Q9H2W6 (RM46_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L46, mitochondrial
Short name=L46mt
Short name=MRP-L46

Alternative name(s):
P2ECSL

Gene names

Name:	MRPL46
Synonyms:	C15orf4, LIECG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein L46 family.
Sequence caution	The sequence AAG33698.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 279		39S ribosomal protein L46, mitochondrial		PRO_0000030576
Amino acid modifications
	Modified residue	230	1	N6-acetyllysine Ref.7
Natural variations
	Natural variant	106	1	H → Y. Corresponds to variant rs16941888 [ dbSNP | Ensembl ].		VAR_052046
Experimental info
	Sequence conflict	197	1	E → K in AAG33698. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H2W6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: EDA966D758715378	FASTA	279	31,705
	10 20 30 40 50 60 MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS 70 80 90 100 110 120 KPLTPLQEEM ASLLQQIEIE RSLYSDHELR ALDENQRLAK KKADLHDEED EQDILLAQDL 130 140 150 160 170 180 EDMWEQKFLQ FKLGARITEA DEKNDRTSLN RKLDRNLVLL VREKFGDQDV WILPQAEWQP 190 200 210 220 230 240 GETLRGTAER TLATLSENNM EAKFLGNAPC GHYTFKFPQA MRTESNLGAK VFFFKALLLT 250 260 270 GDFSQAGNKG HHVWVTKDEL GDYLKPKYLA QVRRFVSDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene." Carim-Todd L., Sumoy L., Andreu N., Estivill X., Escarceller M. DNA Seq. 12:91-96(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel gene identified in vascular endothelial cells." Zhang K.M., Chen B.S. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[6]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-230, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF210056 mRNA. Translation: AAG43507.1. AF205435 mRNA. Translation: AAG33698.1. Different initiation. AK315434 mRNA. Translation: BAG37822.1. CH471101 Genomic DNA. Translation: EAX01995.1. BC017883 mRNA. Translation: AAH17883.1.
IPI	IPI00023161.
RefSeq	NP_071446.2. NM_022163.3.
UniGene	Hs.534261.
3D structure databases
ProteinModelPortal	Q9H2W6.
SMR	Q9H2W6. Positions 156-262.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H2W6. 1 interaction.
STRING	9606.ENSP00000312311.
PTM databases
PhosphoSite	Q9H2W6.
Polymorphism databases
DMDM	52783325.
Proteomic databases
PaxDb	Q9H2W6.
PRIDE	Q9H2W6.
Protocols and materials databases
DNASU	26589.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312475; ENSP00000312311; ENSG00000259494.
GeneID	26589.
KEGG	hsa:26589.
UCSC	uc002bmj.2. human.
Organism-specific databases
CTD	26589.
GeneCards	GC15M089002. GC15M089003.
H-InvDB	HIX0012555.
HGNC	HGNC:1192. MRPL46.
HPA	HPA050166.
MIM	611851. gene.
neXtProt	NX_Q9H2W6.
PharmGKB	PA30978.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG256490.
HOGENOM	HOG000047532.
HOVERGEN	HBG057426.
InParanoid	Q9H2W6.
OMA	GHHVWVT.
OrthoDB	EOG46MBKN.
PhylomeDB	Q9H2W6.
Gene expression databases
ArrayExpress	Q9H2W6.
Bgee	Q9H2W6.
CleanEx	HS_MRPL46.
Genevestigator	Q9H2W6.
GermOnline	ENSG00000173867. Homo sapiens.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
InterPro	IPR015797. NUDIX_hydrolase_dom-like. IPR021757. Ribosomal_L46. [Graphical view]
Pfam	PF11788. MRP-L46. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26589.
NextBio	48962.
SOURCE	Search...

Entry information

Entry name

RM46_HUMAN

Accession

Primary (citable) accession number: Q9H2W6
Secondary accession number(s): B2RD75, Q9HBU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.