Q9H310 (RHBG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ammonium transporter Rh type B

Alternative name(s):
Rhesus blood group family type B glycoprotein
Short name=Rh family type B glycoprotein
Short name=Rh type B glycoprotein

Gene names

Name:

RHBG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a specific ammonium transporter. Ref.7 Ref.8
Subunit structure	Interacts (via C-terminus) with ANK2 and ANK3; required for targeting to the basolateral membrane. Ref.9
Subcellular location	Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Ref.1 Ref.9.
Tissue specificity	Specifically expressed in kidney. Also detected in liver and ovary. Ref.1
Developmental stage	Fetally expressed by kidney and to a lower extent in liver. Ref.1
Post-translational modification	N-glycosylated By similarity. Ref.1
Sequence similarities	Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. [View classification]
Sequence caution	The sequence AAG01086.1 differs from that shown. Reason: Frameshift at position 425. The sequence AAL05978.1 differs from that shown. Reason: Frameshift at position 425. The sequence AAN34363.1 differs from that shown. Reason: Frameshift at position 425. The sequence AAN34364.1 differs from that shown. Reason: Frameshift at position 425.

Ontologies

Keywords
Biological process	Ammonia transport Transport
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transepithelial ammonium transport Inferred from direct assay PubMed 18032481. Source: UniProtKB
Cellular_component	anchored to plasma membrane Inferred from mutant phenotype Ref.9. Source: UniProtKB basolateral plasma membrane Inferred from direct assay Ref.9PubMed 18635543. Source: UniProtKB cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Inferred from direct assay Ref.1. Source: UniProtKB spectrin-associated cytoskeleton Inferred from mutant phenotype PubMed 18635543. Source: UniProtKB
Molecular_function	ammonia transmembrane transporter activity Inferred from direct assay PubMed 18032481PubMed 18635543. Source: UniProtKB ammonium transmembrane transporter activity Inferred from direct assay Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H310-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H310-2)

Also known as: RhBG-2A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     31-63: AVFVRYNHKTDAALWHRSNHSNADNEFYFRYPS → MNFTFATQKSLTLLPRLECNGAISAHCNLHLPG

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H310-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
     175-175: G → GVRVWGGMESGVGGGQGQPLSQERGGGGGVLPLTPPPQ

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9H310-4)

