ID   Q9H348_HUMAN            Unreviewed;       779 AA.
AC   Q9H348;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 126.
DE   RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|ARBA:ARBA00029538, ECO:0000256|PIRNR:PIRNR028921};
GN   Name=HVPS41 {ECO:0000313|EMBL:AAG43279.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG43279.1};
RN   [1] {ECO:0000313|EMBL:AAG43279.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Aorta {ECO:0000313|EMBL:AAG43279.1};
RA   Zhao Y., Cao H., Jiang Y., Meng X., Zhao X., Liu D., Ding J.;
RT   "Cloning and characterization of an alternative splice variant of HVSP41
RT   gene in human aorta.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC       lysosomal compartments including the endocytic membrane transport
CC       pathways. {ECO:0000256|PIRNR:PIRNR028921}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028921}. Late endosome membrane
CC       {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028921}. Early endosome membrane
CC       {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028921}. Lysosome membrane
CC       {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network
CC       {ECO:0000256|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated
CC       vesicle {ECO:0000256|PIRNR:PIRNR028921}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- SIMILARITY: Belongs to the VPS41 family.
CC       {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR   EMBL; AF135593; AAG43279.1; -; mRNA.
DR   AlphaFoldDB; Q9H348; -.
DR   PeptideAtlas; Q9H348; -.
DR   ChiTaRS; VPS41; human.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IEA:UniProtKB-UniRule.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR   GO; GO:0007034; P:vacuolar transport; IEA:UniProtKB-UniRule.
DR   CDD; cd16690; RING-H2_Vps41; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR016902; VPS41.
DR   InterPro; IPR045111; Vps41/Vps8.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR   PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   PIRSF; PIRSF028921; VPS41; 1.
DR   SMART; SM00299; CLH; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50236; CHCR; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR028921};
KW   Endosome {ECO:0000256|PIRNR:PIRNR028921};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW   ECO:0000256|PIRNR:PIRNR028921}; Lysosome {ECO:0000256|PIRNR:PIRNR028921};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW   Transport {ECO:0000256|PIRNR:PIRNR028921};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          716..764
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   779 AA;  90333 MW;  B75D88ACC3F3145D CRC64;
     MTVHDKFLAL GTHYGKVYLL DVQGNITQKF DVVQVFGLYS GEEFHETFDC PIKIIAVHPH
     FVRSSCKQFV TGGKKLLLFE RSWMNRWKSA VLHEGEGNIR SVKWRGHLIA WANNMGVKIF
     DIISKQRITN VPRDDISLRP DMYPCSLCWK DNVTLIIGWG TSVKVCSVKE RHASEMRDLP
     SRYVEIVSQF ETEFYISGLA PLCDQLVVLS YVKEISEKTE REYCARPRLD IIQPLSETCE
     EISSDALTVR GFQENECRDY HLEYSEGESL FYIVSPRDVV VAKERDQDDH IDWLLEKKKY
     EEALMAAEIS QKNIKRHKIL DIGLAYINHL VERGDYDIAA RKCQKILGKN AALWEYEVYK
     FKEIGQLKAI SPYLPRGDPV LKPLIYEMIL HEFLESDYEG FATLIREWPG DLYNNSVIVQ
     AVRDHLKKDS QNKTLLKTLA ELYTYDKNYG NALEIYLTLR HKDVFQLIHK HNLFSSIKDK
     IVLLMDFDSE KAVDMLLDNE DKISIKKVVE ELEDRPELQH VYLHKLFKRD HHKGQRYHEK
     QISLYAEYDR PNLLPFLRDS THCPLEKALE ICQQRNFVEE TVYLLSRMGN SRSALKMIME
     ELHDVDKAIE FAKEQDDGEL WEDLILYSID KPPFITGLLN NIGTHVDPIL LIHRIKEGME
     IPNLRDSLVK ILQDYNLQIL LREGCKKILV ADSLSLLKKM HRTQMKGVLV DEENICESCL
     SPILPSDAAK PFSVVVFHCR HMFHKECLPM PSMNSAAQFC NICSAKNRGP GSAILEMKK
//