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Protein

Variable charge X-linked protein 1

Gene

VCX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • brain development Source: GO_Central
  • chromatin organization Source: UniProtKB
  • ribosome assembly Source: UniProtKB
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Variable charge X-linked protein 1
Alternative name(s):
Variable charge protein on X with ten repeats
Short name:
VCX-10r
Variably charged protein X-B1
Short name:
VCX-B1
Gene namesi
Name:VCX
Synonyms:VCX1, VCX10R, VCXB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12667. VCX.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi26609.
OpenTargetsiENSG00000182583.
PharmGKBiPA37290.

Polymorphism and mutation databases

BioMutaiVCX.
DMDMi17368950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846591 – 206Variable charge X-linked protein 1Add BLAST206

Proteomic databases

PaxDbiQ9H320.
PRIDEiQ9H320.

PTM databases

iPTMnetiQ9H320.
PhosphoSitePlusiQ9H320.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiENSG00000182583.
CleanExiHS_VCX.
ExpressionAtlasiQ9H320. baseline and differential.
GenevisibleiQ9H320. HS.

Organism-specific databases

HPAiHPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370447.

Structurei

3D structure databases

ProteinModelPortaliQ9H320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 113110
Repeati114 – 123210
Repeati124 – 133310
Repeati134 – 143410
Repeati144 – 153510
Repeati154 – 163610
Repeati164 – 173710
Repeati174 – 183810
Repeati184 – 193910
Repeati194 – 2031010

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 20310 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-PAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 206Glu-richAdd BLAST124

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H320.
OMAiDETQMED.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120 130 140 150
HDPLSQEAEL EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV
160 170 180 190 200
EEPLSQESEV EEPLSQESQV EEPLSQESEM EEPLSQESQV EEPPSQESEM

EELPSV
Length:206
Mass (Da):22,289
Last modified:March 1, 2001 - v1
Checksum:i070880B5587C2BB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 17TEA → KET in AAH98123 (PubMed:15489334).Curated3
Sequence conflicti108A → S in AAH98123 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07043170A → G.2 PublicationsCorresponds to variant rs6639946dbSNPEnsembl.1
Natural variantiVAR_070432194P → L.1 PublicationCorresponds to variant rs78342118dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167081 mRNA. Translation: AAG41767.1.
AF159129 mRNA. Translation: AAF28174.1.
BC098123 mRNA. Translation: AAH98123.1.
BC126903 mRNA. Translation: AAI26904.1.
CCDSiCCDS14128.1.
RefSeqiNP_038480.2. NM_013452.2.
UniGeneiHs.278906.
Hs.567503.

Genome annotation databases

EnsembliENST00000381059; ENSP00000370447; ENSG00000182583.
GeneIDi26609.
KEGGihsa:26609.
UCSCiuc004crz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167081 mRNA. Translation: AAG41767.1.
AF159129 mRNA. Translation: AAF28174.1.
BC098123 mRNA. Translation: AAH98123.1.
BC126903 mRNA. Translation: AAI26904.1.
CCDSiCCDS14128.1.
RefSeqiNP_038480.2. NM_013452.2.
UniGeneiHs.278906.
Hs.567503.

3D structure databases

ProteinModelPortaliQ9H320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370447.

PTM databases

iPTMnetiQ9H320.
PhosphoSitePlusiQ9H320.

Polymorphism and mutation databases

BioMutaiVCX.
DMDMi17368950.

Proteomic databases

PaxDbiQ9H320.
PRIDEiQ9H320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381059; ENSP00000370447; ENSG00000182583.
GeneIDi26609.
KEGGihsa:26609.
UCSCiuc004crz.3. human.

Organism-specific databases

CTDi26609.
DisGeNETi26609.
GeneCardsiVCX.
HGNCiHGNC:12667. VCX.
HPAiHPA044996.
HPA049357.
MIMi300229. gene.
neXtProtiNX_Q9H320.
OpenTargetsiENSG00000182583.
PharmGKBiPA37290.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiQ9H320.
OMAiDETQMED.

Miscellaneous databases

GeneWikiiVCX.
GenomeRNAii26609.
PROiQ9H320.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182583.
CleanExiHS_VCX.
ExpressionAtlasiQ9H320. baseline and differential.
GenevisibleiQ9H320. HS.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCX1_HUMAN
AccessioniPrimary (citable) accession number: Q9H320
Secondary accession number(s): A0JNS5, Q4V774, Q9P0H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.