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Q9H305

- CDIP1_HUMAN

UniProt

Q9H305 - CDIP1_HUMAN

Protein

Cell death-inducing p53-target protein 1

Gene

CDIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.1 Publication

    GO - Biological processi

    1. apoptotic process Source: MGI
    2. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
    3. tumor necrosis factor-mediated signaling pathway Source: MGI

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell death-inducing p53-target protein 1
    Alternative name(s):
    Cell death involved p53-target
    Cell death-inducing protein
    LITAF-like protein
    Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein
    Transmembrane protein I1
    Gene namesi
    Name:CDIP1
    Synonyms:C16orf5, CDIP, LITAFL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13234. CDIP1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879441.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Cell death-inducing p53-target protein 1PRO_0000280336Add
    BLAST

    Proteomic databases

    MaxQBiQ9H305.
    PaxDbiQ9H305.
    PRIDEiQ9H305.

    PTM databases

    PhosphoSiteiQ9H305.

    Expressioni

    Tissue specificityi

    Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung.1 Publication

    Inductioni

    Up-regulated by p53/TP53.1 Publication

    Gene expression databases

    ArrayExpressiQ9H305.
    BgeeiQ9H305.
    CleanExiHS_C16orf5.
    GenevestigatoriQ9H305.

    Organism-specific databases

    HPAiHPA049352.

    Interactioni

    Protein-protein interaction databases

    BioGridi118998. 2 interactions.
    IntActiQ9H305. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 108104Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CDIP1/LITAF family.Curated

    Phylogenomic databases

    eggNOGiNOG82337.
    HOGENOMiHOG000039586.
    HOVERGENiHBG006272.
    OMAiGFIPPHV.
    OrthoDBiEOG7XH6RR.
    PhylomeDBiQ9H305.
    TreeFamiTF313294.

    Family and domain databases

    InterProiIPR006629. LITAF.
    [Graphical view]
    PfamiPF10601. zf-LITAF-like. 1 hit.
    [Graphical view]
    SMARTiSM00714. LITAF. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H305-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG    50
    PPPYEPPGHP MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY 100
    TPGPYPGPGG HTATVLVPSG AATTVTVLQG EIFEGAPVQT VCPHCQQAIT 150
    TKISYEIGLM NFVLGFFCCF MGCDLGCCLI PCLINDFKDV THTCPSCKAY 200
    IYTYKRLC 208
    Length:208
    Mass (Da):21,892
    Last modified:March 1, 2001 - v1
    Checksum:i6C7334668A3C15A7
    GO
    Isoform 2 (identifier: Q9H305-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-120: Missing.

    Note: No experimental confirmation available. May be due to competing acceptor splice site.

    Show »
    Length:169
    Mass (Da):17,935
    Checksum:iC7B4A5D61FFCCC08
    GO
    Isoform 3 (identifier: Q9H305-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-120: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:129
    Mass (Da):13,763
    Checksum:iCEADF14389C46703
    GO

    Sequence cautioni

    The sequence AAF26619.1 differs from that shown. Reason: Frameshift at position 200.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501T → A in CAB66633. (PubMed:11230166)Curated
    Sequence conflicti150 – 1501T → A in CAG38477. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 12079Missing in isoform 3. 1 PublicationVSP_046928Add
    BLAST
    Alternative sequencei82 – 12039Missing in isoform 2. 1 PublicationVSP_046929Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF131218 mRNA. Translation: AAF26619.1. Frameshift.
    AF195661 mRNA. Translation: AAG35583.1.
    DQ167023 mRNA. Translation: AAZ94626.1.
    AL136698 mRNA. Translation: CAB66633.1.
    CR533446 mRNA. Translation: CAG38477.1.
    AK292036 mRNA. Translation: BAF84725.1.
    AK294257 mRNA. Translation: BAG57552.1.
    AK302297 mRNA. Translation: BAG63637.1.
    AL833853 mRNA. Translation: CAD38712.1.
    AC007606 Genomic DNA. No translation available.
    AC023830 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85291.1.
    CH471112 Genomic DNA. Translation: EAW85292.1.
    CH471112 Genomic DNA. Translation: EAW85293.1.
    CH471112 Genomic DNA. Translation: EAW85294.1.
    CH471112 Genomic DNA. Translation: EAW85296.1.
    BC002882 mRNA. Translation: AAH02882.1.
    BC007604 mRNA. Translation: AAH07604.1.
    CCDSiCCDS42114.1. [Q9H305-1]
    CCDS58419.1. [Q9H305-2]
    CCDS58420.1. [Q9H305-3]
    RefSeqiNP_001185983.1. NM_001199054.1. [Q9H305-1]
    NP_001185984.1. NM_001199055.1. [Q9H305-2]
    NP_001185985.1. NM_001199056.1. [Q9H305-3]
    NP_037531.2. NM_013399.2. [Q9H305-1]
    UniGeneiHs.654653.

