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Q9H2Z4 (NKX24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Nkx-2.4
Alternative name(s):
Homeobox protein NK-2 homolog D
Gene names
Name:NKX2-4
Synonyms:NKX2D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the NK-2 homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Homeobox protein Nkx-2.4
PRO_0000048935

Regions

DNA binding189 – 24860Homeobox
Compositional bias44 – 474Poly-Ala
Compositional bias76 – 9116Poly-Ala
Compositional bias181 – 1877Poly-Ala
Compositional bias264 – 2729Poly-Pro

Experimental info

Sequence conflict971P → A in AAG35617. Ref.3
Sequence conflict2751V → A in AAG35617. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9H2Z4 [UniParc].

Last modified September 23, 2008. Version 3.
Checksum: A2A8963F9A2C5356

FASTA35436,179
        10         20         30         40         50         60 
MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA PPPGPSSQAA 

        70         80         90        100        110        120 
TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS QFPHGAMGSY CNGGLGNMGE 

       130        140        150        160        170        180 
LPAYTDGMRG GAATGWYGAN PDPRYSSISR FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH 

       190        200        210        220        230        240 
AAAAAAAPRR KRRVLFSQAQ VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH 

       250        260        270        280        290        300 
RYKMKRQAKD KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG 

       310        320        330        340        350 
PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY GRTW 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals."
Wang C.-C., Brodnicki T., Copeland N.G., Jenkins N.A., Harvey R.P.
Mamm. Genome 11:466-468(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-289.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL158013 Genomic DNA. Translation: CAH71494.1.
CH471133 Genomic DNA. Translation: EAX10185.1.
AF202037 Genomic DNA. Translation: AAG35617.1.
CCDSCCDS42855.1.
RefSeqNP_149416.1. NM_033176.1.
UniGeneHs.456662.

3D structure databases

ProteinModelPortalQ9H2Z4.
SMRQ9H2Z4. Positions 189-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000345147.

Polymorphism databases

DMDM206729913.

Proteomic databases

MaxQBQ9H2Z4.
PaxDbQ9H2Z4.
PRIDEQ9H2Z4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000351817; ENSP00000345147; ENSG00000125816.
GeneID644524.
KEGGhsa:644524.
UCSCuc010gcz.3. human.

Organism-specific databases

CTD644524.
GeneCardsGC20M021371.
HGNCHGNC:7837. NKX2-4.
MIM607808. gene.
neXtProtNX_Q9H2Z4.
PharmGKBPA31644.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328614.
HOGENOMHOG000231923.
HOVERGENHBG006689.
InParanoidQ9H2Z4.
KOK09344.
OMACQNGSNT.
OrthoDBEOG769ZK0.
PhylomeDBQ9H2Z4.
TreeFamTF351204.

Gene expression databases

BgeeQ9H2Z4.
CleanExHS_NKX2-4.
GenevestigatorQ9H2Z4.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi644524.
NextBio116331.
PROQ9H2Z4.
SOURCESearch...

Entry information

Entry nameNKX24_HUMAN
AccessionPrimary (citable) accession number: Q9H2Z4
Secondary accession number(s): Q5VZV8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM