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Protein

Vacuolar protein sorting-associated protein 41 homolog

Gene

HVPS41

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 41 homologUniRule annotation
Gene namesi
Name:HVPS41Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicleUniRule annotation, EndosomeUniRule annotation, Golgi apparatusUniRule annotation, LysosomeUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ9H348

Structurei

3D structure databases

ProteinModelPortaliQ9H348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati493 – 637CHCRPROSITE-ProRule annotationAdd BLAST145
Domaini716 – 764RING-typeInterPro annotationAdd BLAST49

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili595 – 615Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the VPS41 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2066 Eukaryota
ENOG410XQBC LUCA
HOGENOMiHOG000247002
HOVERGENiHBG056494

Family and domain databases

Gene3Di1.25.40.101 hit
InterProiView protein in InterPro
IPR000547 Clathrin_H-chain/VPS_repeat
IPR011990 TPR-like_helical_dom_sf
IPR016902 VPS41
IPR036322 WD40_repeat_dom_sf
IPR001841 Znf_RING
PfamiView protein in Pfam
PF00637 Clathrin, 1 hit
PIRSFiPIRSF028921 VPS41, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVHDKFLAL GTHYGKVYLL DVQGNITQKF DVVQVFGLYS GEEFHETFDC
60 70 80 90 100
PIKIIAVHPH FVRSSCKQFV TGGKKLLLFE RSWMNRWKSA VLHEGEGNIR
110 120 130 140 150
SVKWRGHLIA WANNMGVKIF DIISKQRITN VPRDDISLRP DMYPCSLCWK
160 170 180 190 200
DNVTLIIGWG TSVKVCSVKE RHASEMRDLP SRYVEIVSQF ETEFYISGLA
210 220 230 240 250
PLCDQLVVLS YVKEISEKTE REYCARPRLD IIQPLSETCE EISSDALTVR
260 270 280 290 300
GFQENECRDY HLEYSEGESL FYIVSPRDVV VAKERDQDDH IDWLLEKKKY
310 320 330 340 350
EEALMAAEIS QKNIKRHKIL DIGLAYINHL VERGDYDIAA RKCQKILGKN
360 370 380 390 400
AALWEYEVYK FKEIGQLKAI SPYLPRGDPV LKPLIYEMIL HEFLESDYEG
410 420 430 440 450
FATLIREWPG DLYNNSVIVQ AVRDHLKKDS QNKTLLKTLA ELYTYDKNYG
460 470 480 490 500
NALEIYLTLR HKDVFQLIHK HNLFSSIKDK IVLLMDFDSE KAVDMLLDNE
510 520 530 540 550
DKISIKKVVE ELEDRPELQH VYLHKLFKRD HHKGQRYHEK QISLYAEYDR
560 570 580 590 600
PNLLPFLRDS THCPLEKALE ICQQRNFVEE TVYLLSRMGN SRSALKMIME
610 620 630 640 650
ELHDVDKAIE FAKEQDDGEL WEDLILYSID KPPFITGLLN NIGTHVDPIL
660 670 680 690 700
LIHRIKEGME IPNLRDSLVK ILQDYNLQIL LREGCKKILV ADSLSLLKKM
710 720 730 740 750
HRTQMKGVLV DEENICESCL SPILPSDAAK PFSVVVFHCR HMFHKECLPM
760 770
PSMNSAAQFC NICSAKNRGP GSAILEMKK
Length:779
Mass (Da):90,333
Last modified:March 1, 2001 - v1
Checksum:iB75D88ACC3F3145D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135593 mRNA Translation: AAG43279.1

Similar proteinsi

Entry informationi

Entry nameiQ9H348_HUMAN
AccessioniPrimary (citable) accession number: Q9H348
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.