Also known as: RhBG-1A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Isoform 5 (identifier: Q9H310-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
     372-441: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Ammonium transporter Rh type B		PRO_0000283597
Regions
	Topological domain	1 – 13	13	Cytoplasmic Potential
	Transmembrane	14 – 34	21	Helical; Potential
	Topological domain	35 – 61	27	Extracellular Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 86	4	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Topological domain	108 – 124	17	Extracellular Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Topological domain	146 – 149	4	Cytoplasmic Potential
	Transmembrane	150 – 170	21	Helical; Potential
	Topological domain	171 – 178	8	Extracellular Potential
	Transmembrane	179 – 201	23	Helical; Potential
	Topological domain	202 – 219	18	Cytoplasmic Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Topological domain	241 – 251	11	Extracellular Potential
	Transmembrane	252 – 272	21	Helical; Potential
	Topological domain	273 – 282	10	Cytoplasmic Potential
	Transmembrane	283 – 303	21	Helical; Potential
	Topological domain	304	1	Extracellular Potential
	Transmembrane	305 – 325	21	Helical; Potential
	Topological domain	326 – 346	21	Cytoplasmic Potential
	Transmembrane	347 – 367	21	Helical; Potential
	Topological domain	368 – 393	26	Extracellular Potential
	Transmembrane	394 – 414	21	Helical; Potential
	Topological domain	415 – 441	27	Cytoplasmic Potential
	Region	416 – 424	9	Interaction with ANK3
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 69	69	Missing in isoform 3, isoform 4 and isoform 5.		VSP_024340
	Alternative sequence	1 – 30	30	Missing in isoform 2.		VSP_024341
	Alternative sequence	31 – 63	33	AVFVR…FRYPS → MNFTFATQKSLTLLPRLECN GAISAHCNLHLPG in isoform 2.		VSP_024342
	Alternative sequence	175	1	G → GVRVWGGMESGVGGGQGQPL SQERGGGGGVLPLTPPPQ in isoform 3.		VSP_024343
	Alternative sequence	372 – 441	70	Missing in isoform 5.		VSP_037136
	Natural variant	76	1	G → D. Ref.3 Ref.5 Corresponds to variant rs2245623 [ dbSNP | Ensembl ].		VAR_031497
	Natural variant	143	1	V → D. Ref.6 Corresponds to variant rs11586833 [ dbSNP | Ensembl ].		VAR_031498
	Natural variant	315	1	G → R. Ref.6 Corresponds to variant rs3748569 [ dbSNP | Ensembl ].		VAR_031499
	Natural variant	339	1	C → R. Corresponds to variant rs3748567 [ dbSNP | Ensembl ].		VAR_053637
Experimental info
	Mutagenesis	419	1	F → A: Loss of interaction with ANK3. Intracellular retention; when associated with A-420 and A-421. Ref.9
	Mutagenesis	420	1	L → A: Partial loss of interaction with ANK3. Intracellular retention; when associated with A-419 and A-421. Ref.9
	Mutagenesis	421	1	D → A: Partial loss of interaction with ANK3. Intracellular retention; when associated with A-419 and A-420. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 21EE1FE592F2E1EE	FASTA	441	47,231
	10 20 30 40 50 60 MAGSPSRAAG RRLQLPLLCL FLQGATAVLF AVFVRYNHKT DAALWHRSNH SNADNEFYFR 70 80 90 100 110 120 YPSFQDVHAM VFVGFGFLMV FLQRYGFSSV GFTFLLAAFA LQWSTLVQGF LHSFHGGHIH 130 140 150 160 170 180 VGVESMINAD FCAGAVLISF GAVLGKTGPT QLLLMALLEV VLFGINEFVL LHLLGVRDAG 190 200 210 220 230 240 GSMTIHTFGA YFGLVLSRVL YRPQLEKSKH RQGSVYHSDL FAMIGTIFLW IFWPSFNAAL 250 260 270 280 290 300 TALGAGQHRT ALNTYYSLAA STLGTFALSA LVGEDGRLDM VHIQNAALAG GVVVGTSSEM 310 320 330 340 350 360 MLTPFGALAA GFLAGTVSTL GYKFFTPILE SKFKVQDTCG VHNLHGMPGV LGALLGVLVA 370 380 390 400 410 420 GLATHEAYGD GLESVFPLIA EGQRSATSQA MHQLFGLFVT LMFASVGGGL GGLLLKLPFL 430 440 DSPPRLPALR GPSSLAGAWR A
