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Protein

39S ribosomal protein L46, mitochondrial

Gene

MRPL46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L46, mitochondrial
Short name:
L46mt
Short name:
MRP-L46
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL461 Publication
P2ECSL
Gene namesi
Name:MRPL46
Synonyms:C15orf4, LIECG2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:1192. MRPL46.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi26589.
PharmGKBiPA30978.

Polymorphism and mutation databases

BioMutaiMRPL46.
DMDMi52783325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030576? – 27939S ribosomal protein L46, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H2W6.
MaxQBiQ9H2W6.
PaxDbiQ9H2W6.
PeptideAtlasiQ9H2W6.
PRIDEiQ9H2W6.

PTM databases

iPTMnetiQ9H2W6.
PhosphoSitePlusiQ9H2W6.
SwissPalmiQ9H2W6.

Expressioni

Gene expression databases

BgeeiENSG00000259494.
CleanExiHS_MRPL46.
ExpressionAtlasiQ9H2W6. baseline and differential.
GenevisibleiQ9H2W6. HS.

Organism-specific databases

HPAiHPA050166.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL46 is located at the central protuberance.3 Publications

Protein-protein interaction databases

BioGridi117757. 44 interactors.
IntActiQ9H2W6. 14 interactors.
MINTiMINT-4830900.
STRINGi9606.ENSP00000312311.

Structurei

Secondary structure

1279
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi146 – 148Combined sources3
Beta strandi151 – 154Combined sources4
Beta strandi157 – 161Combined sources5
Turni165 – 167Combined sources3
Helixi184 – 196Combined sources13
Beta strandi201 – 204Combined sources4
Turni213 – 215Combined sources3
Beta strandi220 – 223Combined sources4
Beta strandi230 – 232Combined sources3
Beta strandi235 – 237Combined sources3
Beta strandi252 – 255Combined sources4
Beta strandi257 – 259Combined sources3
Beta strandi265 – 267Combined sources3
Helixi270 – 277Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40e1-279[»]
3J9Melectron microscopy3.50e1-279[»]
ProteinModelPortaliQ9H2W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4548. Eukaryota.
ENOG4111HSF. LUCA.
GeneTreeiENSGT00390000015400.
HOGENOMiHOG000047532.
HOVERGENiHBG057426.
InParanoidiQ9H2W6.
KOiK17427.
OMAiNNMEAKF.
OrthoDBiEOG091G0CQP.
PhylomeDBiQ9H2W6.

Family and domain databases

CDDicd04661. MRP_L46. 1 hit.
InterProiView protein in InterPro
IPR033650. MRP_L46_NUDIX.
IPR015797. NUDIX_hydrolase_dom-like.
IPR021757. Ribosomal_L46.
PfamiView protein in Pfam
PF11788. MRP-L46. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H2W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA
60 70 80 90 100
LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHELR ALDENQRLAK
110 120 130 140 150
KKADLHDEED EQDILLAQDL EDMWEQKFLQ FKLGARITEA DEKNDRTSLN
160 170 180 190 200
RKLDRNLVLL VREKFGDQDV WILPQAEWQP GETLRGTAER TLATLSENNM
210 220 230 240 250
EAKFLGNAPC GHYTFKFPQA MRTESNLGAK VFFFKALLLT GDFSQAGNKG
260 270
HHVWVTKDEL GDYLKPKYLA QVRRFVSDL
Length:279
Mass (Da):31,705
Last modified:March 1, 2001 - v1
Checksum:iEDA966D758715378
GO

Sequence cautioni

The sequence AAG33698 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197E → K in AAG33698 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052046106H → Y. Corresponds to variant dbSNP:rs16941888Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210056 mRNA. Translation: AAG43507.1.
AF205435 mRNA. Translation: AAG33698.1. Different initiation.
AK315434 mRNA. Translation: BAG37822.1.
CH471101 Genomic DNA. Translation: EAX01995.1.
BC017883 mRNA. Translation: AAH17883.1.
CCDSiCCDS10341.1.
RefSeqiNP_071446.2. NM_022163.3.
UniGeneiHs.534261.

Genome annotation databases

EnsembliENST00000312475; ENSP00000312311; ENSG00000259494.
GeneIDi26589.
KEGGihsa:26589.
UCSCiuc002bmj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRM46_HUMAN
AccessioniPrimary (citable) accession number: Q9H2W6
Secondary accession number(s): B2RD75, Q9HBU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families