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Q9H2Z4

- NKX24_HUMAN

UniProt

Q9H2Z4 - NKX24_HUMAN

Protein

Homeobox protein Nkx-2.4

Gene

NKX2-4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Probable transcription factor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi189 – 24860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Nkx-2.4
    Alternative name(s):
    Homeobox protein NK-2 homolog D
    Gene namesi
    Name:NKX2-4
    Synonyms:NKX2D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:7837. NKX2-4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31644.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Homeobox protein Nkx-2.4PRO_0000048935Add
    BLAST

    Proteomic databases

    MaxQBiQ9H2Z4.
    PaxDbiQ9H2Z4.
    PRIDEiQ9H2Z4.

    Expressioni

    Gene expression databases

    BgeeiQ9H2Z4.
    CleanExiHS_NKX2-4.
    GenevestigatoriQ9H2Z4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000345147.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2Z4.
    SMRiQ9H2Z4. Positions 189-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 474Poly-Ala
    Compositional biasi76 – 9116Poly-AlaAdd
    BLAST
    Compositional biasi181 – 1877Poly-Ala
    Compositional biasi264 – 2729Poly-Pro

    Sequence similaritiesi

    Belongs to the NK-2 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG328614.
    HOGENOMiHOG000231923.
    HOVERGENiHBG006689.
    InParanoidiQ9H2Z4.
    KOiK09344.
    OMAiCQNGSNT.
    OrthoDBiEOG769ZK0.
    PhylomeDBiQ9H2Z4.
    TreeFamiTF351204.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H2Z4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA    50
    PPPGPSSQAA TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS 100
    QFPHGAMGSY CNGGLGNMGE LPAYTDGMRG GAATGWYGAN PDPRYSSISR 150
    FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH AAAAAAAPRR KRRVLFSQAQ 200
    VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH RYKMKRQAKD 250
    KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG 300
    PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY 350
    GRTW 354
    Length:354
    Mass (Da):36,179
    Last modified:September 23, 2008 - v3
    Checksum:iA2A8963F9A2C5356
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971P → A in AAG35617. (PubMed:10818213)Curated
    Sequence conflicti275 – 2751V → A in AAG35617. (PubMed:10818213)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL158013 Genomic DNA. Translation: CAH71494.1.
    CH471133 Genomic DNA. Translation: EAX10185.1.
    AF202037 Genomic DNA. Translation: AAG35617.1.
    CCDSiCCDS42855.1.
    RefSeqiNP_149416.1. NM_033176.1.
    UniGeneiHs.456662.

    Genome annotation databases

    EnsembliENST00000351817; ENSP00000345147; ENSG00000125816.
    GeneIDi644524.
    KEGGihsa:644524.
    UCSCiuc010gcz.3. human.

    Polymorphism databases

    DMDMi206729913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL158013 Genomic DNA. Translation: CAH71494.1 .
    CH471133 Genomic DNA. Translation: EAX10185.1 .
    AF202037 Genomic DNA. Translation: AAG35617.1 .
    CCDSi CCDS42855.1.
    RefSeqi NP_149416.1. NM_033176.1.
    UniGenei Hs.456662.

    3D structure databases

    ProteinModelPortali Q9H2Z4.
    SMRi Q9H2Z4. Positions 189-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000345147.

    Polymorphism databases

    DMDMi 206729913.

    Proteomic databases

    MaxQBi Q9H2Z4.
    PaxDbi Q9H2Z4.
    PRIDEi Q9H2Z4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000351817 ; ENSP00000345147 ; ENSG00000125816 .
    GeneIDi 644524.
    KEGGi hsa:644524.
    UCSCi uc010gcz.3. human.

    Organism-specific databases

    CTDi 644524.
    GeneCardsi GC20M021371.
    HGNCi HGNC:7837. NKX2-4.
    MIMi 607808. gene.
    neXtProti NX_Q9H2Z4.
    PharmGKBi PA31644.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328614.
    HOGENOMi HOG000231923.
    HOVERGENi HBG006689.
    InParanoidi Q9H2Z4.
    KOi K09344.
    OMAi CQNGSNT.
    OrthoDBi EOG769ZK0.
    PhylomeDBi Q9H2Z4.
    TreeFami TF351204.

    Miscellaneous databases

    GenomeRNAii 644524.
    NextBioi 116331.
    PROi Q9H2Z4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H2Z4.
    CleanExi HS_NKX2-4.
    Genevestigatori Q9H2Z4.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals."
      Wang C.-C., Brodnicki T., Copeland N.G., Jenkins N.A., Harvey R.P.
      Mamm. Genome 11:466-468(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-289.

    Entry informationi

    Entry nameiNKX24_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2Z4
    Secondary accession number(s): Q5VZV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3