SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H2Z4

- NKX24_HUMAN

UniProt

Q9H2Z4 - NKX24_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein Nkx-2.4

Gene
NKX2-4, NKX2D
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi189 – 24860HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.4
Alternative name(s):
Homeobox protein NK-2 homolog D
Gene namesi
Name:NKX2-4
Synonyms:NKX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:7837. NKX2-4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homeobox protein Nkx-2.4PRO_0000048935Add
BLAST

Proteomic databases

MaxQBiQ9H2Z4.
PaxDbiQ9H2Z4.
PRIDEiQ9H2Z4.

Expressioni

Gene expression databases

BgeeiQ9H2Z4.
CleanExiHS_NKX2-4.
GenevestigatoriQ9H2Z4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345147.

Structurei

3D structure databases

ProteinModelPortaliQ9H2Z4.
SMRiQ9H2Z4. Positions 189-255.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Ala
Compositional biasi76 – 9116Poly-AlaAdd
BLAST
Compositional biasi181 – 1877Poly-Ala
Compositional biasi264 – 2729Poly-Pro

Sequence similaritiesi

Belongs to the NK-2 homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG328614.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ9H2Z4.
KOiK09344.
OMAiCQNGSNT.
OrthoDBiEOG769ZK0.
PhylomeDBiQ9H2Z4.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2Z4-1 [UniParc]FASTAAdd to Basket

« Hide

MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA    50
PPPGPSSQAA TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS 100
QFPHGAMGSY CNGGLGNMGE LPAYTDGMRG GAATGWYGAN PDPRYSSISR 150
FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH AAAAAAAPRR KRRVLFSQAQ 200
VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH RYKMKRQAKD 250
KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG 300
PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY 350
GRTW 354
Length:354
Mass (Da):36,179
Last modified:September 23, 2008 - v3
Checksum:iA2A8963F9A2C5356
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971P → A in AAG35617. 1 Publication
Sequence conflicti275 – 2751V → A in AAG35617. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL158013 Genomic DNA. Translation: CAH71494.1.
CH471133 Genomic DNA. Translation: EAX10185.1.
AF202037 Genomic DNA. Translation: AAG35617.1.
CCDSiCCDS42855.1.
RefSeqiNP_149416.1. NM_033176.1.
UniGeneiHs.456662.

Genome annotation databases

EnsembliENST00000351817; ENSP00000345147; ENSG00000125816.
GeneIDi644524.
KEGGihsa:644524.
UCSCiuc010gcz.3. human.

Polymorphism databases

DMDMi206729913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL158013 Genomic DNA. Translation: CAH71494.1 .
CH471133 Genomic DNA. Translation: EAX10185.1 .
AF202037 Genomic DNA. Translation: AAG35617.1 .
CCDSi CCDS42855.1.
RefSeqi NP_149416.1. NM_033176.1.
UniGenei Hs.456662.

3D structure databases

ProteinModelPortali Q9H2Z4.
SMRi Q9H2Z4. Positions 189-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000345147.

Polymorphism databases

DMDMi 206729913.

Proteomic databases

MaxQBi Q9H2Z4.
PaxDbi Q9H2Z4.
PRIDEi Q9H2Z4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000351817 ; ENSP00000345147 ; ENSG00000125816 .
GeneIDi 644524.
KEGGi hsa:644524.
UCSCi uc010gcz.3. human.

Organism-specific databases

CTDi 644524.
GeneCardsi GC20M021371.
HGNCi HGNC:7837. NKX2-4.
MIMi 607808. gene.
neXtProti NX_Q9H2Z4.
PharmGKBi PA31644.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328614.
HOGENOMi HOG000231923.
HOVERGENi HBG006689.
InParanoidi Q9H2Z4.
KOi K09344.
OMAi CQNGSNT.
OrthoDBi EOG769ZK0.
PhylomeDBi Q9H2Z4.
TreeFami TF351204.

Miscellaneous databases

GenomeRNAii 644524.
NextBioi 116331.
PROi Q9H2Z4.
SOURCEi Search...

Gene expression databases

Bgeei Q9H2Z4.
CleanExi HS_NKX2-4.
Genevestigatori Q9H2Z4.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals."
    Wang C.-C., Brodnicki T., Copeland N.G., Jenkins N.A., Harvey R.P.
    Mamm. Genome 11:466-468(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-289.

Entry informationi

Entry nameiNKX24_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Z4
Secondary accession number(s): Q5VZV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi