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Protein

Homeobox protein Nkx-2.4

Gene

NKX2-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi189 – 248HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.4
Alternative name(s):
Homeobox protein NK-2 homolog D
Gene namesi
Name:NKX2-4
Synonyms:NKX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:7837. NKX2-4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125816.
PharmGKBiPA31644.

Polymorphism and mutation databases

BioMutaiNKX2-4.
DMDMi206729913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489351 – 354Homeobox protein Nkx-2.4Add BLAST354

Proteomic databases

MaxQBiQ9H2Z4.
PaxDbiQ9H2Z4.
PeptideAtlasiQ9H2Z4.
PRIDEiQ9H2Z4.

PTM databases

iPTMnetiQ9H2Z4.
PhosphoSitePlusiQ9H2Z4.

Expressioni

Gene expression databases

BgeeiENSG00000125816.
CleanExiHS_NKX2-4.

Organism-specific databases

HPAiHPA074996.

Interactioni

Protein-protein interaction databases

IntActiQ9H2Z4. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9H2Z4.
SMRiQ9H2Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 47Poly-Ala4
Compositional biasi76 – 91Poly-AlaAdd BLAST16
Compositional biasi181 – 187Poly-Ala7
Compositional biasi264 – 272Poly-Pro9

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00870000136367.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ9H2Z4.
KOiK09344.
OMAiYCNGGLG.
OrthoDBiEOG091G0LZ2.
PhylomeDBiQ9H2Z4.
TreeFamiTF351204.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H2Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA
60 70 80 90 100
PPPGPSSQAA TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS
110 120 130 140 150
QFPHGAMGSY CNGGLGNMGE LPAYTDGMRG GAATGWYGAN PDPRYSSISR
160 170 180 190 200
FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH AAAAAAAPRR KRRVLFSQAQ
210 220 230 240 250
VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH RYKMKRQAKD
260 270 280 290 300
KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG
310 320 330 340 350
PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY

GRTW
Length:354
Mass (Da):36,179
Last modified:September 23, 2008 - v3
Checksum:iA2A8963F9A2C5356
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97P → A in AAG35617 (PubMed:10818213).Curated1
Sequence conflicti275V → A in AAG35617 (PubMed:10818213).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158013 Genomic DNA. No translation available.
CH471133 Genomic DNA. Translation: EAX10185.1.
AF202037 Genomic DNA. Translation: AAG35617.1.
CCDSiCCDS42855.1.
RefSeqiNP_149416.1. NM_033176.1.
UniGeneiHs.456662.

Genome annotation databases

EnsembliENST00000351817; ENSP00000345147; ENSG00000125816.
GeneIDi644524.
KEGGihsa:644524.
UCSCiuc010gcz.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNKX24_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Z4
Secondary accession number(s): Q5VZV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 23, 2008
Last modified: July 5, 2017
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families