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Q9H306

- MMP27_HUMAN

UniProt

Q9H306 - MMP27_HUMAN

Protein

Matrix metalloproteinase-27

Gene

MMP27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.By similarity

    Cofactori

    Binds 4 calcium ions per subunit.By similarity
    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911Zinc 2; in inhibited formBy similarity
    Metal bindingi121 – 1211Calcium 1By similarity
    Metal bindingi155 – 1551Calcium 2By similarity
    Metal bindingi165 – 1651Zinc 1By similarity
    Metal bindingi173 – 1731Calcium 3By similarity
    Metal bindingi174 – 1741Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi178 – 1781Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi181 – 1811Zinc 1By similarity
    Metal bindingi188 – 1881Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi192 – 1921Calcium 2By similarity
    Metal bindingi194 – 1941Zinc 1By similarity
    Metal bindingi196 – 1961Calcium 3By similarity
    Metal bindingi199 – 1991Calcium 1By similarity
    Metal bindingi199 – 1991Calcium 3By similarity
    Metal bindingi216 – 2161Zinc 2; catalyticBy similarity
    Active sitei217 – 2171PROSITE-ProRule annotation
    Metal bindingi220 – 2201Zinc 2; catalyticBy similarity
    Metal bindingi226 – 2261Zinc 2; catalyticBy similarity
    Metal bindingi286 – 2861Calcium 4; via carbonyl oxygenBy similarity
    Metal bindingi377 – 3771Calcium 4; via carbonyl oxygenBy similarity
    Metal bindingi426 – 4261Calcium 4; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Collagen degradation

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM10.027.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix metalloproteinase-27 (EC:3.4.24.-)
    Short name:
    MMP-27
    Gene namesi
    Name:MMP27
    ORF Names:UNQ2503/PRO5992
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14250. MMP27.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 9881Activation peptideBy similarityPRO_0000287561Add
    BLAST
    Chaini99 – 513415Matrix metalloproteinase-27PRO_0000287562Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi279 ↔ 465By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9H306.
    PRIDEiQ9H306.

    PTM databases

    PhosphoSiteiQ9H306.

    Expressioni

    Tissue specificityi

    Expressed in B-cells.1 Publication

    Gene expression databases

    BgeeiQ9H306.
    CleanExiHS_MMP27.
    GenevestigatoriQ9H306.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H306.
    SMRiQ9H306. Positions 30-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati276 – 32550Hemopexin 1Add
    BLAST
    Repeati326 – 37146Hemopexin 2Add
    BLAST
    Repeati373 – 42149Hemopexin 3Add
    BLAST
    Repeati422 – 46544Hemopexin 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi89 – 968Cysteine switchBy similarity

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Belongs to the peptidase M10A family.Curated
    Contains 4 hemopexin repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG260291.
    HOGENOMiHOG000217927.
    HOVERGENiHBG052484.
    InParanoidiQ9H306.
    KOiK08005.
    OMAiQFYSLEI.
    OrthoDBiEOG7XPZ57.
    PhylomeDBiQ9H306.
    TreeFamiTF315428.

    Family and domain databases

    Gene3Di2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR028732. MMP27.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR021158. Pept_M10A_Zn_BS.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view]
    PANTHERiPTHR10201:SF115. PTHR10201:SF115. 1 hit.
    PfamiPF00045. Hemopexin. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
    PS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 4 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRLLLLFLF FITFSSAFPL VRMTENEENM QLAQAYLNQF YSLEIEGNHL    50
    VQSKNRSLID DKIREMQAFF GLTVTGKLDS NTLEIMKTPR CGVPDVGQYG 100
    YTLPGWRKYN LTYRIINYTP DMARAAVDEA IQEGLEVWSK VTPLKFTKIS 150
    KGIADIMIAF RTRVHGRCPR YFDGPLGVLG HAFPPGPGLG GDTHFDEDEN 200
    WTKDGAGFNL FLVAAHEFGH ALGLSHSNDQ TALMFPNYVS LDPRKYPLSQ 250
    DDINGIQSIY GGLPKEPAKP KEPTIPHACD PDLTFDAITT FRREVMFFKG 300
    RHLWRIYYDI TDVEFELIAS FWPSLPADLQ AAYENPRDKI LVFKDENFWM 350
    IRGYAVLPDY PKSIHTLGFP GRVKKIDAAV CDKTTRKTYF FVGIWCWRFD 400
    EMTQTMDKGF PQRVVKHFPG ISIRVDAAFQ YKGFFFFSRG SKQFEYDIKT 450
    KNITRIMRTN TWFQCKEPKN SSFGFDINKE KAHSGGIKIL YHKSLSLFIF 500
    GIVHLLKNTS IYQ 513
    Length:513
    Mass (Da):59,026
    Last modified:May 18, 2010 - v2
    Checksum:i941D5B8DA55BD32A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221R → W.
    Corresponds to variant rs12099177 [ dbSNP | Ensembl ].
    VAR_032326
    Natural varianti24 – 241T → M.1 Publication
    Corresponds to variant rs1939015 [ dbSNP | Ensembl ].
    VAR_032327
    Natural varianti30 – 301M → V.1 Publication
    Corresponds to variant rs2846707 [ dbSNP | Ensembl ].
    VAR_032328
    Natural varianti266 – 2661E → V.1 Publication
    Corresponds to variant rs1276286 [ dbSNP | Ensembl ].
    VAR_032329
    Natural varianti304 – 3041W → L.
    Corresponds to variant rs35616217 [ dbSNP | Ensembl ].
    VAR_032330
    Natural varianti447 – 4471D → N.1 Publication
    Corresponds to variant rs2509010 [ dbSNP | Ensembl ].
    VAR_032331
    Natural varianti477 – 4771I → V.
    Corresponds to variant rs35822551 [ dbSNP | Ensembl ].
    VAR_032332

