SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H334

- FOXP1_HUMAN

UniProt

Q9H334 - FOXP1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Forkhead box protein P1

Gene
FOXP1, HSPC215
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei59 – 602Breakpoint for translocation to form PAX5-FOXP1

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri306 – 33126C2H2-typeAdd
BLAST
DNA bindingi465 – 55591Fork-headAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: RefGenome
  2. DNA binding, bending Source: RefGenome
  3. metal ion binding Source: UniProtKB-KW
  4. protein heterodimerization activity Source: RefGenome
  5. protein homodimerization activity Source: RefGenome
  6. sequence-specific DNA binding Source: InterPro
  7. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cardiac muscle cell differentiation Source: RefGenome
  2. immunoglobulin V(D)J recombination Source: RefGenome
  3. lung development Source: RefGenome
  4. negative regulation of transcription, DNA-templated Source: UniProtKB
  5. pattern specification process Source: RefGenome
  6. positive regulation of epithelial cell proliferation Source: RefGenome
  7. positive regulation of immunoglobulin production Source: RefGenome
  8. positive regulation of mesenchymal cell proliferation Source: RefGenome
  9. pre-B cell differentiation Source: RefGenome
  10. skeletal muscle tissue development Source: RefGenome
  11. smooth muscle tissue development Source: RefGenome
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9H334.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P1
Gene namesi
Name:FOXP1
ORF Names:HSPC215
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3823. FOXP1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Mental retardation

Organism-specific databases

MIMi613670. phenotype.
Orphaneti391372. Intellectual disability-severe speech delay-mild dysmorphism syndrome.
52417. MALT lymphoma.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA28241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Forkhead box protein P1PRO_0000091877Add
BLAST

Proteomic databases

MaxQBiQ9H334.
PaxDbiQ9H334.
PRIDEiQ9H334.

PTM databases

PhosphoSiteiQ9H334.

Expressioni

Gene expression databases

ArrayExpressiQ9H334.
BgeeiQ9H334.
CleanExiHS_FOXP1.
GenevestigatoriQ9H334.

Organism-specific databases

HPAiCAB011501.
HPA003876.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.

Protein-protein interaction databases

BioGridi117989. 11 interactions.
DIPiDIP-36585N.
IntActiQ9H334. 9 interactions.
STRINGi9606.ENSP00000318902.

Structurei

Secondary structure

1
677
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi470 – 47910
Beta strandi481 – 4866
Helixi488 – 49811
Helixi500 – 5023
Helixi506 – 51914
Beta strandi523 – 5264
Beta strandi533 – 5364
Helixi538 – 5436

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KIUNMR-A462-548[»]
ProteinModelPortaliQ9H334.
SMRiQ9H334. Positions 311-369, 462-548.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni348 – 36922Leucine-zipperAdd
BLAST
Regioni382 – 3865CTBP1-binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 230176Gln-richAdd
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression By similarity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri306 – 33126C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ9H334.
OrthoDBiEOG7M6D7G.
PhylomeDBiQ9H334.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9H334-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD    50
LAHAQQQQQQ ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA 100
MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ 150
QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ 200
RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT AEETTGNNHS 250
SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH 300
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ 350
LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP 400
QSLPHTPTTP TAPLTPVTQG PSVITTTSMH TVGPIRRRYS DKYNVPISSA 450
DIAQNQEFYK NAEVRPPFTY ASLIRQAILE SPEKQLTLNE IYNWFTRMFA 500
YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE FQKRRPQKIS 550
GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS 600
AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS 650
LVTTANHSPD FDHDRDYEDE PVNEDME 677
Length:677
Mass (Da):75,317
Last modified:March 1, 2001 - v1
Checksum:iAEE92D47BB20964B
GO
Isoform 2 (identifier: Q9H334-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     140-227: Missing.

Show »
Length:489
Mass (Da):54,563
Checksum:i63DDAAD1B033BAF0
GO
Isoform 3 (identifier: Q9H334-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → CRSTLVDPKN...APFAKLFIFS
     95-170: Missing.

