Q9H322 (VCX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Variable charge X-linked protein 2

Alternative name(s):
Variable charge protein on X with two repeats
Short name=VCX-2r
Variably charged protein X-B
Short name=VCX-B

Gene names

Name:	VCX2
Synonyms:	VCX2R, VCXB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
Tissue specificity	Expressed exclusively in testis.
Sequence similarities	Belongs to the VCX/VCY family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	Variable charge X-linked protein 2		PRO_0000184660
Regions
	Repeat	104 – 113	10	1
	Repeat	114 – 123	10	2
	Region	104 – 123	20	2 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P
Natural variations
	Natural variant	70	1	A → G. Ref.1 Ref.2 Ref.4 Corresponds to variant rs41309545 [ dbSNP | Ensembl ].		VAR_047772
	Natural variant	104	1	L → P. Ref.1 Ref.2 Ref.4 Corresponds to variant rs41305169 [ dbSNP | Ensembl ].		VAR_047773
	Natural variant	110	1	V → L. Ref.1 Ref.2 Ref.4 Corresponds to variant rs1058237 [ dbSNP | Ensembl ].		VAR_047774
	Natural variant	138	1	T → S. Ref.1 Ref.2 Ref.4 Corresponds to variant rs1058239 [ dbSNP | Ensembl ].		VAR_047775
Experimental info
	Sequence conflict	40	1	K → E in AAF28172. Ref.2
	Sequence conflict	108	1	S → A in AAG41765. Ref.1
	Sequence conflict	108	1	S → A in AAF28172. Ref.2
	Sequence conflict	108	1	S → A in AAH98113. Ref.4
	Sequence conflict	108	1	S → A in AAH96715. Ref.4
	Sequence conflict	108	1	S → A in AAH98163. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9H322 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 0AE8B40CF2A3B739	FASTA	139	14,661
	10 20 30 40 50 60 MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 70 80 90 100 110 120 AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEV EEPLSQESEV 130 EEPLTVWMAS FSPVSESTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation." Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B., Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W., Ogata T., Rappold G.A. Am. J. Hum. Genet. 67:563-573(2000) [PubMed: 10903929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-70; PRO-104; LEU-110 AND SER-138.
[2]	"A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins." Lahn B.T., Page D.C. Hum. Mol. Genet. 9:311-319(2000) [PubMed: 10607842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-70; PRO-104; LEU-110 AND SER-138.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-70; PRO-104; LEU-110 AND SER-138.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF167079 mRNA. Translation: AAG41765.1. AF159127 mRNA. Translation: AAF28172.1. AC097626 Genomic DNA. No translation available. BC096715 mRNA. Translation: AAH96715.1. BC098113 mRNA. Translation: AAH98113.1. BC098163 mRNA. Translation: AAH98163.1. BC134350 mRNA. Translation: AAI34351.1.
IPI	IPI00301073.
RefSeq	NP_057462.2. NM_016378.2.
UniGene	Hs.279737.
3D structure databases
ProteinModelPortal	Q9H322.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H322.
PTM databases
PhosphoSite	Q9H322.
Polymorphism databases
DMDM	215274108.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317103; ENSP00000321309; ENSG00000177504.
GeneID	51480.
KEGG	hsa:51480.
Organism-specific databases
CTD	51480.
GeneCards	GC0XM008097.
HGNC	HGNC:18158. VCX2.
neXtProt	NX_Q9H322.
PharmGKB	PA134891971.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00440000034745.
InParanoid	Q9H322.
Gene expression databases
ArrayExpress	Q9H322.
Bgee	Q9H322.
CleanEx	HS_VCX2.
Genevestigator	Q9H322.
GermOnline	ENSG00000177504. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	55134.

Entry information

Entry name

VCX2_HUMAN

Accession

Primary (citable) accession number: Q9H322
Secondary accession number(s): A3KPB6, Q4V9T2, Q9P0H5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.