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Q9H324

- ATS10_HUMAN

UniProt

Q9H324 - ATS10_HUMAN

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Protein
A disintegrin and metalloproteinase with thrombospondin motifs 10
Gene
ADAMTS10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.1 Publication

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi392 – 3921Zinc; catalytic By similarity
Active sitei393 – 3931 By similarity
Metal bindingi396 – 3961Zinc; catalytic By similarity
Metal bindingi402 – 4021Zinc; catalytic By similarity

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. protein binding Source: UniProtKB
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.

    Protein family/group databases

    MEROPSiM12.235.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 10 (EC:3.4.24.-)
    Short name:
    ADAM-TS 10
    Short name:
    ADAM-TS10
    Short name:
    ADAMTS-10
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13201. ADAMTS10.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix 1 Publication

    GO - Cellular componenti

    1. extracellular matrix Source: UniProtKB
    2. microfibril Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Weill-Marchesani syndrome 1 (WMS1) [MIM:277600]: A rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma.
    Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251A → T in WMS1; shows consistent and significantly diminished protein secretion. 1 Publication
    VAR_054439

    Keywords - Diseasei

    Disease mutation, Dwarfism

    Organism-specific databases

    MIMi277600. phenotype.
    Orphaneti3449. Weill-Marchesani syndrome.
    PharmGKBiPA24537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 Reviewed prediction
    Add
    BLAST
    Propeptidei26 – 233208 By similarity
    PRO_0000029184Add
    BLAST
    Chaini234 – 1103870A disintegrin and metalloproteinase with thrombospondin motifs 10
    PRO_0000029185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi315 ↔ 376 By similarity
    Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi351 ↔ 358 By similarity
    Disulfide bondi370 ↔ 452 By similarity
    Disulfide bondi409 ↔ 436 By similarity
    Disulfide bondi479 ↔ 501 By similarity
    Disulfide bondi490 ↔ 508 By similarity
    Disulfide bondi496 ↔ 531 By similarity
    Disulfide bondi521 ↔ 536 By similarity
    Disulfide bondi559 ↔ 596 By similarity
    Disulfide bondi563 ↔ 601 By similarity
    Disulfide bondi574 ↔ 586 By similarity
    Glycosylationi740 – 7401N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi795 – 7951N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi892 – 8921N-linked (GlcNAc...) Reviewed prediction

    Post-translational modificationi

    Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9H324.
    PRIDEiQ9H324.

    PTM databases

    PhosphoSiteiQ9H324.

    Expressioni

    Tissue specificityi

    Widely expressed in adult tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9H324.
    BgeeiQ9H324.
    CleanExiHS_ADAMTS10.
    GenevestigatoriQ9H324.

    Organism-specific databases

    HPAiHPA040223.

    Interactioni

    Subunit structurei

    Interacts with FBN1; this interaction promotes microfibrils assembly.1 Publication

    Protein-protein interaction databases

    BioGridi123586. 7 interactions.
    IntActiQ9H324. 7 interactions.
    MINTiMINT-8247349.
    STRINGi9606.ENSP00000270328.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H324.
    SMRiQ9H324. Positions 236-805.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini239 – 457219Peptidase M12B
    Add
    BLAST
    Domaini460 – 54687Disintegrin
    Add
    BLAST
    Domaini547 – 60256TSP type-1 1
    Add
    BLAST
    Domaini825 – 88359TSP type-1 2
    Add
    BLAST
    Domaini884 – 94562TSP type-1 3
    Add
    BLAST
    Domaini947 – 100155TSP type-1 4
    Add
    BLAST
    Domaini1003 – 105856TSP type-1 5
    Add
    BLAST
    Domaini1065 – 110339PLAC
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni706 – 828123Spacer
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 614Poly-Pro
    Compositional biasi568 – 5714Poly-Ser
    Compositional biasi604 – 705102Cys-rich
    Add
    BLAST

    Domaini

    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix By similarity.

    Sequence similaritiesi

    Contains 1 disintegrin domain.
    Contains 1 PLAC domain.
    Contains 5 TSP type-1 domains.

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG288089.
    HOGENOMiHOG000004800.
    HOVERGENiHBG004315.
    InParanoidiQ9H324.
    KOiK08625.
    OMAiLENYEIA.
    OrthoDBiEOG78WKQV.
    PhylomeDBiQ9H324.
    TreeFamiTF313537.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF08686. PLAC. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 5 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 5 hits.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H324-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN     50
    GALLAFSPPP PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG 100
    HVSVEYWTRE GLAWQRAARP HCLYAGHLQG QASTSHVAIS TCGGLHGLIV 150
    ADEEEYLIEP LHGGPKGSRS PEESGPHVVY KRSSLRHPHL DTACGVRDEK 200
    PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY VETLVVADKM 250
    MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT 300
    LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI 350
    CIYKNKPCGT LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM 400
    NHDGVGNSCG ARGQDPAKLM AAHITMKTNP FVWSSCSRDY ITSFLDSGLG 450
    LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR FQHGVKSRQC KYGEVCSELW 500
    CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG SRPEGVDGAW 550
    GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD 600
    CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF 650
    YTERAAAVVD GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG 700
    DGSACETIEG VFSPASPGAG YEDVVWIPKG SVHIFIQDLN LSLSHLALKG 750
    DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ GPDQVQSLEA LGPINASLIV 800
    MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ CAGGSQVQAV 850
    ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC 900
    DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA 950
    LDWSECTPSC GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR 1000
    RCPPARWVAG EWGECSAQCG VGQRQRSVRC TSHTGQASHE CTEALRPPTT 1050
    QQCEAKCDSP TPGDGPEECK DVNKVAYCPL VLKFQFCSRA YFRQMCCKTC 1100
    HGH 1103
    Length:1,103
    Mass (Da):120,874
    Last modified:June 12, 2007 - v2
    Checksum:iD7558271C303A87C
    GO
    Isoform 2 (identifier: Q9H324-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-637: MAPACQILRW...WKTYRGGGVK → MGPTSVLRAG...NSTSGKRTGE

    Note: No experimental confirmation available. Gene prediction based on partial mRNA and EST data.

    Show »
    Length:590
    Mass (Da):62,530
    Checksum:i346AE6537FB016C6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251A → T in WMS1; shows consistent and significantly diminished protein secretion. 1 Publication
    VAR_054439
    Natural varianti119 – 1191R → Q.
    Corresponds to variant rs3814291 [ dbSNP | Ensembl ].
    VAR_054440
    Natural varianti134 – 1341T → S.1 Publication
    Corresponds to variant rs7255721 [ dbSNP | Ensembl ].
    VAR_054441

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 637637MAPAC…GGGVK → MGPTSVLRAGLTPSCLPPPS GATNGSVSPLGRAQRVWTEP GGRGLHGATAAGPVAAACPL LAVTATAPGQPSGASTVWVR EGGTAPATRMTVPLAPRTSE KCSVLNLTASLSVGNSTSGK RTGE in isoform 2.
    VSP_054707Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti385 – 3862AT → PQ in AAG35563. 1 Publication
    Sequence conflicti437 – 4371S → N in AAG35563. 1 Publication
    Sequence conflicti643 – 6431C → S in AAG35563. 1 Publication
    Sequence conflicti1101 – 11011H → Q in AAG35563. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092315 Genomic DNA. No translation available.
    AC130469 Genomic DNA. No translation available.
    AF163762 mRNA. Translation: AAG35563.1.
    CCDSiCCDS12206.1. [Q9H324-1]
    CCDS62529.1. [Q9H324-2]
    RefSeqiNP_001269281.1. NM_001282352.1. [Q9H324-2]
    NP_112219.3. NM_030957.3.
    UniGeneiHs.657508.

    Genome annotation databases

    EnsembliENST00000270328; ENSP00000270328; ENSG00000142303.
    ENST00000595838; ENSP00000470501; ENSG00000142303.
    ENST00000597188; ENSP00000471851; ENSG00000142303.
    GeneIDi81794.
    KEGGihsa:81794.
    UCSCiuc002mkj.1. human. [Q9H324-1]

    Polymorphism databases

    DMDMi148887344.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC092315 Genomic DNA. No translation available.
    AC130469 Genomic DNA. No translation available.
    AF163762 mRNA. Translation: AAG35563.1 .
    CCDSi CCDS12206.1. [Q9H324-1 ]
    CCDS62529.1. [Q9H324-2 ]
    RefSeqi NP_001269281.1. NM_001282352.1. [Q9H324-2 ]
    NP_112219.3. NM_030957.3.
    UniGenei Hs.657508.

    3D structure databases

    ProteinModelPortali Q9H324.
    SMRi Q9H324. Positions 236-805.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 123586. 7 interactions.
    IntActi Q9H324. 7 interactions.
    MINTi MINT-8247349.
    STRINGi 9606.ENSP00000270328.

    Protein family/group databases

    MEROPSi M12.235.

    PTM databases

    PhosphoSitei Q9H324.

    Polymorphism databases

    DMDMi 148887344.

    Proteomic databases

    PaxDbi Q9H324.
    PRIDEi Q9H324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270328 ; ENSP00000270328 ; ENSG00000142303 .
    ENST00000595838 ; ENSP00000470501 ; ENSG00000142303 .
    ENST00000597188 ; ENSP00000471851 ; ENSG00000142303 .
    GeneIDi 81794.
    KEGGi hsa:81794.
    UCSCi uc002mkj.1. human. [Q9H324-1 ]

    Organism-specific databases

    CTDi 81794.
    GeneCardsi GC19M008645.
    GeneReviewsi ADAMTS10.
    HGNCi HGNC:13201. ADAMTS10.
    HPAi HPA040223.
    MIMi 277600. phenotype.
    608990. gene.
    neXtProti NX_Q9H324.
    Orphaneti 3449. Weill-Marchesani syndrome.
    PharmGKBi PA24537.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288089.
    HOGENOMi HOG000004800.
    HOVERGENi HBG004315.
    InParanoidi Q9H324.
    KOi K08625.
    OMAi LENYEIA.
    OrthoDBi EOG78WKQV.
    PhylomeDBi Q9H324.
    TreeFami TF313537.

    Enzyme and pathway databases

    Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.

    Miscellaneous databases

    GeneWikii ADAMTS10.
    GenomeRNAii 81794.
    NextBioi 72110.
    PROi Q9H324.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H324.
    Bgeei Q9H324.
    CleanExi HS_ADAMTS10.
    Genevestigatori Q9H324.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR002870. Peptidase_M12B_N.
    IPR010909. PLAC.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF08686. PLAC. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 5 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 5 hits.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50900. PLAC. 1 hit.
    PS50092. TSP1. 5 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation."
      Somerville R.P.T., Jungers K.A., Apte S.S.
      J. Biol. Chem. 279:51208-51217(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-1103 (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-134.
    3. Cited for: INVOLVEMENT IN WMS1.
    4. "ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts."
      Kutz W.E., Wang L.W., Bader H.L., Majors A.K., Iwata K., Traboulsi E.I., Sakai L.Y., Keene D.R., Apte S.S.
      J. Biol. Chem. 286:17156-17167(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FBN1.
    5. "Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme."
      Kutz W.E., Wang L.W., Dagoneau N., Odrcic K.J., Cormier-Daire V., Traboulsi E.I., Apte S.S.
      Hum. Mutat. 29:1425-1434(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT WMS1 THR-25, CHARACTERIZATION OF VARIANT WMS1 THR-25.

    Entry informationi

    Entry nameiATS10_HUMAN
    AccessioniPrimary (citable) accession number: Q9H324
    Secondary accession number(s): M0QZE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: June 12, 2007
    Last modified: September 3, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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