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Protein

Transmembrane protein 245

Gene

TMEM245

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106771-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 245
Alternative name(s):
Protein CG-2
Gene namesi
Name:TMEM245
Synonyms:C9orf5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1363. TMEM245.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei776 – 796HelicalSequence analysisAdd BLAST21
Transmembranei815 – 835HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23731.
OpenTargetsiENSG00000106771.
PharmGKBiPA25980.

Polymorphism and mutation databases

BioMutaiTMEM245.
DMDMi71152403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000896702 – 911Transmembrane protein 245Add BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei36PhosphothreonineCombined sources1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Modified residuei324PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei330PhosphoserineBy similarity1
Modified residuei332PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Glycosylationi551N-linked (GlcNAc...)1 Publication1
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1
Isoform 3 (identifier: Q9H330-3)
Modified residuei429PhosphoserineCombined sources1
Isoform 2 (identifier: Q9H330-2)
Modified residuei877PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9H330.
MaxQBiQ9H330.
PaxDbiQ9H330.
PeptideAtlasiQ9H330.
PRIDEiQ9H330.

PTM databases

iPTMnetiQ9H330.
PhosphoSitePlusiQ9H330.
SwissPalmiQ9H330.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000106771.
CleanExiHS_C9orf5.
ExpressionAtlasiQ9H330. baseline and differential.
GenevisibleiQ9H330. HS.

Organism-specific databases

HPAiHPA023892.

Interactioni

Protein-protein interaction databases

BioGridi117237. 11 interactors.
IntActiQ9H330. 4 interactors.
STRINGi9606.ENSP00000363714.

Structurei

3D structure databases

ProteinModelPortaliQ9H330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0118 (TMEM245) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2365. Eukaryota.
ENOG410XRXR. LUCA.
GeneTreeiENSGT00390000001667.
HOGENOMiHOG000049264.
HOVERGENiHBG080525.
InParanoidiQ9H330.
OMAiPLLWAFL.
OrthoDBiEOG091G0BL2.
PhylomeDBiQ9H330.
TreeFamiTF315224.

Family and domain databases

InterProiIPR002549. AI-2E-like.
[Graphical view]
PANTHERiPTHR21716. PTHR21716. 2 hits.
PfamiPF01594. AI-2E_transport. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H330-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGGGPKDA PSLRSSPGPA PRVPRAVGPS GGGGETPRTA ALALRFDKPI
60 70 80 90 100
KQAFYNTGAV LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS
110 120 130 140 150
LTRLGRHWLQ RLHRAHTPIV LAALLLPLCF VDYGVEALGE QALRRRRLLL
160 170 180 190 200
LLGAGGPLLY GLYCLGSYLG VQVLLVHAAT LICRGLDYFS SLWIWTLVVG
210 220 230 240 250
YVLTVSFKWN ASTERYLRAV SIPVWIILLF HLASLAGSWR IPVFLVIVFL
260 270 280 290 300
MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQP
310 320 330 340 350
STQPAEAVDR GESAPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK
360 370 380 390 400
TSDIYFVSLV WAIVVMQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL
410 420 430 440 450
EKRYHVWWGI IESFLKERQG ALAPWPIVGL GKFLLKVDSK LWHWLNKKMI
460 470 480 490 500
IWLEKMLDKI ISIFIIFLLV IGTLLLALLL TAKVHQESVH MIEVTSNLIN
510 520 530 540 550
ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH KLHKILGDKV
560 570 580 590 600
NNTAVIEKQV LELWDRLYHS WFVKNVTHSG RHKGQKLHVS RQNSWLGDIL
610 620 630 640 650
DWQDIVSFVH ENIETFLSIL ESLWIVMSRN VSLLFTTVTT LLTILFYSGT
660 670 680 690 700
ALLNFVLSLI IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG
710 720 730 740 750
QSVEEAIRGV FDASLKMAGF YGLYTWLTHT MFGINIVFIP SALAAILGAV
760 770 780 790 800
PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL IFHLLPTYFV DTAIYSDISG
810 820 830 840 850
GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY SAMLVSPTNS
860 870 880 890 900
VPTPNQTPWP AQPQRTFRDI SERSEIFSKV DVVSSAVIFL RKFKFDSEFS
910
SAVAFCPSSC A
Length:911
Mass (Da):100,945
Last modified:July 19, 2005 - v2
Checksum:i96BB43C65BE31F29
GO
Isoform 2 (identifier: Q9H330-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     873-879: RSEIFSK → DLKSSVG
     880-911: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:879
Mass (Da):97,357
Checksum:iAD26DE952B1D94AE
GO
Isoform 3 (identifier: Q9H330-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-448: Missing.
     873-879: RSEIFSK → DLKSSVG
     880-911: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:431
Mass (Da):48,042
Checksum:i341EA2D18CE658DE
GO
Isoform 4 (identifier: Q9H330-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-447: Missing.
     512-911: Missing.

