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Protein

Olfactory receptor 51I1

Gene

OR51I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51I1
Alternative name(s):
Odorant receptor HOR5'beta11
Olfactory receptor OR11-39
Gene namesi
Name:OR51I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15200. OR51I1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27515ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 31418CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32380.

Polymorphism and mutation databases

BioMutaiOR51I1.
DMDMi14423835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 51I1PRO_0000150757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H343.
PRIDEiQ9H343.

Expressioni

Gene expression databases

CleanExiHS_OR51I1.
GenevisibleiQ9H343. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369559.

Structurei

3D structure databases

ProteinModelPortaliQ9H343.
SMRiQ9H343. Positions 18-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVHZ. Eukaryota.
ENOG41114MS. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H343.
KOiK04257.
OMAiHNHILAM.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H343.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLNGTPFQ PATLQLTGIP GIQTGLTWVA LIFCILYMIS IVGNLSILTL
60 70 80 90 100
VFWEPALHQP MYYFLSMLAL NDLGVSFSTL PTVISTFCFN YNHVAFNACL
110 120 130 140 150
VQMFFIHTFS FMESGILLAM SLDRFVAICY PLRYVTVLTH NRILAMGLGI
160 170 180 190 200
LTKSFTTLFP FPFVVKRLPF CKGNVLHHSY CLHPDLMKVA CGDIHVNNIY
210 220 230 240 250
GLLVIIFTYG MDSTFILLSY ALILRAMLVI ISQEQRLKAL NTCMSHICAV
260 270 280 290 300
LAFYVPIIAV SMIHRFWKSA PPVVHVMMSN VYLFVPPMLN PIIYSVKTKE
310
IRKGILKFFH KSQA
Length:314
Mass (Da):35,484
Last modified:March 1, 2001 - v1
Checksum:i08B40AD79CB94911
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241R → H.
Corresponds to variant rs16930982 [ dbSNP | Ensembl ].
VAR_053328
Natural varianti164 – 1641V → L.
Corresponds to variant rs11037445 [ dbSNP | Ensembl ].
VAR_034320
Natural varianti252 – 2521A → S.
Corresponds to variant rs1498486 [ dbSNP | Ensembl ].
VAR_024142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41679.1.
CH471064 Genomic DNA. Translation: EAW68794.1.
BC151148 mRNA. Translation: AAI51149.1.
BK004429 Genomic DNA. Translation: DAA04827.1.
CCDSiCCDS31382.1.
RefSeqiNP_001005288.1. NM_001005288.2.
UniGeneiHs.553732.

Genome annotation databases

EnsembliENST00000380211; ENSP00000369559; ENSG00000167359.
GeneIDi390063.
KEGGihsa:390063.
UCSCiuc010qze.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41679.1.
CH471064 Genomic DNA. Translation: EAW68794.1.
BC151148 mRNA. Translation: AAI51149.1.
BK004429 Genomic DNA. Translation: DAA04827.1.
CCDSiCCDS31382.1.
RefSeqiNP_001005288.1. NM_001005288.2.
UniGeneiHs.553732.

3D structure databases

ProteinModelPortaliQ9H343.
SMRiQ9H343. Positions 18-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369559.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR51I1.
DMDMi14423835.

Proteomic databases

PaxDbiQ9H343.
PRIDEiQ9H343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380211; ENSP00000369559; ENSG00000167359.
GeneIDi390063.
KEGGihsa:390063.
UCSCiuc010qze.3. human.

Organism-specific databases

CTDi390063.
GeneCardsiOR51I1.
HGNCiHGNC:15200. OR51I1.
neXtProtiNX_Q9H343.
PharmGKBiPA32380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVHZ. Eukaryota.
ENOG41114MS. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H343.
KOiK04257.
OMAiHNHILAM.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H343.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51I1.
GenomeRNAii390063.
PROiQ9H343.

Gene expression databases

CleanExiHS_OR51I1.
GenevisibleiQ9H343. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51I1_HUMAN
AccessioniPrimary (citable) accession number: Q9H343
Secondary accession number(s): B9EKW2, Q6IF33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.