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Protein

Forkhead box protein P1

Gene

FOXP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).By similarity2 Publications6 Publications
Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 331C2H2-typeAdd BLAST26
DNA bindingi465 – 555Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein self-association Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • chemokine (C-C motif) ligand 2 secretion Source: UniProtKB
  • endothelial cell activation Source: UniProtKB
  • interleukin-21 secretion Source: UniProtKB
  • macrophage activation Source: UniProtKB
  • monocyte activation Source: UniProtKB
  • negative regulation of androgen receptor signaling pathway Source: UniProtKB
  • negative regulation of B cell apoptotic process Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • osteoclast development Source: UniProtKB
  • osteoclast differentiation Source: UniProtKB
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of smooth muscle cell proliferation Source: UniProtKB
  • regulation of defense response to bacterium Source: UniProtKB
  • regulation of endothelial tube morphogenesis Source: UniProtKB
  • regulation of inflammatory response Source: UniProtKB
  • regulation of interleukin-12 secretion Source: UniProtKB
  • regulation of interleukin-1 beta secretion Source: UniProtKB
  • regulation of macrophage colony-stimulating factor production Source: UniProtKB
  • regulation of monocyte differentiation Source: UniProtKB
  • regulation of tumor necrosis factor production Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
  • T follicular helper cell differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114861-MONOMER.
SignaLinkiQ9H334.
SIGNORiQ9H334.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P1
Alternative name(s):
Mac-1-regulated forkhead1 Publication
Short name:
MFH1 Publication
Gene namesi
Name:FOXP1
ORF Names:HSPC215
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:3823. FOXP1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.

Mental retardation with language impairment and autistic features (MRLIAF)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.
See also OMIM:613670
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075247465R → G in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 Publication1
Natural variantiVAR_075248514R → C in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 Publication1
Natural variantiVAR_075249534W → R in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant rs587777855dbSNPEnsembl.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Breakpoint for translocation to form PAX5-FOXP12

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi27086.
MalaCardsiFOXP1.
MIMi613670. phenotype.
OpenTargetsiENSG00000114861.
Orphaneti391372. Intellectual disability-severe speech delay-mild dysmorphism syndrome.
52417. MALT lymphoma.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA28241.

Polymorphism and mutation databases

BioMutaiFOXP1.
DMDMi14548062.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918771 – 677Forkhead box protein P1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineCombined sources1
Modified residuei653PhosphothreonineCombined sources1
Modified residuei658PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H334.
MaxQBiQ9H334.
PaxDbiQ9H334.
PeptideAtlasiQ9H334.
PRIDEiQ9H334.

PTM databases

iPTMnetiQ9H334.
PhosphoSitePlusiQ9H334.

Expressioni

Tissue specificityi

Isoform 8 is specifically expressed in embryonic stem cells.1 Publication

Inductioni

By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced.1 Publication

Gene expression databases

BgeeiENSG00000114861.
CleanExiHS_FOXP1.
ExpressionAtlasiQ9H334. baseline and differential.
GenevisibleiQ9H334. HS.

Organism-specific databases

HPAiCAB011501.
HPA003876.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308). Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR (PubMed:18347093, PubMed:18640093). Interacts with FOXP2 (PubMed:26647308).By similarity4 Publications

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi117989. 40 interactors.
DIPiDIP-36585N.
IntActiQ9H334. 40 interactors.
STRINGi9606.ENSP00000318902.

Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi470 – 479Combined sources10
Beta strandi481 – 486Combined sources6
Helixi488 – 498Combined sources11
Helixi500 – 502Combined sources3
Helixi506 – 519Combined sources14
Beta strandi523 – 526Combined sources4
Beta strandi533 – 536Combined sources4
Helixi538 – 543Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KIUNMR-A462-548[»]
ProteinModelPortaliQ9H334.
SMRiQ9H334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 369Leucine-zipperAdd BLAST22
Regioni382 – 386CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 230Gln-richAdd BLAST176

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri306 – 331C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ9H334.
KOiK09409.
PhylomeDBiQ9H334.
TreeFamiTF326978.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9H334-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD
60 70 80 90 100
LAHAQQQQQQ ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA
110 120 130 140 150
MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ
160 170 180 190 200
QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ
210 220 230 240 250
RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT AEETTGNNHS
260 270 280 290 300
SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH
310 320 330 340 350
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ
360 370 380 390 400
LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP
410 420 430 440 450
QSLPHTPTTP TAPLTPVTQG PSVITTTSMH TVGPIRRRYS DKYNVPISSA
460 470 480 490 500
DIAQNQEFYK NAEVRPPFTY ASLIRQAILE SPEKQLTLNE IYNWFTRMFA
510 520 530 540 550
YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE FQKRRPQKIS
560 570 580 590 600
GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS
610 620 630 640 650
AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS
660 670
LVTTANHSPD FDHDRDYEDE PVNEDME
Length:677
Mass (Da):75,317
Last modified:March 1, 2001 - v1
Checksum:iAEE92D47BB20964B
GO
Isoform 2 (identifier: Q9H334-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     140-227: Missing.

Show »
Length:489
Mass (Da):54,563
Checksum:i63DDAAD1B033BAF0
GO
Isoform 3 (identifier: Q9H334-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → CRSTLVDPKN...APFAKLFIFS
     95-170: Missing.

Note: Incomplete sequence.
Show »
Length:586
Mass (Da):65,431
Checksum:i099643CD5B363BDF
GO
Isoform 4 (identifier: Q9H334-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MMQESGTETK...LAHAQQQQQQ → CRSTLVDPKN...APFAKLFIFS

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:662
Mass (Da):74,330
Checksum:i168D2B3165278F9E
GO
Isoform 5 (identifier: Q9H334-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-114: ALQVARQLLL...QVITPQQMQQ → WHLINHQPSR...PVCQPNPSPF
     115-677: Missing.

Show »
Length:114
Mass (Da):12,256
Checksum:iA1CC32BD8BBC4EA5
GO
Isoform 6 (identifier: Q9H334-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-170: Missing.

Show »
Length:601
Mass (Da):66,417
Checksum:i599FC834381D194C
GO
Isoform 7 (identifier: Q9H334-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-450: Missing.

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:676
Mass (Da):75,246
Checksum:iF70967CCDB289929
GO
Isoform 8 (identifier: Q9H334-8) [UniParc]FASTAAdd to basket
Also known as: FOXP1-ES

The sequence of this isoform differs from the canonical sequence as follows:
     511-551: NAVRHNLSLH...QKRRPQKISG → GAIRTLSLHK...DENFDELVAH

