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Protein

Solute carrier organic anion transporter family member 5A1

Gene

SLCO5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137571-MONOMER.

Protein family/group databases

MEROPSiI01.972.
TCDBi2.A.60.1.16. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 5A1
Alternative name(s):
Organic anion transporter polypeptide-related protein 4
Short name:
OATP-RP4
Short name:
OATPRP4
Solute carrier family 21 member 15
Gene namesi
Name:SLCO5A1
Synonyms:OATP5A1, SLC21A15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19046. SLCO5A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 128CytoplasmicSequence analysisAdd BLAST128
Transmembranei129 – 149Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini150 – 168ExtracellularSequence analysisAdd BLAST19
Transmembranei169 – 189Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini190 – 195CytoplasmicSequence analysis6
Transmembranei196 – 220Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini221 – 260ExtracellularSequence analysisAdd BLAST40
Transmembranei261 – 290Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini291 – 309CytoplasmicSequence analysisAdd BLAST19
Transmembranei310 – 329Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini330 – 344ExtracellularSequence analysisAdd BLAST15
Transmembranei345 – 369Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini370 – 427CytoplasmicSequence analysisAdd BLAST58
Transmembranei428 – 449Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini450 – 469ExtracellularSequence analysisAdd BLAST20
Transmembranei470 – 493Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini494 – 497CytoplasmicSequence analysis4
Transmembranei498 – 521Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini522 – 651ExtracellularSequence analysisAdd BLAST130
Transmembranei652 – 674Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini675 – 683CytoplasmicSequence analysis9
Transmembranei684 – 709Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini710 – 742ExtracellularSequence analysisAdd BLAST33
Transmembranei743 – 760Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini761 – 808CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81796.
OpenTargetsiENSG00000137571.
PharmGKBiPA134948571.

Polymorphism and mutation databases

BioMutaiSLCO5A1.
DMDMi296452911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910701 – 848Solute carrier organic anion transporter family member 5A1Add BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Glycosylationi550N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi555 ↔ 581PROSITE-ProRule annotation
Disulfide bondi559 ↔ 570PROSITE-ProRule annotation
Disulfide bondi561 ↔ 585PROSITE-ProRule annotation
Glycosylationi590N-linked (GlcNAc...)Sequence analysis1
Glycosylationi597N-linked (GlcNAc...)Sequence analysis1
Glycosylationi730N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H2Y9.
PRIDEiQ9H2Y9.

PTM databases

iPTMnetiQ9H2Y9.
PhosphoSitePlusiQ9H2Y9.

Expressioni

Gene expression databases

BgeeiENSG00000137571.
CleanExiHS_SLCO5A1.
ExpressionAtlasiQ9H2Y9. baseline and differential.
GenevisibleiQ9H2Y9. HS.

Organism-specific databases

HPAiHPA025062.

Interactioni

Protein-protein interaction databases

IntActiQ9H2Y9. 1 interactor.
STRINGi9606.ENSP00000260126.

Structurei

3D structure databases

ProteinModelPortaliQ9H2Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini549 – 603Kazal-likePROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi377 – 383Poly-Lys7

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000060097.
HOVERGENiHBG069241.
InParanoidiQ9H2Y9.
KOiK14356.
OMAiCFDIGNL.
OrthoDBiEOG091G02FX.
PhylomeDBiQ9H2Y9.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 2 hits.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2Y9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEGTGLQPG AGEQLEAPAT AEAVQERCEP ETLRSKSLPV LSSASCRPSL
60 70 80 90 100
SPTSGDANPA FGCVDSSGHQ ELKQGPNPLA PSPSAPSTSA GLGDCNHRVD
110 120 130 140 150
LSKTFSVSSA LAMLQERRCL YVVLTDSRCF LVCMCFLTFI QALMVSGYLS
160 170 180 190 200
SVITTIERRY SLKSSESGLL VSCFDIGNLV VVVFVSYFGG RGRRPLWLAV
210 220 230 240 250
GGLLIAFGAA LFALPHFISP PYQIQELNAS APNDGLCQGG NSTATLEPPA
260 270 280 290 300
CPKDSGGNNH WVYVALFICA QILIGMGSTP IYTLGPTYLD DNVKKENSSL
310 320 330 340 350
YLAIMYVMGA LGPAVGYLLG GLLIGFYVDP RNPVHLDQND PRFIGNWWSG
360 370 380 390 400
FLLCAIAMFL VIFPMFTFPK KLPPRHKKKK KKKFSVDAVS DDDVLKEKSN
410 420 430 440 450
NSEQADKKVS SMGFGKDVRD LPRAAVRILS NMTFLFVSLS YTAESAIVTA
460 470 480 490 500
FITFIPKFIE SQFGIPASNA SIYTGVIIVP SAGVGIVLGG YIIKKLKLGA
510 520 530 540 550
RESAKLAMIC SGVSLLCFST LFIVGCESIN LGGINIPYTT GPSLTMPHRN
560 570 580 590 600
LTGSCNVNCG CKIHEYEPVC GSDGITYFNP CLAGCVNSGN LSTGIRNYTE
610 620 630 640 650
CTCVQSRQVI TPPTVGQRSQ LRVVIVKTYL NENGYAVSGK CKRTCNTLIP
660 670 680 690 700
FLVFLFIVTF ITACAQPSAI IVTLRSVEDE ERPFALGMQF VLLRTLAYIP
710 720 730 740 750
TPIYFGAVID TTCMLWQQEC GVQGSCWEYN VTSFRFVYFG LAAGLKFVGF
760 770 780 790 800
IFIFLAWYSI KYKEDGLQRR RQREFPLSTV SERVGHPDNA RTRSCPAFST
810 820 830 840
QGEFHEETGL QKGIQCAAQT YPGPFPEAIS SSADPGLEES PAALEPPS
Length:848
Mass (Da):91,864
Last modified:May 18, 2010 - v2
Checksum:iF213B18FE8389596
GO
Isoform 2 (identifier: Q9H2Y9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-474: Missing.

Note: No experimental confirmation available.
Show »
Length:793
Mass (Da):85,850
Checksum:iB1031ACFCC20CCB8
GO
Isoform 3 (identifier: Q9H2Y9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-687: RSVEDEERPFALG → SIHSYSNLLWSSH
     688-848: Missing.

Note: No experimental confirmation available.
Show »
Length:687
Mass (Da):73,843
Checksum:i772B469C80E2BEEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40V → A in BAG51109 (PubMed:14702039).Curated1
Sequence conflicti264V → L in AAG42207 (Ref. 1) Curated1
Sequence conflicti457K → E in BAG51109 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02204133L → F.1 PublicationCorresponds to variant rs3750266dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045498420 – 474Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_045499675 – 687RSVED…PFALG → SIHSYSNLLWSSH in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_045500688 – 848Missing in isoform 3. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205075 mRNA. Translation: AAG42207.1.
AK022760 mRNA. Translation: BAG51109.1.
AC024680 Genomic DNA. No translation available.
AC079089 Genomic DNA. No translation available.
AC091047 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86957.1.
CH471068 Genomic DNA. Translation: EAW86958.1.
BC137424 mRNA. Translation: AAI37425.1.
BC139755 mRNA. Translation: AAI39756.1.
CCDSiCCDS55242.1. [Q9H2Y9-2]
CCDS55243.1. [Q9H2Y9-3]
CCDS6205.1. [Q9H2Y9-1]
RefSeqiNP_001139480.1. NM_001146008.1. [Q9H2Y9-3]
NP_001139481.1. NM_001146009.1. [Q9H2Y9-2]
NP_112220.2. NM_030958.2. [Q9H2Y9-1]
XP_005251370.1. XM_005251313.2. [Q9H2Y9-2]
XP_016869372.1. XM_017013883.1. [Q9H2Y9-3]
UniGeneiHs.152460.
Hs.443609.

Genome annotation databases

EnsembliENST00000260126; ENSP00000260126; ENSG00000137571. [Q9H2Y9-1]
ENST00000524945; ENSP00000434422; ENSG00000137571. [Q9H2Y9-3]
ENST00000530307; ENSP00000431611; ENSG00000137571. [Q9H2Y9-2]
GeneIDi81796.
KEGGihsa:81796.
UCSCiuc003xyk.4. human. [Q9H2Y9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205075 mRNA. Translation: AAG42207.1.
AK022760 mRNA. Translation: BAG51109.1.
AC024680 Genomic DNA. No translation available.
AC079089 Genomic DNA. No translation available.
AC091047 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86957.1.
CH471068 Genomic DNA. Translation: EAW86958.1.
BC137424 mRNA. Translation: AAI37425.1.
BC139755 mRNA. Translation: AAI39756.1.
CCDSiCCDS55242.1. [Q9H2Y9-2]
CCDS55243.1. [Q9H2Y9-3]
CCDS6205.1. [Q9H2Y9-1]
RefSeqiNP_001139480.1. NM_001146008.1. [Q9H2Y9-3]
NP_001139481.1. NM_001146009.1. [Q9H2Y9-2]
NP_112220.2. NM_030958.2. [Q9H2Y9-1]
XP_005251370.1. XM_005251313.2. [Q9H2Y9-2]
XP_016869372.1. XM_017013883.1. [Q9H2Y9-3]
UniGeneiHs.152460.
Hs.443609.

3D structure databases

ProteinModelPortaliQ9H2Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H2Y9. 1 interactor.
STRINGi9606.ENSP00000260126.

Protein family/group databases

MEROPSiI01.972.
TCDBi2.A.60.1.16. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ9H2Y9.
PhosphoSitePlusiQ9H2Y9.

Polymorphism and mutation databases

BioMutaiSLCO5A1.
DMDMi296452911.

Proteomic databases

PaxDbiQ9H2Y9.
PRIDEiQ9H2Y9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260126; ENSP00000260126; ENSG00000137571. [Q9H2Y9-1]
ENST00000524945; ENSP00000434422; ENSG00000137571. [Q9H2Y9-3]
ENST00000530307; ENSP00000431611; ENSG00000137571. [Q9H2Y9-2]
GeneIDi81796.
KEGGihsa:81796.
UCSCiuc003xyk.4. human. [Q9H2Y9-1]

Organism-specific databases

CTDi81796.
DisGeNETi81796.
GeneCardsiSLCO5A1.
HGNCiHGNC:19046. SLCO5A1.
HPAiHPA025062.
MIMi613543. gene.
neXtProtiNX_Q9H2Y9.
OpenTargetsiENSG00000137571.
PharmGKBiPA134948571.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000060097.
HOVERGENiHBG069241.
InParanoidiQ9H2Y9.
KOiK14356.
OMAiCFDIGNL.
OrthoDBiEOG091G02FX.
PhylomeDBiQ9H2Y9.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137571-MONOMER.

Miscellaneous databases

GenomeRNAii81796.
PROiQ9H2Y9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137571.
CleanExiHS_SLCO5A1.
ExpressionAtlasiQ9H2Y9. baseline and differential.
GenevisibleiQ9H2Y9. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 2 hits.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO5A1_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Y9
Secondary accession number(s): A4QPC2
, B2RPF7, B3KMU7, E9PKK5, G3V1C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.