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195192 mRNA. Translation: AAG28453.1.
    AY358752 mRNA. Translation: AAQ89112.1.
    AP000647 Genomic DNA. No translation available.
    AP000851 Genomic DNA. No translation available.
    CCDSiCCDS8319.1.
    RefSeqiNP_071405.2. NM_022122.2.
    UniGeneiHs.534479.

    Genome annotation databases

    EnsembliENST00000260229; ENSP00000260229; ENSG00000137675.
    GeneIDi64066.
    KEGGihsa:64066.
    UCSCiuc001phd.1. human.

    Polymorphism databases

    DMDMi296437372.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF195192 mRNA. Translation: AAG28453.1 .
    AY358752 mRNA. Translation: AAQ89112.1 .
    AP000647 Genomic DNA. No translation available.
    AP000851 Genomic DNA. No translation available.
    CCDSi CCDS8319.1.
    RefSeqi NP_071405.2. NM_022122.2.
    UniGenei Hs.534479.

    3D structure databases

    ProteinModelPortali Q9H306.
    SMRi Q9H306. Positions 30-465.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M10.027.

    PTM databases

    PhosphoSitei Q9H306.

    Polymorphism databases

    DMDMi 296437372.

    Proteomic databases

    PaxDbi Q9H306.
    PRIDEi Q9H306.

    Protocols and materials databases

    DNASUi 64066.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260229 ; ENSP00000260229 ; ENSG00000137675 .
    GeneIDi 64066.
    KEGGi hsa:64066.
    UCSCi uc001phd.1. human.

    Organism-specific databases

    CTDi 64066.
    GeneCardsi GC11M102596.
    H-InvDB HIX0201706.
    HGNCi HGNC:14250. MMP27.
    neXtProti NX_Q9H306.
    PharmGKBi PA30884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260291.
    HOGENOMi HOG000217927.
    HOVERGENi HBG052484.
    InParanoidi Q9H306.
    KOi K08005.
    OMAi QFYSLEI.
    OrthoDBi EOG7XPZ57.
    PhylomeDBi Q9H306.
    TreeFami TF315428.

    Miscellaneous databases

    GeneWikii MMP27.
    GenomeRNAii 64066.
    NextBioi 65838.
    PROi Q9H306.

    Gene expression databases

    Bgeei Q9H306.
    CleanExi HS_MMP27.
    Genevestigatori Q9H306.

    Family and domain databases

    Gene3Di 2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR018486. Hemopexin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR028732. MMP27.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR021158. Pept_M10A_Zn_BS.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view ]
    PANTHERi PTHR10201:SF115. PTHR10201:SF115. 1 hit.
    Pfami PF00045. Hemopexin. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEi PS00546. CYSTEINE_SWITCH. 1 hit.
    PS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 4 hits.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel matrix metalloproteinase homologous to stromelysins."
      Benoit de Coignac A., Elson G., Magistrelli G., Jeannin P., Delneste Y., Aubry J.-P., Berthier O., Bonnefoy J.-Y., Gauchat J.-F.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MET-24 AND VAL-30.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-266 AND ASN-447.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis."
      Bar-Or A., Nuttall R.K., Duddy M., Alter A., Kim H.J., Ifergan I., Pennington C.J., Bourgoin P., Edwards D.R., Yong V.W.
      Brain 126:2738-2749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMMP27_HUMAN
    AccessioniPrimary (citable) accession number: Q9H306
    Secondary accession number(s): Q6UWK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3