Note: Incomplete sequence.

Show »
Length:586
Mass (Da):65,431
Checksum:i099643CD5B363BDF
GO
Isoform 4 (identifier: Q9H334-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → CRSTLVDPKN...APFAKLFIFS

Note: Incomplete sequence. No experimental confirmation available.

Show »
Length:662
Mass (Da):74,330
Checksum:i168D2B3165278F9E
GO
Isoform 5 (identifier: Q9H334-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-114: ALQVARQLLL...QVITPQQMQQ → WHLINHQPSR...PVCQPNPSPF
     115-677: Missing.

Show »
Length:114
Mass (Da):12,256
Checksum:iA1CC32BD8BBC4EA5
GO
Isoform 6 (identifier: Q9H334-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-170: Missing.

Show »
Length:601
Mass (Da):66,417
Checksum:i599FC834381D194C
GO
Isoform 7 (identifier: Q9H334-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: Missing.

Note: No experimental confirmation available. May be due to competing acceptor splice site.

Show »
Length:676
Mass (Da):75,246
Checksum:iF70967CCDB289929
GO

Sequence cautioni

The sequence AAF36135.1 differs from that shown. Reason: Frameshift at positions 531 and 545.
The sequence ABI33105.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55005.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51S → P.1 Publication
VAR_065067
Natural varianti101 – 1011M → V.1 Publication
VAR_065068
Natural varianti215 – 2151P → A.3 Publications
Corresponds to variant rs146606219 [ dbSNP | Ensembl ].
VAR_065069
Natural varianti261 – 2611S → P.1 Publication
VAR_065070
Natural varianti390 – 3901T → S.1 Publication
VAR_065071
Natural varianti445 – 4451V → M.1 Publication
Corresponds to variant rs147756430 [ dbSNP | Ensembl ].
VAR_065072
Natural varianti570 – 5701N → S.2 Publications
VAR_065073
Natural varianti597 – 5971N → T.1 Publication
VAR_065074
Natural varianti613 – 6131T → N.1 Publication
VAR_065075

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100Missing in isoform 2. VSP_001553Add
BLAST
Alternative sequencei1 – 6060MMQES…QQQQQ → CRSTLVDPKNSARASQKQPE PIYSKKTEIQRQTVRAPFAK LFIFS in isoform 3 and isoform 4. VSP_001555Add
BLAST
Alternative sequencei61 – 11454ALQVA…QQMQQ → WHLINHQPSRSPSSWLKRLI SSPWELEVLQVPLWGAVAET KMSGPVCQPNPSPF in isoform 5. VSP_043462Add
BLAST
Alternative sequencei95 – 17076Missing in isoform 3 and isoform 6. VSP_001556Add
BLAST
Alternative sequencei115 – 677563Missing in isoform 5. VSP_043463Add
BLAST
Alternative sequencei140 – 22788Missing in isoform 2. VSP_001554Add
BLAST
Alternative sequencei450 – 4501Missing in isoform 7. VSP_046930

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381L → P in BAG53682. 1 Publication
Sequence conflicti173 – 1731Q → R in BAB55005. 1 Publication
Sequence conflicti205 – 2051L → V in BAB55005. 1 Publication
Sequence conflicti210 – 2123GQP → ARA in AAK69408. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF146696 mRNA. Translation: AAG47632.1.
AF146697 mRNA. Translation: AAG47633.1.
AF146698 mRNA. Translation: AAG47634.1.
AF275309 mRNA. Translation: AAK69408.1.
BT006643 mRNA. Translation: AAP35289.1.
AK092383 mRNA. Translation: BAC03875.1.
AK122710 mRNA. Translation: BAG53682.1.
AC097632 Genomic DNA. No translation available.
AC097634 Genomic DNA. No translation available.
AC103586 Genomic DNA. No translation available.
AC104442 Genomic DNA. No translation available.
AC104645 Genomic DNA. No translation available.
AC138058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65494.1.
CH471055 Genomic DNA. Translation: EAW65499.1.
BC005055 mRNA. Translation: AAH05055.1.
BC054815 mRNA. Translation: AAH54815.1.
BC071893 mRNA. Translation: AAH71893.1.
BC080521 mRNA. Translation: AAH80521.1.
DQ845346 mRNA. Translation: ABI33105.1. Different initiation.
AK027264 mRNA. Translation: BAB55005.1. Different initiation.
AF151049 mRNA. Translation: AAF36135.1. Frameshift.
CCDSiCCDS2914.1. [Q9H334-1]
CCDS33785.1. [Q9H334-5]
CCDS58838.1. [Q9H334-6]
CCDS58839.1. [Q9H334-7]
RefSeqiNP_001012523.1. NM_001012505.1. [Q9H334-5]
NP_001231737.1. NM_001244808.1. [Q9H334-7]
NP_001231739.1. NM_001244810.1.
NP_001231741.1. NM_001244812.1. [Q9H334-6]
NP_001231743.1. NM_001244814.1. [Q9H334-1]
NP_001231744.1. NM_001244815.1.
NP_001231745.1. NM_001244816.1. [Q9H334-1]
NP_116071.2. NM_032682.5. [Q9H334-1]
XP_005264795.1. XM_005264738.2. [Q9H334-7]
XP_006713165.1. XM_006713102.1. [Q9H334-1]
XP_006713166.1. XM_006713103.1. [Q9H334-1]
XP_006713167.1. XM_006713104.1. [Q9H334-1]
XP_006713170.1. XM_006713107.1. [Q9H334-5]
UniGeneiHs.59368.

Genome annotation databases

EnsembliENST00000318779; ENSP00000318721; ENSG00000114861. [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861. [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861. [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861. [Q9H334-6]
ENST00000493089; ENSP00000418524; ENSG00000114861. [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861. [Q9H334-1]
GeneIDi27086.
KEGGihsa:27086.
UCSCiuc003doi.3. human. [Q9H334-1]
uc003dom.3. human.
uc003doo.3. human.
uc003dos.3. human. [Q9H334-5]

Polymorphism databases

DMDMi14548062.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF146696 mRNA. Translation: AAG47632.1 .
AF146697 mRNA. Translation: AAG47633.1 .
AF146698 mRNA. Translation: AAG47634.1 .
AF275309 mRNA. Translation: AAK69408.1 .
BT006643 mRNA. Translation: AAP35289.1 .
AK092383 mRNA. Translation: BAC03875.1 .
AK122710 mRNA. Translation: BAG53682.1 .
AC097632 Genomic DNA. No translation available.
AC097634 Genomic DNA. No translation available.
AC103586 Genomic DNA. No translation available.
AC104442 Genomic DNA. No translation available.
AC104645 Genomic DNA. No translation available.
AC138058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65494.1 .
CH471055 Genomic DNA. Translation: EAW65499.1 .
BC005055 mRNA. Translation: AAH05055.1 .
BC054815 mRNA. Translation: AAH54815.1 .
BC071893 mRNA. Translation: AAH71893.1 .
BC080521 mRNA. Translation: AAH80521.1 .
DQ845346 mRNA. Translation: ABI33105.1 . Different initiation.
AK027264 mRNA. Translation: BAB55005.1 . Different initiation.
AF151049 mRNA. Translation: AAF36135.1 . Frameshift.
CCDSi CCDS2914.1. [Q9H334-1 ]
CCDS33785.1. [Q9H334-5 ]
CCDS58838.1. [Q9H334-6 ]
CCDS58839.1. [Q9H334-7 ]
RefSeqi NP_001012523.1. NM_001012505.1. [Q9H334-5 ]
NP_001231737.1. NM_001244808.1. [Q9H334-7 ]
NP_001231739.1. NM_001244810.1.
NP_001231741.1. NM_001244812.1. [Q9H334-6 ]
NP_001231743.1. NM_001244814.1. [Q9H334-1 ]
NP_001231744.1. NM_001244815.1.
NP_001231745.1. NM_001244816.1. [Q9H334-1 ]
NP_116071.2. NM_032682.5. [Q9H334-1 ]
XP_005264795.1. XM_005264738.2. [Q9H334-7 ]
XP_006713165.1. XM_006713102.1. [Q9H334-1 ]
XP_006713166.1. XM_006713103.1. [Q9H334-1 ]
XP_006713167.1. XM_006713104.1. [Q9H334-1 ]
XP_006713170.1. XM_006713107.1. [Q9H334-5 ]
UniGenei Hs.59368.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KIU NMR - A 462-548 [» ]
ProteinModelPortali Q9H334.
SMRi Q9H334. Positions 311-369, 462-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117989. 11 interactions.
DIPi DIP-36585N.
IntActi Q9H334. 9 interactions.
STRINGi 9606.ENSP00000318902.

