSEF.
OrthoDBi EOG7RV9FP.
PhylomeDBi Q9H361.
TreeFami TF300458.

Miscellaneous databases

EvolutionaryTracei Q9H361.
GeneWikii PABPC3.
GenomeRNAii 5042.
NextBioi 19414.
PROi Q9H361.
SOURCEi Search...

Gene expression databases

Bgeei Q9H361.
CleanExi HS_PABPC3.
ExpressionAtlasi Q9H361. baseline and differential.
Genevestigatori Q9H361.

Family and domain databases

Gene3Di 1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view ]
SMARTi SM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
[Graphical view ]
SUPFAMi SSF63570. SSF63570. 1 hit.
TIGRFAMsi TIGR01628. PABP-1234. 1 hit.
PROSITEi PS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human testis expresses a specific poly(A)-binding protein."
    Feral C., Guellaen G., Pawlak A.
    Nucleic Acids Res. 29:1872-1883(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Solution structure of RNA binding domain 4 in polyadenylation binding protein 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 286-376.

Entry informationi

Entry nameiPABP3_HUMAN
AccessioniPrimary (citable) accession number: Q9H361
Secondary accession number(s): Q8NHV0, Q9H086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3