Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 51M1

Gene

OR51M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31053-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51M1
Alternative name(s):
Odorant receptor HOR5'beta7
Olfactory receptor OR11-40
Gene namesi
Name:OR51M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14847. OR51M1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini62 – 76CytoplasmicSequence analysisAdd BLAST15
Transmembranei77 – 97Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini98 – 110ExtracellularSequence analysisAdd BLAST13
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini132 – 165CytoplasmicSequence analysisAdd BLAST34
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 213ExtracellularSequence analysisAdd BLAST27
Transmembranei214 – 234Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini235 – 252CytoplasmicSequence analysisAdd BLAST18
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 282ExtracellularSequence analysis9
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 326CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184698.

Polymorphism and mutation databases

DMDMi84028232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507601 – 326Olfactory receptor 51M1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 201PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H341.
PeptideAtlasiQ9H341.
PRIDEiQ9H341.

PTM databases

iPTMnetiQ9H341.
PhosphoSitePlusiQ9H341.

Expressioni

Gene expression databases

CleanExiHS_OR51M1.
GenevisibleiQ9H341. HS.

Organism-specific databases

HPAiHPA056773.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333196.

Structurei

3D structure databases

ProteinModelPortaliQ9H341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVFV. Eukaryota.
ENOG4111D9B. LUCA.
GeneTreeiENSGT00840000129672.
HOVERGENiHBG017625.
InParanoidiQ9H341.
KOiK04257.
OMAiSVIITGQ.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H341.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQYSLSPQ FMLLSNITQF SPIFYLTSFP GLEGIKHWIF IPFFFMYMVA
60 70 80 90 100
ISGNCFILII IKTNPRLHTP MYYLLSLLAL TDLGLCVSTL PTTMGIFWFN
110 120 130 140 150
SHSIYFGACQ IQMFCIHSFS FMESSVLLMM SFDRLVAICH PLRYSVIITG
160 170 180 190 200
QQVVRAGLIV IFRGPVATIP IVLLLKAFPY CGSVVLSHSF CLHQEVIQLA
210 220 230 240 250
CTDITFNNLY GLMVVVFTVM LDLVLIALSY GLILHTVAGL ASQEEQRRAF
260 270 280 290 300
QTCTAPLCAV LVFFVPMMGL SLVHRFGKHA PPAIHLLMAN VYLFVPPMLN
310 320
PIIYSIKTKE IHRAIIKFLG LKKASK
Length:326
Mass (Da):36,669
Last modified:March 19, 2014 - v4
Checksum:i6082F43BF5A2D417
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070593102H → Q.2 PublicationsCorresponds to variant rs1498467dbSNPEnsembl.1
Natural variantiVAR_070594135L → F.2 PublicationsCorresponds to variant rs1498468dbSNPEnsembl.1
Natural variantiVAR_070595204I → T.2 PublicationsCorresponds to variant rs1498469dbSNPEnsembl.1
Natural variantiVAR_070596256P → H.2 PublicationsCorresponds to variant rs9783355dbSNPEnsembl.1
Natural variantiVAR_070597257L → R.1 PublicationCorresponds to variant rs2736531dbSNPEnsembl.1
Natural variantiVAR_070598318F → L.2 PublicationsCorresponds to variant rs369353765dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41681.1.
BK004382 Genomic DNA. Translation: DAA04780.1.
CCDSiCCDS53596.1.
RefSeqiNP_001004756.2. NM_001004756.2.
UniGeneiHs.553731.

Genome annotation databases

EnsembliENST00000328611; ENSP00000333196; ENSG00000184698.
GeneIDi390059.
KEGGihsa:390059.
UCSCiuc010qzc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41681.1.
BK004382 Genomic DNA. Translation: DAA04780.1.
CCDSiCCDS53596.1.
RefSeqiNP_001004756.2. NM_001004756.2.
UniGeneiHs.553731.

3D structure databases

ProteinModelPortaliQ9H341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333196.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H341.
PhosphoSitePlusiQ9H341.

Polymorphism and mutation databases

DMDMi84028232.

Proteomic databases

PaxDbiQ9H341.
PeptideAtlasiQ9H341.
PRIDEiQ9H341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328611; ENSP00000333196; ENSG00000184698.
GeneIDi390059.
KEGGihsa:390059.
UCSCiuc010qzc.3. human.

Organism-specific databases

CTDi390059.
GeneCardsiOR51M1.
HGNCiHGNC:14847. OR51M1.
HPAiHPA056773.
neXtProtiNX_Q9H341.
OpenTargetsiENSG00000184698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVFV. Eukaryota.
ENOG4111D9B. LUCA.
GeneTreeiENSGT00840000129672.
HOVERGENiHBG017625.
InParanoidiQ9H341.
KOiK04257.
OMAiSVIITGQ.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H341.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:G66-31053-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51M1.
GenomeRNAii390059.
PROiQ9H341.

Gene expression databases

CleanExiHS_OR51M1.
GenevisibleiQ9H341. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51M1_HUMAN
AccessioniPrimary (citable) accession number: Q9H341
Secondary accession number(s): Q6IF80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 19, 2014
Last modified: November 2, 2016
This is version 130 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.