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Protein

Variable charge X-linked protein 3B

Gene

VCX3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169059-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Variable charge X-linked protein 3B
Alternative name(s):
Variably charged protein X-C
Short name:
VCX-C
Gene namesi
Name:VCX3B
Synonyms:VCXC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:31838. VCX3B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi425054.
OpenTargetsiENSG00000205642.
PharmGKBiPA134866686.

Polymorphism and mutation databases

BioMutaiVCX3B.
DMDMi166215027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846621 – 246Variable charge X-linked protein 3BAdd BLAST246

Proteomic databases

PaxDbiQ9H321.
PeptideAtlasiQ9H321.
PRIDEiQ9H321.

PTM databases

iPTMnetiQ9H321.
PhosphoSitePlusiQ9H321.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiENSG00000205642.
CleanExiHS_VCX3B.
ExpressionAtlasiQ9H321. baseline and differential.
GenevisibleiQ9H321. HS.

Organism-specific databases

HPAiHPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370420.

Structurei

3D structure databases

ProteinModelPortaliQ9H321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 113110
Repeati114 – 123210
Repeati124 – 133310
Repeati134 – 143410
Repeati144 – 153510
Repeati154 – 163610
Repeati164 – 173710
Repeati174 – 183810
Repeati184 – 193910
Repeati194 – 2031010
Repeati204 – 2131110
Repeati214 – 2231210
Repeati224 – 2331310
Repeati234 – 2431410

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 24314 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-PAdd BLAST140

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H321.
OMAiSDEPVCE.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H321-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPKPRASGP PAKAKEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120 130 140 150
HDPLSQESEL EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV
160 170 180 190 200
EEPLSQESEV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV
210 220 230 240
EEPLSQESEM EEPLSQESQV EEPLSQESEM EEPLSQESEM EELPSV
Length:246
Mass (Da):26,878
Last modified:April 16, 2014 - v4
Checksum:iBAEE4B909BE74AD7
GO
Isoform 2 (identifier: Q9H321-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-198: Missing.

Show »
Length:216
Mass (Da):23,494
Checksum:iE484B89804562E95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98 – 102GTQHD → VEE in AAH98143 (PubMed:15489334).Curated5
Sequence conflicti109 – 110EL → QV in AAH98143 (PubMed:15489334).Curated2
Sequence conflicti120V → M in AAH98143 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03764415K → T.1 PublicationCorresponds to variant rs5934423dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054105169 – 198Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006062 Genomic DNA. No translation available.
AF167080 mRNA. Translation: AAG41766.2.
BC098143 mRNA. Translation: AAH98143.1.
CCDSiCCDS48077.2. [Q9H321-1]
RefSeqiNP_001001888.3. NM_001001888.3. [Q9H321-1]
UniGeneiHs.279737.
Hs.534814.

Genome annotation databases

EnsembliENST00000381032; ENSP00000370420; ENSG00000205642. [Q9H321-1]
GeneIDi425054.
KEGGihsa:425054.
UCSCiuc011mht.3. human. [Q9H321-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006062 Genomic DNA. No translation available.
AF167080 mRNA. Translation: AAG41766.2.
BC098143 mRNA. Translation: AAH98143.1.
CCDSiCCDS48077.2. [Q9H321-1]
RefSeqiNP_001001888.3. NM_001001888.3. [Q9H321-1]
UniGeneiHs.279737.
Hs.534814.

3D structure databases

ProteinModelPortaliQ9H321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370420.

PTM databases

iPTMnetiQ9H321.
PhosphoSitePlusiQ9H321.

Polymorphism and mutation databases

BioMutaiVCX3B.
DMDMi166215027.

Proteomic databases

PaxDbiQ9H321.
PeptideAtlasiQ9H321.
PRIDEiQ9H321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381032; ENSP00000370420; ENSG00000205642. [Q9H321-1]
GeneIDi425054.
KEGGihsa:425054.
UCSCiuc011mht.3. human. [Q9H321-1]

Organism-specific databases

CTDi425054.
DisGeNETi425054.
GeneCardsiVCX3B.
HGNCiHGNC:31838. VCX3B.
HPAiHPA044996.
HPA049357.
neXtProtiNX_Q9H321.
OpenTargetsiENSG00000205642.
PharmGKBiPA134866686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H321.
OMAiSDEPVCE.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169059-MONOMER.

Miscellaneous databases

GenomeRNAii425054.
PROiQ9H321.

Gene expression databases

BgeeiENSG00000205642.
CleanExiHS_VCX3B.
ExpressionAtlasiQ9H321. baseline and differential.
GenevisibleiQ9H321. HS.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCX3B_HUMAN
AccessioniPrimary (citable) accession number: Q9H321
Secondary accession number(s): C9JS46, Q4KN12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 16, 2014
Last modified: November 2, 2016
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.