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Protein

Solute carrier organic anion transporter family member 5A1

Gene

SLCO5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

MEROPSiI01.972
TCDBi2.A.60.1.16 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 5A1
Alternative name(s):
Organic anion transporter polypeptide-related protein 4
Short name:
OATP-RP4
Short name:
OATPRP4
Solute carrier family 21 member 15
Gene namesi
Name:SLCO5A1
Synonyms:OATP5A1, SLC21A15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000137571.10
HGNCiHGNC:19046 SLCO5A1
MIMi613543 gene
neXtProtiNX_Q9H2Y9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 128CytoplasmicSequence analysisAdd BLAST128
Transmembranei129 – 149Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini150 – 168ExtracellularSequence analysisAdd BLAST19
Transmembranei169 – 189Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini190 – 195CytoplasmicSequence analysis6
Transmembranei196 – 220Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini221 – 260ExtracellularSequence analysisAdd BLAST40
Transmembranei261 – 290Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini291 – 309CytoplasmicSequence analysisAdd BLAST19
Transmembranei310 – 329Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini330 – 344ExtracellularSequence analysisAdd BLAST15
Transmembranei345 – 369Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini370 – 427CytoplasmicSequence analysisAdd BLAST58
Transmembranei428 – 449Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini450 – 469ExtracellularSequence analysisAdd BLAST20
Transmembranei470 – 493Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini494 – 497CytoplasmicSequence analysis4
Transmembranei498 – 521Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini522 – 651ExtracellularSequence analysisAdd BLAST130
Transmembranei652 – 674Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini675 – 683CytoplasmicSequence analysis9
Transmembranei684 – 709Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini710 – 742ExtracellularSequence analysisAdd BLAST33
Transmembranei743 – 760Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini761 – 808CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81796
OpenTargetsiENSG00000137571
PharmGKBiPA134948571

Polymorphism and mutation databases

BioMutaiSLCO5A1
DMDMi296452911

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910701 – 848Solute carrier organic anion transporter family member 5A1Add BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi555 ↔ 581PROSITE-ProRule annotation
Disulfide bondi559 ↔ 570PROSITE-ProRule annotation
Disulfide bondi561 ↔ 585PROSITE-ProRule annotation
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H2Y9
PRIDEiQ9H2Y9

PTM databases

iPTMnetiQ9H2Y9
PhosphoSitePlusiQ9H2Y9

Expressioni

Gene expression databases

BgeeiENSG00000137571
CleanExiHS_SLCO5A1
ExpressionAtlasiQ9H2Y9 baseline and differential
GenevisibleiQ9H2Y9 HS

Organism-specific databases

HPAiHPA025062

Interactioni

Protein-protein interaction databases

BioGridi123587, 1 interactor
IntActiQ9H2Y9, 1 interactor
STRINGi9606.ENSP00000260126

