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Protein

Cysteine-rich secretory protein LCCL domain-containing 1

Gene

CRISPLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • face morphogenesis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein LCCL domain-containing 1
Alternative name(s):
CocoaCrisp
Cysteine-rich secretory protein 10
Short name:
CRISP-10
LCCL domain-containing cysteine-rich secretory protein 1
Trypsin inhibitor Hl
Gene namesi
Name:CRISPLD1
Synonyms:CRISP10, LCRISP1
ORF Names:UNQ342/PRO541
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18206. CRISPLD1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi83690.
OpenTargetsiENSG00000121005.
PharmGKBiPA142672076.

Polymorphism and mutation databases

BioMutaiCRISPLD1.
DMDMi74733568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000024814624 – 500Cysteine-rich secretory protein LCCL domain-containing 1Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi295 ↔ 313PROSITE-ProRule annotation
Disulfide bondi317 ↔ 337PROSITE-ProRule annotation
Disulfide bondi396 ↔ 418PROSITE-ProRule annotation
Disulfide bondi422 ↔ 445PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9H336.
PaxDbiQ9H336.
PeptideAtlasiQ9H336.
PRIDEiQ9H336.

PTM databases

iPTMnetiQ9H336.
PhosphoSitePlusiQ9H336.

Expressioni

Gene expression databases

BgeeiENSG00000121005.
CleanExiHS_CRISPLD1.
ExpressionAtlasiQ9H336. baseline and differential.
GenevisibleiQ9H336. HS.

Organism-specific databases

HPAiHPA024725.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262207.

Structurei

3D structure databases

ProteinModelPortaliQ9H336.
SMRiQ9H336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 206SCPAdd BLAST141
Domaini289 – 384LCCL 1PROSITE-ProRule annotationAdd BLAST96
Domaini390 – 492LCCL 2PROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 2 LCCL domains.PROSITE-ProRule annotation
Contains 1 SCP domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000294224.
HOVERGENiHBG062505.
InParanoidiQ9H336.
OMAiGCAINLC.
OrthoDBiEOG091G048D.
PhylomeDBiQ9H336.
TreeFamiTF316148.

Family and domain databases

Gene3Di2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 2 hits.
PfamiPF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEiPS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H336-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKCTAREWLR VTTVLFMARA IPAMVVPNAT LLEKLLEKYM DEDGEWWIAK
60 70 80 90 100
QRGKRAITDN DMQSILDLHN KLRSQVYPTA SNMEYMTWDV ELERSAESWA
110 120 130 140 150
ESCLWEHGPA SLLPSIGQNL GAHWGRYRPP TFHVQSWYDE VKDFSYPYEH
160 170 180 190 200
ECNPYCPFRC SGPVCTHYTQ VVWATSNRIG CAINLCHNMN IWGQIWPKAV
210 220 230 240 250
YLVCNYSPKG NWWGHAPYKH GRPCSACPPS FGGGCRENLC YKEGSDRYYP
260 270 280 290 300
PREEETNEIE RQQSQVHDTH VRTRSDDSSR NEVISAQQMS QIVSCEVRLR
310 320 330 340 350
DQCKGTTCNR YECPAGCLDS KAKVIGSVHY EMQSSICRAA IHYGIIDNDG
360 370 380 390 400
GWVDITRQGR KHYFIKSNRN GIQTIGKYQS ANSFTVSKVT VQAVTCETTV
410 420 430 440 450
EQLCPFHKPA SHCPRVYCPR NCMQANPHYA RVIGTRVYSD LSSICRAAVH
460 470 480 490 500
AGVVRNHGGY VDVMPVDKRK TYIASFQNGI FSESLQNPPG GKAFRVFAVV
Length:500
Mass (Da):56,888
Last modified:March 1, 2001 - v1
Checksum:i203B1DC4DDA003CB
GO
Isoform 2 (identifier: Q9H336-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MKCTAREWLRVTTVLFMARAIPA → MNMNATHIVHSGVLALYVHIIHR
     24-209: Missing.

Note: No experimental confirmation available.
Show »
Length:314
Mass (Da):35,172
Checksum:i6492A86B51890971
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027255286A → S.Corresponds to variant rs1945dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552811 – 23MKCTA…RAIPA → MNMNATHIVHSGVLALYVHI IHR in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_05528224 – 209Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142573 mRNA. Translation: AAG43287.1.
AF329197 mRNA. Translation: AAK16495.1.
AY358564 mRNA. Translation: AAQ88927.1.
AK304350 mRNA. Translation: BAH14165.1.
AK314048 mRNA. Translation: BAG36757.1.
AL834301 mRNA. Translation: CAH56361.1.
AC100782 Genomic DNA. No translation available.
AC102801 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87038.1.
BC020514 mRNA. Translation: AAH20514.1.
CCDSiCCDS6219.1. [Q9H336-1]
CCDS69497.1. [Q9H336-2]
RefSeqiNP_001273706.1. NM_001286777.1. [Q9H336-2]
NP_113649.1. NM_031461.5. [Q9H336-1]
UniGeneiHs.436542.

Genome annotation databases

EnsembliENST00000262207; ENSP00000262207; ENSG00000121005. [Q9H336-1]
ENST00000517786; ENSP00000429746; ENSG00000121005. [Q9H336-2]
GeneIDi83690.
KEGGihsa:83690.
UCSCiuc003yan.5. human. [Q9H336-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142573 mRNA. Translation: AAG43287.1.
AF329197 mRNA. Translation: AAK16495.1.
AY358564 mRNA. Translation: AAQ88927.1.
AK304350 mRNA. Translation: BAH14165.1.
AK314048 mRNA. Translation: BAG36757.1.
AL834301 mRNA. Translation: CAH56361.1.
AC100782 Genomic DNA. No translation available.
AC102801 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87038.1.
BC020514 mRNA. Translation: AAH20514.1.
CCDSiCCDS6219.1. [Q9H336-1]
CCDS69497.1. [Q9H336-2]
RefSeqiNP_001273706.1. NM_001286777.1. [Q9H336-2]
NP_113649.1. NM_031461.5. [Q9H336-1]
UniGeneiHs.436542.

3D structure databases

ProteinModelPortaliQ9H336.
SMRiQ9H336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262207.

PTM databases

iPTMnetiQ9H336.
PhosphoSitePlusiQ9H336.

Polymorphism and mutation databases

BioMutaiCRISPLD1.
DMDMi74733568.

Proteomic databases

EPDiQ9H336.
PaxDbiQ9H336.
PeptideAtlasiQ9H336.
PRIDEiQ9H336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262207; ENSP00000262207; ENSG00000121005. [Q9H336-1]
ENST00000517786; ENSP00000429746; ENSG00000121005. [Q9H336-2]
GeneIDi83690.
KEGGihsa:83690.
UCSCiuc003yan.5. human. [Q9H336-1]

Organism-specific databases

CTDi83690.
DisGeNETi83690.
GeneCardsiCRISPLD1.
HGNCiHGNC:18206. CRISPLD1.
HPAiHPA024725.
neXtProtiNX_Q9H336.
OpenTargetsiENSG00000121005.
PharmGKBiPA142672076.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000294224.
HOVERGENiHBG062505.
InParanoidiQ9H336.
OMAiGCAINLC.
OrthoDBiEOG091G048D.
PhylomeDBiQ9H336.
TreeFamiTF316148.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121005-MONOMER.

Miscellaneous databases

GenomeRNAii83690.
PROiQ9H336.

Gene expression databases

BgeeiENSG00000121005.
CleanExiHS_CRISPLD1.
ExpressionAtlasiQ9H336. baseline and differential.
GenevisibleiQ9H336. HS.

Family and domain databases

Gene3Di2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 2 hits.
PfamiPF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEiPS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRLD1_HUMAN
AccessioniPrimary (citable) accession number: Q9H336
Secondary accession number(s): B2RA60, B7Z929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.