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Protein

Variable charge X-linked protein 2

Gene

VCX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Variable charge X-linked protein 2
Alternative name(s):
Variable charge protein on X with two repeats
Short name:
VCX-2r
Variably charged protein X-B
Short name:
VCX-B
Gene namesi
Name:VCX2
Synonyms:VCX2R, VCXB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18158. VCX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891971.

Polymorphism and mutation databases

BioMutaiVCX2.
DMDMi313104263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Variable charge X-linked protein 2PRO_0000184660Add
BLAST

Proteomic databases

PaxDbiQ9H322.

PTM databases

iPTMnetiQ9H322.
PhosphoSiteiQ9H322.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiQ9H322.
CleanExiHS_VCX2.
GenevisibleiQ9H322. HS.

Organism-specific databases

HPAiHPA044642.
HPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321309.

Structurei

3D structure databases

ProteinModelPortaliQ9H322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati104 – 113101
Repeati114 – 123102

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 123202 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-PAdd
BLAST

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H322.
OMAiLTVWMAS.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120 130
HDPLSQESEV EEPLSQESEV EEPLTVWMAS FSPVSESTD
Length:139
Mass (Da):14,661
Last modified:November 30, 2010 - v3
Checksum:i0AE8B40CF2A3B739
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401K → E in AAF28172 (PubMed:10607842).Curated
Sequence conflicti108 – 1081S → A in AAG41765 (PubMed:10903929).Curated
Sequence conflicti108 – 1081S → A in AAF28172 (PubMed:10607842).Curated
Sequence conflicti108 – 1081S → A in AAH98113 (PubMed:15489334).Curated
Sequence conflicti108 – 1081S → A in AAH96715 (PubMed:15489334).Curated
Sequence conflicti108 – 1081S → A in AAH98163 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701A → G.3 Publications
Corresponds to variant rs41309545 [ dbSNP | Ensembl ].
VAR_047772
Natural varianti104 – 1041L → P.3 Publications
Corresponds to variant rs41305169 [ dbSNP | Ensembl ].
VAR_047773
Natural varianti110 – 1101V → L.3 Publications
Corresponds to variant rs1058237 [ dbSNP | Ensembl ].
VAR_047774
Natural varianti138 – 1381T → S.3 Publications
Corresponds to variant rs1058239 [ dbSNP | Ensembl ].
VAR_047775

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167079 mRNA. Translation: AAG41765.1.
AF159127 mRNA. Translation: AAF28172.1.
AC097626 Genomic DNA. No translation available.
BC096715 mRNA. Translation: AAH96715.1.
BC098113 mRNA. Translation: AAH98113.1.
BC098163 mRNA. Translation: AAH98163.1.
BC134350 mRNA. Translation: AAI34351.1.
CCDSiCCDS35200.1.
RefSeqiNP_057462.2. NM_016378.3.
UniGeneiHs.279737.

Genome annotation databases

EnsembliENST00000317103; ENSP00000321309; ENSG00000177504.
GeneIDi51480.
KEGGihsa:51480.
UCSCiuc004csb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167079 mRNA. Translation: AAG41765.1.
AF159127 mRNA. Translation: AAF28172.1.
AC097626 Genomic DNA. No translation available.
BC096715 mRNA. Translation: AAH96715.1.
BC098113 mRNA. Translation: AAH98113.1.
BC098163 mRNA. Translation: AAH98163.1.
BC134350 mRNA. Translation: AAI34351.1.
CCDSiCCDS35200.1.
RefSeqiNP_057462.2. NM_016378.3.
UniGeneiHs.279737.

3D structure databases

ProteinModelPortaliQ9H322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321309.

PTM databases

iPTMnetiQ9H322.
PhosphoSiteiQ9H322.

Polymorphism and mutation databases

BioMutaiVCX2.
DMDMi313104263.

Proteomic databases

PaxDbiQ9H322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317103; ENSP00000321309; ENSG00000177504.
GeneIDi51480.
KEGGihsa:51480.
UCSCiuc004csb.3. human.

Organism-specific databases

CTDi51480.
GeneCardsiVCX2.
HGNCiHGNC:18158. VCX2.
HPAiHPA044642.
HPA044996.
HPA049357.
MIMi300532. gene.
neXtProtiNX_Q9H322.
PharmGKBiPA134891971.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H322.
OMAiLTVWMAS.

Miscellaneous databases

GenomeRNAii51480.
PROiQ9H322.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H322.
CleanExiHS_VCX2.
GenevisibleiQ9H322. HS.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation."
    Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B., Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W., Ogata T., Rappold G.A.
    Am. J. Hum. Genet. 67:563-573(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-70; PRO-104; LEU-110 AND SER-138.
  2. "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins."
    Lahn B.T., Page D.C.
    Hum. Mol. Genet. 9:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-70; PRO-104; LEU-110 AND SER-138.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-70; PRO-104; LEU-110 AND SER-138.

Entry informationi

Entry nameiVCX2_HUMAN
AccessioniPrimary (citable) accession number: Q9H322
Secondary accession number(s): A3KPB6, Q4V9T2, Q9P0H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.