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Q9H334

- FOXP1_HUMAN

UniProt

Q9H334 - FOXP1_HUMAN

Protein

Forkhead box protein P1

Gene

FOXP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei59 – 602Breakpoint for translocation to form PAX5-FOXP1

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri306 – 33126C2H2-typeAdd
    BLAST
    DNA bindingi465 – 55591Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ9H334.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein P1
    Gene namesi
    Name:FOXP1
    ORF Names:HSPC215
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:3823. FOXP1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
    Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Mental retardation

    Organism-specific databases

    MIMi613670. phenotype.
    Orphaneti391372. Intellectual disability-severe speech delay-mild dysmorphism syndrome.
    52417. MALT lymphoma.
    99860. Precursor B-cell acute lymphoblastic leukemia.
    PharmGKBiPA28241.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 677677Forkhead box protein P1PRO_0000091877Add
    BLAST

    Proteomic databases

    MaxQBiQ9H334.
    PaxDbiQ9H334.
    PRIDEiQ9H334.

    PTM databases

    PhosphoSiteiQ9H334.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H334.
    BgeeiQ9H334.
    CleanExiHS_FOXP1.
    GenevestigatoriQ9H334.

    Organism-specific databases

    HPAiCAB011501.
    HPA003876.

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi117989. 11 interactions.
    DIPiDIP-36585N.
    IntActiQ9H334. 10 interactions.
    STRINGi9606.ENSP00000318902.

    Structurei

    Secondary structure

    1
    677
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi470 – 47910
    Beta strandi481 – 4866
    Helixi488 – 49811
    Helixi500 – 5023
    Helixi506 – 51914
    Beta strandi523 – 5264
    Beta strandi533 – 5364
    Helixi538 – 5436

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KIUNMR-A462-548[»]
    ProteinModelPortaliQ9H334.
    SMRiQ9H334. Positions 311-369, 462-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni348 – 36922Leucine-zipperAdd
    BLAST
    Regioni382 – 3865CTBP1-bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 230176Gln-richAdd
    BLAST

    Domaini

    The leucine-zipper is required for dimerization and transcriptional repression.By similarity

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri306 – 33126C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000092089.
    HOVERGENiHBG051657.
    InParanoidiQ9H334.
    OrthoDBiEOG7M6D7G.
    PhylomeDBiQ9H334.
    TreeFamiTF326978.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9H334-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD    50
    LAHAQQQQQQ ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA 100
    MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ 150
    QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ 200
    RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT AEETTGNNHS 250
    SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH 300
    PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ 350
    LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP 400
    QSLPHTPTTP TAPLTPVTQG PSVITTTSMH TVGPIRRRYS DKYNVPISSA 450
    DIAQNQEFYK NAEVRPPFTY ASLIRQAILE SPEKQLTLNE IYNWFTRMFA 500
    YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE FQKRRPQKIS 550
    GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS 600
    AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS 650
    LVTTANHSPD FDHDRDYEDE PVNEDME 677
    Length:677
    Mass (Da):75,317
    Last modified:March 1, 2001 - v1
    Checksum:iAEE92D47BB20964B
    GO
    Isoform 2 (identifier: Q9H334-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-100: Missing.
         140-227: Missing.

    Show »
    Length:489
    Mass (Da):54,563
    Checksum:i63DDAAD1B033BAF0
    GO
    Isoform 3 (identifier: Q9H334-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MMQESGTETK...LAHAQQQQQQ → CRSTLVDPKN...APFAKLFIFS
         95-170: Missing.

    Note: Incomplete sequence.

    Show »
    Length:586
    Mass (Da):65,431
    Checksum:i099643CD5B363BDF
    GO
    Isoform 4 (identifier: Q9H334-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MMQESGTETK...LAHAQQQQQQ → CRSTLVDPKN...APFAKLFIFS

    Note: Incomplete sequence. No experimental confirmation available.

    Show »
    Length:662
    Mass (Da):74,330
    Checksum:i168D2B3165278F9E
    GO
    Isoform 5 (identifier: Q9H334-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         61-114: ALQVARQLLL...QVITPQQMQQ → WHLINHQPSR...PVCQPNPSPF
         115-677: Missing.

