ID   O51I2_HUMAN             Reviewed;         312 AA.
AC   Q9H344; B9EIL6; Q6IF81;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=Olfactory receptor 51I2;
DE   AltName: Full=Odorant receptor HOR5'beta12;
DE   AltName: Full=Olfactory receptor OR11-38;
GN   Name=OR51I2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA   Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA   Felsenfeld G., Groudine M., Hardison R.;
RT   "Comparative structural and functional analysis of the olfactory receptor
RT   genes flanking the human and mouse beta-globin gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-263.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR51I2/term:OR51I2/type:keyword";
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DR   EMBL; AF137396; AAG41678.1; -; Genomic_DNA.
DR   EMBL; BC140730; AAI40731.1; -; mRNA.
DR   EMBL; BK004381; DAA04779.1; -; Genomic_DNA.
DR   CCDS; CCDS31383.1; -.
DR   RefSeq; NP_001004754.1; NM_001004754.2.
DR   AlphaFoldDB; Q9H344; -.
DR   SMR; Q9H344; -.
DR   STRING; 9606.ENSP00000493016; -.
DR   GlyCosmos; Q9H344; 1 site, No reported glycans.
DR   GlyGen; Q9H344; 1 site.
DR   iPTMnet; Q9H344; -.
DR   PhosphoSitePlus; Q9H344; -.
DR   BioMuta; OR51I2; -.
DR   DMDM; 14423836; -.
DR   PaxDb; 9606-ENSP00000341987; -.
DR   Antibodypedia; 57765; 76 antibodies from 19 providers.
DR   DNASU; 390064; -.
DR   Ensembl; ENST00000641930.1; ENSP00000493016.1; ENSG00000187918.6.
DR   GeneID; 390064; -.
DR   KEGG; hsa:390064; -.
DR   MANE-Select; ENST00000641930.1; ENSP00000493016.1; NM_001004754.3; NP_001004754.1.
DR   UCSC; uc010qzf.3; human.
DR   AGR; HGNC:15201; -.
DR   CTD; 390064; -.
DR   DisGeNET; 390064; -.
DR   GeneCards; OR51I2; -.
DR   HGNC; HGNC:15201; OR51I2.
DR   HPA; ENSG00000187918; Not detected.
DR   neXtProt; NX_Q9H344; -.
DR   OpenTargets; ENSG00000187918; -.
DR   PharmGKB; PA32381; -.
DR   VEuPathDB; HostDB:ENSG00000187918; -.
DR   eggNOG; ENOG502RTZR; Eukaryota.
DR   GeneTree; ENSGT01090000259999; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9H344; -.
DR   OMA; CLNARSI; -.
DR   OrthoDB; 4578140at2759; -.
DR   PhylomeDB; Q9H344; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q9H344; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390064; 23 hits in 739 CRISPR screens.
DR   GeneWiki; OR51I2; -.
DR   GenomeRNAi; 390064; -.
DR   Pharos; Q9H344; Tdark.
DR   PRO; PR:Q9H344; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H344; Protein.
DR   Bgee; ENSG00000187918; Expressed in tibialis anterior and 3 other cell types or tissues.
DR   ExpressionAtlas; Q9H344; baseline and differential.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15222; 7tmA_OR51-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26450:SF112; OLFACTORY RECEPTOR 51I2; 1.
DR   PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9H344; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 51I2"
FT                   /id="PRO_0000150758"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..273
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         122
FT                   /note="R -> C (in dbSNP:rs10450603)"
FT                   /id="VAR_034321"
FT   VARIANT         134
FT                   /note="T -> A (in dbSNP:rs12577167)"
FT                   /id="VAR_034322"
FT   VARIANT         151
FT                   /note="R -> P (in dbSNP:rs16931292)"
FT                   /id="VAR_034323"
FT   VARIANT         263
FT                   /note="R -> H (in dbSNP:rs11037502)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024143"
SQ   SEQUENCE   312 AA;  35002 MW;  F17CD16C95FD1AF6 CRC64;
     MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR VEPSLHEPMY
     YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ MFLIHFFSMM ESGILLAMSF
     DRYVAICDPL RYATVLTTEV IAAMGLGAAA RSFITLFPLP FLIKRLPICR SNVLSHSYCL
     HPDMMRLACA DISINSIYGL FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT
     CVSHILAVLA FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR
     RAIFRMFHHI KI
//