	Isoform 2 (RhBG-2A) [UniParc]. Checksum: B9C06223F4445B97	FASTA	411	43,675
	10 20 30 40 50 60 MNFTFATQKS LTLLPRLECN GAISAHCNLH LPGFQDVHAM VFVGFGFLMV FLQRYGFSSV 70 80 90 100 110 120 GFTFLLAAFA LQWSTLVQGF LHSFHGGHIH VGVESMINAD FCAGAVLISF GAVLGKTGPT 130 140 150 160 170 180 QLLLMALLEV VLFGINEFVL LHLLGVRDAG GSMTIHTFGA YFGLVLSRVL YRPQLEKSKH 190 200 210 220 230 240 RQGSVYHSDL FAMIGTIFLW IFWPSFNAAL TALGAGQHRT ALNTYYSLAA STLGTFALSA 250 260 270 280 290 300 LVGEDGRLDM VHIQNAALAG GVVVGTSSEM MLTPFGALAA GFLAGTVSTL GYKFFTPILE 310 320 330 340 350 360 SKFKVQDTCG VHNLHGMPGV LGALLGVLVA GLATHEAYGD GLESVFPLIA EGQRSATSQA 370 380 390 400 410 MHQLFGLFVT LMFASVGGGL GGLLLKLPFL DSPPRLPALR GPSSLAGAWR A
	Isoform 3 [UniParc]. Checksum: D0FE23FCAC1344ED	FASTA	409	42,978
	10 20 30 40 50 60 MVFVGFGFLM VFLQRYGFSS VGFTFLLAAF ALQWSTLVQG FLHSFHGGHI HVGVESMINA 70 80 90 100 110 120 DFCAGAVLIS FGAVLGKTGP TQLLLMALLE VVLFGINEFV LLHLLGVRVW GGMESGVGGG 130 140 150 160 170 180 QGQPLSQERG GGGGVLPLTP PPQVRDAGGS MTIHTFGAYF GLVLSRVLYR PQLEKSKHRQ 190 200 210 220 230 240 GSVYHSDLFA MIGTIFLWIF WPSFNAALTA LGAGQHRTAL NTYYSLAAST LGTFALSALV 250 260 270 280 290 300 GEDGRLDMVH IQNAALAGGV VVGTSSEMML TPFGALAAGF LAGTVSTLGY KFFTPILESK 310 320 330 340 350 360 FKVQDTCGVH NLHGMPGVLG ALLGVLVAGL ATHEAYGDGL ESVFPLIAEG QRSATSQAMH 370 380 390 400 QLFGLFVTLM FASVGGGLGG LLLKLPFLDS PPRLPALRGP SSLAGAWRA
	Isoform 4 (RhBG-1A) [UniParc]. Checksum: 47C840C8A19763F5	FASTA	372	39,396
	10 20 30 40 50 60 MVFVGFGFLM VFLQRYGFSS VGFTFLLAAF ALQWSTLVQG FLHSFHGGHI HVGVESMINA 70 80 90 100 110 120 DFCAGAVLIS FGAVLGKTGP TQLLLMALLE VVLFGINEFV LLHLLGVRDA GGSMTIHTFG 130 140 150 160 170 180 AYFGLVLSRV LYRPQLEKSK HRQGSVYHSD LFAMIGTIFL WIFWPSFNAA LTALGAGQHR 190 200 210 220 230 240 TALNTYYSLA ASTLGTFALS ALVGEDGRLD MVHIQNAALA GGVVVGTSSE MMLTPFGALA 250 260 270 280 290 300 AGFLAGTVST LGYKFFTPIL ESKFKVQDTC GVHNLHGMPG VLGALLGVLV AGLATHEAYG 310 320 330 340 350 360 DGLESVFPLI AEGQRSATSQ AMHQLFGLFV TLMFASVGGG LGGLLLKLPF LDSPPRLPAL 370 RGPSSLAGAW RA
	Isoform 5 [UniParc]. Checksum: B758ABDDBA1E2E90	FASTA	302	32,092
	10 20 30 40 50 60 MVFVGFGFLM VFLQRYGFSS VGFTFLLAAF ALQWSTLVQG FLHSFHGGHI HVGVESMINA 70 80 90 100 110 120 DFCAGAVLIS FGAVLGKTGP TQLLLMALLE VVLFGINEFV LLHLLGVRDA GGSMTIHTFG 130 140 150 160 170 180 AYFGLVLSRV LYRPQLEKSK HRQGSVYHSD LFAMIGTIFL WIFWPSFNAA LTALGAGQHR 190 200 210 220 230 240 TALNTYYSLA ASTLGTFALS ALVGEDGRLD MVHIQNAALA GGVVVGTSSE MMLTPFGALA 250 260 270 280 290 300 AGFLAGTVST LGYKFFTPIL ESKFKVQDTC GVHNLHGMPG VLGALLGVLV AGLATHEAYG DG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals." Liu Z., Peng J., Mo R., Hui C.-C., Huang C.-H. J. Biol. Chem. 276:1424-1433(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION. Tissue: Liver.
[2]	"Characterization of alternatively spliced Rh type B glycoprotein (RhBG) isoforms in human tissues resulting from exonic inclusion of Alu repeat like sequences." Liu Z., Chen Y., Huang C.-H. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4). Tissue: Liver.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT ASP-76. Tissue: Cerebellum and Liver.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-76.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS ASP-143 AND ARG-315. Tissue: Ovary.