    Show »
    Length:114
    Mass (Da):12,256
    Checksum:iA1CC32BD8BBC4EA5
    GO
    Isoform 6 (identifier: Q9H334-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-170: Missing.

    Show »
    Length:601
    Mass (Da):66,417
    Checksum:i599FC834381D194C
    GO
    Isoform 7 (identifier: Q9H334-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         450-450: Missing.

    Note: No experimental confirmation available. May be due to competing acceptor splice site.

    Show »
    Length:676
    Mass (Da):75,246
    Checksum:iF70967CCDB289929
    GO

    Sequence cautioni

    The sequence AAF36135.1 differs from that shown. Reason: Frameshift at positions 531 and 545.
    The sequence ABI33105.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55005.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381L → P in BAG53682. (PubMed:14702039)Curated
    Sequence conflicti173 – 1731Q → R in BAB55005. (PubMed:14702039)Curated
    Sequence conflicti205 – 2051L → V in BAB55005. (PubMed:14702039)Curated
    Sequence conflicti210 – 2123GQP → ARA in AAK69408. (PubMed:11751404)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51S → P.1 Publication
    VAR_065067
    Natural varianti101 – 1011M → V.1 Publication
    VAR_065068
    Natural varianti215 – 2151P → A.3 Publications
    Corresponds to variant rs146606219 [ dbSNP | Ensembl ].
    VAR_065069
    Natural varianti261 – 2611S → P.1 Publication
    VAR_065070
    Natural varianti390 – 3901T → S.1 Publication
    VAR_065071
    Natural varianti445 – 4451V → M.1 Publication
    Corresponds to variant rs147756430 [ dbSNP | Ensembl ].
    VAR_065072
    Natural varianti570 – 5701N → S.2 Publications
    VAR_065073
    Natural varianti597 – 5971N → T.1 Publication
    VAR_065074
    Natural varianti613 – 6131T → N.1 Publication
    VAR_065075

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 100100Missing in isoform 2. 1 PublicationVSP_001553Add
    BLAST
    Alternative sequencei1 – 6060MMQES…QQQQQ → CRSTLVDPKNSARASQKQPE PIYSKKTEIQRQTVRAPFAK LFIFS in isoform 3 and isoform 4. 1 PublicationVSP_001555Add
    BLAST
    Alternative sequencei61 – 11454ALQVA…QQMQQ → WHLINHQPSRSPSSWLKRLI SSPWELEVLQVPLWGAVAET KMSGPVCQPNPSPF in isoform 5. 2 PublicationsVSP_043462Add
    BLAST
    Alternative sequencei95 – 17076Missing in isoform 3 and isoform 6. 1 PublicationVSP_001556Add
    BLAST
    Alternative sequencei115 – 677563Missing in isoform 5. 2 PublicationsVSP_043463Add
    BLAST
    Alternative sequencei140 – 22788Missing in isoform 2. 1 PublicationVSP_001554Add
    BLAST
    Alternative sequencei450 – 4501Missing in isoform 7. 2 PublicationsVSP_046930

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146696 mRNA. Translation: AAG47632.1.
    AF146697 mRNA. Translation: AAG47633.1.
    AF146698 mRNA. Translation: AAG47634.1.
    AF275309 mRNA. Translation: AAK69408.1.
    BT006643 mRNA. Translation: AAP35289.1.
    AK092383 mRNA. Translation: BAC03875.1.
    AK122710 mRNA. Translation: BAG53682.1.
    AC097632 Genomic DNA. No translation available.
    AC097634 Genomic DNA. No translation available.
    AC103586 Genomic DNA. No translation available.
    AC104442 Genomic DNA. No translation available.
    AC104645 Genomic DNA. No translation available.
    AC138058 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65494.1.
    CH471055 Genomic DNA. Translation: EAW65499.1.
    BC005055 mRNA. Translation: AAH05055.1.
    BC054815 mRNA. Translation: AAH54815.1.
    BC071893 mRNA. Translation: AAH71893.1.
    BC080521 mRNA. Translation: AAH80521.1.
    DQ845346 mRNA. Translation: ABI33105.1. Different initiation.
    AK027264 mRNA. Translation: BAB55005.1. Different initiation.
    AF151049 mRNA. Translation: AAF36135.1. Frameshift.
    CCDSiCCDS2914.1. [Q9H334-1]
    CCDS33785.1. [Q9H334-5]
    CCDS58838.1. [Q9H334-6]
    CCDS58839.1. [Q9H334-7]
    RefSeqiNP_001012523.1. NM_001012505.1. [Q9H334-5]
    NP_001231737.1. NM_001244808.1. [Q9H334-7]
    NP_001231739.1. NM_001244810.1.
    NP_001231741.1. NM_001244812.1. [Q9H334-6]
    NP_001231743.1. NM_001244814.1. [Q9H334-1]
    NP_001231744.1. NM_001244815.1.
    NP_001231745.1. NM_001244816.1. [Q9H334-1]
    NP_116071.2. NM_032682.5. [Q9H334-1]
    XP_005264795.1. XM_005264738.2. [Q9H334-7]
    XP_006713165.1. XM_006713102.1. [Q9H334-1]
    XP_006713166.1. XM_006713103.1. [Q9H334-1]
    XP_006713167.1. XM_006713104.1. [Q9H334-1]
    XP_006713170.1. XM_006713107.1. [Q9H334-5]
    UniGeneiHs.59368.

    Genome annotation databases

    EnsembliENST00000318779; ENSP00000318721; ENSG00000114861. [Q9H334-5]
    ENST00000318789; ENSP00000318902; ENSG00000114861. [Q9H334-1]
    ENST00000475937; ENSP00000419393; ENSG00000114861. [Q9H334-1]
    ENST00000484350; ENSP00000417857; ENSG00000114861. [Q9H334-6]
    ENST00000493089; ENSP00000418524; ENSG00000114861. [Q9H334-7]
    ENST00000498215; ENSP00000418102; ENSG00000114861. [Q9H334-1]
    GeneIDi27086.
    KEGGihsa:27086.
    UCSCiuc003doi.3. human. [Q9H334-1]
    uc003dom.3. human.
    uc003doo.3. human.
    uc003dos.3. human. [Q9H334-5]

    Polymorphism databases

    DMDMi14548062.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146696 mRNA. Translation: AAG47632.1 .
    AF146697 mRNA. Translation: AAG47633.1 .
    AF146698 mRNA. Translation: AAG47634.1 .
    AF275309 mRNA. Translation: AAK69408.1 .
    BT006643 mRNA. Translation: AAP35289.1 .
    AK092383 mRNA. Translation: BAC03875.1 .
    AK122710 mRNA. Translation: BAG53682.1 .
    AC097632 Genomic DNA. No translation available.
    AC097634 Genomic DNA. No translation available.
    AC103586 Genomic DNA. No translation available.
    AC104442 Genomic DNA. No translation available.
    AC104645 Genomic DNA. No translation available.
    AC138058 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW65494.1 .
    CH471055 Genomic DNA. Translation: EAW65499.1 .
    BC005055 mRNA. Translation: AAH05055.1 .
    BC054815 mRNA. Translation: AAH54815.1 .
    BC071893 mRNA. Translation: AAH71893.1 .
    BC080521 mRNA. Translation: AAH80521.1 .
    DQ845346 mRNA. Translation: ABI33105.1 . Different initiation.
    AK027264 mRNA. Translation: BAB55005.1 . Different initiation.
    AF151049 mRNA. Translation: AAF36135.1 . Frameshift.
    CCDSi CCDS2914.1. [Q9H334-1 ]
    CCDS33785.1. [Q9H334-5 ]
    CCDS58838.1. [Q9H334-6 ]
    CCDS58839.1. [Q9H334-7 ]
    RefSeqi NP_001012523.1. NM_001012505.1. [Q9H334-5 ]
    NP_001231737.1. NM_001244808.1. [Q9H334-7 ]
    NP_001231739.1. NM_001244810.1.
    NP_001231741.1. NM_001244812.1. [Q9H334-6 ]
    NP_001231743.1. NM_001244814.1. [Q9H334-1 ]
    NP_001231744.1. NM_001244815.1.
    NP_001231745.1. NM_001244816.1. [Q9H334-1 ]
    NP_116071.2. NM_032682.5. [Q9H334-1 ]
    XP_005264795.1. XM_005264738.2. [Q9H334-7 ]
    XP_006713165.1. XM_006713102.1. [Q9H334-1 ]
    XP_006713166.1. XM_006713103.1. [Q9H334-1 ]
    XP_006713167.1. XM_006713104.1. [Q9H334-1 ]
    XP_006713170.1. XM_006713107.1. [Q9H334-5 ]
    UniGenei Hs.59368.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KIU NMR - A 462-548 [» ]
    ProteinModelPortali Q9H334.
    SMRi Q9H334. Positions 311-369, 462-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117989. 11 interactions.
    DIPi DIP-36585N.
    IntActi Q9H334. 10 interactions.
    STRINGi 9606.ENSP00000318902.

