Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Nkx-2.4

Gene

NKX2-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi189 – 24860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.4
Alternative name(s):
Homeobox protein NK-2 homolog D
Gene namesi
Name:NKX2-4
Synonyms:NKX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:7837. NKX2-4.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homeobox protein Nkx-2.4PRO_0000048935Add
BLAST

Proteomic databases

MaxQBiQ9H2Z4.
PaxDbiQ9H2Z4.
PRIDEiQ9H2Z4.

Expressioni

Gene expression databases

BgeeiQ9H2Z4.
CleanExiHS_NKX2-4.
GenevestigatoriQ9H2Z4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345147.

Structurei

3D structure databases

ProteinModelPortaliQ9H2Z4.
SMRiQ9H2Z4. Positions 189-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Ala
Compositional biasi76 – 9116Poly-AlaAdd
BLAST
Compositional biasi181 – 1877Poly-Ala
Compositional biasi264 – 2729Poly-Pro

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG328614.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ9H2Z4.
KOiK09344.
OMAiCQNGSNT.
OrthoDBiEOG769ZK0.
PhylomeDBiQ9H2Z4.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2Z4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA
60 70 80 90 100
PPPGPSSQAA TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS
110 120 130 140 150
QFPHGAMGSY CNGGLGNMGE LPAYTDGMRG GAATGWYGAN PDPRYSSISR
160 170 180 190 200
FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH AAAAAAAPRR KRRVLFSQAQ
210 220 230 240 250
VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH RYKMKRQAKD
260 270 280 290 300
KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG
310 320 330 340 350
PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY

GRTW
Length:354
Mass (Da):36,179
Last modified:September 23, 2008 - v3
Checksum:iA2A8963F9A2C5356
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971P → A in AAG35617. (PubMed:10818213)Curated
Sequence conflicti275 – 2751V → A in AAG35617. (PubMed:10818213)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158013 Genomic DNA. Translation: CAH71494.1.
CH471133 Genomic DNA. Translation: EAX10185.1.
AF202037 Genomic DNA. Translation: AAG35617.1.
CCDSiCCDS42855.1.
RefSeqiNP_149416.1. NM_033176.1.
UniGeneiHs.456662.

Genome annotation databases

EnsembliENST00000351817; ENSP00000345147; ENSG00000125816.
GeneIDi644524.
KEGGihsa:644524.
UCSCiuc010gcz.3. human.

Polymorphism databases

DMDMi206729913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158013 Genomic DNA. Translation: CAH71494.1.
CH471133 Genomic DNA. Translation: EAX10185.1.
AF202037 Genomic DNA. Translation: AAG35617.1.
CCDSiCCDS42855.1.
RefSeqiNP_149416.1. NM_033176.1.
UniGeneiHs.456662.

3D structure databases

ProteinModelPortaliQ9H2Z4.
SMRiQ9H2Z4. Positions 189-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345147.

Polymorphism databases

DMDMi206729913.

Proteomic databases

MaxQBiQ9H2Z4.
PaxDbiQ9H2Z4.
PRIDEiQ9H2Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351817; ENSP00000345147; ENSG00000125816.
GeneIDi644524.
KEGGihsa:644524.
UCSCiuc010gcz.3. human.

Organism-specific databases

CTDi644524.
GeneCardsiGC20M021371.
HGNCiHGNC:7837. NKX2-4.
MIMi607808. gene.
neXtProtiNX_Q9H2Z4.
PharmGKBiPA31644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG328614.
GeneTreeiENSGT00760000118779.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ9H2Z4.
KOiK09344.
OMAiCQNGSNT.
OrthoDBiEOG769ZK0.
PhylomeDBiQ9H2Z4.
TreeFamiTF351204.

Miscellaneous databases

GenomeRNAii644524.
NextBioi116331.
PROiQ9H2Z4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2Z4.
CleanExiHS_NKX2-4.
GenevestigatoriQ9H2Z4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals."
    Wang C.-C., Brodnicki T., Copeland N.G., Jenkins N.A., Harvey R.P.
    Mamm. Genome 11:466-468(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-289.

Entry informationi

Entry nameiNKX24_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Z4
Secondary accession number(s): Q5VZV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.