Q9H305 (CDIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell death-inducing p53-target protein 1

Alternative name(s):
Cell death involved p53-target
Cell death-inducing protein
LITAF-like protein
Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein
Transmembrane protein I1

Gene names

Name:	CDIP1
Synonyms:	C16orf5, CDIP, LITAFL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. Ref.3
Tissue specificity	Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung. Ref.1
Induction	Up-regulated by p53/TP53. Ref.3
Sequence similarities	Belongs to the CDIP1 family.
Sequence caution	The sequence AAF26619.1 differs from that shown. Reason: Frameshift at position 200.

Ontologies

Keywords
Biological process	Apoptosis
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	induction of apoptosis Inferred from direct assay Ref.3. Source: MGI intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Inferred from mutant phenotype Ref.3. Source: MGI tumor necrosis factor-mediated signaling pathway Inferred from genetic interaction Ref.3. Source: MGI
Cellular_component	nucleus Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Cell death-inducing p53-target protein 1		PRO_0000280336
Regions
	Compositional bias	5 – 108	104	Pro-rich
Experimental info
	Sequence conflict	150	1	T → A in CAB66633. Ref.4
	Sequence conflict	150	1	T → A in CAG38477. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9H305 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6C7334668A3C15A7	FASTA	208	21,892
	10 20 30 40 50 60 MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG PPPYEPPGHP 70 80 90 100 110 120 MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY TPGPYPGPGG HTATVLVPSG 130 140 150 160 170 180 AATTVTVLQG EIFEGAPVQT VCPHCQQAIT TKISYEIGLM NFVLGFFCCF MGCDLGCCLI 190 200 PCLINDFKDV THTCPSCKAY IYTYKRLC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain." Bhalla K., Eyre H.J., Whitmore S.A., Sutherland G.R., Callen D.F. J. Hum. Genet. 44:383-387(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Cloning a novel human cDNA encoding a novel transmembrane protein." Zhou Y., Du G., Wang J., Yuan J., Qiang B. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner." Brown L., Ongusaha P.P., Kim H.G., Nuti S., Mandinova A., Lee J.W., Khosravi-Far R., Aaronson S.A., Lee S.W. EMBO J. 26:3410-3422(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION.
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[7]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF131218 mRNA. Translation: AAF26619.1. Frameshift. AF195661 mRNA. Translation: AAG35583.1. DQ167023 mRNA. Translation: AAZ94626.1. CR533446 mRNA. Translation: CAG38477.1. AL136698 mRNA. Translation: CAB66633.1. AK292036 mRNA. Translation: BAF84725.1. AL833853 mRNA. Translation: CAD38712.1. AC007606 Genomic DNA. No translation available. AC023830 Genomic DNA. No translation available. CH471112 Genomic DNA. Translation: EAW85291.1. CH471112 Genomic DNA. Translation: EAW85292.1. CH471112 Genomic DNA. Translation: EAW85293.1. CH471112 Genomic DNA. Translation: EAW85294.1. CH471112 Genomic DNA. Translation: EAW85296.1. BC002882 mRNA. Translation: AAH02882.1. BC007604 mRNA. Translation: AAH07604.1.
IPI	IPI00003012.
RefSeq	NP_001185983.1. NM_001199054.1. NP_037531.2. NM_013399.2.
UniGene	Hs.654653.
3D structure databases
ProteinModelPortal	Q9H305.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H305. 3 interactions.
PTM databases
PhosphoSite	Q9H305.
Polymorphism databases
DMDM	74733567.
Proteomic databases
PaxDb	Q9H305.
PRIDE	Q9H305.
Protocols and materials databases
DNASU	29965.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000399599; ENSP00000382508; ENSG00000089486. ENST00000563332; ENSP00000454994; ENSG00000089486. ENST00000567695; ENSP00000457877; ENSG00000089486.
GeneID	29965.
KEGG	hsa:29965.
UCSC	uc002cwu.3. human.
Organism-specific databases
CTD	29965.
GeneCards	GC16M004500.
HGNC	HGNC:13234. CDIP1.
HPA	HPA049352.
MIM	610503. gene.
neXtProt	NX_Q9H305.
PharmGKB	PA134879441.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82337.
HOGENOM	HOG000039586.
HOVERGEN	HBG006272.
OMA	RTSPAVM.
Gene expression databases
ArrayExpress	Q9H305.
Bgee	Q9H305.
CleanEx	HS_C16orf5.
Genevestigator	Q9H305.
Family and domain databases
InterPro	IPR006629. LITAF. [Graphical view]
Pfam	PF10601. zf-LITAF-like. 1 hit. [Graphical view]
SMART	SM00714. LITAF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29965.
NextBio	52691.
SOURCE	Search...

Entry information

Entry name

CDIP1_HUMAN

Accession

Primary (citable) accession number: Q9H305
Secondary accession number(s): A8K7M1 , D3DUD6, Q96ID8, Q9H0Q4, Q9P112

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.