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Q9H2V7

- SPNS1_HUMAN

UniProt

Q9H2V7 - SPNS1_HUMAN

Protein

Protein spinster homolog 1

Gene

SPNS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Sphingolipid transporter By similarity. May be involved in necrotic or autophagic cell death.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW
    2. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Lipid transport, Transport

    Protein family/group databases

    TCDBi2.A.1.49.2. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein spinster homolog 1
    Alternative name(s):
    HSpin1
    Spinster-like protein 1
    Gene namesi
    Name:SPNS1
    Synonyms:SPIN1
    ORF Names:PP20300
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:30621. SPNS1.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Colocalizes with SDHB.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: UniProtKB
    3. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404561.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 528527Protein spinster homolog 1PRO_0000305039Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei518 – 5181Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H2V7.
    PaxDbiQ9H2V7.
    PRIDEiQ9H2V7.

    PTM databases

    PhosphoSiteiQ9H2V7.

    Expressioni

    Gene expression databases

    BgeeiQ9H2V7.
    CleanExiHS_SPIN1.
    HS_SPNS1.
    GenevestigatoriQ9H2V7.

    Organism-specific databases

    HPAiHPA041995.
    HPA042988.

    Interactioni

    Subunit structurei

    Interacts with BCL2 and BCL2L1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BCL2L1Q078173EBI-1386527,EBI-78035

    Protein-protein interaction databases

    BioGridi123836. 5 interactions.
    IntActiQ9H2V7. 7 interactions.
    MINTiMINT-2817616.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2V7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOVERGENiHBG055503.
    InParanoidiQ9H2V7.
    PhylomeDBiQ9H2V7.
    TreeFamiTF314395.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H2V7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGSDTAPFL SQADDPDDGP VPGTPGLPGS TGNPKSEEPE VPDQEGLQRI    50
    TGLSPGRSAL IVAVLCYINL LNYMDRFTVA GVLPDIEQFF NIGDSSSGLI 100
    QTVFISSYMV LAPVFGYLGD RYNRKYLMCG GIAFWSLVTL GSSFIPGEHF 150
    WLLLLTRGLV GVGEASYSTI APTLIADLFV ADQRSRMLSI FYFAIPVGSG 200
    LGYIAGSKVK DMAGDWHWAL RVTPGLGVVA VLLLFLVVRE PPRGAVERHS 250
    DLPPLNPTSW WADLRALARN PSFVLSSLGF TAVAFVTGSL ALWAPAFLLR 300
    SRVVLGETPP CLPGDSCSSS DSLIFGLITC LTGVLGVGLG VEISRRLRHS 350
    NPRADPLVCA TGLLGSAPFL FLSLACARGS IVATYIFIFI GETLLSMNWA 400
    IVADILLYVV IPTRRSTAEA FQIVLSHLLG DAGSPYLIGL ISDRLRRNWP 450
    PSFLSEFRAL QFSLMLCAFV GALGGAAFLG TAIFIEADRR RAQLHVQGLL 500
    HEAGSTDDRI VVPQRGRSTR VPVASVLI 528
    Length:528
    Mass (Da):56,630
    Last modified:March 1, 2001 - v1
    Checksum:iF1B9D2EB3F9F1B48
    GO
    Isoform 2 (identifier: Q9H2V7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         271-322: Missing.

    Show »
    Length:476
    Mass (Da):51,333
    Checksum:i99272BB60BA81889
    GO
    Isoform 3 (identifier: Q9H2V7-3) [UniParc]FASTAAdd to Basket

    Also known as: CRA_d

    The sequence of this isoform differs from the canonical sequence as follows:
         81-102: Missing.
         271-322: Missing.

    Show »
    Length:454
    Mass (Da):49,013
    Checksum:i4A393F34239B87CF
    GO
    Isoform 4 (identifier: Q9H2V7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:455
    Mass (Da):49,139
    Checksum:i63B25A8A61A99C30
    GO
    Isoform 5 (identifier: Q9H2V7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-528: TPGLGVVAVL...TRVPVASVLI → SLVLAWG

    Note: No experimental confirmation available.

    Show »
    Length:229
    Mass (Da):24,594
    Checksum:i07FF7E3B57DF8B8A
    GO

    Sequence cautioni

    The sequence AAQ15259.1 differs from that shown. Reason: Frameshift at position 97.
    The sequence AAQ15259.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti230 – 2301A → P.1 Publication
    Corresponds to variant rs17855956 [ dbSNP | Ensembl ].
    VAR_035157

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7373Missing in isoform 4. 1 PublicationVSP_028194Add
    BLAST
    Alternative sequencei81 – 10222Missing in isoform 3. 1 PublicationVSP_028195Add
    BLAST
    Alternative sequencei223 – 528306TPGLG…ASVLI → SLVLAWG in isoform 5. 1 PublicationVSP_036389Add
    BLAST
    Alternative sequencei271 – 32252Missing in isoform 2 and isoform 3. 2 PublicationsVSP_028196Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212371 mRNA. Translation: AAG43830.1.
    AK095677 mRNA. Translation: BAC04603.1.
    AK289787 mRNA. Translation: BAF82476.1.
    AF370423 mRNA. Translation: AAQ15259.1. Sequence problems.
    AL390215 mRNA. Translation: CAB99229.1.
    AC109460 Genomic DNA. No translation available.
    CH471267 Genomic DNA. Translation: EAW52018.1.
    CH471267 Genomic DNA. Translation: EAW52019.1.
    BC006156 mRNA. Translation: AAH06156.1.
    BC008325 mRNA. Translation: AAH08325.1.
    BC038961 mRNA. Translation: AAH38961.1.
    BC047741 mRNA. Translation: AAH47741.1.
    BC065235 mRNA. Translation: AAH65235.1.
    CCDSiCCDS10646.1. [Q9H2V7-1]
    CCDS45452.1. [Q9H2V7-2]
    CCDS45453.1. [Q9H2V7-3]
    CCDS45454.1. [Q9H2V7-4]
    RefSeqiNP_001135920.1. NM_001142448.1. [Q9H2V7-1]
    NP_001135921.1. NM_001142449.1. [Q9H2V7-3]
    NP_001135922.1. NM_001142450.1. [Q9H2V7-4]
    NP_001135923.1. NM_001142451.1. [Q9H2V7-2]
    NP_114427.1. NM_032038.2. [Q9H2V7-1]
    UniGeneiHs.617449.

    Genome annotation databases

    EnsembliENST00000311008; ENSP00000309945; ENSG00000169682. [Q9H2V7-1]
    ENST00000323081; ENSP00000318228; ENSG00000169682. [Q9H2V7-4]
    ENST00000334536; ENSP00000335494; ENSG00000169682. [Q9H2V7-2]
    ENST00000352260; ENSP00000306050; ENSG00000169682. [Q9H2V7-3]
    GeneIDi83985.
    KEGGihsa:83985.
    UCSCiuc002drx.2. human. [Q9H2V7-1]
    uc002dry.2. human. [Q9H2V7-5]
    uc002drz.2. human. [Q9H2V7-2]
    uc010byp.2. human. [Q9H2V7-3]

