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Protein

Olfactory receptor 51I2

Gene

OR51I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167360-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51I2
Alternative name(s):
Odorant receptor HOR5'beta12
Olfactory receptor OR11-38
Gene namesi
Name:OR51I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15201. OR51I2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 273ExtracellularSequence analysisAdd BLAST15
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 312CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187918.
PharmGKBiPA32381.

Polymorphism and mutation databases

BioMutaiOR51I2.
DMDMi14423836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507581 – 312Olfactory receptor 51I2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H344.
PeptideAtlasiQ9H344.
PRIDEiQ9H344.

PTM databases

iPTMnetiQ9H344.
PhosphoSitePlusiQ9H344.

Expressioni

Gene expression databases

BgeeiENSG00000187918.
CleanExiHS_OR51I2.
ExpressionAtlasiQ9H344. baseline and differential.
GenevisibleiQ9H344. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341987.

Structurei

3D structure databases

ProteinModelPortaliQ9H344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE3K. Eukaryota.
ENOG410ZSD7. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H344.
KOiK04257.
OMAiGKHVPRY.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H344.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLFNVTHPA FFLLTGIPGL ESSHSWLSGP LCVMYAVALG GNTVILQAVR
60 70 80 90 100
VEPSLHEPMY YFLSMLSFSD VAISMATLPT VLRTFCLNAR NITFDACLIQ
110 120 130 140 150
MFLIHFFSMM ESGILLAMSF DRYVAICDPL RYATVLTTEV IAAMGLGAAA
160 170 180 190 200
RSFITLFPLP FLIKRLPICR SNVLSHSYCL HPDMMRLACA DISINSIYGL
210 220 230 240 250
FVLVSTFGMD LFFIFLSYVL ILRSVMATAS REERLKALNT CVSHILAVLA
260 270 280 290 300
FYVPMIGVST VHRFGKHVPC YIHVLMSNVY LFVPPVLNPL IYSAKTKEIR
310
RAIFRMFHHI KI
Length:312
Mass (Da):35,002
Last modified:March 1, 2001 - v1
Checksum:iF17CD16C95FD1AF6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034321122R → C.Corresponds to variant rs10450603dbSNPEnsembl.1
Natural variantiVAR_034322134T → A.Corresponds to variant rs12577167dbSNPEnsembl.1
Natural variantiVAR_034323151R → P.Corresponds to variant rs16931292dbSNPEnsembl.1
Natural variantiVAR_024143263R → H.Corresponds to variant rs11037502dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41678.1.
BK004381 Genomic DNA. Translation: DAA04779.1.
CCDSiCCDS31383.1.
RefSeqiNP_001004754.1. NM_001004754.2.
UniGeneiHs.553733.

Genome annotation databases

EnsembliENST00000341449; ENSP00000341987; ENSG00000187918.
GeneIDi390064.
KEGGihsa:390064.
UCSCiuc010qzf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41678.1.
BK004381 Genomic DNA. Translation: DAA04779.1.
CCDSiCCDS31383.1.
RefSeqiNP_001004754.1. NM_001004754.2.
UniGeneiHs.553733.

3D structure databases

ProteinModelPortaliQ9H344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341987.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H344.
PhosphoSitePlusiQ9H344.

Polymorphism and mutation databases

BioMutaiOR51I2.
DMDMi14423836.

Proteomic databases

PaxDbiQ9H344.
PeptideAtlasiQ9H344.
PRIDEiQ9H344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341449; ENSP00000341987; ENSG00000187918.
GeneIDi390064.
KEGGihsa:390064.
UCSCiuc010qzf.3. human.

Organism-specific databases

CTDi390064.
GeneCardsiOR51I2.
HGNCiHGNC:15201. OR51I2.
neXtProtiNX_Q9H344.
OpenTargetsiENSG00000187918.
PharmGKBiPA32381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE3K. Eukaryota.
ENOG410ZSD7. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H344.
KOiK04257.
OMAiGKHVPRY.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H344.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167360-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51I2.
GenomeRNAii390064.
PROiQ9H344.

Gene expression databases

BgeeiENSG00000187918.
CleanExiHS_OR51I2.
ExpressionAtlasiQ9H344. baseline and differential.
GenevisibleiQ9H344. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51I2_HUMAN
AccessioniPrimary (citable) accession number: Q9H344
Secondary accession number(s): Q6IF81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.