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Q9H344

- O51I2_HUMAN

UniProt

Q9H344 - O51I2_HUMAN

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Protein

Olfactory receptor 51I2

Gene
OR51I2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51I2
Alternative name(s):
Odorant receptor HOR5'beta12
Olfactory receptor OR11-38
Gene namesi
Name:OR51I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15201. OR51I2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini76 – 9924Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 19636Extracellular Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27315Extracellular Reviewed predictionAdd
BLAST
Transmembranei274 – 29421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini295 – 31218Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 51I2PRO_0000150758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H344.
PRIDEiQ9H344.

Expressioni

Gene expression databases

BgeeiQ9H344.
CleanExiHS_OR51I2.
GenevestigatoriQ9H344.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341987.

Structurei

3D structure databases

ProteinModelPortaliQ9H344.
SMRiQ9H344. Positions 37-137.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148345.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H344.
KOiK04257.
OMAiFFSMMES.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H344.
TreeFamiTF342735.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H344-1 [UniParc]FASTAAdd to Basket

« Hide

MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR    50
VEPSLHEPMY YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ 100
MFLIHFFSMM ESGILLAMSF DRYVAICDPL RYATVLTTEV IAAMGLGAAA 150
RSFITLFPLP FLIKRLPICR SNVLSHSYCL HPDMMRLACA DISINSIYGL 200
FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT CVSHILAVLA 250
FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR 300
RAIFRMFHHI KI 312
Length:312
Mass (Da):35,002
Last modified:March 1, 2001 - v1
Checksum:iF17CD16C95FD1AF6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221R → C.
Corresponds to variant rs10450603 [ dbSNP | Ensembl ].
VAR_034321
Natural varianti134 – 1341T → A.
Corresponds to variant rs12577167 [ dbSNP | Ensembl ].
VAR_034322
Natural varianti151 – 1511R → P.
Corresponds to variant rs16931292 [ dbSNP | Ensembl ].
VAR_034323
Natural varianti263 – 2631R → H.
Corresponds to variant rs11037502 [ dbSNP | Ensembl ].
VAR_024143

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137396 Genomic DNA. Translation: AAG41678.1.
BK004381 Genomic DNA. Translation: DAA04779.1.
CCDSiCCDS31383.1.
RefSeqiNP_001004754.1. NM_001004754.2.
UniGeneiHs.553733.

Genome annotation databases

EnsembliENST00000341449; ENSP00000341987; ENSG00000187918.
GeneIDi390064.
KEGGihsa:390064.
UCSCiuc010qzf.2. human.

Polymorphism databases

DMDMi14423836.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF137396 Genomic DNA. Translation: AAG41678.1 .
BK004381 Genomic DNA. Translation: DAA04779.1 .
CCDSi CCDS31383.1.
RefSeqi NP_001004754.1. NM_001004754.2.
UniGenei Hs.553733.

3D structure databases

ProteinModelPortali Q9H344.
SMRi Q9H344. Positions 37-137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341987.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 14423836.

Proteomic databases

PaxDbi Q9H344.
PRIDEi Q9H344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341449 ; ENSP00000341987 ; ENSG00000187918 .
GeneIDi 390064.
KEGGi hsa:390064.
UCSCi uc010qzf.2. human.

Organism-specific databases

CTDi 390064.
GeneCardsi GC11P005476.
HGNCi HGNC:15201. OR51I2.
neXtProti NX_Q9H344.
PharmGKBi PA32381.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148345.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q9H344.
KOi K04257.
OMAi FFSMMES.
OrthoDBi EOG754HPV.
PhylomeDBi Q9H344.
TreeFami TF342735.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR51I2.
GenomeRNAii 390064.
NextBioi 103337.
PROi Q9H344.

Gene expression databases

Bgeei Q9H344.
CleanExi HS_OR51I2.
Genevestigatori Q9H344.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51I2_HUMAN
AccessioniPrimary (citable) accession number: Q9H344
Secondary accession number(s): Q6IF81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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