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Protein

Variable charge X-linked protein 2

Gene

VCX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177504-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Variable charge X-linked protein 2
Alternative name(s):
Variable charge protein on X with two repeats
Short name:
VCX-2r
Variably charged protein X-B
Short name:
VCX-B
Gene namesi
Name:VCX2
Synonyms:VCX2R, VCXB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18158. VCX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi51480.
OpenTargetsiENSG00000177504.
PharmGKBiPA134891971.

Polymorphism and mutation databases

BioMutaiVCX2.
DMDMi313104263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846601 – 139Variable charge X-linked protein 2Add BLAST139

Proteomic databases

PaxDbiQ9H322.
PRIDEiQ9H322.

PTM databases

iPTMnetiQ9H322.
PhosphoSitePlusiQ9H322.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiENSG00000177504.
CleanExiHS_VCX2.
GenevisibleiQ9H322. HS.

Organism-specific databases

HPAiHPA044642.
HPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321309.

Structurei

3D structure databases

ProteinModelPortaliQ9H322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 113110
Repeati114 – 123210

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 1232 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-PAdd BLAST20

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H322.
OMAiEEPLTVW.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120 130
HDPLSQESEV EEPLSQESEV EEPLTVWMAS FSPVSESTD
Length:139
Mass (Da):14,661
Last modified:November 30, 2010 - v3
Checksum:i0AE8B40CF2A3B739
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40K → E in AAF28172 (PubMed:10607842).Curated1
Sequence conflicti108S → A in AAG41765 (PubMed:10903929).Curated1
Sequence conflicti108S → A in AAF28172 (PubMed:10607842).Curated1
Sequence conflicti108S → A in AAH98113 (PubMed:15489334).Curated1
Sequence conflicti108S → A in AAH96715 (PubMed:15489334).Curated1
Sequence conflicti108S → A in AAH98163 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04777270A → G.3 PublicationsCorresponds to variant rs41309545dbSNPEnsembl.1
Natural variantiVAR_047773104L → P.3 PublicationsCorresponds to variant rs41305169dbSNPEnsembl.1
Natural variantiVAR_047774110V → L.3 PublicationsCorresponds to variant rs1058237dbSNPEnsembl.1
Natural variantiVAR_047775138T → S.3 PublicationsCorresponds to variant rs1058239dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167079 mRNA. Translation: AAG41765.1.
AF159127 mRNA. Translation: AAF28172.1.
AC097626 Genomic DNA. No translation available.
BC096715 mRNA. Translation: AAH96715.1.
BC098113 mRNA. Translation: AAH98113.1.
BC098163 mRNA. Translation: AAH98163.1.
BC134350 mRNA. Translation: AAI34351.1.
CCDSiCCDS35200.1.
RefSeqiNP_057462.2. NM_016378.3.
UniGeneiHs.279737.

Genome annotation databases

EnsembliENST00000317103; ENSP00000321309; ENSG00000177504.
GeneIDi51480.
KEGGihsa:51480.
UCSCiuc004csb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167079 mRNA. Translation: AAG41765.1.
AF159127 mRNA. Translation: AAF28172.1.
AC097626 Genomic DNA. No translation available.
BC096715 mRNA. Translation: AAH96715.1.
BC098113 mRNA. Translation: AAH98113.1.
BC098163 mRNA. Translation: AAH98163.1.
BC134350 mRNA. Translation: AAI34351.1.
CCDSiCCDS35200.1.
RefSeqiNP_057462.2. NM_016378.3.
UniGeneiHs.279737.

3D structure databases

ProteinModelPortaliQ9H322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321309.

PTM databases

iPTMnetiQ9H322.
PhosphoSitePlusiQ9H322.

Polymorphism and mutation databases

BioMutaiVCX2.
DMDMi313104263.

Proteomic databases

PaxDbiQ9H322.
PRIDEiQ9H322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317103; ENSP00000321309; ENSG00000177504.
GeneIDi51480.
KEGGihsa:51480.
UCSCiuc004csb.3. human.

Organism-specific databases

CTDi51480.
DisGeNETi51480.
GeneCardsiVCX2.
HGNCiHGNC:18158. VCX2.
HPAiHPA044642.
HPA044996.
HPA049357.
MIMi300532. gene.
neXtProtiNX_Q9H322.
OpenTargetsiENSG00000177504.
PharmGKBiPA134891971.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H322.
OMAiEEPLTVW.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177504-MONOMER.

Miscellaneous databases

GenomeRNAii51480.
PROiQ9H322.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177504.
CleanExiHS_VCX2.
GenevisibleiQ9H322. HS.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCX2_HUMAN
AccessioniPrimary (citable) accession number: Q9H322
Secondary accession number(s): A3KPB6, Q4V9T2, Q9P0H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.