    Genome annotation databases

    EnsembliENST00000399599; ENSP00000382508; ENSG00000089486. [Q9H305-1]
    ENST00000562334; ENSP00000455050; ENSG00000089486. [Q9H305-3]
    ENST00000563332; ENSP00000454994; ENSG00000089486. [Q9H305-1]
    ENST00000563507; ENSP00000455462; ENSG00000089486. [Q9H305-2]
    ENST00000567695; ENSP00000457877; ENSG00000089486. [Q9H305-1]
    GeneIDi29965.
    KEGGihsa:29965.
    UCSCiuc002cwu.3. human. [Q9H305-1]

    Polymorphism databases

    DMDMi74733567.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF131218 mRNA. Translation: AAF26619.1 . Frameshift.
    AF195661 mRNA. Translation: AAG35583.1 .
    DQ167023 mRNA. Translation: AAZ94626.1 .
    AL136698 mRNA. Translation: CAB66633.1 .
    CR533446 mRNA. Translation: CAG38477.1 .
    AK292036 mRNA. Translation: BAF84725.1 .
    AK294257 mRNA. Translation: BAG57552.1 .
    AK302297 mRNA. Translation: BAG63637.1 .
    AL833853 mRNA. Translation: CAD38712.1 .
    AC007606 Genomic DNA. No translation available.
    AC023830 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85291.1 .
    CH471112 Genomic DNA. Translation: EAW85292.1 .
    CH471112 Genomic DNA. Translation: EAW85293.1 .
    CH471112 Genomic DNA. Translation: EAW85294.1 .
    CH471112 Genomic DNA. Translation: EAW85296.1 .
    BC002882 mRNA. Translation: AAH02882.1 .
    BC007604 mRNA. Translation: AAH07604.1 .
    CCDSi CCDS42114.1. [Q9H305-1 ]
    CCDS58419.1. [Q9H305-2 ]
    CCDS58420.1. [Q9H305-3 ]
    RefSeqi NP_001185983.1. NM_001199054.1. [Q9H305-1 ]
    NP_001185984.1. NM_001199055.1. [Q9H305-2 ]
    NP_001185985.1. NM_001199056.1. [Q9H305-3 ]
    NP_037531.2. NM_013399.2. [Q9H305-1 ]
    UniGenei Hs.654653.

    3D structure databases

    ProteinModelPortali Q9H305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118998. 2 interactions.
    IntActi Q9H305. 4 interactions.

    PTM databases

    PhosphoSitei Q9H305.

    Polymorphism databases

    DMDMi 74733567.

    Proteomic databases

    MaxQBi Q9H305.
    PaxDbi Q9H305.
    PRIDEi Q9H305.

    Protocols and materials databases

    DNASUi 29965.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399599 ; ENSP00000382508 ; ENSG00000089486 . [Q9H305-1 ]
    ENST00000562334 ; ENSP00000455050 ; ENSG00000089486 . [Q9H305-3 ]
    ENST00000563332 ; ENSP00000454994 ; ENSG00000089486 . [Q9H305-1 ]
    ENST00000563507 ; ENSP00000455462 ; ENSG00000089486 . [Q9H305-2 ]
    ENST00000567695 ; ENSP00000457877 ; ENSG00000089486 . [Q9H305-1 ]
    GeneIDi 29965.
    KEGGi hsa:29965.
    UCSCi uc002cwu.3. human. [Q9H305-1 ]

    Organism-specific databases

    CTDi 29965.
    GeneCardsi GC16M004560.
    HGNCi HGNC:13234. CDIP1.
    HPAi HPA049352.
    MIMi 610503. gene.
    neXtProti NX_Q9H305.
    PharmGKBi PA134879441.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82337.
    HOGENOMi HOG000039586.
    HOVERGENi HBG006272.
    OMAi GFIPPHV.
    OrthoDBi EOG7XH6RR.
    PhylomeDBi Q9H305.
    TreeFami TF313294.

    Miscellaneous databases

    GenomeRNAii 29965.
    NextBioi 52691.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H305.
    Bgeei Q9H305.
    CleanExi HS_C16orf5.
    Genevestigatori Q9H305.

    Family and domain databases

    InterProi IPR006629. LITAF.
    [Graphical view ]
    Pfami PF10601. zf-LITAF-like. 1 hit.
    [Graphical view ]
    SMARTi SM00714. LITAF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain."
      Bhalla K., Eyre H.J., Whitmore S.A., Sutherland G.R., Callen D.F.
      J. Hum. Genet. 44:383-387(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Cloning a novel human cDNA encoding a novel transmembrane protein."
      Zhou Y., Du G., Wang J., Yuan J., Qiang B.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner."
      Brown L., Ongusaha P.P., Kim H.G., Nuti S., Mandinova A., Lee J.W., Khosravi-Far R., Aaronson S.A., Lee S.W.
      EMBO J. 26:3410-3422(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, FUNCTION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Amygdala, Spleen and Testis.
    7. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Lung.

    Entry informationi

    Entry nameiCDIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H305
    Secondary accession number(s): A8K7M1
    , B4DFU1, B4DY75, D3DUD6, Q96ID8, Q9H0Q4, Q9P112
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3