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Q9H341

- O51M1_HUMAN

UniProt

Q9H341 - O51M1_HUMAN

Protein

Olfactory receptor 51M1

Gene

OR51M1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 4 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 51M1
    Alternative name(s):
    Odorant receptor HOR5'beta7
    Olfactory receptor OR11-40
    Gene namesi
    Name:OR51M1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14847. OR51M1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Olfactory receptor 51M1PRO_0000150760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 201PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H341.
    PRIDEiQ9H341.

    Expressioni

    Gene expression databases

    CleanExiHS_OR51M1.
    GenevestigatoriQ9H341.

    Organism-specific databases

    HPAiHPA056773.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H341.
    SMRiQ9H341. Positions 39-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 7615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 16534CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini187 – 21327ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 25218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 2829ExtracellularSequence Analysis
    Topological domaini304 – 32623CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG38847.
    HOVERGENiHBG017625.
    InParanoidiQ9H341.
    KOiK04257.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ9H341.
    TreeFamiTF342735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H341-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVQYSLSPQ FMLLSNITQF SPIFYLTSFP GLEGIKHWIF IPFFFMYMVA    50
    ISGNCFILII IKTNPRLHTP MYYLLSLLAL TDLGLCVSTL PTTMGIFWFN 100
    SHSIYFGACQ IQMFCIHSFS FMESSVLLMM SFDRLVAICH PLRYSVIITG 150
    QQVVRAGLIV IFRGPVATIP IVLLLKAFPY CGSVVLSHSF CLHQEVIQLA 200
    CTDITFNNLY GLMVVVFTVM LDLVLIALSY GLILHTVAGL ASQEEQRRAF 250
    QTCTAPLCAV LVFFVPMMGL SLVHRFGKHA PPAIHLLMAN VYLFVPPMLN 300
    PIIYSIKTKE IHRAIIKFLG LKKASK 326
    Length:326
    Mass (Da):36,669
    Last modified:March 19, 2014 - v4
    Checksum:i6082F43BF5A2D417
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021H → Q.2 Publications
    Corresponds to variant rs1498467 [ dbSNP | Ensembl ].
    VAR_070593
    Natural varianti135 – 1351L → F.2 Publications
    Corresponds to variant rs1498468 [ dbSNP | Ensembl ].
    VAR_070594
    Natural varianti204 – 2041I → T.2 Publications
    Corresponds to variant rs1498469 [ dbSNP | Ensembl ].
    VAR_070595
    Natural varianti256 – 2561P → H.2 Publications
    Corresponds to variant rs9783355 [ dbSNP | Ensembl ].
    VAR_070596
    Natural varianti257 – 2571L → R.1 Publication
    Corresponds to variant rs2736531 [ dbSNP | Ensembl ].
    VAR_070597
    Natural varianti318 – 3181F → L.2 Publications
    Corresponds to variant rs369353765 [ dbSNP | Ensembl ].
    VAR_070598

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137396 Genomic DNA. Translation: AAG41681.1.
    BK004382 Genomic DNA. Translation: DAA04780.1.
    CCDSiCCDS53596.1.
    RefSeqiNP_001004756.2. NM_001004756.2.
    UniGeneiHs.553731.

    Genome annotation databases

    EnsembliENST00000328611; ENSP00000333196; ENSG00000184698.
    GeneIDi390059.
    KEGGihsa:390059.
    UCSCiuc010qzc.2. human.

    Polymorphism databases

    DMDMi84028232.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF137396 Genomic DNA. Translation: AAG41681.1 .
    BK004382 Genomic DNA. Translation: DAA04780.1 .
    CCDSi CCDS53596.1.
    RefSeqi NP_001004756.2. NM_001004756.2.
    UniGenei Hs.553731.

    3D structure databases

    ProteinModelPortali Q9H341.
    SMRi Q9H341. Positions 39-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333196.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 84028232.

    Proteomic databases

    PaxDbi Q9H341.
    PRIDEi Q9H341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328611 ; ENSP00000333196 ; ENSG00000184698 .
    GeneIDi 390059.
    KEGGi hsa:390059.
    UCSCi uc010qzc.2. human.

    Organism-specific databases

    CTDi 390059.
    GeneCardsi GC11P005410.
    HGNCi HGNC:14847. OR51M1.
    HPAi HPA056773.
    neXtProti NX_Q9H341.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38847.
    HOVERGENi HBG017625.
    InParanoidi Q9H341.
    KOi K04257.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q9H341.
    TreeFami TF342735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    ChiTaRSi OR51M1. human.
    GeneWikii OR51M1.
    PROi Q9H341.

    Gene expression databases

    CleanExi HS_OR51M1.
    Genevestigatori Q9H341.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
      Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
      Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-102; PHE-135; THR-204; HIS-256; ARG-257 AND LEU-318.
    2. Cited for: IDENTIFICATION, VARIANTS GLN-102; PHE-135; THR-204; HIS-256 AND LEU-318.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO51M1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H341
    Secondary accession number(s): Q6IF80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 109 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-12 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3