Show »
Length:692
Mass (Da):77,249
Checksum:i54B850510CD39CB1
GO

Sequence cautioni

The sequence AAF36135 differs from that shown. Reason: Frameshift at positions 531 and 545.Curated
The sequence ABI33105 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55005 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138L → P in BAG53682 (PubMed:14702039).Curated1
Sequence conflicti173Q → R in BAB55005 (PubMed:14702039).Curated1
Sequence conflicti205L → V in BAB55005 (PubMed:14702039).Curated1
Sequence conflicti210 – 212GQP → ARA in AAK69408 (PubMed:11751404).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0650675S → P.1 PublicationCorresponds to variant rs762898505dbSNPEnsembl.1
Natural variantiVAR_065068101M → V.1 PublicationCorresponds to variant rs564508875dbSNPEnsembl.1
Natural variantiVAR_075246107I → T Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 1 Publication1
Natural variantiVAR_065069215P → A Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 4 PublicationsCorresponds to variant rs146606219dbSNPEnsembl.1
Natural variantiVAR_065070261S → P.1 Publication1
Natural variantiVAR_065071390T → S.1 PublicationCorresponds to variant rs761840006dbSNPEnsembl.1
Natural variantiVAR_065072445V → M.1 PublicationCorresponds to variant rs147756430dbSNPEnsembl.1
Natural variantiVAR_075247465R → G in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 Publication1
Natural variantiVAR_075248514R → C in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 Publication1
Natural variantiVAR_075249534W → R in MRLIAF; nuclear and cytoplasmic aggregation; loss of transcriptional repression activity; loss of ability to self-associate; loss of interaction with FOXP2. 1 PublicationCorresponds to variant rs587777855dbSNPEnsembl.1
Natural variantiVAR_065073570N → S Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 3 PublicationsCorresponds to variant rs140161845dbSNPEnsembl.1
Natural variantiVAR_065074597N → T Polymorphism; does not affect nuclear localization; no loss of transcriptional repression activity; no loss of ability to self-associate; no loss of interaction with FOXP2. 2 Publications1
Natural variantiVAR_065075613T → N.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0015531 – 100Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_0015551 – 60MMQES…QQQQQ → CRSTLVDPKNSARASQKQPE PIYSKKTEIQRQTVRAPFAK LFIFS in isoform 3 and isoform 4. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_04346261 – 114ALQVA…QQMQQ → WHLINHQPSRSPSSWLKRLI SSPWELEVLQVPLWGAVAET KMSGPVCQPNPSPF in isoform 5. 2 PublicationsAdd BLAST54
Alternative sequenceiVSP_00155695 – 170Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_043463115 – 677Missing in isoform 5. 2 PublicationsAdd BLAST563
Alternative sequenceiVSP_001554140 – 227Missing in isoform 2. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_046930450Missing in isoform 7. 2 Publications1
Alternative sequenceiVSP_057341511 – 551NAVRH…QKISG → GAIRTLSLHKCFIRVEDEFG SFWTVDDEEFKRGRHIQRGR PRKYCPDENFDELVAH in isoform 8. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146696 mRNA. Translation: AAG47632.1.
AF146697 mRNA. Translation: AAG47633.1.
AF146698 mRNA. Translation: AAG47634.1.
AF275309 mRNA. Translation: AAK69408.1.
BT006643 mRNA. Translation: AAP35289.1.
AK092383 mRNA. Translation: BAC03875.1.
AK122710 mRNA. Translation: BAG53682.1.
AC097632 Genomic DNA. No translation available.
AC097634 Genomic DNA. No translation available.
AC103586 Genomic DNA. No translation available.
AC104442 Genomic DNA. No translation available.
AC104645 Genomic DNA. No translation available.
AC138058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65494.1.
CH471055 Genomic DNA. Translation: EAW65499.1.
BC005055 mRNA. Translation: AAH05055.1.
BC054815 mRNA. Translation: AAH54815.1.
BC071893 mRNA. Translation: AAH71893.1.
BC080521 mRNA. Translation: AAH80521.1.
DQ845346 mRNA. Translation: ABI33105.1. Different initiation.
AK027264 mRNA. Translation: BAB55005.1. Different initiation.
AF151049 mRNA. Translation: AAF36135.1. Frameshift.
CCDSiCCDS2914.1. [Q9H334-1]
CCDS33785.1. [Q9H334-5]
CCDS58838.1. [Q9H334-6]
CCDS58839.1. [Q9H334-7]
RefSeqiNP_001012523.1. NM_001012505.1. [Q9H334-5]
NP_001231737.1. NM_001244808.1. [Q9H334-7]
NP_001231739.1. NM_001244810.1.
NP_001231741.1. NM_001244812.1. [Q9H334-6]
NP_001231743.1. NM_001244814.1. [Q9H334-1]
NP_001231744.1. NM_001244815.1.
NP_001231745.1. NM_001244816.1. [Q9H334-1]
NP_116071.2. NM_032682.5. [Q9H334-1]
XP_006713165.1. XM_006713102.2. [Q9H334-1]
XP_006713166.1. XM_006713103.2. [Q9H334-1]
XP_006713167.1. XM_006713104.2. [Q9H334-1]
XP_011531886.1. XM_011533584.2. [Q9H334-1]
XP_011531887.1. XM_011533585.2. [Q9H334-1]
XP_016861654.1. XM_017006165.1. [Q9H334-1]
XP_016861655.1. XM_017006166.1. [Q9H334-1]
XP_016861657.1. XM_017006168.1. [Q9H334-5]
UniGeneiHs.59368.

