Q9H340 (O51B6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 51B6

Alternative name(s):
Odorant receptor HOR5'beta6

Gene names

Name:

OR51B6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 51B6		PRO_0000150748
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 97	24	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 158	21	Helical; Name=4; Potential
	Topological domain	159 – 194	36	Extracellular Potential
	Transmembrane	195 – 215	21	Helical; Name=5; Potential
	Topological domain	216 – 235	20	Cytoplasmic Potential
	Transmembrane	236 – 256	21	Helical; Name=6; Potential
	Topological domain	257 – 271	15	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 312	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	5	1	K → T. Ref.1 Corresponds to variant rs4910755 [ dbSNP | Ensembl ].		VAR_053312
	Natural variant	40	1	N → S. Ref.1 Corresponds to variant rs4910756 [ dbSNP | Ensembl ].		VAR_053313
	Natural variant	90	1	I → T. Ref.1 Corresponds to variant rs7483122 [ dbSNP | Ensembl ].		VAR_053314
	Natural variant	123	1	T → A. Corresponds to variant rs5006889 [ dbSNP | Ensembl ].		VAR_053315
	Natural variant	125	1	R → H. Corresponds to variant rs7479477 [ dbSNP | Ensembl ].		VAR_060035
	Natural variant	126	1	S → N. Corresponds to variant rs5006888 [ dbSNP | Ensembl ].		VAR_060036
	Natural variant	131	1	T → I. Ref.1 Corresponds to variant rs5006887 [ dbSNP | Ensembl ].		VAR_053316
	Natural variant	145	1	R → G. Ref.1 Corresponds to variant rs5006886 [ dbSNP | Ensembl ].		VAR_053317
	Natural variant	169	1	S → A. Ref.1 Corresponds to variant rs5006885 [ dbSNP | Ensembl ].		VAR_053318
	Natural variant	172	1	L → F. Ref.1 Corresponds to variant rs5006884 [ dbSNP | Ensembl ].		VAR_053319
	Natural variant	192	1	F → L. Ref.1 Corresponds to variant rs5006883 [ dbSNP | Ensembl ].		VAR_053320
	Natural variant	254	1	V → L. Corresponds to variant rs7106330 [ dbSNP | Ensembl ].		VAR_053321
	Natural variant	275	1	S → R. Ref.1 Corresponds to variant rs5024042 [ dbSNP | Ensembl ].		VAR_053322
Experimental info
	Sequence conflict	123 – 126	4	TIRS → AIHN in AAG41682. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H340 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: E7CCFDBD1FA50B45	FASTA	312	35,269
	10 20 30 40 50 60 MGLNKSASTF QLTGFPGMEK AHHWIFIPLL AAYISILLGN GTLLFLIRND HNLHEPMYYF 70 80 90 100 110 120 LAMLAATDLG VTLTTMPTVL GVLWLDHREI GHGACFSQAY FIHTLSVMES GVLLAMAYDC 130 140 150 160 170 180 FITIRSPLRY TSILTNTQVM KIGVRVLTRA GLSIMPIVVR LHWFPYCRSH VLSHAFCLHQ 190 200 210 220 230 240 DVIKLACADI TFNRLYPVVV LFAMVLLDFL IIFFSYILIL KTVMGIGSGG ERAKALNTCV 250 260 270 280 290 300 SHICCILVFY VTVVCLTFIH RFGKHVPHVV HITMSYIHFL FPPFMNPFIY SIKTKQIQSG 310 ILRLFSLPHS RA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters." Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R. Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-5; SER-40; THR-90; ILE-131; GLY-145; ALA-169; PHE-172; LEU-192 AND ARG-275.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF137396 Genomic DNA. Translation: AAG41682.1. AC104389 Genomic DNA. No translation available.
IPI	IPI00023118.
RefSeq	NP_001004750.1. NM_001004750.1.
UniGene	Hs.553730.
3D structure databases
ProteinModelPortal	Q9H340.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369568.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9H340.
Polymorphism databases
DMDM	209572656.
Proteomic databases
PaxDb	Q9H340.
PRIDE	Q9H340.
Protocols and materials databases
DNASU	390058.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380219; ENSP00000369568; ENSG00000176239.
GeneID	390058.
KEGG	hsa:390058.
UCSC	uc010qzb.2. human.
Organism-specific databases
CTD	390058.
GeneCards	GC11P005301.
HGNC	HGNC:19600. OR51B6.
neXtProt	NX_Q9H340.
PharmGKB	PA134989095.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42936.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q9H340.
KO	K04257.
OMA	AMWLNTT.
OrthoDB	EOG454903.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q9H340.
CleanEx	HS_OR51B6.
Genevestigator	Q9H340.
GermOnline	ENSG00000176239. Homo sapiens.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	103321.

Entry information

Entry name

O51B6_HUMAN

Accession

Primary (citable) accession number: Q9H340

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.