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Protein

Cell death-inducing p53-target protein 1

Gene

CDIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.1 Publication

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi142ZincBy similarity1
Metal bindingi145ZincBy similarity1
Metal bindingi194ZincBy similarity1
Metal bindingi197ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • tumor necrosis factor-mediated signaling pathway Source: MGI

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death-inducing p53-target protein 1
Alternative name(s):
Cell death involved p53-target
Cell death-inducing protein
LITAF-like protein
Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein
Transmembrane protein I1
Gene namesi
Name:CDIP1
Synonyms:C16orf5, CDIP, LITAFL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000089486.16
HGNCiHGNC:13234 CDIP1
MIMi610503 gene
neXtProtiNX_Q9H305

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29965
OpenTargetsiENSG00000089486
PharmGKBiPA134879441

Polymorphism and mutation databases

BioMutaiCDIP1
DMDMi74733567

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803361 – 208Cell death-inducing p53-target protein 1Add BLAST208

Proteomic databases

MaxQBiQ9H305
PaxDbiQ9H305
PeptideAtlasiQ9H305
PRIDEiQ9H305

PTM databases

iPTMnetiQ9H305
PhosphoSitePlusiQ9H305
SwissPalmiQ9H305

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung.1 Publication

Inductioni

Up-regulated by p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000089486
CleanExiHS_C16orf5
ExpressionAtlasiQ9H305 baseline and differential
GenevisibleiQ9H305 HS

Organism-specific databases

HPAiHPA049352

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNIP1Q150254EBI-2876678,EBI-357849

Protein-protein interaction databases

BioGridi1189983 interactors.
IntActiQ9H305 15 interactors.
MINTiQ9H305
STRINGi9606.ENSP00000382508

Structurei

3D structure databases

ProteinModelPortaliQ9H305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 206LITAFPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 184Membrane-binding amphipathic helixCuratedAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 108Pro-richAdd BLAST104

Domaini

The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphiphatic helix that mediates interaction with lipid membranes.By similarity

Sequence similaritiesi

Belongs to the CDIP1/LITAF family.Curated

Phylogenomic databases

eggNOGiENOG410IXMF Eukaryota
ENOG4111SC9 LUCA
GeneTreeiENSGT00540000071542
HOGENOMiHOG000039586
HOVERGENiHBG006272
InParanoidiQ9H305
OMAiVTHTCPN
OrthoDBiEOG091G0XNM
PhylomeDBiQ9H305
TreeFamiTF313294

Family and domain databases

InterProiView protein in InterPro
IPR006629 LITAF
IPR037519 LITAF_fam
PANTHERiPTHR23292 PTHR23292, 1 hit
PfamiView protein in Pfam
PF10601 zf-LITAF-like, 1 hit
SMARTiView protein in SMART
SM00714 LITAF, 1 hit
PROSITEiView protein in PROSITE
PS51837 LITAF, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG
60 70 80 90 100
PPPYEPPGHP MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY
110 120 130 140 150
TPGPYPGPGG HTATVLVPSG AATTVTVLQG EIFEGAPVQT VCPHCQQAIT
160 170 180 190 200
TKISYEIGLM NFVLGFFCCF MGCDLGCCLI PCLINDFKDV THTCPSCKAY

IYTYKRLC
Length:208
Mass (Da):21,892
Last modified:March 1, 2001 - v1
Checksum:i6C7334668A3C15A7
GO
Isoform 2 (identifier: Q9H305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-120: Missing.

Note: No experimental confirmation available. May be due to competing acceptor splice site.
Show »
Length:169
Mass (Da):17,935
Checksum:iC7B4A5D61FFCCC08
GO
Isoform 3 (identifier: Q9H305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-120: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):13,763
Checksum:iCEADF14389C46703
GO

Sequence cautioni

The sequence AAF26619 differs from that shown. Reason: Frameshift at position 200.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150T → A in CAB66633 (PubMed:11230166).Curated1
Sequence conflicti150T → A in CAG38477 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04692842 – 120Missing in isoform 3. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_04692982 – 120Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131218 mRNA Translation: AAF26619.1 Frameshift.
AF195661 mRNA Translation: AAG35583.1
DQ167023 mRNA Translation: AAZ94626.1
AL136698 mRNA Translation: CAB66633.1
CR533446 mRNA Translation: CAG38477.1
AK292036 mRNA Translation: BAF84725.1
AK294257 mRNA Translation: BAG57552.1
AK302297 mRNA Translation: BAG63637.1
AL833853 mRNA Translation: CAD38712.1
AC007606 Genomic DNA No translation available.
AC023830 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85291.1
CH471112 Genomic DNA Translation: EAW85292.1
CH471112 Genomic DNA Translation: EAW85293.1
CH471112 Genomic DNA Translation: EAW85294.1
CH471112 Genomic DNA Translation: EAW85296.1
BC002882 mRNA Translation: AAH02882.1
BC007604 mRNA Translation: AAH07604.1
CCDSiCCDS42114.1 [Q9H305-1]
CCDS58419.1 [Q9H305-2]
CCDS58420.1 [Q9H305-3]
RefSeqiNP_001185983.1, NM_001199054.1 [Q9H305-1]
NP_001185984.1, NM_001199055.1 [Q9H305-2]
NP_001185985.1, NM_001199056.1 [Q9H305-3]
NP_037531.2, NM_013399.2 [Q9H305-1]
UniGeneiHs.654653

Genome annotation databases

EnsembliENST00000399599; ENSP00000382508; ENSG00000089486 [Q9H305-1]
ENST00000562334; ENSP00000455050; ENSG00000089486 [Q9H305-3]
ENST00000563332; ENSP00000454994; ENSG00000089486 [Q9H305-1]
ENST00000563507; ENSP00000455462; ENSG00000089486 [Q9H305-2]
ENST00000567695; ENSP00000457877; ENSG00000089486 [Q9H305-1]
ENST00000611166; ENSP00000480842; ENSG00000274336 [Q9H305-1]
ENST00000631859; ENSP00000488843; ENSG00000274336 [Q9H305-3]
ENST00000632680; ENSP00000488474; ENSG00000274336 [Q9H305-1]
ENST00000632937; ENSP00000488066; ENSG00000274336 [Q9H305-1]
ENST00000633324; ENSP00000487657; ENSG00000274336 [Q9H305-2]
GeneIDi29965
KEGGihsa:29965
UCSCiuc002cwu.4 human [Q9H305-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H305
Secondary accession number(s): A8K7M1
, B4DFU1, B4DY75, D3DUD6, Q96ID8, Q9H0Q4, Q9P112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome