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Protein

Ubiquilin-3

Gene

UBQLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquilin-3
Gene namesi
Name:UBQLN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12510. UBQLN3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37157.

Polymorphism and mutation databases

BioMutaiUBQLN3.
DMDMi48474643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Ubiquilin-3PRO_0000211013Add
BLAST

Proteomic databases

PaxDbiQ9H347.
PRIDEiQ9H347.

PTM databases

iPTMnetiQ9H347.
PhosphoSiteiQ9H347.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiQ9H347.
CleanExiHS_UBQLN3.
ExpressionAtlasiQ9H347. baseline and differential.
GenevisibleiQ9H347. HS.

Organism-specific databases

HPAiHPA020547.
HPA062018.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347997.

Structurei

Secondary structure

1
655
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 277Combined sources
Beta strandi32 – 387Combined sources
Helixi43 – 5412Combined sources
Helixi58 – 603Combined sources
Beta strandi61 – 655Combined sources
Helixi76 – 794Combined sources
Beta strandi86 – 916Combined sources
Helixi617 – 62610Combined sources
Helixi631 – 64111Combined sources
Helixi645 – 65511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WX7NMR-A12-104[»]
1YQBX-ray2.00A19-99[»]
2DAHNMR-A615-655[»]
ProteinModelPortaliQ9H347.
SMRiQ9H347. Positions 15-98, 614-655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H347.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9877Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini194 – 23340STI1Sequence analysisAdd
BLAST
Domaini609 – 65547UBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STI1 domain.Sequence analysis
Contains 1 UBA domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISS6. Eukaryota.
ENOG410XT8C. LUCA.
GeneTreeiENSGT00390000005720.
HOGENOMiHOG000234878.
HOVERGENiHBG064537.
InParanoidiQ9H347.
KOiK04523.
OMAiPMLNAVQ.
OrthoDBiEOG7HF1J8.
PhylomeDBiQ9H347.
TreeFamiTF314412.

Family and domain databases

InterProiIPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGGEALPQ GSPAPVQDPH LIKVTVKTPK DKEDFSVTDT CTIQQLKEEI
60 70 80 90 100
SQRFKAHPDQ LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKRQHRAMGN
110 120 130 140 150
ECPAASVPTQ GPSPGSLPQP SSIYPADGPP AFSLGLLTGL SRLGLAYRGF
160 170 180 190 200
PDQPSSLMRQ HVSVPEFVTQ LIDDPFIPGL LSNTGLVRQL VLDNPHMQQL
210 220 230 240 250
IQHNPEIGHI LNNPEIMRQT LEFLRNPAMM QEMIRSQDRV LSNLESIPGG
260 270 280 290 300
YNVLCTMYTD IMDPMLNAVQ EQFGGNPFAT ATTDNATTTT SQPSRMENCD
310 320 330 340 350
PLPNPWTSTH GGSGSRQGRQ DGDQDAPDIR NRFPNFLGII RLYDYLQQLH
360 370 380 390 400
ENPQSLGTYL QGTASALSQS QEPPPSVNRV PPSSPSSQEP GSGQPLPEES
410 420 430 440 450
VAIKGRSSCP AFLRYPTENS TGQGGDQDGA GKSSTGHSTN LPDLVSGLGD
460 470 480 490 500
SANRVPFAPL SFSPTAAIPG IPEPPWLPSP AYPRSLRPDG MNPAPQLQDE
510 520 530 540 550
IQPQLPLLMH LQAAMANPRA LQALRQIEQG LQVLATEAPR LLLWFMPCLA
560 570 580 590 600
GTGSVAGGIE SREDPLMSED PLPNPPPEVF PALDSAELGF LSPPFLHMLQ
610 620 630 640 650
DLVSTNPQQL QPEAHFQVQL EQLRSMGFLN REANLQALIA TGGDVDAAVE

KLRQS
Length:655
Mass (Da):70,841
Last modified:March 29, 2004 - v2
Checksum:i6961DA801CE91F27
GO

Sequence cautioni

The sequence AAG41675.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551C → R.
Corresponds to variant rs2234446 [ dbSNP | Ensembl ].
VAR_052681
Natural varianti285 – 2851N → D.
Corresponds to variant rs2234449 [ dbSNP | Ensembl ].
VAR_052682
Natural varianti287 – 2871T → A.
Corresponds to variant rs2234450 [ dbSNP | Ensembl ].
VAR_052683
Natural varianti290 – 2901T → S.
Corresponds to variant rs2234451 [ dbSNP | Ensembl ].
VAR_052684
Natural varianti546 – 5461M → T.
Corresponds to variant rs2234455 [ dbSNP | Ensembl ].
VAR_034578
Natural varianti624 – 6241R → Q.
Corresponds to variant rs2227271 [ dbSNP | Ensembl ].
VAR_020363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41675.1. Sequence problems.
AF230481 mRNA. Translation: AAF67143.1.
BC036743 mRNA. Translation: AAH36743.1.
CCDSiCCDS7758.1.
RefSeqiNP_059509.1. NM_017481.2.
XP_011518446.1. XM_011520144.1.
UniGeneiHs.189184.

Genome annotation databases

EnsembliENST00000311659; ENSP00000347997; ENSG00000175520.
GeneIDi50613.
KEGGihsa:50613.
UCSCiuc001may.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41675.1. Sequence problems.
AF230481 mRNA. Translation: AAF67143.1.
BC036743 mRNA. Translation: AAH36743.1.
CCDSiCCDS7758.1.
RefSeqiNP_059509.1. NM_017481.2.
XP_011518446.1. XM_011520144.1.
UniGeneiHs.189184.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WX7NMR-A12-104[»]
1YQBX-ray2.00A19-99[»]
2DAHNMR-A615-655[»]
ProteinModelPortaliQ9H347.
SMRiQ9H347. Positions 15-98, 614-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347997.

PTM databases

iPTMnetiQ9H347.
PhosphoSiteiQ9H347.

Polymorphism and mutation databases

BioMutaiUBQLN3.
DMDMi48474643.

Proteomic databases

PaxDbiQ9H347.
PRIDEiQ9H347.

Protocols and materials databases

DNASUi50613.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311659; ENSP00000347997; ENSG00000175520.
GeneIDi50613.
KEGGihsa:50613.
UCSCiuc001may.2. human.

Organism-specific databases

CTDi50613.
GeneCardsiUBQLN3.
HGNCiHGNC:12510. UBQLN3.
HPAiHPA020547.
HPA062018.
MIMi605473. gene.
neXtProtiNX_Q9H347.
PharmGKBiPA37157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISS6. Eukaryota.
ENOG410XT8C. LUCA.
GeneTreeiENSGT00390000005720.
HOGENOMiHOG000234878.
HOVERGENiHBG064537.
InParanoidiQ9H347.
KOiK04523.
OMAiPMLNAVQ.
OrthoDBiEOG7HF1J8.
PhylomeDBiQ9H347.
TreeFamiTF314412.

Miscellaneous databases

EvolutionaryTraceiQ9H347.
GenomeRNAii50613.
PROiQ9H347.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H347.
CleanExiHS_UBQLN3.
ExpressionAtlasiQ9H347. baseline and differential.
GenevisibleiQ9H347. HS.

Family and domain databases

InterProiIPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00627. UBA. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain."
    Conklin D., Holderman S., Whitmore T.E., Maurer M., Feldhaus A.L.
    Gene 249:91-98(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The ubiquilin gene family: evolutionary patterns and functional insights."
    Marin I.
    BMC Evol. Biol. 14:63-63(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. "Solution structure of the N-terminal ubiquitin-like domain in the human ubiquilin 3 (UBQLN3)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 11-104.
  6. "The ubiquitin-like domain of human ubiquilin 3."
    Structural genomics consortium (SGC)
    Submitted (JAN-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 19-99.

Entry informationi

Entry nameiUBQL3_HUMAN
AccessioniPrimary (citable) accession number: Q9H347
Secondary accession number(s): Q9NRE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: June 8, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.