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Q9H306

- MMP27_HUMAN

UniProt

Q9H306 - MMP27_HUMAN

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Protein

Matrix metalloproteinase-27

Gene
MMP27, UNQ2503/PRO5992
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens By similarity.

Cofactori

Binds 4 calcium ions per subunit By similarity.
Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Zinc 2; in inhibited form By similarity
Metal bindingi121 – 1211Calcium 1 By similarity
Metal bindingi155 – 1551Calcium 2 By similarity
Metal bindingi165 – 1651Zinc 1 By similarity
Metal bindingi173 – 1731Calcium 3 By similarity
Metal bindingi174 – 1741Calcium 3; via carbonyl oxygen By similarity
Metal bindingi178 – 1781Calcium 3; via carbonyl oxygen By similarity
Metal bindingi181 – 1811Zinc 1 By similarity
Metal bindingi188 – 1881Calcium 2; via carbonyl oxygen By similarity
Metal bindingi192 – 1921Calcium 2 By similarity
Metal bindingi194 – 1941Zinc 1 By similarity
Metal bindingi196 – 1961Calcium 3 By similarity
Metal bindingi199 – 1991Calcium 1 By similarity
Metal bindingi199 – 1991Calcium 3 By similarity
Metal bindingi216 – 2161Zinc 2; catalytic By similarity
Active sitei217 – 2171 By similarity
Metal bindingi220 – 2201Zinc 2; catalytic By similarity
Metal bindingi226 – 2261Zinc 2; catalytic By similarity
Metal bindingi286 – 2861Calcium 4; via carbonyl oxygen By similarity
Metal bindingi377 – 3771Calcium 4; via carbonyl oxygen By similarity
Metal bindingi426 – 4261Calcium 4; via carbonyl oxygen By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM10.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-27 (EC:3.4.24.-)
Short name:
MMP-27
Gene namesi
Name:MMP27
ORF Names:UNQ2503/PRO5992
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14250. MMP27.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 9881Activation peptide By similarityPRO_0000287561Add
BLAST
Chaini99 – 513415Matrix metalloproteinase-27PRO_0000287562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi279 ↔ 465 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9H306.
PRIDEiQ9H306.

PTM databases

PhosphoSiteiQ9H306.

Expressioni

Tissue specificityi

Expressed in B-cells.1 Publication

Gene expression databases

BgeeiQ9H306.
CleanExiHS_MMP27.
GenevestigatoriQ9H306.

Structurei

3D structure databases

ProteinModelPortaliQ9H306.
SMRiQ9H306. Positions 30-465.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati276 – 32550Hemopexin 1Add
BLAST
Repeati326 – 37146Hemopexin 2Add
BLAST
Repeati373 – 42149Hemopexin 3Add
BLAST
Repeati422 – 46544Hemopexin 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi89 – 968Cysteine switch By similarity

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG260291.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiQ9H306.
KOiK08005.
OMAiQFYSLEI.
OrthoDBiEOG7XPZ57.
PhylomeDBiQ9H306.
TreeFamiTF315428.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR028732. MMP27.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF115. PTHR10201:SF115. 1 hit.
PfamiPF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H306-1 [UniParc]FASTAAdd to Basket

