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Q9H344 (O51I2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 51I2
Alternative name(s):
Odorant receptor HOR5'beta12
Olfactory receptor OR11-38
Gene names
Name:OR51I2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 51I2
PRO_0000150758

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19636Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27315Extracellular Potential
Transmembrane274 – 29421Helical; Name=7; Potential
Topological domain295 – 31218Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1221R → C.
Corresponds to variant rs10450603 [ dbSNP | Ensembl ].
VAR_034321
Natural variant1341T → A.
Corresponds to variant rs12577167 [ dbSNP | Ensembl ].
VAR_034322
Natural variant1511R → P.
Corresponds to variant rs16931292 [ dbSNP | Ensembl ].
VAR_034323
Natural variant2631R → H.
Corresponds to variant rs11037502 [ dbSNP | Ensembl ].
VAR_024143

Sequences

Sequence LengthMass (Da)Tools
Q9H344 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F17CD16C95FD1AF6

FASTA31235,002
        10         20         30         40         50         60 
MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR VEPSLHEPMY 

        70         80         90        100        110        120 
YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ MFLIHFFSMM ESGILLAMSF 

       130        140        150        160        170        180 
DRYVAICDPL RYATVLTTEV IAAMGLGAAA RSFITLFPLP FLIKRLPICR SNVLSHSYCL 

       190        200        210        220        230        240 
HPDMMRLACA DISINSIYGL FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT 

       250        260        270        280        290        300 
CVSHILAVLA FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR 

       310 
RAIFRMFHHI KI 

« Hide

References

[1]"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF137396 Genomic DNA. Translation: AAG41678.1.
BK004381 Genomic DNA. Translation: DAA04779.1.
RefSeqNP_001004754.1. NM_001004754.2.
UniGeneHs.553733.

3D structure databases

ProteinModelPortalQ9H344.
SMRQ9H344. Positions 37-137, 279-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341987.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM14423836.

Proteomic databases

PaxDbQ9H344.
PRIDEQ9H344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341449; ENSP00000341987; ENSG00000187918.
GeneID390064.
KEGGhsa:390064.
UCSCuc010qzf.2. human.

Organism-specific databases

CTD390064.
GeneCardsGC11P005476.
HGNCHGNC:15201. OR51I2.
neXtProtNX_Q9H344.
PharmGKBPA32381.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148345.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ9H344.
KOK04257.
OMAFFSMMES.
OrthoDBEOG754HPV.
PhylomeDBQ9H344.
TreeFamTF342735.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9H344.
CleanExHS_OR51I2.
GenevestigatorQ9H344.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR51I2.
GenomeRNAi390064.
NextBio103337.
PROQ9H344.

Entry information

Entry nameO51I2_HUMAN
AccessionPrimary (citable) accession number: Q9H344
Secondary accession number(s): Q6IF81
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries