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Q9H2U9 (ADAM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disintegrin and metalloproteinase domain-containing protein 7

Short name=ADAM 7
Alternative name(s):
Sperm maturation-related glycoprotein GP-83
Gene names
Name:ADAM7
Synonyms:GP83
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Not detected in healthy melanocytes. Expressed in melanoma cells. Ref.4

Involvement in disease

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 peptidase M12B domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 176158 By similarity
PRO_0000029052
Chain177 – 754578Disintegrin and metalloproteinase domain-containing protein 7
PRO_0000029053

Regions

Topological domain19 – 668650Extracellular Potential
Transmembrane669 – 68921Helical; Potential
Topological domain690 – 75465Cytoplasmic Potential
Domain199 – 394196Peptidase M12B
Domain402 – 48887Disintegrin
Compositional bias489 – 668180Cys-rich

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation5841N-linked (GlcNAc...) Potential
Glycosylation6681N-linked (GlcNAc...) Potential
Disulfide bond310 ↔ 389 By similarity
Disulfide bond350 ↔ 373 By similarity
Disulfide bond352 ↔ 357 By similarity
Disulfide bond460 ↔ 480 By similarity

Natural variations

Natural variant141P → S in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066296
Natural variant251E → Q.
Corresponds to variant rs34852692 [ dbSNP | Ensembl ].
VAR_046728
Natural variant311R → C in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066297
Natural variant361P → S in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066298
Natural variant1061H → Y in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066299
Natural variant1731L → P Detected in a melanoma cell line. Ref.4
VAR_066300
Natural variant1801V → A in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066301
Natural variant2051I → V.
Corresponds to variant rs7829386 [ dbSNP | Ensembl ].
VAR_046729
Natural variant2431H → Y in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to laminin-1. Ref.4
VAR_066302
Natural variant2441V → M.
Corresponds to variant rs13255694 [ dbSNP | Ensembl ].
VAR_046730
Natural variant3021G → E in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066303
Natural variant3591M → I in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to collagen IV. Ref.4
VAR_066304
Natural variant4531I → T.
Corresponds to variant rs3736281 [ dbSNP | Ensembl ].
VAR_046731
Natural variant5331G → E in a cutaneous metastatic melanoma sample; somatic mutation. Ref.4
VAR_066305
Natural variant5701L → V.
Corresponds to variant rs2307044 [ dbSNP | Ensembl ].
VAR_046732
Natural variant5931F → L Detected in a melanoma cell line. Ref.4
VAR_066306
Natural variant6381N → H.
Corresponds to variant rs13259668 [ dbSNP | Ensembl ].
VAR_046733
Natural variant6391E → K in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to collagen IV and laminin-1; increases cell migration capabilities compared to wild-type. Ref.4
VAR_066307
Natural variant7031S → N in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to collagen IV and laminin-1; increases cell migration capabilities compared to wild-type. Ref.4
VAR_066308
Natural variant7351L → P.
Corresponds to variant rs6980829 [ dbSNP | Ensembl ].
VAR_046734

Experimental info

Sequence conflict951E → G in AAG43987. Ref.1
Sequence conflict369 – 3702KF → DL in AAC36742. Ref.3
Sequence conflict3741S → R in AAC36742. Ref.3
Sequence conflict5181E → D in AAG43987. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9H2U9 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: D9E9DF9B5812B0A7

FASTA75485,669
        10         20         30         40         50         60 
MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL 

        70         80         90        100        110        120 
YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH PQIMDHCFYQ GSIVHEYDSA 

       130        140        150        160        170        180 
ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV 

       190        200        210        220        230        240 
PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL 

       250        260        270        280        290        300 
NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV 

       310        320        330        340        350        360 
QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD 

       370        380        390        400        410        420 
SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP 

       430        440        450        460        470        480 
AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC 

       490        500        510        520        530        540 
PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDEAI ESHDICYKMN TKGNKFGYCK 

       550        560        570        580        590        600 
NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD 

       610        620        630        640        650        660 
IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC 

       670        680        690        700        710        720 
EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE 

       730        740        750 
QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK 

« Hide

References

« Hide 'large scale' references
[1]"Expression of human ADAM7 (GP-83)."
Lin Y.C., Lee Y.M., Sun G.H., Liu H.W.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Epididymis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"A ADAM-like cDNA sequence identified in cDNA library of human epididymis."
Liu H.W., Lin Y.C., Sun G.H.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-754.
Tissue: Epididymis.
[4]"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN CUTANEOUS MELANOMA, VARIANTS SER-14; CYS-31; SER-36; TYR-106; PRO-173; ALA-180; TYR-243; GLU-302; ILE-359; GLU-533; LEU-593; LYS-639 AND ASN-703, CHARACTERIZATION OF VARIANTS TYR-243; ILE-359; LYS-639 AND ASN-703.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF215824 mRNA. Translation: AAG43987.1.
AK292492 mRNA. Translation: BAF85181.1.
AF090327 mRNA. Translation: AAC36742.1.
CCDSCCDS6045.1.
RefSeqNP_003808.2. NM_003817.3.
UniGeneHs.116147.

3D structure databases

ProteinModelPortalQ9H2U9.
SMRQ9H2U9. Positions 195-628, 634-662.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000175238.

Protein family/group databases

MEROPSM12.956.

PTM databases

PhosphoSiteQ9H2U9.

Polymorphism databases

DMDM296439449.

Proteomic databases

PaxDbQ9H2U9.
PRIDEQ9H2U9.

Protocols and materials databases

DNASU8756.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000175238; ENSP00000175238; ENSG00000069206.
GeneID8756.
KEGGhsa:8756.
UCSCuc003xeb.3. human.

Organism-specific databases

CTD8756.
GeneCardsGC08P024354.
HGNCHGNC:214. ADAM7.
HPAHPA008879.
MIM607310. gene.
neXtProtNX_Q9H2U9.
PharmGKBPA24532.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277164.
HOGENOMHOG000230883.
HOVERGENHBG006978.
KOK16071.
OrthoDBEOG7X0VGD.
PhylomeDBQ9H2U9.
TreeFamTF314733.

Gene expression databases

ArrayExpressQ9H2U9.
BgeeQ9H2U9.
CleanExHS_ADAM7.
GenevestigatorQ9H2U9.

Family and domain databases

Gene3D3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSPR00289. DISINTEGRIN.
SMARTSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMSSF57552. SSF57552. 1 hit.
PROSITEPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8756.
NextBio32854.
PROQ9H2U9.
SOURCESearch...

Entry information

Entry nameADAM7_HUMAN
AccessionPrimary (citable) accession number: Q9H2U9
Secondary accession number(s): A8K8X7, O75959
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM