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Q9H2W6

- RM46_HUMAN

UniProt

Q9H2W6 - RM46_HUMAN

Protein

39S ribosomal protein L46, mitochondrial

Gene

MRPL46

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hydrolase activity Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L46, mitochondrial
    Short name:
    L46mt
    Short name:
    MRP-L46
    Alternative name(s):
    P2ECSL
    Gene namesi
    Name:MRPL46
    Synonyms:C15orf4, LIECG2
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:1192. MRPL46.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30978.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 27939S ribosomal protein L46, mitochondrialPRO_0000030576
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei230 – 2301N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H2W6.
    PaxDbiQ9H2W6.
    PRIDEiQ9H2W6.

    PTM databases

    PhosphoSiteiQ9H2W6.

    Expressioni

    Gene expression databases

    BgeeiQ9H2W6.
    CleanExiHS_MRPL46.
    GenevestigatoriQ9H2W6.

    Organism-specific databases

    HPAiHPA050166.

    Interactioni

    Protein-protein interaction databases

    BioGridi117757. 12 interactions.
    IntActiQ9H2W6. 3 interactions.
    MINTiMINT-4830900.
    STRINGi9606.ENSP00000312311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2W6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L46 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG256490.
    HOGENOMiHOG000047532.
    HOVERGENiHBG057426.
    InParanoidiQ9H2W6.
    KOiK17427.
    OMAiNAPCGVY.
    OrthoDBiEOG7GN2NC.
    PhylomeDBiQ9H2W6.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    InterProiIPR015797. NUDIX_hydrolase_dom-like.
    IPR021757. Ribosomal_L46.
    [Graphical view]
    PfamiPF11788. MRP-L46. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H2W6-1 [UniParc]FASTAAdd to Basket

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    MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA    50
    LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHELR ALDENQRLAK 100
    KKADLHDEED EQDILLAQDL EDMWEQKFLQ FKLGARITEA DEKNDRTSLN 150
    RKLDRNLVLL VREKFGDQDV WILPQAEWQP GETLRGTAER TLATLSENNM 200
    EAKFLGNAPC GHYTFKFPQA MRTESNLGAK VFFFKALLLT GDFSQAGNKG 250
    HHVWVTKDEL GDYLKPKYLA QVRRFVSDL 279
    Length:279
    Mass (Da):31,705
    Last modified:March 1, 2001 - v1
    Checksum:iEDA966D758715378
    GO

    Sequence cautioni

    The sequence AAG33698.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti197 – 1971E → K in AAG33698. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061H → Y.
    Corresponds to variant rs16941888 [ dbSNP | Ensembl ].
    VAR_052046

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF210056 mRNA. Translation: AAG43507.1.
    AF205435 mRNA. Translation: AAG33698.1. Different initiation.
    AK315434 mRNA. Translation: BAG37822.1.
    CH471101 Genomic DNA. Translation: EAX01995.1.
    BC017883 mRNA. Translation: AAH17883.1.
    CCDSiCCDS10341.1.
    RefSeqiNP_071446.2. NM_022163.3.
    UniGeneiHs.534261.

    Genome annotation databases

    EnsembliENST00000312475; ENSP00000312311; ENSG00000259494.
    GeneIDi26589.
    KEGGihsa:26589.
    UCSCiuc002bmj.2. human.

    Polymorphism databases

    DMDMi52783325.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF210056 mRNA. Translation: AAG43507.1 .
    AF205435 mRNA. Translation: AAG33698.1 . Different initiation.
    AK315434 mRNA. Translation: BAG37822.1 .
    CH471101 Genomic DNA. Translation: EAX01995.1 .
    BC017883 mRNA. Translation: AAH17883.1 .
    CCDSi CCDS10341.1.
    RefSeqi NP_071446.2. NM_022163.3.
    UniGenei Hs.534261.

    3D structure databases

    ProteinModelPortali Q9H2W6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117757. 12 interactions.
    IntActi Q9H2W6. 3 interactions.
    MINTi MINT-4830900.
    STRINGi 9606.ENSP00000312311.

    PTM databases

    PhosphoSitei Q9H2W6.

    Polymorphism databases

    DMDMi 52783325.

    Proteomic databases

    MaxQBi Q9H2W6.
    PaxDbi Q9H2W6.
    PRIDEi Q9H2W6.

    Protocols and materials databases

    DNASUi 26589.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312475 ; ENSP00000312311 ; ENSG00000259494 .
    GeneIDi 26589.
    KEGGi hsa:26589.
    UCSCi uc002bmj.2. human.

    Organism-specific databases

    CTDi 26589.
    GeneCardsi GC15M089002.
    H-InvDB HIX0012555.
    HGNCi HGNC:1192. MRPL46.
    HPAi HPA050166.
    MIMi 611851. gene.
    neXtProti NX_Q9H2W6.
    PharmGKBi PA30978.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256490.
    HOGENOMi HOG000047532.
    HOVERGENi HBG057426.
    InParanoidi Q9H2W6.
    KOi K17427.
    OMAi NAPCGVY.
    OrthoDBi EOG7GN2NC.
    PhylomeDBi Q9H2W6.

    Miscellaneous databases

    GenomeRNAii 26589.
    NextBioi 48962.
    PROi Q9H2W6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H2W6.
    CleanExi HS_MRPL46.
    Genevestigatori Q9H2W6.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    InterProi IPR015797. NUDIX_hydrolase_dom-like.
    IPR021757. Ribosomal_L46.
    [Graphical view ]
    Pfami PF11788. MRP-L46. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene."
      Carim-Todd L., Sumoy L., Andreu N., Estivill X., Escarceller M.
      DNA Seq. 12:91-96(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel gene identified in vascular endothelial cells."
      Zhang K.M., Chen B.S.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM46_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2W6
    Secondary accession number(s): B2RD75, Q9HBU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3