[7]	"Electroneutral ammonium transport by basolateral rhesus B glycoprotein." Ludewig U. J. Physiol. (Lond.) 559:751-759(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells." Zidi-Yahiaoui N., Mouro-Chanteloup I., D'Ambrosio A.-M., Lopez C., Gane P., Le van Kim C., Cartron J.-P., Colin Y., Ripoche P. Biochem. J. 391:33-40(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells." Lopez C., Metral S., Eladari D., Drevensek S., Gane P., Chambrey R., Bennett V., Cartron J.-P., Le Van Kim C., Colin Y. J. Biol. Chem. 280:8221-8228(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF PHE-419; LEU-420 AND ASP-421, INTERACTION WITH ANK2 AND ANK3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF193807 mRNA. Translation: AAG01086.1. Frameshift. AF219980 , AF219977, AF219978, AF219979 Genomic DNA. Translation: AAL05978.1. Frameshift. AY139092 mRNA. Translation: AAN34363.1. Frameshift. AY139093 mRNA. Translation: AAN34364.1. Frameshift. AK054780 mRNA. Translation: BAG51423.1. AK290840 mRNA. Translation: BAF83529.1. AL589685, AL139130 Genomic DNA. Translation: CAI14175.1. AL589685, AL139130 Genomic DNA. Translation: CAI14176.1. AL589685, AL139130 Genomic DNA. Translation: CAI14177.1. AL139130, AL589685 Genomic DNA. Translation: CAI12178.1. AL139130, AL589685 Genomic DNA. Translation: CAI12179.1. AL139130, AL589685 Genomic DNA. Translation: CAI12180.1. CH471121 Genomic DNA. Translation: EAW52961.1. BC065218 mRNA. Translation: AAH65218.1.
IPI	IPI00006978. IPI00439781. IPI00925309. IPI00929353. IPI01012709.
RefSeq	NP_001243324.1. NM_001256395.1. NP_001243325.1. NM_001256396.1. NP_065140.3. NM_020407.4.
UniGene	Hs.131835.
3D structure databases
ProteinModelPortal	Q9H310.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H310. 1 interaction.
STRING	9606.ENSP00000255013.
Protein family/group databases
TCDB	1.A.11.4.2. ammonia transporter channel (Amt) family.
Polymorphism databases
DMDM	209572666.
Proteomic databases
PaxDb	Q9H310.
PRIDE	Q9H310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255013; ENSP00000255013; ENSG00000132677. ENST00000368249; ENSP00000357232; ENSG00000132677. ENST00000400992; ENSP00000383777; ENSG00000132677.
GeneID	57127.
KEGG	hsa:57127.
UCSC	uc001for.3. human. uc001fos.3. human. uc009wrz.3. human.
Organism-specific databases
CTD	57127.
GeneCards	GC01P156339.
HGNC	HGNC:14572. RHBG.
MIM	607079. gene.
neXtProt	NX_Q9H310.
PharmGKB	PA34385.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276393.
HOVERGEN	HBG004374.
KO	K06580.
OrthoDB	EOG45DWPJ.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_20679. Amine compound SLC transporters.
Gene expression databases
ArrayExpress	Q9H310.
Bgee	Q9H310.
Genevestigator	Q9H310.
Family and domain databases
InterPro	IPR024041. NH4_transpt_AmtB-like_dom. IPR002229. RhesusRHD. [Graphical view]
Pfam	PF00909. Ammonium_transp. 1 hit. [Graphical view]
PRINTS	PR00342. RHESUSRHD.
SUPFAM	SSF111352. RH_like_transpt. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	57127.
NextBio	63029.
SOURCE	Search...

Entry information

Entry name

RHBG_HUMAN

Accession

Primary (citable) accession number: Q9H310
Secondary accession number(s): A8K475 , Q5SZW4, Q5SZW6, Q5SZW7, Q6P193, Q6YJI2, Q6YJI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.