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Q9H305 (CDIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell death-inducing p53-target protein 1
Alternative name(s):
Cell death involved p53-target
Cell death-inducing protein
LITAF-like protein
Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein
Transmembrane protein I1
Gene names
Name:CDIP1
Synonyms:C16orf5, CDIP, LITAFL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. Ref.3

Tissue specificity

Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung. Ref.1

Induction

Up-regulated by p53/TP53. Ref.3

Sequence similarities

Belongs to the CDIP1/LITAF family.

Sequence caution

The sequence AAF26619.1 differs from that shown. Reason: Frameshift at position 200.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H305-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H305-2)

The sequence of this isoform differs from the canonical sequence as follows:
     82-120: Missing.
Note: No experimental confirmation available. May be due to competing acceptor splice site.
Isoform 3 (identifier: Q9H305-3)

The sequence of this isoform differs from the canonical sequence as follows:
     42-120: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Cell death-inducing p53-target protein 1
PRO_0000280336

Regions

Compositional bias5 – 108104Pro-rich

Natural variations

Alternative sequence42 – 12079Missing in isoform 3.
VSP_046928
Alternative sequence82 – 12039Missing in isoform 2.
VSP_046929

Experimental info

Sequence conflict1501T → A in CAB66633. Ref.4
Sequence conflict1501T → A in CAG38477. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 6C7334668A3C15A7

FASTA20821,892
        10         20         30         40         50         60 
MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG PPPYEPPGHP 

        70         80         90        100        110        120 
MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY TPGPYPGPGG HTATVLVPSG 

       130        140        150        160        170        180 
AATTVTVLQG EIFEGAPVQT VCPHCQQAIT TKISYEIGLM NFVLGFFCCF MGCDLGCCLI 

       190        200 
PCLINDFKDV THTCPSCKAY IYTYKRLC 

« Hide

Isoform 2 [UniParc].

Checksum: C7B4A5D61FFCCC08
Show »

FASTA16917,935
Isoform 3 [UniParc].

Checksum: CEADF14389C46703
Show »

FASTA12913,763

References

« Hide 'large scale' references
[1]"C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain."
Bhalla K., Eyre H.J., Whitmore S.A., Sutherland G.R., Callen D.F.
J. Hum. Genet. 44:383-387(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Cloning a novel human cDNA encoding a novel transmembrane protein."
Zhou Y., Du G., Wang J., Yuan J., Qiang B.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner."
Brown L., Ongusaha P.P., Kim H.G., Nuti S., Mandinova A., Lee J.W., Khosravi-Far R., Aaronson S.A., Lee S.W.
EMBO J. 26:3410-3422(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, FUNCTION.
[4]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Amygdala, Spleen and Testis.
[7]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Amygdala.
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye and Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF131218 mRNA. Translation: AAF26619.1. Frameshift.
AF195661 mRNA. Translation: AAG35583.1.
DQ167023 mRNA. Translation: AAZ94626.1.
AL136698 mRNA. Translation: CAB66633.1.
CR533446 mRNA. Translation: CAG38477.1.
AK292036 mRNA. Translation: BAF84725.1.
AK294257 mRNA. Translation: BAG57552.1.
AK302297 mRNA. Translation: BAG63637.1.
AL833853 mRNA. Translation: CAD38712.1.
AC007606 Genomic DNA. No translation available.
AC023830 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85291.1.
CH471112 Genomic DNA. Translation: EAW85292.1.
CH471112 Genomic DNA. Translation: EAW85293.1.
CH471112 Genomic DNA. Translation: EAW85294.1.
CH471112 Genomic DNA. Translation: EAW85296.1.
BC002882 mRNA. Translation: AAH02882.1.
BC007604 mRNA. Translation: AAH07604.1.
CCDSCCDS42114.1. [Q9H305-1]
CCDS58419.1. [Q9H305-2]
CCDS58420.1. [Q9H305-3]
RefSeqNP_001185983.1. NM_001199054.1. [Q9H305-1]
NP_001185984.1. NM_001199055.1. [Q9H305-2]
NP_001185985.1. NM_001199056.1. [Q9H305-3]
NP_037531.2. NM_013399.2. [Q9H305-1]
UniGeneHs.654653.

3D structure databases

ProteinModelPortalQ9H305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118998. 2 interactions.
IntActQ9H305. 4 interactions.

PTM databases

PhosphoSiteQ9H305.

Polymorphism databases

DMDM74733567.

Proteomic databases

MaxQBQ9H305.
PaxDbQ9H305.
PRIDEQ9H305.

Protocols and materials databases

DNASU29965.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399599; ENSP00000382508; ENSG00000089486. [Q9H305-1]
ENST00000562334; ENSP00000455050; ENSG00000089486. [Q9H305-3]
ENST00000563332; ENSP00000454994; ENSG00000089486. [Q9H305-1]
ENST00000563507; ENSP00000455462; ENSG00000089486. [Q9H305-2]
ENST00000567695; ENSP00000457877; ENSG00000089486. [Q9H305-1]
GeneID29965.
KEGGhsa:29965.
UCSCuc002cwu.3. human. [Q9H305-1]

Organism-specific databases

CTD29965.
GeneCardsGC16M004560.
HGNCHGNC:13234. CDIP1.
HPAHPA049352.
MIM610503. gene.
neXtProtNX_Q9H305.
PharmGKBPA134879441.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82337.
HOGENOMHOG000039586.
HOVERGENHBG006272.
OMAGFIPPHV.
OrthoDBEOG7XH6RR.
PhylomeDBQ9H305.
TreeFamTF313294.

Gene expression databases

ArrayExpressQ9H305.
BgeeQ9H305.
CleanExHS_C16orf5.
GenevestigatorQ9H305.

Family and domain databases

InterProIPR006629. LITAF.
[Graphical view]
PfamPF10601. zf-LITAF-like. 1 hit.
[Graphical view]
SMARTSM00714. LITAF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi29965.
NextBio52691.
SOURCESearch...

Entry information

Entry nameCDIP1_HUMAN
AccessionPrimary (citable) accession number: Q9H305
Secondary accession number(s): A8K7M1 expand/collapse secondary AC list , B4DFU1, B4DY75, D3DUD6, Q96ID8, Q9H0Q4, Q9P112
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM