Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 52D1

Gene

OR52D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167362-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52D1
Alternative name(s):
Odorant receptor HOR5'beta14
Olfactory receptor OR11-43
Gene namesi
Name:OR52D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15212. OR52D1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 102ExtracellularSequence analysisAdd BLAST24
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 199ExtracellularSequence analysisAdd BLAST36
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 277ExtracellularSequence analysisAdd BLAST16
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 318CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390066.
OpenTargetsiENSG00000181609.
PharmGKBiPA32401.

Polymorphism and mutation databases

BioMutaiOR52D1.
DMDMi14423837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507701 – 318Olfactory receptor 52D1Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H346.
PRIDEiQ9H346.

PTM databases

iPTMnetiQ9H346.
PhosphoSitePlusiQ9H346.

Expressioni

Gene expression databases

BgeeiENSG00000181609.
CleanExiHS_OR52D1.
ExpressionAtlasiQ9H346. baseline and differential.
GenevisibleiQ9H346. HS.

Organism-specific databases

HPAiHPA046965.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326232.

Structurei

3D structure databases

ProteinModelPortaliQ9H346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II1I. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H346.
KOiK04257.
OMAiGHRVMTH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H346.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSNLSDNH LPDTFFLTGI PGLEAAHFWI AIPFCAMYLV ALVGNAALIL
60 70 80 90 100
VIAMDNALHA PMYLFLCLLS LTDLALSSTT VPKMLAILWL HAGEISFGGC
110 120 130 140 150
LAQMFCVHSI YALESSILLA MAFDRYVAIC NPLRYTTILN HAVIGRIGFV
160 170 180 190 200
GLFRSVAIVS PFIFLLRRLP YCGHRVMTHT YCEHMGIARL ACANITVNIV
210 220 230 240 250
YGLTVALLAM GLDSILIAIS YGFILHAVFH LPSHDAQHKA LSTCGSHIGI
260 270 280 290 300
ILVFYIPAFF SFLTHRFGHH EVPKHVHIFL ANLYVLVPPV LNPILYGART
310
KEIRSRLLKL LHLGKTSI
Length:318
Mass (Da):35,122
Last modified:March 1, 2001 - v1
Checksum:i178968087D613CB2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034331154R → C.Corresponds to variant rs7935144dbSNPEnsembl.1
Natural variantiVAR_034332213D → E.Corresponds to variant rs7924754dbSNPEnsembl.1
Natural variantiVAR_034333221Y → F.Corresponds to variant rs7950082dbSNPEnsembl.1
Natural variantiVAR_024146251I → T.Corresponds to variant rs7101919dbSNPEnsembl.1
Natural variantiVAR_034334304R → W.Corresponds to variant rs11037758dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41676.1.
CH471064 Genomic DNA. Translation: EAW68791.1.
BC136928 mRNA. Translation: AAI36929.1.
BC136930 mRNA. Translation: AAI36931.1.
BK004276 Genomic DNA. Translation: DAA04674.1.
CCDSiCCDS31384.1.
RefSeqiNP_001005163.1. NM_001005163.2.
UniGeneiHs.553734.

Genome annotation databases

EnsembliENST00000322641; ENSP00000326232; ENSG00000181609.
GeneIDi390066.
KEGGihsa:390066.
UCSCiuc010qzg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41676.1.
CH471064 Genomic DNA. Translation: EAW68791.1.
BC136928 mRNA. Translation: AAI36929.1.
BC136930 mRNA. Translation: AAI36931.1.
BK004276 Genomic DNA. Translation: DAA04674.1.
CCDSiCCDS31384.1.
RefSeqiNP_001005163.1. NM_001005163.2.
UniGeneiHs.553734.

3D structure databases

ProteinModelPortaliQ9H346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326232.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H346.
PhosphoSitePlusiQ9H346.

Polymorphism and mutation databases

BioMutaiOR52D1.
DMDMi14423837.

Proteomic databases

PaxDbiQ9H346.
PRIDEiQ9H346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322641; ENSP00000326232; ENSG00000181609.
GeneIDi390066.
KEGGihsa:390066.
UCSCiuc010qzg.3. human.

Organism-specific databases

CTDi390066.
DisGeNETi390066.
GeneCardsiOR52D1.
HGNCiHGNC:15212. OR52D1.
HPAiHPA046965.
neXtProtiNX_Q9H346.
OpenTargetsiENSG00000181609.
PharmGKBiPA32401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1I. Eukaryota.
ENOG410YB92. LUCA.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H346.
KOiK04257.
OMAiGHRVMTH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H346.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167362-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52D1.
GenomeRNAii390066.
PROiQ9H346.

Gene expression databases

BgeeiENSG00000181609.
CleanExiHS_OR52D1.
ExpressionAtlasiQ9H346. baseline and differential.
GenevisibleiQ9H346. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52D1_HUMAN
AccessioniPrimary (citable) accession number: Q9H346
Secondary accession number(s): B9EGY9, Q6IFI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.