« Hide

MKRLLLLFLF FITFSSAFPL VRMTENEENM QLAQAYLNQF YSLEIEGNHL    50
VQSKNRSLID DKIREMQAFF GLTVTGKLDS NTLEIMKTPR CGVPDVGQYG 100
YTLPGWRKYN LTYRIINYTP DMARAAVDEA IQEGLEVWSK VTPLKFTKIS 150
KGIADIMIAF RTRVHGRCPR YFDGPLGVLG HAFPPGPGLG GDTHFDEDEN 200
WTKDGAGFNL FLVAAHEFGH ALGLSHSNDQ TALMFPNYVS LDPRKYPLSQ 250
DDINGIQSIY GGLPKEPAKP KEPTIPHACD PDLTFDAITT FRREVMFFKG 300
RHLWRIYYDI TDVEFELIAS FWPSLPADLQ AAYENPRDKI LVFKDENFWM 350
IRGYAVLPDY PKSIHTLGFP GRVKKIDAAV CDKTTRKTYF FVGIWCWRFD 400
EMTQTMDKGF PQRVVKHFPG ISIRVDAAFQ YKGFFFFSRG SKQFEYDIKT 450
KNITRIMRTN TWFQCKEPKN SSFGFDINKE KAHSGGIKIL YHKSLSLFIF 500
GIVHLLKNTS IYQ 513
Length:513
Mass (Da):59,026
Last modified:May 18, 2010 - v2
Checksum:i941D5B8DA55BD32A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221R → W.
Corresponds to variant rs12099177 [ dbSNP | Ensembl ].
VAR_032326
Natural varianti24 – 241T → M.1 Publication
Corresponds to variant rs1939015 [ dbSNP | Ensembl ].
VAR_032327
Natural varianti30 – 301M → V.1 Publication
Corresponds to variant rs2846707 [ dbSNP | Ensembl ].
VAR_032328
Natural varianti266 – 2661E → V.1 Publication
Corresponds to variant rs1276286 [ dbSNP | Ensembl ].
VAR_032329
Natural varianti304 – 3041W → L.
Corresponds to variant rs35616217 [ dbSNP | Ensembl ].
VAR_032330
Natural varianti447 – 4471D → N.1 Publication
Corresponds to variant rs2509010 [ dbSNP | Ensembl ].
VAR_032331
Natural varianti477 – 4771I → V.
Corresponds to variant rs35822551 [ dbSNP | Ensembl ].
VAR_032332

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF195192 mRNA. Translation: AAG28453.1.
AY358752 mRNA. Translation: AAQ89112.1.
AP000647 Genomic DNA. No translation available.
AP000851 Genomic DNA. No translation available.
CCDSiCCDS8319.1.
RefSeqiNP_071405.2. NM_022122.2.
UniGeneiHs.534479.

Genome annotation databases

EnsembliENST00000260229; ENSP00000260229; ENSG00000137675.
GeneIDi64066.
KEGGihsa:64066.
UCSCiuc001phd.1. human.

Polymorphism databases

DMDMi296437372.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF195192 mRNA. Translation: AAG28453.1 .
AY358752 mRNA. Translation: AAQ89112.1 .
AP000647 Genomic DNA. No translation available.
AP000851 Genomic DNA. No translation available.
CCDSi CCDS8319.1.
RefSeqi NP_071405.2. NM_022122.2.
UniGenei Hs.534479.

3D structure databases

ProteinModelPortali Q9H306.
SMRi Q9H306. Positions 30-465.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M10.027.

PTM databases

PhosphoSitei Q9H306.

Polymorphism databases

DMDMi 296437372.

Proteomic databases

PaxDbi Q9H306.
PRIDEi Q9H306.

Protocols and materials databases

DNASUi 64066.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260229 ; ENSP00000260229 ; ENSG00000137675 .
GeneIDi 64066.
KEGGi hsa:64066.
UCSCi uc001phd.1. human.

Organism-specific databases

CTDi 64066.
GeneCardsi GC11M102596.
H-InvDB HIX0201706.
HGNCi HGNC:14250. MMP27.
neXtProti NX_Q9H306.
PharmGKBi PA30884.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260291.
HOGENOMi HOG000217927.
HOVERGENi HBG052484.
InParanoidi Q9H306.
KOi K08005.
OMAi QFYSLEI.
OrthoDBi EOG7XPZ57.
PhylomeDBi Q9H306.
TreeFami TF315428.

Miscellaneous databases

GeneWikii MMP27.
GenomeRNAii 64066.
NextBioi 65838.
PROi Q9H306.

Gene expression databases

Bgeei Q9H306.
CleanExi HS_MMP27.
Genevestigatori Q9H306.

Family and domain databases

Gene3Di 2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR028732. MMP27.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
PANTHERi PTHR10201:SF115. PTHR10201:SF115. 1 hit.
Pfami PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEi PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel matrix metalloproteinase homologous to stromelysins."
    Benoit de Coignac A., Elson G., Magistrelli G., Jeannin P., Delneste Y., Aubry J.-P., Berthier O., Bonnefoy J.-Y., Gauchat J.-F.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-24 AND VAL-30.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-266 AND ASN-447.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis."
    Bar-Or A., Nuttall R.K., Duddy M., Alter A., Kim H.J., Ifergan I., Pennington C.J., Bourgoin P., Edwards D.R., Yong V.W.
    Brain 126:2738-2749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiMMP27_HUMAN
AccessioniPrimary (citable) accession number: Q9H306
Secondary accession number(s): Q6UWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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