Q9H321 (VCX3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Variable charge X-linked protein 3B

Alternative name(s):
Variably charged protein X-C
Short name=VCX-C

Gene names

Name:	VCX3B
Synonyms:	VCXC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
Tissue specificity	Expressed exclusively in testis.
Sequence similarities	Belongs to the VCX/VCY family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Variable charge X-linked protein 3B		PRO_0000184662
Regions
	Repeat	104 – 113	10	1
	Repeat	114 – 123	10	2
	Repeat	124 – 133	10	3
	Repeat	134 – 143	10	4
	Repeat	144 – 153	10	5
	Repeat	154 – 163	10	6
	Repeat	164 – 173	10	7
	Repeat	174 – 183	10	8
	Repeat	184 – 193	10	9
	Repeat	194 – 203	10	10
	Repeat	204 – 213	10	11
	Region	104 – 213	110	11 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P
Natural variations
	Natural variant	15	1	K → T. Ref.1 Corresponds to variant rs5934423 [ dbSNP | Ensembl ].		VAR_037644
Experimental info
	Sequence conflict	98 – 102	5	GTQHD → VEE in AAH98143. Ref.2
	Sequence conflict	109 – 110	2	EL → QV in AAH98143. Ref.2
	Sequence conflict	120	1	V → M in AAH98143. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H321 [UniParc]. Last modified January 15, 2008. Version 3. Checksum: E484B89804562E95	FASTA	216	23,494
	10 20 30 40 50 60 MSPKPRASGP PAKAKEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 70 80 90 100 110 120 AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSQESEV 130 140 150 160 170 180 EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM 190 200 210 EEPLSQESQV EEPLSQESEM EEPLSQESEM EELPSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation." Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B., Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W., Ogata T., Rappold G.A. Am. J. Hum. Genet. 67:563-573(2000) [PubMed: 10903929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-15.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF167080 mRNA. Translation: AAG41766.2. BC098143 mRNA. Translation: AAH98143.1.
IPI	IPI00385888.
RefSeq	NP_001001888.3. NM_001001888.3.
UniGene	Hs.279737. Hs.534814.
3D structure databases
ProteinModelPortal	Q9H321.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H321.
Polymorphism databases
DMDM	166215027.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000434876; ENSP00000391767; ENSG00000205642. ENST00000444481; ENSP00000414780; ENSG00000205642.
GeneID	425054.
KEGG	hsa:425054.
UCSC	uc010ndo.1. human.
Organism-specific databases
CTD	425054.
GeneCards	GC0XP008393.
HGNC	HGNC:31838. VCX3B.
neXtProt	NX_Q9H321.
PharmGKB	PA134866686.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG18775.
GeneTree	ENSGT00440000034745.
InParanoid	Q9H321.
Gene expression databases
CleanEx	HS_VCX3B.
Genevestigator	Q9H321.
GermOnline	ENSG00000205642. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	108691.

Entry information

Entry name

VCX3B_HUMAN

Accession

Primary (citable) accession number: Q9H321
Secondary accession number(s): Q4KN12

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	January 15, 2008
Last modified:	December 14, 2011
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.