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Protein

Olfactory receptor 51B6

Gene

OR51B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176239-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51B6
Alternative name(s):
Odorant receptor HOR5'beta6
Gene namesi
Name:OR51B6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19600. OR51B6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 271ExtracellularSequence analysisAdd BLAST15
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176239.
PharmGKBiPA134989095.

Polymorphism and mutation databases

BioMutaiOR51B6.
DMDMi209572656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507481 – 312Olfactory receptor 51B6Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H340.
PeptideAtlasiQ9H340.
PRIDEiQ9H340.

PTM databases

iPTMnetiQ9H340.
PhosphoSitePlusiQ9H340.

Expressioni

Gene expression databases

BgeeiENSG00000176239.
CleanExiHS_OR51B6.
GenevisibleiQ9H340. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369568.

Structurei

3D structure databases

ProteinModelPortaliQ9H340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H340.
KOiK04257.
OMAiLSIMPIV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H340.
TreeFamiTF342735.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNKSASTF QLTGFPGMEK AHHWIFIPLL AAYISILLGN GTLLFLIRND
60 70 80 90 100
HNLHEPMYYF LAMLAATDLG VTLTTMPTVL GVLWLDHREI GHGACFSQAY
110 120 130 140 150
FIHTLSVMES GVLLAMAYDC FITIRSPLRY TSILTNTQVM KIGVRVLTRA
160 170 180 190 200
GLSIMPIVVR LHWFPYCRSH VLSHAFCLHQ DVIKLACADI TFNRLYPVVV
210 220 230 240 250
LFAMVLLDFL IIFFSYILIL KTVMGIGSGG ERAKALNTCV SHICCILVFY
260 270 280 290 300
VTVVCLTFIH RFGKHVPHVV HITMSYIHFL FPPFMNPFIY SIKTKQIQSG
310
ILRLFSLPHS RA
Length:312
Mass (Da):35,269
Last modified:October 14, 2008 - v2
Checksum:iE7CCFDBD1FA50B45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123 – 126TIRS → AIHN in AAG41682 (PubMed:11121057).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0533125K → T.1 PublicationCorresponds to variant rs4910755dbSNPEnsembl.1
Natural variantiVAR_05331340N → S.1 PublicationCorresponds to variant rs4910756dbSNPEnsembl.1
Natural variantiVAR_05331490I → T.1 PublicationCorresponds to variant rs7483122dbSNPEnsembl.1
Natural variantiVAR_053315123T → A.Corresponds to variant rs5006889dbSNPEnsembl.1
Natural variantiVAR_060035125R → H.Corresponds to variant rs7479477dbSNPEnsembl.1
Natural variantiVAR_060036126S → N.Corresponds to variant rs5006888dbSNPEnsembl.1
Natural variantiVAR_053316131T → I.1 PublicationCorresponds to variant rs5006887dbSNPEnsembl.1
Natural variantiVAR_053317145R → G.1 PublicationCorresponds to variant rs5006886dbSNPEnsembl.1
Natural variantiVAR_053318169S → A.1 PublicationCorresponds to variant rs5006885dbSNPEnsembl.1
Natural variantiVAR_053319172L → F.1 PublicationCorresponds to variant rs5006884dbSNPEnsembl.1
Natural variantiVAR_053320192F → L.1 PublicationCorresponds to variant rs5006883dbSNPEnsembl.1
Natural variantiVAR_053321254V → L.Corresponds to variant rs7106330dbSNPEnsembl.1
Natural variantiVAR_053322275S → R.1 PublicationCorresponds to variant rs5024042dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41682.1.
AC104389 Genomic DNA. No translation available.
CCDSiCCDS31379.1.
RefSeqiNP_001004750.1. NM_001004750.1.
UniGeneiHs.553730.

Genome annotation databases

EnsembliENST00000380219; ENSP00000369568; ENSG00000176239.
GeneIDi390058.
KEGGihsa:390058.
UCSCiuc010qzb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137396 Genomic DNA. Translation: AAG41682.1.
AC104389 Genomic DNA. No translation available.
CCDSiCCDS31379.1.
RefSeqiNP_001004750.1. NM_001004750.1.
UniGeneiHs.553730.

3D structure databases

ProteinModelPortaliQ9H340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369568.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H340.
PhosphoSitePlusiQ9H340.

Polymorphism and mutation databases

BioMutaiOR51B6.
DMDMi209572656.

Proteomic databases

PaxDbiQ9H340.
PeptideAtlasiQ9H340.
PRIDEiQ9H340.

Protocols and materials databases

DNASUi390058.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380219; ENSP00000369568; ENSG00000176239.
GeneIDi390058.
KEGGihsa:390058.
UCSCiuc010qzb.2. human.

Organism-specific databases

CTDi390058.
GeneCardsiOR51B6.
HGNCiHGNC:19600. OR51B6.
neXtProtiNX_Q9H340.
OpenTargetsiENSG00000176239.
PharmGKBiPA134989095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVJQ. Eukaryota.
ENOG4111CPY. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H340.
KOiK04257.
OMAiLSIMPIV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H340.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176239-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51B6.
GenomeRNAii390058.
PROiQ9H340.

Gene expression databases

BgeeiENSG00000176239.
CleanExiHS_OR51B6.
GenevisibleiQ9H340. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51B6_HUMAN
AccessioniPrimary (citable) accession number: Q9H340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.