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Protein

Cell death-inducing p53-target protein 1

Gene

CDIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.1 Publication

GO - Biological processi

  • apoptotic process Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • tumor necrosis factor-mediated signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death-inducing p53-target protein 1
Alternative name(s):
Cell death involved p53-target
Cell death-inducing protein
LITAF-like protein
Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein
Transmembrane protein I1
Gene namesi
Name:CDIP1
Synonyms:C16orf5, CDIP, LITAFL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13234. CDIP1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879441.

Polymorphism and mutation databases

BioMutaiCDIP1.
DMDMi74733567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Cell death-inducing p53-target protein 1PRO_0000280336Add
BLAST

Proteomic databases

MaxQBiQ9H305.
PaxDbiQ9H305.
PRIDEiQ9H305.

PTM databases

PhosphoSiteiQ9H305.

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung.1 Publication

Inductioni

Up-regulated by p53/TP53.1 Publication

Gene expression databases

BgeeiQ9H305.
CleanExiHS_C16orf5.
ExpressionAtlasiQ9H305. baseline and differential.
GenevisibleiQ9H305. HS.

Organism-specific databases

HPAiHPA049352.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNIP1Q150254EBI-2876678,EBI-357849

Protein-protein interaction databases

BioGridi118998. 2 interactions.
IntActiQ9H305. 4 interactions.
STRINGi9606.ENSP00000382508.

Structurei

3D structure databases

ProteinModelPortaliQ9H305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 108104Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CDIP1/LITAF family.Curated

Phylogenomic databases

eggNOGiNOG82337.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039586.
HOVERGENiHBG006272.
InParanoidiQ9H305.
OMAiGFIPPHV.
OrthoDBiEOG7XH6RR.
PhylomeDBiQ9H305.
TreeFamiTF313294.

Family and domain databases

InterProiIPR006629. LITAF.
[Graphical view]
PfamiPF10601. zf-LITAF-like. 1 hit.
[Graphical view]
SMARTiSM00714. LITAF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG
60 70 80 90 100
PPPYEPPGHP MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY
110 120 130 140 150
TPGPYPGPGG HTATVLVPSG AATTVTVLQG EIFEGAPVQT VCPHCQQAIT
160 170 180 190 200
TKISYEIGLM NFVLGFFCCF MGCDLGCCLI PCLINDFKDV THTCPSCKAY

IYTYKRLC
Length:208
Mass (Da):21,892
Last modified:March 1, 2001 - v1
Checksum:i6C7334668A3C15A7
GO
Isoform 2 (identifier: Q9H305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-120: Missing.

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:169
Mass (Da):17,935
Checksum:iC7B4A5D61FFCCC08
GO
Isoform 3 (identifier: Q9H305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-120: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):13,763
Checksum:iCEADF14389C46703
GO

Sequence cautioni

The sequence AAF26619.1 differs from that shown. Reason: Frameshift at position 200. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501T → A in CAB66633 (PubMed:11230166).Curated
Sequence conflicti150 – 1501T → A in CAG38477 (Ref. 5) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 12079Missing in isoform 3. 1 PublicationVSP_046928Add
BLAST
Alternative sequencei82 – 12039Missing in isoform 2. 1 PublicationVSP_046929Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131218 mRNA. Translation: AAF26619.1. Frameshift.
AF195661 mRNA. Translation: AAG35583.1.
DQ167023 mRNA. Translation: AAZ94626.1.
AL136698 mRNA. Translation: CAB66633.1.
CR533446 mRNA. Translation: CAG38477.1.
AK292036 mRNA. Translation: BAF84725.1.
AK294257 mRNA. Translation: BAG57552.1.
AK302297 mRNA. Translation: BAG63637.1.
AL833853 mRNA. Translation: CAD38712.1.
AC007606 Genomic DNA. No translation available.
AC023830 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85291.1.
CH471112 Genomic DNA. Translation: EAW85292.1.
CH471112 Genomic DNA. Translation: EAW85293.1.
CH471112 Genomic DNA. Translation: EAW85294.1.
CH471112 Genomic DNA. Translation: EAW85296.1.
BC002882 mRNA. Translation: AAH02882.1.
BC007604 mRNA. Translation: AAH07604.1.
CCDSiCCDS42114.1. [Q9H305-1]
CCDS58419.1. [Q9H305-2]
CCDS58420.1. [Q9H305-3]
RefSeqiNP_001185983.1. NM_001199054.1. [Q9H305-1]
NP_001185984.1. NM_001199055.1. [Q9H305-2]
NP_001185985.1. NM_001199056.1. [Q9H305-3]
NP_037531.2. NM_013399.2. [Q9H305-1]
XP_011520770.1. XM_011522468.1. [Q9H305-1]
UniGeneiHs.654653.

