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Protein

Olfactory receptor 51I2

Gene

OR51I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51I2
Alternative name(s):
Odorant receptor HOR5'beta12
Olfactory receptor OR11-38
Gene namesi
Name:OR51I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15201. OR51I2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini295 – 31218CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 51I2PRO_0000150758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H344.
PRIDEiQ9H344.

Expressioni

Gene expression databases

BgeeiQ9H344.
CleanExiHS_OR51I2.
GenevestigatoriQ9H344.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341987.

Structurei

3D structure databases

ProteinModelPortaliQ9H344.
SMRiQ9H344. Positions 37-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148345.
GeneTreeiENSGT00770000120456.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H344.
KOiK04257.
OMAiFFSMMES.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H344.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H344-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR
60 70 80 90 100
VEPSLHEPMY YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ
110 120 130 140 150
MFLIHFFSMM ESGILLAMSF DRYVAICDPL RYATVLTTEV IAAMGLGAAA
160 170 180 190 200
RSFITLFPLP FLIKRLPICR SNVLSHSYCL HPDMMRLACA DISINSIYGL
210 220 230 240 250
FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT CVSHILAVLA
260 270 280 290 300
FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR
310
RAIFRMFHHI KI
Length:312
Mass (Da):35,002
Last modified:March 1, 2001 - v1
Checksum:iF17CD16C95FD1AF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221R → C.
Corresponds to variant rs10450603 [ dbSNP | Ensembl ].
VAR_034321
Natural varianti134 – 1341T → A.
Corresponds to variant rs12577167 [ dbSNP | Ensembl ].
VAR_034322
Natural varianti151 – 1511R → P.
Corresponds to variant rs16931292 [ dbSNP | Ensembl ].
VAR_034323
Natural varianti263 – 2631R → H.
Corresponds to variant rs11037502 [ dbSNP | Ensembl ].
VAR_024143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41678.1.
BK004381 Genomic DNA. Translation: DAA04779.1.
CCDSiCCDS31383.1.
RefSeqiNP_001004754.1. NM_001004754.2.
UniGeneiHs.553733.

Genome annotation databases

EnsembliENST00000341449; ENSP00000341987; ENSG00000187918.
GeneIDi390064.
KEGGihsa:390064.
UCSCiuc010qzf.2. human.

Polymorphism databases

DMDMi14423836.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41678.1.
BK004381 Genomic DNA. Translation: DAA04779.1.
CCDSiCCDS31383.1.
RefSeqiNP_001004754.1. NM_001004754.2.
UniGeneiHs.553733.

3D structure databases

ProteinModelPortaliQ9H344.
SMRiQ9H344. Positions 37-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341987.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi14423836.

Proteomic databases

PaxDbiQ9H344.
PRIDEiQ9H344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341449; ENSP00000341987; ENSG00000187918.
GeneIDi390064.
KEGGihsa:390064.
UCSCiuc010qzf.2. human.

Organism-specific databases

CTDi390064.
GeneCardsiGC11P005476.
HGNCiHGNC:15201. OR51I2.
neXtProtiNX_Q9H344.
PharmGKBiPA32381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148345.
GeneTreeiENSGT00770000120456.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H344.
KOiK04257.
OMAiFFSMMES.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H344.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51I2.
GenomeRNAii390064.
NextBioi103337.
PROiQ9H344.

Gene expression databases

BgeeiQ9H344.
CleanExiHS_OR51I2.
GenevestigatoriQ9H344.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51I2_HUMAN
AccessioniPrimary (citable) accession number: Q9H344
Secondary accession number(s): Q6IF81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.