Note: No experimental confirmation available.
Show »
Length:503
Mass (Da):55,419
Checksum:i867DA48BC071FE0E
GO

Sequence cautioni

The sequence CAI39474 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511N → K in CAD38810 (PubMed:17974005).Curated1
Sequence conflicti785L → V in BAG61779 (PubMed:14702039).Curated1
Sequence conflicti855N → I in BAD18785 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0596049D → E.1 PublicationCorresponds to variant rs12001627dbSNPEnsembl.1
Natural variantiVAR_056815314A → T.Corresponds to variant rs2271877dbSNPEnsembl.1
Natural variantiVAR_056816787T → A.Corresponds to variant rs3750455dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0146801 – 448Missing in isoform 3. 1 PublicationAdd BLAST448
Alternative sequenceiVSP_014681440 – 447Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_014682512 – 911Missing in isoform 4. 1 PublicationAdd BLAST400
Alternative sequenceiVSP_014683873 – 879RSEIFSK → DLKSSVG in isoform 2 and isoform 3. 1 Publication7
Alternative sequenceiVSP_014684880 – 911Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153415 mRNA. Translation: AAG43365.1.
AK299952 mRNA. Translation: BAG61779.1.
AK172815 mRNA. Translation: BAD18785.1.
AL669894, AL354797, AL358815 Genomic DNA. Translation: CAI13317.1.
AL358815, AL354797, AL669894 Genomic DNA. Translation: CAI15128.1.
AL354797, AL358815, AL669894 Genomic DNA. Translation: CAI39466.1.
AL354797 Genomic DNA. Translation: CAI39474.1. Sequence problems.
BC014248 mRNA. Translation: AAH14248.2.
AL833960 mRNA. Translation: CAD38810.1.
CCDSiCCDS43858.1. [Q9H330-2]
RefSeqiNP_114401.2. NM_032012.3. [Q9H330-2]
UniGeneiHs.308074.
Hs.621479.

Genome annotation databases

EnsembliENST00000374586; ENSP00000363714; ENSG00000106771. [Q9H330-2]
GeneIDi23731.
KEGGihsa:23731.
UCSCiuc004bdt.5. human. [Q9H330-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153415 mRNA. Translation: AAG43365.1.
AK299952 mRNA. Translation: BAG61779.1.
AK172815 mRNA. Translation: BAD18785.1.
AL669894, AL354797, AL358815 Genomic DNA. Translation: CAI13317.1.
AL358815, AL354797, AL669894 Genomic DNA. Translation: CAI15128.1.
AL354797, AL358815, AL669894 Genomic DNA. Translation: CAI39466.1.
AL354797 Genomic DNA. Translation: CAI39474.1. Sequence problems.
BC014248 mRNA. Translation: AAH14248.2.
AL833960 mRNA. Translation: CAD38810.1.
CCDSiCCDS43858.1. [Q9H330-2]
RefSeqiNP_114401.2. NM_032012.3. [Q9H330-2]
UniGeneiHs.308074.
Hs.621479.

3D structure databases

ProteinModelPortaliQ9H330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117237. 11 interactors.
IntActiQ9H330. 4 interactors.
STRINGi9606.ENSP00000363714.

PTM databases

iPTMnetiQ9H330.
PhosphoSitePlusiQ9H330.
SwissPalmiQ9H330.

Polymorphism and mutation databases

BioMutaiTMEM245.
DMDMi71152403.

Proteomic databases

EPDiQ9H330.
MaxQBiQ9H330.
PaxDbiQ9H330.
PeptideAtlasiQ9H330.
PRIDEiQ9H330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374586; ENSP00000363714; ENSG00000106771. [Q9H330-2]
GeneIDi23731.
KEGGihsa:23731.
UCSCiuc004bdt.5. human. [Q9H330-1]

Organism-specific databases

CTDi23731.
DisGeNETi23731.
GeneCardsiTMEM245.
H-InvDBHIX0008268.
HGNCiHGNC:1363. TMEM245.
HPAiHPA023892.
neXtProtiNX_Q9H330.
OpenTargetsiENSG00000106771.
PharmGKBiPA25980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2365. Eukaryota.
ENOG410XRXR. LUCA.
GeneTreeiENSGT00390000001667.
HOGENOMiHOG000049264.
HOVERGENiHBG080525.
InParanoidiQ9H330.
OMAiPLLWAFL.
OrthoDBiEOG091G0BL2.
PhylomeDBiQ9H330.
TreeFamiTF315224.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106771-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM245. human.
GenomeRNAii23731.
PROiQ9H330.

Gene expression databases

BgeeiENSG00000106771.
CleanExiHS_C9orf5.
ExpressionAtlasiQ9H330. baseline and differential.
GenevisibleiQ9H330. HS.

Family and domain databases

InterProiIPR002549. AI-2E-like.
[Graphical view]
PANTHERiPTHR21716. PTHR21716. 2 hits.
PfamiPF01594. AI-2E_transport. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM245_HUMAN
AccessioniPrimary (citable) accession number: Q9H330
Secondary accession number(s): B4DSW7
, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.