ID   O51M1_HUMAN             Reviewed;         326 AA.
AC   Q9H341; Q6IF80;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 4.
DT   24-JAN-2024, entry version 171.
DE   RecName: Full=Olfactory receptor 51M1;
DE   AltName: Full=Odorant receptor HOR5'beta7;
DE   AltName: Full=Olfactory receptor OR11-40;
GN   Name=OR51M1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-102; PHE-135; THR-204;
RP   HIS-256; ARG-257 AND LEU-318.
RX   PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
RA   Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
RA   Felsenfeld G., Groudine M., Hardison R.;
RT   "Comparative structural and functional analysis of the olfactory receptor
RT   genes flanking the human and mouse beta-globin gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
RN   [2]
RP   IDENTIFICATION, AND VARIANTS GLN-102; PHE-135; THR-204; HIS-256 AND
RP   LEU-318.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51M1";
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DR   EMBL; AF137396; AAG41681.1; -; Genomic_DNA.
DR   EMBL; BK004382; DAA04780.1; -; Genomic_DNA.
DR   CCDS; CCDS53596.1; -.
DR   RefSeq; NP_001004756.2; NM_001004756.2.
DR   AlphaFoldDB; Q9H341; -.
DR   SMR; Q9H341; -.
DR   BioGRID; 133378; 2.
DR   IntAct; Q9H341; 1.
DR   STRING; 9606.ENSP00000493005; -.
DR   GlyCosmos; Q9H341; 1 site, No reported glycans.
DR   GlyGen; Q9H341; 1 site.
DR   iPTMnet; Q9H341; -.
DR   PhosphoSitePlus; Q9H341; -.
DR   BioMuta; OR51M1; -.
DR   DMDM; 84028232; -.
DR   PaxDb; 9606-ENSP00000333196; -.
DR   PeptideAtlas; Q9H341; -.
DR   Antibodypedia; 66884; 80 antibodies from 20 providers.
DR   DNASU; 390059; -.
DR   Ensembl; ENST00000328611.5; ENSP00000333196.3; ENSG00000184698.5.
DR   Ensembl; ENST00000642046.1; ENSP00000493005.1; ENSG00000184698.5.
DR   GeneID; 390059; -.
DR   KEGG; hsa:390059; -.
DR   MANE-Select; ENST00000642046.1; ENSP00000493005.1; NM_001004756.3; NP_001004756.2.
DR   UCSC; uc010qzc.3; human.
DR   AGR; HGNC:14847; -.
DR   CTD; 390059; -.
DR   DisGeNET; 390059; -.
DR   GeneCards; OR51M1; -.
DR   HGNC; HGNC:14847; OR51M1.
DR   HPA; ENSG00000184698; Not detected.
DR   neXtProt; NX_Q9H341; -.
DR   VEuPathDB; HostDB:ENSG00000184698; -.
DR   eggNOG; ENOG502SMGT; Eukaryota.
DR   GeneTree; ENSGT01100000263554; -.
DR   HOGENOM; CLU_012526_0_0_1; -.
DR   InParanoid; Q9H341; -.
DR   OMA; SPMFYLT; -.
DR   OrthoDB; 4578140at2759; -.
DR   PhylomeDB; Q9H341; -.
DR   TreeFam; TF342735; -.
DR   PathwayCommons; Q9H341; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q9H341; -.
DR   BioGRID-ORCS; 390059; 9 hits in 742 CRISPR screens.
DR   GeneWiki; OR51M1; -.
DR   GenomeRNAi; 390059; -.
DR   Pharos; Q9H341; Tdark.
DR   PRO; PR:Q9H341; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H341; Protein.
DR   Bgee; ENSG00000184698; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15222; 7tmA_OR51-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26450:SF44; OLFACTORY RECEPTOR 51M1; 1.
DR   PANTHER; PTHR26450; OLFACTORY RECEPTOR 56B1-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9H341; HS.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Olfactory receptor 51M1"
FT                   /id="PRO_0000150760"
FT   TOPO_DOM        1..40
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        62..76
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..110
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..165
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..252
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        274..282
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..326
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..201
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         102
FT                   /note="H -> Q (in dbSNP:rs1498467)"
FT                   /evidence="ECO:0000269|PubMed:11121057,
FT                   ECO:0000269|PubMed:14983052"
FT                   /id="VAR_070593"
FT   VARIANT         135
FT                   /note="L -> F (in dbSNP:rs1498468)"
FT                   /evidence="ECO:0000269|PubMed:11121057,
FT                   ECO:0000269|PubMed:14983052"
FT                   /id="VAR_070594"
FT   VARIANT         204
FT                   /note="I -> T (in dbSNP:rs1498469)"
FT                   /evidence="ECO:0000269|PubMed:11121057,
FT                   ECO:0000269|PubMed:14983052"
FT                   /id="VAR_070595"
FT   VARIANT         256
FT                   /note="P -> H (in dbSNP:rs9783355)"
FT                   /evidence="ECO:0000269|PubMed:11121057,
FT                   ECO:0000269|PubMed:14983052"
FT                   /id="VAR_070596"
FT   VARIANT         257
FT                   /note="L -> R (in dbSNP:rs2736531)"
FT                   /evidence="ECO:0000269|PubMed:11121057"
FT                   /id="VAR_070597"
FT   VARIANT         318
FT                   /note="F -> L (in dbSNP:rs10768907)"
FT                   /evidence="ECO:0000269|PubMed:11121057,
FT                   ECO:0000269|PubMed:14983052"
FT                   /id="VAR_070598"
SQ   SEQUENCE   326 AA;  36669 MW;  6082F43BF5A2D417 CRC64;
     MSVQYSLSPQ FMLLSNITQF SPIFYLTSFP GLEGIKHWIF IPFFFMYMVA ISGNCFILII
     IKTNPRLHTP MYYLLSLLAL TDLGLCVSTL PTTMGIFWFN SHSIYFGACQ IQMFCIHSFS
     FMESSVLLMM SFDRLVAICH PLRYSVIITG QQVVRAGLIV IFRGPVATIP IVLLLKAFPY
     CGSVVLSHSF CLHQEVIQLA CTDITFNNLY GLMVVVFTVM LDLVLIALSY GLILHTVAGL
     ASQEEQRRAF QTCTAPLCAV LVFFVPMMGL SLVHRFGKHA PPAIHLLMAN VYLFVPPMLN
     PIIYSIKTKE IHRAIIKFLG LKKASK
//