    PTM databases

    PhosphoSitei Q9H334.

    Polymorphism databases

    DMDMi 14548062.

    Proteomic databases

    MaxQBi Q9H334.
    PaxDbi Q9H334.
    PRIDEi Q9H334.

    Protocols and materials databases

    DNASUi 27086.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318779 ; ENSP00000318721 ; ENSG00000114861 . [Q9H334-5 ]
    ENST00000318789 ; ENSP00000318902 ; ENSG00000114861 . [Q9H334-1 ]
    ENST00000475937 ; ENSP00000419393 ; ENSG00000114861 . [Q9H334-1 ]
    ENST00000484350 ; ENSP00000417857 ; ENSG00000114861 . [Q9H334-6 ]
    ENST00000493089 ; ENSP00000418524 ; ENSG00000114861 . [Q9H334-7 ]
    ENST00000498215 ; ENSP00000418102 ; ENSG00000114861 . [Q9H334-1 ]
    GeneIDi 27086.
    KEGGi hsa:27086.
    UCSCi uc003doi.3. human. [Q9H334-1 ]
    uc003dom.3. human.
    uc003doo.3. human.
    uc003dos.3. human. [Q9H334-5 ]

    Organism-specific databases

    CTDi 27086.
    GeneCardsi GC03M071088.
    HGNCi HGNC:3823. FOXP1.
    HPAi CAB011501.
    HPA003876.
    MIMi 605515. gene.
    613670. phenotype.
    neXtProti NX_Q9H334.
    Orphaneti 391372. Intellectual disability-severe speech delay-mild dysmorphism syndrome.
    52417. MALT lymphoma.
    99860. Precursor B-cell acute lymphoblastic leukemia.
    PharmGKBi PA28241.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000092089.
    HOVERGENi HBG051657.
    InParanoidi Q9H334.
    OrthoDBi EOG7M6D7G.
    PhylomeDBi Q9H334.
    TreeFami TF326978.

    Enzyme and pathway databases

    SignaLinki Q9H334.

    Miscellaneous databases

    ChiTaRSi FOXP1. human.
    GeneWikii FOXP1.
    GenomeRNAii 27086.
    NextBioi 49693.
    PROi Q9H334.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H334.
    Bgeei Q9H334.
    CleanExi HS_FOXP1.
    Genevestigatori Q9H334.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p."
      Banham A.H., Beasley N., Campo E., Fernandez P.L., Fidler C., Gatter K., Jones M., Mason D.Y., Prime J.E., Trougouboff P., Wood K., Cordell J.L.
      Cancer Res. 61:8820-8829(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [MRNA] OF 210-677 (ISOFORM 7), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Testis.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-677 (ISOFORM 4).
      Tissue: Embryonic head and Tongue.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Lung.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-677, CHROMOSOMAL TRANSLOCATION WITH PAX5.
    8. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-677.
      Tissue: Umbilical cord blood.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: FUNCTION, INVOLVEMENT IN MRLIAF, VARIANTS ALA-215; MET-445; SER-570 AND ASN-613.
    11. "Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia."
      Vernes S.C., MacDermot K.D., Monaco A.P., Fisher S.E.
      Eur. J. Hum. Genet. 17:1354-1358(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ALA-215.
    12. Cited for: VARIANTS PRO-5; VAL-101; ALA-215; PRO-261; SER-390; SER-570 AND THR-597.

    Entry informationi

    Entry nameiFOXP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H334
    Secondary accession number(s): A3QVP8
    , B3KV70, G5E9V8, Q8NAN6, Q9BSG9, Q9H332, Q9H333, Q9P0R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3