Q9H320 (VCX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Variable charge X-linked protein 1

Alternative name(s):
Variable charge protein on X with ten repeats
Short name=VCX-10r
Variably charged protein X-B1
Short name=VCX-B1

Gene names

Name:	VCX
Synonyms:	VCX1, VCX10R, VCXB1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
Tissue specificity	Expressed exclusively in testis.
Sequence similarities	Belongs to the VCX/VCY family.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chromatin organization Traceable author statement. Source: UniProtKB ribosome assembly Non-traceable author statement. Source: UniProtKB spermatogenesis Traceable author statement. Source: ProtInc
Cellular component	nucleolus Inferred from direct assay. Source: UniProtKB
Molecular function	chromatin binding Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Variable charge X-linked protein 1		PRO_0000184659
Regions
	Repeat	104 – 113	10	1
	Repeat	114 – 123	10	2
	Repeat	124 – 133	10	3
	Repeat	134 – 143	10	4
	Repeat	144 – 153	10	5
	Repeat	154 – 163	10	6
	Repeat	164 – 173	10	7
	Repeat	174 – 183	10	8
	Repeat	184 – 193	10	9
	Repeat	194 – 203	10	10
	Region	104 – 203	100	10 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P
	Compositional bias	83 – 206	124	Glu-rich
Experimental info
	Sequence conflict	70	1	A → G in AAF28174. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H320 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 070880B5587C2BB0	FASTA	206	22,289
	10 20 30 40 50 60 MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 70 80 90 100 110 120 AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQEAEL EEPLSQESEV 130 140 150 160 170 180 EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM 190 200 EEPLSQESQV EEPPSQESEM EELPSV

References

[1]	"A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation." Fukami M., Kirsch S., Schiller S., Richter A., Benes V., Franco B., Muroya K., Rao E., Merker S., Niesler B., Ballabio A., Ansorge W., Ogata T., Rappold G.A. Am. J. Hum. Genet. 67:563-573(2000) [PubMed: 10903929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins." Lahn B.T., Page D.C. Hum. Mol. Genet. 9:311-319(2000) [PubMed: 10607842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF167081 mRNA. Translation: AAG41767.1. AF159129 mRNA. Translation: AAF28174.1.
IPI	IPI00301071.
RefSeq	NP_038480.2. NM_013452.2.
UniGene	Hs.567503.
3D structure databases
ProteinModelPortal	Q9H320.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H320.
Polymorphism databases
DMDM	17368950.
Proteomic databases
PRIDE	Q9H320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341408; ENSP00000344144; ENSG00000182583. ENST00000381059; ENSP00000370447; ENSG00000182583.
GeneID	26609.
KEGG	hsa:26609.
UCSC	uc004crz.1. human.
Organism-specific databases
CTD	26609.
GeneCards	GC0XP007770.
H-InvDB	HIX0056151.
HGNC	HGNC:12667. VCX.
neXtProt	NX_Q9H320.
PharmGKB	PA37290.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00440000034745.
InParanoid	Q9H320.
Gene expression databases
Bgee	Q9H320.
CleanEx	HS_VCX.
Genevestigator	Q9H320.
GermOnline	ENSG00000182583. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	48980.

Entry information

Entry name

VCX1_HUMAN

Accession

Primary (citable) accession number: Q9H320
Secondary accession number(s): Q9P0H3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.