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Protein

Olfactory receptor 52D1

Gene

OR52D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52D1
Alternative name(s):
Odorant receptor HOR5'beta14
Olfactory receptor OR11-43
Gene namesi
Name:OR52D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15212. OR52D1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 10224ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14219CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 19936ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 24020CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 27716ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini299 – 31820CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32401.

Polymorphism and mutation databases

BioMutaiOR52D1.
DMDMi14423837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Olfactory receptor 52D1PRO_0000150770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H346.
PRIDEiQ9H346.

PTM databases

iPTMnetiQ9H346.

Expressioni

Gene expression databases

BgeeiQ9H346.
CleanExiHS_OR52D1.
GenevisibleiQ9H346. HS.

Organism-specific databases

HPAiHPA046965.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326232.

Structurei

3D structure databases

ProteinModelPortaliQ9H346.
SMRiQ9H346. Positions 14-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II1I. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H346.
KOiK04257.
OMAiGHRVMTH.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H346.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSNLSDNH LPDTFFLTGI PGLEAAHFWI AIPFCAMYLV ALVGNAALIL
60 70 80 90 100
VIAMDNALHA PMYLFLCLLS LTDLALSSTT VPKMLAILWL HAGEISFGGC
110 120 130 140 150
LAQMFCVHSI YALESSILLA MAFDRYVAIC NPLRYTTILN HAVIGRIGFV
160 170 180 190 200
GLFRSVAIVS PFIFLLRRLP YCGHRVMTHT YCEHMGIARL ACANITVNIV
210 220 230 240 250
YGLTVALLAM GLDSILIAIS YGFILHAVFH LPSHDAQHKA LSTCGSHIGI
260 270 280 290 300
ILVFYIPAFF SFLTHRFGHH EVPKHVHIFL ANLYVLVPPV LNPILYGART
310
KEIRSRLLKL LHLGKTSI
Length:318
Mass (Da):35,122
Last modified:March 1, 2001 - v1
Checksum:i178968087D613CB2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541R → C.
Corresponds to variant rs7935144 [ dbSNP | Ensembl ].
VAR_034331
Natural varianti213 – 2131D → E.
Corresponds to variant rs7924754 [ dbSNP | Ensembl ].
VAR_034332
Natural varianti221 – 2211Y → F.
Corresponds to variant rs7950082 [ dbSNP | Ensembl ].
VAR_034333
Natural varianti251 – 2511I → T.
Corresponds to variant rs7101919 [ dbSNP | Ensembl ].
VAR_024146
Natural varianti304 – 3041R → W.
Corresponds to variant rs11037758 [ dbSNP | Ensembl ].
VAR_034334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41676.1.
CH471064 Genomic DNA. Translation: EAW68791.1.
BC136928 mRNA. Translation: AAI36929.1.
BC136930 mRNA. Translation: AAI36931.1.
BK004276 Genomic DNA. Translation: DAA04674.1.
CCDSiCCDS31384.1.
RefSeqiNP_001005163.1. NM_001005163.2.
UniGeneiHs.553734.

Genome annotation databases

EnsembliENST00000322641; ENSP00000326232; ENSG00000181609.
GeneIDi390066.
KEGGihsa:390066.
UCSCiuc010qzg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41676.1.
CH471064 Genomic DNA. Translation: EAW68791.1.
BC136928 mRNA. Translation: AAI36929.1.
BC136930 mRNA. Translation: AAI36931.1.
BK004276 Genomic DNA. Translation: DAA04674.1.
CCDSiCCDS31384.1.
RefSeqiNP_001005163.1. NM_001005163.2.
UniGeneiHs.553734.

3D structure databases

ProteinModelPortaliQ9H346.
SMRiQ9H346. Positions 14-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326232.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H346.

Polymorphism and mutation databases

BioMutaiOR52D1.
DMDMi14423837.

Proteomic databases

PaxDbiQ9H346.
PRIDEiQ9H346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322641; ENSP00000326232; ENSG00000181609.
GeneIDi390066.
KEGGihsa:390066.
UCSCiuc010qzg.3. human.

Organism-specific databases

CTDi390066.
GeneCardsiOR52D1.
HGNCiHGNC:15212. OR52D1.
HPAiHPA046965.
neXtProtiNX_Q9H346.
PharmGKBiPA32401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1I. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H346.
KOiK04257.
OMAiGHRVMTH.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H346.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52D1.
GenomeRNAii390066.
PROiQ9H346.

Gene expression databases

BgeeiQ9H346.
CleanExiHS_OR52D1.
GenevisibleiQ9H346. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52D1_HUMAN
AccessioniPrimary (citable) accession number: Q9H346
Secondary accession number(s): B9EGY9, Q6IFI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.