Structurei

3D structure databases

ProteinModelPortaliQ9H2Y9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini549 – 603Kazal-likePROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi377 – 383Poly-Lys7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000060097
HOVERGENiHBG069241
InParanoidiQ9H2Y9
KOiK14356
OMAiWVYVALF
OrthoDBiEOG091G02FX
PhylomeDBiQ9H2Y9
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 4 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2Y9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEGTGLQPG AGEQLEAPAT AEAVQERCEP ETLRSKSLPV LSSASCRPSL
60 70 80 90 100
SPTSGDANPA FGCVDSSGHQ ELKQGPNPLA PSPSAPSTSA GLGDCNHRVD
110 120 130 140 150
LSKTFSVSSA LAMLQERRCL YVVLTDSRCF LVCMCFLTFI QALMVSGYLS
160 170 180 190 200
SVITTIERRY SLKSSESGLL VSCFDIGNLV VVVFVSYFGG RGRRPLWLAV
210 220 230 240 250
GGLLIAFGAA LFALPHFISP PYQIQELNAS APNDGLCQGG NSTATLEPPA
260 270 280 290 300
CPKDSGGNNH WVYVALFICA QILIGMGSTP IYTLGPTYLD DNVKKENSSL
310 320 330 340 350
YLAIMYVMGA LGPAVGYLLG GLLIGFYVDP RNPVHLDQND PRFIGNWWSG
360 370 380 390 400
FLLCAIAMFL VIFPMFTFPK KLPPRHKKKK KKKFSVDAVS DDDVLKEKSN
410 420 430 440 450
NSEQADKKVS SMGFGKDVRD LPRAAVRILS NMTFLFVSLS YTAESAIVTA
460 470 480 490 500
FITFIPKFIE SQFGIPASNA SIYTGVIIVP SAGVGIVLGG YIIKKLKLGA
510 520 530 540 550
RESAKLAMIC SGVSLLCFST LFIVGCESIN LGGINIPYTT GPSLTMPHRN
560 570 580 590 600
LTGSCNVNCG CKIHEYEPVC GSDGITYFNP CLAGCVNSGN LSTGIRNYTE
610 620 630 640 650
CTCVQSRQVI TPPTVGQRSQ LRVVIVKTYL NENGYAVSGK CKRTCNTLIP
660 670 680 690 700
FLVFLFIVTF ITACAQPSAI IVTLRSVEDE ERPFALGMQF VLLRTLAYIP
710 720 730 740 750
TPIYFGAVID TTCMLWQQEC GVQGSCWEYN VTSFRFVYFG LAAGLKFVGF
760 770 780 790 800
IFIFLAWYSI KYKEDGLQRR RQREFPLSTV SERVGHPDNA RTRSCPAFST
810 820 830 840
QGEFHEETGL QKGIQCAAQT YPGPFPEAIS SSADPGLEES PAALEPPS
Length:848
Mass (Da):91,864
Last modified:May 18, 2010 - v2
Checksum:iF213B18FE8389596
GO
Isoform 2 (identifier: Q9H2Y9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-474: Missing.

Note: No experimental confirmation available.
Show »
Length:793
Mass (Da):85,850
Checksum:iB1031ACFCC20CCB8
GO
Isoform 3 (identifier: Q9H2Y9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-687: RSVEDEERPFALG → SIHSYSNLLWSSH
     688-848: Missing.

Note: No experimental confirmation available.
Show »
Length:687
Mass (Da):73,843
Checksum:i772B469C80E2BEEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40V → A in BAG51109 (PubMed:14702039).Curated1
Sequence conflicti264V → L in AAG42207 (Ref. 1) Curated1
Sequence conflicti457K → E in BAG51109 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02204133L → F1 PublicationCorresponds to variant dbSNP:rs3750266Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045498420 – 474Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_045499675 – 687RSVED…PFALG → SIHSYSNLLWSSH in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_045500688 – 848Missing in isoform 3. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205075 mRNA Translation: AAG42207.1
AK022760 mRNA Translation: BAG51109.1
AC024680 Genomic DNA No translation available.
AC079089 Genomic DNA No translation available.
AC091047 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86957.1
CH471068 Genomic DNA Translation: EAW86958.1
BC137424 mRNA Translation: AAI37425.1
BC139755 mRNA Translation: AAI39756.1
CCDSiCCDS55242.1 [Q9H2Y9-2]
CCDS55243.1 [Q9H2Y9-3]
CCDS6205.1 [Q9H2Y9-1]
RefSeqiNP_001139480.1, NM_001146008.1 [Q9H2Y9-3]
NP_001139481.1, NM_001146009.1 [Q9H2Y9-2]
NP_112220.2, NM_030958.2 [Q9H2Y9-1]
XP_005251370.1, XM_005251313.2 [Q9H2Y9-2]
XP_016869372.1, XM_017013883.1 [Q9H2Y9-3]
UniGeneiHs.152460
Hs.443609

Genome annotation databases

EnsembliENST00000260126; ENSP00000260126; ENSG00000137571 [Q9H2Y9-1]
ENST00000524945; ENSP00000434422; ENSG00000137571 [Q9H2Y9-3]
ENST00000530307; ENSP00000431611; ENSG00000137571 [Q9H2Y9-2]
GeneIDi81796
KEGGihsa:81796
UCSCiuc003xyk.4 human [Q9H2Y9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSO5A1_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Y9
Secondary accession number(s): A4QPC2
, B2RPF7, B3KMU7, E9PKK5, G3V1C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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