    Polymorphism databases

    DMDMi74733566.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF212371 mRNA. Translation: AAG43830.1 .
    AK095677 mRNA. Translation: BAC04603.1 .
    AK289787 mRNA. Translation: BAF82476.1 .
    AF370423 mRNA. Translation: AAQ15259.1 . Sequence problems.
    AL390215 mRNA. Translation: CAB99229.1 .
    AC109460 Genomic DNA. No translation available.
    CH471267 Genomic DNA. Translation: EAW52018.1 .
    CH471267 Genomic DNA. Translation: EAW52019.1 .
    BC006156 mRNA. Translation: AAH06156.1 .
    BC008325 mRNA. Translation: AAH08325.1 .
    BC038961 mRNA. Translation: AAH38961.1 .
    BC047741 mRNA. Translation: AAH47741.1 .
    BC065235 mRNA. Translation: AAH65235.1 .
    CCDSi CCDS10646.1. [Q9H2V7-1 ]
    CCDS45452.1. [Q9H2V7-2 ]
    CCDS45453.1. [Q9H2V7-3 ]
    CCDS45454.1. [Q9H2V7-4 ]
    RefSeqi NP_001135920.1. NM_001142448.1. [Q9H2V7-1 ]
    NP_001135921.1. NM_001142449.1. [Q9H2V7-3 ]
    NP_001135922.1. NM_001142450.1. [Q9H2V7-4 ]
    NP_001135923.1. NM_001142451.1. [Q9H2V7-2 ]
    NP_114427.1. NM_032038.2. [Q9H2V7-1 ]
    UniGenei Hs.617449.

    3D structure databases

    ProteinModelPortali Q9H2V7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123836. 5 interactions.
    IntActi Q9H2V7. 7 interactions.
    MINTi MINT-2817616.

    Protein family/group databases

    TCDBi 2.A.1.49.2. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9H2V7.

    Polymorphism databases

    DMDMi 74733566.

    Proteomic databases

    MaxQBi Q9H2V7.
    PaxDbi Q9H2V7.
    PRIDEi Q9H2V7.

    Protocols and materials databases

    DNASUi 83985.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311008 ; ENSP00000309945 ; ENSG00000169682 . [Q9H2V7-1 ]
    ENST00000323081 ; ENSP00000318228 ; ENSG00000169682 . [Q9H2V7-4 ]
    ENST00000334536 ; ENSP00000335494 ; ENSG00000169682 . [Q9H2V7-2 ]
    ENST00000352260 ; ENSP00000306050 ; ENSG00000169682 . [Q9H2V7-3 ]
    GeneIDi 83985.
    KEGGi hsa:83985.
    UCSCi uc002drx.2. human. [Q9H2V7-1 ]
    uc002dry.2. human. [Q9H2V7-5 ]
    uc002drz.2. human. [Q9H2V7-2 ]
    uc010byp.2. human. [Q9H2V7-3 ]

    Organism-specific databases

    CTDi 83985.
    GeneCardsi GC16P028986.
    HGNCi HGNC:30621. SPNS1.
    HPAi HPA041995.
    HPA042988.
    MIMi 612583. gene.
    neXtProti NX_Q9H2V7.
    PharmGKBi PA162404561.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOVERGENi HBG055503.
    InParanoidi Q9H2V7.
    PhylomeDBi Q9H2V7.
    TreeFami TF314395.

    Miscellaneous databases

    GenomeRNAii 83985.
    NextBioi 73114.
    PROi Q9H2V7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H2V7.
    CleanExi HS_SPIN1.
    HS_SPNS1.
    Genevestigatori Q9H2V7.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster."
      Nakano Y., Fujitani K., Kurihara J., Ragan J., Usui-Aoki K., Shimoda L., Lukacsovich T., Suzuki K., Sezaki M., Sano Y., Ueda R., Awano W., Kaneda M., Umeda M., Yamamoto D.
      Mol. Cell. Biol. 21:3775-3788(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Mammary cancer.
    5. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-230.
      Tissue: Blood, Brain, Pancreas and Skin.
    8. "HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death."
      Yanagisawa H., Miyashita T., Nakano Y., Yamamoto D.
      Cell Death Differ. 10:798-807(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BCL2 AND BCL2L1.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPNS1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2V7
    Secondary accession number(s): B5MDM9
    , Q6P182, Q71RB5, Q7L541, Q86VU7, Q8N953, Q8TCS5, Q9BRN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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