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Q9H341 (O51M1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 51M1
Alternative name(s):
Odorant receptor HOR5'beta7
Olfactory receptor OR11-40
Gene names
Name:OR51M1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Olfactory receptor 51M1
PRO_0000150760

Regions

Topological domain1 – 4040Extracellular Potential
Transmembrane41 – 6121Helical; Name=1; Potential
Topological domain62 – 7615Cytoplasmic Potential
Transmembrane77 – 9721Helical; Name=2; Potential
Topological domain98 – 11013Extracellular Potential
Transmembrane111 – 13121Helical; Name=3; Potential
Topological domain132 – 16534Cytoplasmic Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Topological domain187 – 21327Extracellular Potential
Transmembrane214 – 23421Helical; Name=5; Potential
Topological domain235 – 25218Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 2829Extracellular Potential
Transmembrane283 – 30321Helical; Name=7; Potential
Topological domain304 – 32623Cytoplasmic Potential

Amino acid modifications

Glycosylation161N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 201 By similarity

Natural variations

Natural variant1021H → Q. Ref.1 Ref.2
Corresponds to variant rs1498467 [ dbSNP | Ensembl ].
VAR_070593
Natural variant1351L → F. Ref.1 Ref.2
Corresponds to variant rs1498468 [ dbSNP | Ensembl ].
VAR_070594
Natural variant2041I → T. Ref.1 Ref.2
Corresponds to variant rs1498469 [ dbSNP | Ensembl ].
VAR_070595
Natural variant2561P → H. Ref.1 Ref.2
Corresponds to variant rs9783355 [ dbSNP | Ensembl ].
VAR_070596
Natural variant2571L → R. Ref.1
Corresponds to variant rs2736531 [ dbSNP | Ensembl ].
VAR_070597
Natural variant3181F → L. Ref.1 Ref.2
Corresponds to variant rs369353765 [ dbSNP | Ensembl ].
VAR_070598

Sequences

Sequence LengthMass (Da)Tools
Q9H341 [UniParc].

Last modified March 19, 2014. Version 4.
Checksum: 6082F43BF5A2D417

FASTA32636,669
        10         20         30         40         50         60 
MSVQYSLSPQ FMLLSNITQF SPIFYLTSFP GLEGIKHWIF IPFFFMYMVA ISGNCFILII 

        70         80         90        100        110        120 
IKTNPRLHTP MYYLLSLLAL TDLGLCVSTL PTTMGIFWFN SHSIYFGACQ IQMFCIHSFS 

       130        140        150        160        170        180 
FMESSVLLMM SFDRLVAICH PLRYSVIITG QQVVRAGLIV IFRGPVATIP IVLLLKAFPY 

       190        200        210        220        230        240 
CGSVVLSHSF CLHQEVIQLA CTDITFNNLY GLMVVVFTVM LDLVLIALSY GLILHTVAGL 

       250        260        270        280        290        300 
ASQEEQRRAF QTCTAPLCAV LVFFVPMMGL SLVHRFGKHA PPAIHLLMAN VYLFVPPMLN 

       310        320 
PIIYSIKTKE IHRAIIKFLG LKKASK 

« Hide

References

[1]"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-102; PHE-135; THR-204; HIS-256; ARG-257 AND LEU-318.
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANTS GLN-102; PHE-135; THR-204; HIS-256 AND LEU-318.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF137396 Genomic DNA. Translation: AAG41681.1.
BK004382 Genomic DNA. Translation: DAA04780.1.
RefSeqNP_001004756.2. NM_001004756.2.
UniGeneHs.553731.

3D structure databases

ProteinModelPortalQ9H341.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333196.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM84028232.

Proteomic databases

PaxDbQ9H341.
PRIDEQ9H341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328611; ENSP00000333196; ENSG00000184698.
GeneID390059.
UCSCuc010qzc.2. human.

Organism-specific databases

GeneCardsGC11P005410.
HGNCHGNC:14847. OR51M1.
HPAHPA056773.
neXtProtNX_Q9H341.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38847.
HOVERGENHBG017625.
InParanoidQ9H341.
OrthoDBEOG754HPV.
PhylomeDBQ9H341.
TreeFamTF342735.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR51M1.
GenevestigatorQ9H341.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOR51M1. human.
PROQ9H341.

Entry information

Entry nameO51M1_HUMAN
AccessionPrimary (citable) accession number: Q9H341
Secondary accession number(s): Q6IF80
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 19, 2014
Last modified: April 16, 2014
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries