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Protein

Olfactory receptor 51M1

Gene

OR51M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51M1
Alternative name(s):
Odorant receptor HOR5'beta7
Olfactory receptor OR11-40
Gene namesi
Name:OR51M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14847. OR51M1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 7615CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 11013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 16534CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini187 – 21327ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini235 – 25218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini274 – 2829ExtracellularSequence Analysis
Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 32623CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi84028232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Olfactory receptor 51M1PRO_0000150760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 201PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H341.
PRIDEiQ9H341.

Expressioni

Gene expression databases

CleanExiHS_OR51M1.
GenevestigatoriQ9H341.

Organism-specific databases

HPAiHPA056773.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333196.

Structurei

3D structure databases

ProteinModelPortaliQ9H341.
SMRiQ9H341. Positions 39-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38847.
GeneTreeiENSGT00770000120456.
HOVERGENiHBG017625.
InParanoidiQ9H341.
KOiK04257.
OMAiAFPYCGS.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H341.
TreeFamiTF342735.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQYSLSPQ FMLLSNITQF SPIFYLTSFP GLEGIKHWIF IPFFFMYMVA
60 70 80 90 100
ISGNCFILII IKTNPRLHTP MYYLLSLLAL TDLGLCVSTL PTTMGIFWFN
110 120 130 140 150
SHSIYFGACQ IQMFCIHSFS FMESSVLLMM SFDRLVAICH PLRYSVIITG
160 170 180 190 200
QQVVRAGLIV IFRGPVATIP IVLLLKAFPY CGSVVLSHSF CLHQEVIQLA
210 220 230 240 250
CTDITFNNLY GLMVVVFTVM LDLVLIALSY GLILHTVAGL ASQEEQRRAF
260 270 280 290 300
QTCTAPLCAV LVFFVPMMGL SLVHRFGKHA PPAIHLLMAN VYLFVPPMLN
310 320
PIIYSIKTKE IHRAIIKFLG LKKASK
Length:326
Mass (Da):36,669
Last modified:March 19, 2014 - v4
Checksum:i6082F43BF5A2D417
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021H → Q.2 Publications
Corresponds to variant rs1498467 [ dbSNP | Ensembl ].
VAR_070593
Natural varianti135 – 1351L → F.2 Publications
Corresponds to variant rs1498468 [ dbSNP | Ensembl ].
VAR_070594
Natural varianti204 – 2041I → T.2 Publications
Corresponds to variant rs1498469 [ dbSNP | Ensembl ].
VAR_070595
Natural varianti256 – 2561P → H.2 Publications
Corresponds to variant rs9783355 [ dbSNP | Ensembl ].
VAR_070596
Natural varianti257 – 2571L → R.1 Publication
Corresponds to variant rs2736531 [ dbSNP | Ensembl ].
VAR_070597
Natural varianti318 – 3181F → L.2 Publications
Corresponds to variant rs369353765 [ dbSNP | Ensembl ].
VAR_070598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41681.1.
BK004382 Genomic DNA. Translation: DAA04780.1.
CCDSiCCDS53596.1.
RefSeqiNP_001004756.2. NM_001004756.2.
UniGeneiHs.553731.

Genome annotation databases

EnsembliENST00000328611; ENSP00000333196; ENSG00000184698.
GeneIDi390059.
KEGGihsa:390059.
UCSCiuc010qzc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41681.1.
BK004382 Genomic DNA. Translation: DAA04780.1.
CCDSiCCDS53596.1.
RefSeqiNP_001004756.2. NM_001004756.2.
UniGeneiHs.553731.

3D structure databases

ProteinModelPortaliQ9H341.
SMRiQ9H341. Positions 39-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333196.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi84028232.

Proteomic databases

PaxDbiQ9H341.
PRIDEiQ9H341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328611; ENSP00000333196; ENSG00000184698.
GeneIDi390059.
KEGGihsa:390059.
UCSCiuc010qzc.2. human.

Organism-specific databases

CTDi390059.
GeneCardsiGC11P005410.
HGNCiHGNC:14847. OR51M1.
HPAiHPA056773.
neXtProtiNX_Q9H341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG38847.
GeneTreeiENSGT00770000120456.
HOVERGENiHBG017625.
InParanoidiQ9H341.
KOiK04257.
OMAiAFPYCGS.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H341.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51M1.
GenomeRNAii390059.
PROiQ9H341.

Gene expression databases

CleanExiHS_OR51M1.
GenevestigatoriQ9H341.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-102; PHE-135; THR-204; HIS-256; ARG-257 AND LEU-318.
  2. Cited for: IDENTIFICATION, VARIANTS GLN-102; PHE-135; THR-204; HIS-256 AND LEU-318.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51M1_HUMAN
AccessioniPrimary (citable) accession number: Q9H341
Secondary accession number(s): Q6IF80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 19, 2014
Last modified: April 29, 2015
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.