Genome annotation databases

EnsembliENST00000318779; ENSP00000318721; ENSG00000114861. [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861. [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861. [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861. [Q9H334-6]
ENST00000493089; ENSP00000418524; ENSG00000114861. [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861. [Q9H334-1]
ENST00000622151; ENSP00000477918; ENSG00000114861. [Q9H334-5]
GeneIDi27086.
KEGGihsa:27086.
UCSCiuc003dol.4. human. [Q9H334-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146696 mRNA. Translation: AAG47632.1.
AF146697 mRNA. Translation: AAG47633.1.
AF146698 mRNA. Translation: AAG47634.1.
AF275309 mRNA. Translation: AAK69408.1.
BT006643 mRNA. Translation: AAP35289.1.
AK092383 mRNA. Translation: BAC03875.1.
AK122710 mRNA. Translation: BAG53682.1.
AC097632 Genomic DNA. No translation available.
AC097634 Genomic DNA. No translation available.
AC103586 Genomic DNA. No translation available.
AC104442 Genomic DNA. No translation available.
AC104645 Genomic DNA. No translation available.
AC138058 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW65494.1.
CH471055 Genomic DNA. Translation: EAW65499.1.
BC005055 mRNA. Translation: AAH05055.1.
BC054815 mRNA. Translation: AAH54815.1.
BC071893 mRNA. Translation: AAH71893.1.
BC080521 mRNA. Translation: AAH80521.1.
DQ845346 mRNA. Translation: ABI33105.1. Different initiation.
AK027264 mRNA. Translation: BAB55005.1. Different initiation.
AF151049 mRNA. Translation: AAF36135.1. Frameshift.
CCDSiCCDS2914.1. [Q9H334-1]
CCDS33785.1. [Q9H334-5]
CCDS58838.1. [Q9H334-6]
CCDS58839.1. [Q9H334-7]
RefSeqiNP_001012523.1. NM_001012505.1. [Q9H334-5]
NP_001231737.1. NM_001244808.1. [Q9H334-7]
NP_001231739.1. NM_001244810.1.
NP_001231741.1. NM_001244812.1. [Q9H334-6]
NP_001231743.1. NM_001244814.1. [Q9H334-1]
NP_001231744.1. NM_001244815.1.
NP_001231745.1. NM_001244816.1. [Q9H334-1]
NP_116071.2. NM_032682.5. [Q9H334-1]
XP_006713165.1. XM_006713102.2. [Q9H334-1]
XP_006713166.1. XM_006713103.2. [Q9H334-1]
XP_006713167.1. XM_006713104.2. [Q9H334-1]
XP_011531886.1. XM_011533584.2. [Q9H334-1]
XP_011531887.1. XM_011533585.2. [Q9H334-1]
XP_016861654.1. XM_017006165.1. [Q9H334-1]
XP_016861655.1. XM_017006166.1. [Q9H334-1]
XP_016861657.1. XM_017006168.1. [Q9H334-5]
UniGeneiHs.59368.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KIUNMR-A462-548[»]
ProteinModelPortaliQ9H334.
SMRiQ9H334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117989. 40 interactors.
DIPiDIP-36585N.
IntActiQ9H334. 40 interactors.
STRINGi9606.ENSP00000318902.

PTM databases

iPTMnetiQ9H334.
PhosphoSitePlusiQ9H334.

Polymorphism and mutation databases

BioMutaiFOXP1.
DMDMi14548062.

Proteomic databases

EPDiQ9H334.
MaxQBiQ9H334.
PaxDbiQ9H334.
PeptideAtlasiQ9H334.
PRIDEiQ9H334.

Protocols and materials databases

DNASUi27086.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318779; ENSP00000318721; ENSG00000114861. [Q9H334-5]
ENST00000318789; ENSP00000318902; ENSG00000114861. [Q9H334-1]
ENST00000475937; ENSP00000419393; ENSG00000114861. [Q9H334-1]
ENST00000484350; ENSP00000417857; ENSG00000114861. [Q9H334-6]
ENST00000493089; ENSP00000418524; ENSG00000114861. [Q9H334-7]
ENST00000498215; ENSP00000418102; ENSG00000114861. [Q9H334-1]
ENST00000622151; ENSP00000477918; ENSG00000114861. [Q9H334-5]
GeneIDi27086.
KEGGihsa:27086.
UCSCiuc003dol.4. human. [Q9H334-1]

Organism-specific databases

CTDi27086.
DisGeNETi27086.
GeneCardsiFOXP1.
HGNCiHGNC:3823. FOXP1.
HPAiCAB011501.
HPA003876.
MalaCardsiFOXP1.
MIMi605515. gene.
613670. phenotype.
neXtProtiNX_Q9H334.
OpenTargetsiENSG00000114861.
Orphaneti391372. Intellectual disability-severe speech delay-mild dysmorphism syndrome.
52417. MALT lymphoma.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA28241.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000092089.
HOVERGENiHBG051657.
InParanoidiQ9H334.
KOiK09409.
PhylomeDBiQ9H334.
TreeFamiTF326978.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114861-MONOMER.
SignaLinkiQ9H334.
SIGNORiQ9H334.

Miscellaneous databases

ChiTaRSiFOXP1. human.
GeneWikiiFOXP1.
GenomeRNAii27086.
PROiQ9H334.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114861.
CleanExiHS_FOXP1.
ExpressionAtlasiQ9H334. baseline and differential.
GenevisibleiQ9H334. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H334
Secondary accession number(s): A3QVP8
, B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.