PTM databases

PhosphoSitei Q9H334.

Polymorphism databases

DMDMi 14548062.

Proteomic databases

MaxQBi Q9H334.
PaxDbi Q9H334.
PRIDEi Q9H334.

Protocols and materials databases

DNASUi 27086.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318779 ; ENSP00000318721 ; ENSG00000114861 . [Q9H334-5 ]
ENST00000318789 ; ENSP00000318902 ; ENSG00000114861 . [Q9H334-1 ]
ENST00000475937 ; ENSP00000419393 ; ENSG00000114861 . [Q9H334-1 ]
ENST00000484350 ; ENSP00000417857 ; ENSG00000114861 . [Q9H334-6 ]
ENST00000493089 ; ENSP00000418524 ; ENSG00000114861 . [Q9H334-7 ]
ENST00000498215 ; ENSP00000418102 ; ENSG00000114861 . [Q9H334-1 ]
GeneIDi 27086.
KEGGi hsa:27086.
UCSCi uc003doi.3. human. [Q9H334-1 ]
uc003dom.3. human.
uc003doo.3. human.
uc003dos.3. human. [Q9H334-5 ]

Organism-specific databases

CTDi 27086.
GeneCardsi GC03M071088.
HGNCi HGNC:3823. FOXP1.
HPAi CAB011501.
HPA003876.
MIMi 605515. gene.
613670. phenotype.
neXtProti NX_Q9H334.
Orphaneti 391372. Intellectual disability-severe speech delay-mild dysmorphism syndrome.
52417. MALT lymphoma.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBi PA28241.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000092089.
HOVERGENi HBG051657.
InParanoidi Q9H334.
OrthoDBi EOG7M6D7G.
PhylomeDBi Q9H334.
TreeFami TF326978.

Enzyme and pathway databases

SignaLinki Q9H334.

Miscellaneous databases

ChiTaRSi FOXP1. human.
GeneWikii FOXP1.
GenomeRNAii 27086.
NextBioi 49693.
PROi Q9H334.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H334.
Bgeei Q9H334.
CleanExi HS_FOXP1.
Genevestigatori Q9H334.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p."
    Banham A.H., Beasley N., Campo E., Fernandez P.L., Fidler C., Gatter K., Jones M., Mason D.Y., Prime J.E., Trougouboff P., Wood K., Cordell J.L.
    Cancer Res. 61:8820-8829(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 210-677 (ISOFORM 7), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Testis.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-677 (ISOFORM 4).
    Tissue: Embryonic head and Tongue.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Lung.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-677, CHROMOSOMAL TRANSLOCATION WITH PAX5.
  8. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-677.
    Tissue: Umbilical cord blood.
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: FUNCTION, INVOLVEMENT IN MRLIAF, VARIANTS ALA-215; MET-445; SER-570 AND ASN-613.
  11. "Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia."
    Vernes S.C., MacDermot K.D., Monaco A.P., Fisher S.E.
    Eur. J. Hum. Genet. 17:1354-1358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ALA-215.
  12. Cited for: VARIANTS PRO-5; VAL-101; ALA-215; PRO-261; SER-390; SER-570 AND THR-597.

Entry informationi

Entry nameiFOXP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H334
Secondary accession number(s): A3QVP8
, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi