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Protein

Zinc finger protein 106

Gene

ZNF106

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 44C2H2-type 1; atypicalAdd BLAST25
Zinc fingeri1813 – 1838C2H2-type 2; atypicalAdd BLAST26

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • SH3 domain binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103994-MONOMER.
SignaLinkiQ9H2Y7.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 106
Short name:
Zfp-106
Alternative name(s):
Zinc finger protein 474
Gene namesi
Name:ZNF106
Synonyms:SH3BP3, ZFP106, ZNF474
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:12886. ZNF106.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64397.
OpenTargetsiENSG00000103994.
PharmGKBiPA134896979.

Polymorphism and mutation databases

BioMutaiZNF106.
DMDMi51702191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514671 – 1883Zinc finger protein 106Add BLAST1883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei422PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei859PhosphoserineCombined sources1
Modified residuei861PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Cross-linki911Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei937PhosphoserineCombined sources1
Modified residuei1021PhosphothreonineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1249PhosphoserineCombined sources1
Cross-linki1265Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1279PhosphoserineCombined sources1
Modified residuei1281PhosphoserineBy similarity1
Modified residuei1284PhosphoserineCombined sources1
Modified residuei1302PhosphoserineCombined sources1
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1370PhosphoserineCombined sources1
Modified residuei1372PhosphothreonineCombined sources1
Modified residuei1468PhosphoserineCombined sources1
Cross-linki1737Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H2Y7.
MaxQBiQ9H2Y7.
PaxDbiQ9H2Y7.
PeptideAtlasiQ9H2Y7.
PRIDEiQ9H2Y7.

PTM databases

iPTMnetiQ9H2Y7.
PhosphoSitePlusiQ9H2Y7.

Expressioni

Gene expression databases

BgeeiENSG00000103994.
CleanExiHS_ZFP106.
HS_ZNF474.
ExpressionAtlasiQ9H2Y7. baseline and differential.
GenevisibleiQ9H2Y7. HS.

Organism-specific databases

HPAiHPA054267.
HPA056449.

Interactioni

Subunit structurei

Interacts with KNOP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122154. 23 interactors.
IntActiQ9H2Y7. 20 interactors.
MINTiMINT-1191366.
STRINGi9606.ENSP00000263805.

Structurei

3D structure databases

ProteinModelPortaliQ9H2Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1529 – 1568WD 1Add BLAST40
Repeati1570 – 1611WD 2Add BLAST42
Repeati1654 – 1695WD 3Add BLAST42
Repeati1698 – 1737WD 4Add BLAST40
Repeati1738 – 1775WD 5Add BLAST38
Repeati1778 – 1815WD 6Add BLAST38

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 44C2H2-type 1; atypicalAdd BLAST25
Zinc fingeri1813 – 1838C2H2-type 2; atypicalAdd BLAST26

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119106.
HOVERGENiHBG079376.
InParanoidiQ9H2Y7.
OMAiWQRQEND.
OrthoDBiEOG091G00B2.
PhylomeDBiQ9H2Y7.
TreeFamiTF105569.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA
60 70 80 90 100
QEREDDGKGE EEEEDYFDKE LIQLIKQRKE QSRQDEPSNS NQEINSDDRR
110 120 130 140 150
PQWRREDRIP YQDRESYSQP AWHHRGPPQR DWKWEKDGFN NTRKNSFPHS
160 170 180 190 200
LRNGGGPRGR SGWHKGVAGG SSTWFHNHSN SGGGWLSNSG AVDWNHNGTG
210 220 230 240 250
RNSSWLSEGT GGFSSWHMNN SNGNWKSSVR STNNWNYSGP GDKFQPGRNR
260 270 280 290 300
NSNCQMEDMT MLWNKKSNKS NKYSHDRYNW QRQENDKLGT VATYRGPSEG
310 320 330 340 350
FTSDKFPSEG LLDFNFEQLE SQTTKQADTA TSKVSGKNGS AAREKPRRWT
360 370 380 390 400
PYPSQKTLDL QSGLKDITGN KSEMIEKPLF DFSLITTGIQ EPQTDETRNS
410 420 430 440 450
PTQKTQKEIH TGSLNHKASS DSAASFEVVR QCPTAEKPEQ EHTPNKMPSL
460 470 480 490 500
KSPLLPCPAT KSLSQKQDPK NISKNTKTNF FSPGEHSNPS NKPTVEDNHG
510 520 530 540 550
PYISKLRSSC PHVLKGNKST FGSQKQSGDN LNDTLRKAKE VLQCHESLQN
560 570 580 590 600
PLLSTSKSTR NYAKASRNVE ESEKGSLKIE FQVHALEDES DGETSDTEKH
610 620 630 640 650
GTKIGTLGSA TTELLSGSTR TADEKEEDDR ILKTSRELST SPCNPIVRQK
660 670 680 690 700
ESELQMTSAA SPHPGLLLDL KTSLEDAQVD DSIKSHVSYE TEGFESASLD
710 720 730 740 750
AELQKSDISQ PSGPLLPELS KLGFPASLQR DLTRHISLKS KTGVHLPEPN
760 770 780 790 800
LNSARRIRNI SGHRKSETEK ESGLKPTLRQ ILNASRRNVN WEQVIQQVTK
810 820 830 840 850
KKQELGKGLP RFGIEMVPLV QNEQEALDLD GEPDLSSLEG FQWEGVSISS
860 870 880 890 900
SPGLARKRSL SESSVIMDRA PSVYSFFSEE GTGKENEPQQ MVSPSNSLRA
910 920 930 940 950
GQSQKATMHL KQEVTPRAAS LRTGERAENV ATQRRHSAQL SSDHIIPLMH
960 970 980 990 1000
LAKDLNSQER SIPPSENQNS QESNGEGNCL SSSASSALAI SSLADAATDS
1010 1020 1030 1040 1050
SCTSGAEQND GQSIRKKRRA TGDGSSPELP SLERKNKRRK IKGKKERSQV
1060 1070 1080 1090 1100
DQLLNISLRE EELSKSLQCM DNNLLQARAA LQTAYVEVQR LLMLKQQITM
1110 1120 1130 1140 1150
EMSALRTHRI QILQGLQETY EPSEHPDQVP CSLTRERRNS RSQTSIDAAL
1160 1170 1180 1190 1200
LPTPFFPLFL EPPSSHVSPS PTGASLQITT SPTFQTHGSV PAPDSSVQIK
1210 1220 1230 1240 1250
QEPMSPEQDE NVNAVPPSSA CNVSKELLEA NREISDSCPV YPVITARLSL
1260 1270 1280 1290 1300
PESTESFHEP SQELKFSVEQ RNTRNRENSP SSQSAGLSSI NKEGEEPTKG
1310 1320 1330 1340 1350
NSGSEACTSS FLRLSFASET PLEKEPHSPA DQPEQQAEST LTSAETRGSK
1360 1370 1380 1390 1400
KKKKLRKKKS LRAAHVPENS DTEQDVLTVK PVRKVKAGKL IKGGKVTTST
1410 1420 1430 1440 1450
WEDSRTGREQ ESVRDEPDSD SSLEVLEIPN PQLEVVAIDS SESGEEKPDS
1460 1470 1480 1490 1500
PSKKDIWNST EQNPLETSRS GCDEVSSTSE IGTRYKDGIP VSVAETQTVI
1510 1520 1530 1540 1550
SSIKGSKNSS EISSEPGDDD EPTEGSFEGH QAAVNAIQIF GNLLYTCSAD
1560 1570 1580 1590 1600
KTVRVYNLVS RKCIGVFEGH TSKVNCLLVT QTSGKNAALY TGSSDHTIRC
1610 1620 1630 1640 1650
YNVKSRECVE QLQLEDRVLC LHSRWRILYA GLANGTVVTF NIKNNKRLEI
1660 1670 1680 1690 1700
FECHGPRAVS CLATAQEGAR KLLVVGSYDC TISVRDARNG LLLRTLEGHS
1710 1720 1730 1740 1750
KTILCMKVVN DLVFSGSSDQ SVHAHNIHTG ELVRIYKGHN HAVTVVNILG
1760 1770 1780 1790 1800
KVMVTACLDK FVRVYELQSH DRLQVYGGHK DMIMCMTIHK SMIYTGCYDG
1810 1820 1830 1840 1850
SIQAVRLNLM QNYRCWWHGC SLIFGVVDHL KQHLLTDHTN PNFQTLKCRW
1860 1870 1880
KNCDAFFTAR KGSKQDAAGH IERHAEDDSK IDS
Length:1,883
Mass (Da):208,883
Last modified:March 1, 2001 - v1
Checksum:i7D1CBD6193F8888C
GO
Isoform 2 (identifier: Q9H2Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MPVGRIECPS...EVGLSAYAKH → MVRERKCILC...HHRELENLKG
     39-810: Missing.

Note: No experimental confirmation available.
Show »
Length:1,111
Mass (Da):122,869
Checksum:iAD7FA61E3235E46E
GO

Sequence cautioni

The sequence AAH58023 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70244 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14976 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD91134 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475N → D in BAB71475 (PubMed:14702039).Curated1
Sequence conflicti680D → G in CAD91147 (PubMed:17974005).Curated1
Sequence conflicti757I → V in BAB71475 (PubMed:14702039).Curated1
Sequence conflicti1293E → G in CAD91142 (PubMed:17974005).Curated1
Sequence conflicti1509S → P in BAG63952 (PubMed:14702039).Curated1
Sequence conflicti1606R → L in BAB14976 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053440103W → R.Corresponds to variant rs12440118dbSNPEnsembl.1
Natural variantiVAR_053441646I → T.Corresponds to variant rs12101559dbSNPEnsembl.1
Natural variantiVAR_053442656M → V.Corresponds to variant rs34792942dbSNPEnsembl.1
Natural variantiVAR_0534431162P → T.Corresponds to variant rs34983340dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0571201 – 38MPVGR…AYAKH → MVRERKCILCHIVYSSKKEM DEHMRSMLHHRELENLKG in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_05712139 – 810Missing in isoform 2. 1 PublicationAdd BLAST772

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205632 mRNA. Translation: AAG35666.1.
AF209502 Genomic DNA. Translation: AAL40184.1.
AK024726 mRNA. Translation: BAB14976.1. Different initiation.
AK057410 mRNA. Translation: BAB71475.1.
AK302735 mRNA. Translation: BAG63952.1.
AC012651 Genomic DNA. No translation available.
AC018362 Genomic DNA. No translation available.
BC058023 mRNA. Translation: AAH58023.1. Sequence problems.
BC070244 mRNA. Translation: AAH70244.1. Sequence problems.
AL832455 mRNA. Translation: CAD89926.1.
AL831983 mRNA. Translation: CAD91134.1. Different initiation.
AL833301 mRNA. Translation: CAD91142.1.
AL832014 mRNA. Translation: CAD91147.1.
AL832352 mRNA. Translation: CAD91149.1.
CCDSiCCDS32208.1. [Q9H2Y7-1]
CCDS61603.1. [Q9H2Y7-2]
RefSeqiNP_001271235.1. NM_001284306.1.
NP_001271236.1. NM_001284307.1. [Q9H2Y7-2]
NP_071918.1. NM_022473.2. [Q9H2Y7-1]
UniGeneiHs.511143.
Hs.735946.

Genome annotation databases

EnsembliENST00000263805; ENSP00000263805; ENSG00000103994. [Q9H2Y7-1]
ENST00000565380; ENSP00000455674; ENSG00000103994. [Q9H2Y7-2]
GeneIDi64397.
KEGGihsa:64397.
UCSCiuc001zpv.5. human. [Q9H2Y7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205632 mRNA. Translation: AAG35666.1.
AF209502 Genomic DNA. Translation: AAL40184.1.
AK024726 mRNA. Translation: BAB14976.1. Different initiation.
AK057410 mRNA. Translation: BAB71475.1.
AK302735 mRNA. Translation: BAG63952.1.
AC012651 Genomic DNA. No translation available.
AC018362 Genomic DNA. No translation available.
BC058023 mRNA. Translation: AAH58023.1. Sequence problems.
BC070244 mRNA. Translation: AAH70244.1. Sequence problems.
AL832455 mRNA. Translation: CAD89926.1.
AL831983 mRNA. Translation: CAD91134.1. Different initiation.
AL833301 mRNA. Translation: CAD91142.1.
AL832014 mRNA. Translation: CAD91147.1.
AL832352 mRNA. Translation: CAD91149.1.
CCDSiCCDS32208.1. [Q9H2Y7-1]
CCDS61603.1. [Q9H2Y7-2]
RefSeqiNP_001271235.1. NM_001284306.1.
NP_001271236.1. NM_001284307.1. [Q9H2Y7-2]
NP_071918.1. NM_022473.2. [Q9H2Y7-1]
UniGeneiHs.511143.
Hs.735946.

3D structure databases

ProteinModelPortaliQ9H2Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122154. 23 interactors.
IntActiQ9H2Y7. 20 interactors.
MINTiMINT-1191366.
STRINGi9606.ENSP00000263805.

PTM databases

iPTMnetiQ9H2Y7.
PhosphoSitePlusiQ9H2Y7.

Polymorphism and mutation databases

BioMutaiZNF106.
DMDMi51702191.

Proteomic databases

EPDiQ9H2Y7.
MaxQBiQ9H2Y7.
PaxDbiQ9H2Y7.
PeptideAtlasiQ9H2Y7.
PRIDEiQ9H2Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263805; ENSP00000263805; ENSG00000103994. [Q9H2Y7-1]
ENST00000565380; ENSP00000455674; ENSG00000103994. [Q9H2Y7-2]
GeneIDi64397.
KEGGihsa:64397.
UCSCiuc001zpv.5. human. [Q9H2Y7-1]

Organism-specific databases

CTDi64397.
DisGeNETi64397.
GeneCardsiZNF106.
HGNCiHGNC:12886. ZNF106.
HPAiHPA054267.
HPA056449.
neXtProtiNX_Q9H2Y7.
OpenTargetsiENSG00000103994.
PharmGKBiPA134896979.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119106.
HOVERGENiHBG079376.
InParanoidiQ9H2Y7.
OMAiWQRQEND.
OrthoDBiEOG091G00B2.
PhylomeDBiQ9H2Y7.
TreeFamiTF105569.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103994-MONOMER.
SignaLinkiQ9H2Y7.

Miscellaneous databases

GeneWikiiZFP106.
GenomeRNAii64397.
PROiQ9H2Y7.

Gene expression databases

BgeeiENSG00000103994.
CleanExiHS_ZFP106.
HS_ZNF474.
ExpressionAtlasiQ9H2Y7. baseline and differential.
GenevisibleiQ9H2Y7. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN106_HUMAN
AccessioniPrimary (citable) accession number: Q9H2Y7
Secondary accession number(s): B4DZ40
, E9PE29, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.