Q9H344 (O51I2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 51I2

Alternative name(s):
Odorant receptor HOR5'beta12
Olfactory receptor OR11-38

Gene names

Name:

OR51I2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 51I2		PRO_0000150758
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 196	36	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 273	15	Extracellular Potential
	Transmembrane	274 – 294	21	Helical; Name=7; Potential
	Topological domain	295 – 312	18	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	122	1	R → C. Corresponds to variant rs10450603 [ dbSNP | Ensembl ].		VAR_034321
	Natural variant	134	1	T → A. Corresponds to variant rs12577167 [ dbSNP | Ensembl ].		VAR_034322
	Natural variant	151	1	R → P. Corresponds to variant rs16931292 [ dbSNP | Ensembl ].		VAR_034323
	Natural variant	263	1	R → H. Corresponds to variant rs11037502 [ dbSNP | Ensembl ].		VAR_024143

Sequences

	Sequence		Length	Mass (Da)
	Q9H344 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: F17CD16C95FD1AF6	FASTA	312	35,002
	10 20 30 40 50 60 MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR VEPSLHEPMY 70 80 90 100 110 120 YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ MFLIHFFSMM ESGILLAMSF 130 140 150 160 170 180 DRYVAICDPL RYATVLTTEV IAAMGLGAAA RSFITLFPLP FLIKRLPICR SNVLSHSYCL 190 200 210 220 230 240 HPDMMRLACA DISINSIYGL FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT 250 260 270 280 290 300 CVSHILAVLA FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR 310 RAIFRMFHHI KI

References

[1]	"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters." Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R. Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF137396 Genomic DNA. Translation: AAG41678.1. BK004381 Genomic DNA. Translation: DAA04779.1.
IPI	IPI00023125.
RefSeq	NP_001004754.1. NM_001004754.2.
UniGene	Hs.553733.
3D structure databases
ProteinModelPortal	Q9H344.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341987.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423836.
Proteomic databases
PaxDb	Q9H344.
PRIDE	Q9H344.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341449; ENSP00000341987; ENSG00000187918.
GeneID	390064.
KEGG	hsa:390064.
UCSC	uc010qzf.2. human.
Organism-specific databases
CTD	390064.
GeneCards	GC11P005476.
HGNC	HGNC:15201. OR51I2.
neXtProt	NX_Q9H344.
PharmGKB	PA32381.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148345.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q9H344.
KO	K04257.
OMA	FFSMMES.
OrthoDB	EOG4H19W6.
PhylomeDB	Q9H344.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q9H344.
CleanEx	HS_OR51I2.
Genevestigator	Q9H344.
GermOnline	ENSG00000187918. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390064.
NextBio	103337.

Entry information

Entry name

O51I2_HUMAN

Accession

Primary (citable) accession number: Q9H344
Secondary accession number(s): Q6IF81

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.