Genome annotation databases

EnsembliENST00000399599; ENSP00000382508; ENSG00000089486.
ENST00000562334; ENSP00000455050; ENSG00000089486. [Q9H305-3]
ENST00000563332; ENSP00000454994; ENSG00000089486.
ENST00000563507; ENSP00000455462; ENSG00000089486. [Q9H305-2]
ENST00000567695; ENSP00000457877; ENSG00000089486.
ENST00000611166; ENSP00000480842; ENSG00000274336.
GeneIDi29965.
KEGGihsa:29965.
UCSCiuc002cwu.3. human. [Q9H305-1]
uc010uxl.2. human.
uc010uxm.2. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131218 mRNA. Translation: AAF26619.1. Frameshift.
AF195661 mRNA. Translation: AAG35583.1.
DQ167023 mRNA. Translation: AAZ94626.1.
AL136698 mRNA. Translation: CAB66633.1.
CR533446 mRNA. Translation: CAG38477.1.
AK292036 mRNA. Translation: BAF84725.1.
AK294257 mRNA. Translation: BAG57552.1.
AK302297 mRNA. Translation: BAG63637.1.
AL833853 mRNA. Translation: CAD38712.1.
AC007606 Genomic DNA. No translation available.
AC023830 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85291.1.
CH471112 Genomic DNA. Translation: EAW85292.1.
CH471112 Genomic DNA. Translation: EAW85293.1.
CH471112 Genomic DNA. Translation: EAW85294.1.
CH471112 Genomic DNA. Translation: EAW85296.1.
BC002882 mRNA. Translation: AAH02882.1.
BC007604 mRNA. Translation: AAH07604.1.
CCDSiCCDS42114.1. [Q9H305-1]
CCDS58419.1. [Q9H305-2]
CCDS58420.1. [Q9H305-3]
RefSeqiNP_001185983.1. NM_001199054.1. [Q9H305-1]
NP_001185984.1. NM_001199055.1. [Q9H305-2]
NP_001185985.1. NM_001199056.1. [Q9H305-3]
NP_037531.2. NM_013399.2. [Q9H305-1]
XP_011520770.1. XM_011522468.1. [Q9H305-1]
UniGeneiHs.654653.

3D structure databases

ProteinModelPortaliQ9H305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118998. 2 interactions.
IntActiQ9H305. 4 interactions.
STRINGi9606.ENSP00000382508.

PTM databases

PhosphoSiteiQ9H305.

Polymorphism and mutation databases

BioMutaiCDIP1.
DMDMi74733567.

Proteomic databases

MaxQBiQ9H305.
PaxDbiQ9H305.
PRIDEiQ9H305.

Protocols and materials databases

DNASUi29965.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399599; ENSP00000382508; ENSG00000089486.
ENST00000562334; ENSP00000455050; ENSG00000089486. [Q9H305-3]
ENST00000563332; ENSP00000454994; ENSG00000089486.
ENST00000563507; ENSP00000455462; ENSG00000089486. [Q9H305-2]
ENST00000567695; ENSP00000457877; ENSG00000089486.
ENST00000611166; ENSP00000480842; ENSG00000274336.
GeneIDi29965.
KEGGihsa:29965.
UCSCiuc002cwu.3. human. [Q9H305-1]
uc010uxl.2. human.
uc010uxm.2. human.

Organism-specific databases

CTDi29965.
GeneCardsiGC16M004560.
HGNCiHGNC:13234. CDIP1.
HPAiHPA049352.
MIMi610503. gene.
neXtProtiNX_Q9H305.
PharmGKBiPA134879441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG82337.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039586.
HOVERGENiHBG006272.
InParanoidiQ9H305.
OMAiGFIPPHV.
OrthoDBiEOG7XH6RR.
PhylomeDBiQ9H305.
TreeFamiTF313294.

Miscellaneous databases

GenomeRNAii29965.
NextBioi52691.
PROiQ9H305.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H305.
CleanExiHS_C16orf5.
ExpressionAtlasiQ9H305. baseline and differential.
GenevisibleiQ9H305. HS.

Family and domain databases

InterProiIPR006629. LITAF.
[Graphical view]
PfamiPF10601. zf-LITAF-like. 1 hit.
[Graphical view]
SMARTiSM00714. LITAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain."
    Bhalla K., Eyre H.J., Whitmore S.A., Sutherland G.R., Callen D.F.
    J. Hum. Genet. 44:383-387(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Cloning a novel human cDNA encoding a novel transmembrane protein."
    Zhou Y., Du G., Wang J., Yuan J., Qiang B.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner."
    Brown L., Ongusaha P.P., Kim H.G., Nuti S., Mandinova A., Lee J.W., Khosravi-Far R., Aaronson S.A., Lee S.W.
    EMBO J. 26:3410-3422(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, FUNCTION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Amygdala, Spleen and Testis.
  7. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Lung.

Entry informationi

Entry nameiCDIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H305
Secondary accession number(s): A8K7M1
, B4DFU1, B4DY75, D3DUD6, Q96ID8, Q9H0Q4, Q9P112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.