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Protein

Homeobox protein Nkx-2.4

Gene

NKX2-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi189 – 248HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.4
Alternative name(s):
Homeobox protein NK-2 homolog D
Gene namesi
Name:NKX2-4
Synonyms:NKX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125816.4
HGNCiHGNC:7837 NKX2-4
MIMi607808 gene
neXtProtiNX_Q9H2Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125816
PharmGKBiPA31644

Polymorphism and mutation databases

BioMutaiNKX2-4
DMDMi206729913

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489351 – 354Homeobox protein Nkx-2.4Add BLAST354

Proteomic databases

MaxQBiQ9H2Z4
PaxDbiQ9H2Z4
PeptideAtlasiQ9H2Z4
PRIDEiQ9H2Z4

PTM databases

iPTMnetiQ9H2Z4
PhosphoSitePlusiQ9H2Z4

Expressioni

Gene expression databases

BgeeiENSG00000125816
CleanExiHS_NKX2-4

Organism-specific databases

HPAiHPA074996

Interactioni

Protein-protein interaction databases

IntActiQ9H2Z4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9H2Z4
SMRiQ9H2Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 47Poly-Ala4
Compositional biasi76 – 91Poly-AlaAdd BLAST16
Compositional biasi181 – 187Poly-Ala7
Compositional biasi264 – 272Poly-Pro9

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
HOGENOMiHOG000231923
HOVERGENiHBG006689
InParanoidiQ9H2Z4
KOiK09344
OMAiYCNGGLG
OrthoDBiEOG091G0LZ2
PhylomeDBiQ9H2Z4
TreeFamiTF351204

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H2Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA
60 70 80 90 100
PPPGPSSQAA TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS
110 120 130 140 150
QFPHGAMGSY CNGGLGNMGE LPAYTDGMRG GAATGWYGAN PDPRYSSISR
160 170 180 190 200
FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH AAAAAAAPRR KRRVLFSQAQ
210 220 230 240 250
VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH RYKMKRQAKD
260 270 280 290 300
KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG
310 320 330 340 350
PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY

GRTW
Length:354
Mass (Da):36,179
Last modified:September 23, 2008 - v3
Checksum:iA2A8963F9A2C5356
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97P → A in AAG35617 (PubMed:10818213).Curated1
Sequence conflicti275V → A in AAG35617 (PubMed:10818213).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158013 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10185.1
AF202037 Genomic DNA Translation: AAG35617.1
CCDSiCCDS42855.1
RefSeqiNP_149416.1, NM_033176.1
UniGeneiHs.456662

Genome annotation databases

EnsembliENST00000351817; ENSP00000345147; ENSG00000125816
GeneIDi644524
KEGGihsa:644524
UCSCiuc010gcz.4 human

Similar proteinsi

Entry informationi

Entry nameiNKX24_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Z4
Secondary accession number(s): Q5VZV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health