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Protein

Olfactory receptor 51B6

Gene

OR51B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B6
Alternative name(s):
Odorant receptor HOR5'beta6
Gene namesi
Name:OR51B6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19600. OR51B6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19436ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 27115ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989095.

Polymorphism and mutation databases

BioMutaiOR51B6.
DMDMi209572656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 51B6PRO_0000150748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H340.
PRIDEiQ9H340.

PTM databases

iPTMnetiQ9H340.
PhosphoSiteiQ9H340.

Expressioni

Gene expression databases

BgeeiQ9H340.
CleanExiHS_OR51B6.
GenevisibleiQ9H340. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369568.

Structurei

3D structure databases

ProteinModelPortaliQ9H340.
SMRiQ9H340. Positions 14-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H340.
KOiK04257.
OMAiLSIMPIV.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H340.
TreeFamiTF342735.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNKSASTF QLTGFPGMEK AHHWIFIPLL AAYISILLGN GTLLFLIRND
60 70 80 90 100
HNLHEPMYYF LAMLAATDLG VTLTTMPTVL GVLWLDHREI GHGACFSQAY
110 120 130 140 150
FIHTLSVMES GVLLAMAYDC FITIRSPLRY TSILTNTQVM KIGVRVLTRA
160 170 180 190 200
GLSIMPIVVR LHWFPYCRSH VLSHAFCLHQ DVIKLACADI TFNRLYPVVV
210 220 230 240 250
LFAMVLLDFL IIFFSYILIL KTVMGIGSGG ERAKALNTCV SHICCILVFY
260 270 280 290 300
VTVVCLTFIH RFGKHVPHVV HITMSYIHFL FPPFMNPFIY SIKTKQIQSG
310
ILRLFSLPHS RA
Length:312
Mass (Da):35,269
Last modified:October 14, 2008 - v2
Checksum:iE7CCFDBD1FA50B45
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1264TIRS → AIHN in AAG41682 (PubMed:11121057).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51K → T.1 Publication
Corresponds to variant rs4910755 [ dbSNP | Ensembl ].
VAR_053312
Natural varianti40 – 401N → S.1 Publication
Corresponds to variant rs4910756 [ dbSNP | Ensembl ].
VAR_053313
Natural varianti90 – 901I → T.1 Publication
Corresponds to variant rs7483122 [ dbSNP | Ensembl ].
VAR_053314
Natural varianti123 – 1231T → A.
Corresponds to variant rs5006889 [ dbSNP | Ensembl ].
VAR_053315
Natural varianti125 – 1251R → H.
Corresponds to variant rs7479477 [ dbSNP | Ensembl ].
VAR_060035
Natural varianti126 – 1261S → N.
Corresponds to variant rs5006888 [ dbSNP | Ensembl ].
VAR_060036
Natural varianti131 – 1311T → I.1 Publication
Corresponds to variant rs5006887 [ dbSNP | Ensembl ].
VAR_053316
Natural varianti145 – 1451R → G.1 Publication
Corresponds to variant rs5006886 [ dbSNP | Ensembl ].
VAR_053317
Natural varianti169 – 1691S → A.1 Publication
Corresponds to variant rs5006885 [ dbSNP | Ensembl ].
VAR_053318
Natural varianti172 – 1721L → F.1 Publication
Corresponds to variant rs5006884 [ dbSNP | Ensembl ].
VAR_053319
Natural varianti192 – 1921F → L.1 Publication
Corresponds to variant rs5006883 [ dbSNP | Ensembl ].
VAR_053320
Natural varianti254 – 2541V → L.
Corresponds to variant rs7106330 [ dbSNP | Ensembl ].
VAR_053321
Natural varianti275 – 2751S → R.1 Publication
Corresponds to variant rs5024042 [ dbSNP | Ensembl ].
VAR_053322

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41682.1.
AC104389 Genomic DNA. No translation available.
CCDSiCCDS31379.1.
RefSeqiNP_001004750.1. NM_001004750.1.
UniGeneiHs.553730.

Genome annotation databases

EnsembliENST00000380219; ENSP00000369568; ENSG00000176239.
GeneIDi390058.
KEGGihsa:390058.
UCSCiuc010qzb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41682.1.
AC104389 Genomic DNA. No translation available.
CCDSiCCDS31379.1.
RefSeqiNP_001004750.1. NM_001004750.1.
UniGeneiHs.553730.

3D structure databases

ProteinModelPortaliQ9H340.
SMRiQ9H340. Positions 14-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369568.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H340.
PhosphoSiteiQ9H340.

Polymorphism and mutation databases

BioMutaiOR51B6.
DMDMi209572656.

Proteomic databases

PaxDbiQ9H340.
PRIDEiQ9H340.

Protocols and materials databases

DNASUi390058.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380219; ENSP00000369568; ENSG00000176239.
GeneIDi390058.
KEGGihsa:390058.
UCSCiuc010qzb.2. human.

Organism-specific databases

CTDi390058.
GeneCardsiOR51B6.
HGNCiHGNC:19600. OR51B6.
neXtProtiNX_Q9H340.
PharmGKBiPA134989095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H340.
KOiK04257.
OMAiLSIMPIV.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H340.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51B6.
GenomeRNAii390058.
PROiQ9H340.

Gene expression databases

BgeeiQ9H340.
CleanExiHS_OR51B6.
GenevisibleiQ9H340. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-5; SER-40; THR-90; ILE-131; GLY-145; ALA-169; PHE-172; LEU-192 AND ARG-275.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiO51B6_HUMAN
AccessioniPrimary (citable) accession number: Q9H340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 14, 2008
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.