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Protein

Olfactory receptor 51I1

Gene

OR51I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51I1
Alternative name(s):
Odorant receptor HOR5'beta11
Olfactory receptor OR11-39
Gene namesi
Name:OR51I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167359.8.
HGNCiHGNC:15200. OR51I1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 314CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32380.

Polymorphism and mutation databases

BioMutaiOR51I1.
DMDMi14423835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507571 – 314Olfactory receptor 51I1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H343.
PRIDEiQ9H343.

Expressioni

Gene expression databases

BgeeiENSG00000167359.
CleanExiHS_OR51I1.
ExpressionAtlasiQ9H343. baseline and differential.
GenevisibleiQ9H343. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369559.

Structurei

3D structure databases

ProteinModelPortaliQ9H343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVHZ. Eukaryota.
ENOG41114MS. LUCA.
GeneTreeiENSGT00890000139335.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H343.
KOiK04257.
OMAiFWEPALH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H343.
TreeFamiTF342735.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLNGTPFQ PATLQLTGIP GIQTGLTWVA LIFCILYMIS IVGNLSILTL
60 70 80 90 100
VFWEPALHQP MYYFLSMLAL NDLGVSFSTL PTVISTFCFN YNHVAFNACL
110 120 130 140 150
VQMFFIHTFS FMESGILLAM SLDRFVAICY PLRYVTVLTH NRILAMGLGI
160 170 180 190 200
LTKSFTTLFP FPFVVKRLPF CKGNVLHHSY CLHPDLMKVA CGDIHVNNIY
210 220 230 240 250
GLLVIIFTYG MDSTFILLSY ALILRAMLVI ISQEQRLKAL NTCMSHICAV
260 270 280 290 300
LAFYVPIIAV SMIHRFWKSA PPVVHVMMSN VYLFVPPMLN PIIYSVKTKE
310
IRKGILKFFH KSQA
Length:314
Mass (Da):35,484
Last modified:March 1, 2001 - v1
Checksum:i08B40AD79CB94911
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053328124R → H. Corresponds to variant dbSNP:rs16930982Ensembl.1
Natural variantiVAR_034320164V → L. Corresponds to variant dbSNP:rs11037445Ensembl.1
Natural variantiVAR_024142252A → S. Corresponds to variant dbSNP:rs1498486Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41679.1.
CH471064 Genomic DNA. Translation: EAW68794.1.
BC151148 mRNA. Translation: AAI51149.1.
BK004429 Genomic DNA. Translation: DAA04827.1.
CCDSiCCDS31382.1.
RefSeqiNP_001005288.1. NM_001005288.2.
UniGeneiHs.553732.

Genome annotation databases

EnsembliENST00000380211; ENSP00000369559; ENSG00000167359.
GeneIDi390063.
KEGGihsa:390063.
UCSCiuc010qze.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO51I1_HUMAN
AccessioniPrimary (citable) accession number: Q9H343
Secondary accession number(s): B9EKW2, Q6IF33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families