Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H344

- O51I2_HUMAN

UniProt

Q9H344 - O51I2_HUMAN

Protein

Olfactory receptor 51I2

Gene

OR51I2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 51I2
    Alternative name(s):
    Odorant receptor HOR5'beta12
    Olfactory receptor OR11-38
    Gene namesi
    Name:OR51I2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15201. OR51I2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32381.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 51I2PRO_0000150758Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H344.
    PRIDEiQ9H344.

    Expressioni

    Gene expression databases

    BgeeiQ9H344.
    CleanExiHS_OR51I2.
    GenevestigatoriQ9H344.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341987.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H344.
    SMRiQ9H344. Positions 37-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini295 – 31218CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148345.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ9H344.
    KOiK04257.
    OMAiFFSMMES.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ9H344.
    TreeFamiTF342735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H344-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR    50
    VEPSLHEPMY YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ 100
    MFLIHFFSMM ESGILLAMSF DRYVAICDPL RYATVLTTEV IAAMGLGAAA 150
    RSFITLFPLP FLIKRLPICR SNVLSHSYCL HPDMMRLACA DISINSIYGL 200
    FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT CVSHILAVLA 250
    FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR 300
    RAIFRMFHHI KI 312
    Length:312
    Mass (Da):35,002
    Last modified:March 1, 2001 - v1
    Checksum:iF17CD16C95FD1AF6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti122 – 1221R → C.
    Corresponds to variant rs10450603 [ dbSNP | Ensembl ].
    VAR_034321
    Natural varianti134 – 1341T → A.
    Corresponds to variant rs12577167 [ dbSNP | Ensembl ].
    VAR_034322
    Natural varianti151 – 1511R → P.
    Corresponds to variant rs16931292 [ dbSNP | Ensembl ].
    VAR_034323
    Natural varianti263 – 2631R → H.
    Corresponds to variant rs11037502 [ dbSNP | Ensembl ].
    VAR_024143

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137396 Genomic DNA. Translation: AAG41678.1.
    BK004381 Genomic DNA. Translation: DAA04779.1.
    CCDSiCCDS31383.1.
    RefSeqiNP_001004754.1. NM_001004754.2.
    UniGeneiHs.553733.

    Genome annotation databases

    EnsembliENST00000341449; ENSP00000341987; ENSG00000187918.
    GeneIDi390064.
    KEGGihsa:390064.
    UCSCiuc010qzf.2. human.

    Polymorphism databases

    DMDMi14423836.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137396 Genomic DNA. Translation: AAG41678.1 .
    BK004381 Genomic DNA. Translation: DAA04779.1 .
    CCDSi CCDS31383.1.
    RefSeqi NP_001004754.1. NM_001004754.2.
    UniGenei Hs.553733.

    3D structure databases

    ProteinModelPortali Q9H344.
    SMRi Q9H344. Positions 37-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341987.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423836.

    Proteomic databases

    PaxDbi Q9H344.
    PRIDEi Q9H344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341449 ; ENSP00000341987 ; ENSG00000187918 .
    GeneIDi 390064.
    KEGGi hsa:390064.
    UCSCi uc010qzf.2. human.

    Organism-specific databases

    CTDi 390064.
    GeneCardsi GC11P005476.
    HGNCi HGNC:15201. OR51I2.
    neXtProti NX_Q9H344.
    PharmGKBi PA32381.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148345.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q9H344.
    KOi K04257.
    OMAi FFSMMES.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q9H344.
    TreeFami TF342735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR51I2.
    GenomeRNAii 390064.
    NextBioi 103337.
    PROi Q9H344.

    Gene expression databases

    Bgeei Q9H344.
    CleanExi HS_OR51I2.
    Genevestigatori Q9H344.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
      Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
      Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO51I2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H344
    Secondary accession number(s): Q6IF81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3