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Q9H2U9

- ADAM7_HUMAN

UniProt

Q9H2U9 - ADAM7_HUMAN

Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

ADAM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein By similarity.By similarity

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Protein family/group databases

    MEROPSiM12.956.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
    Short name:
    ADAM 7
    Alternative name(s):
    Sperm maturation-related glycoprotein GP-83
    Gene namesi
    Name:ADAM7
    Synonyms:GP83
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:214. ADAM7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

    Organism-specific databases

    PharmGKBiPA24532.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 176158By similarityPRO_0000029052Add
    BLAST
    Chaini177 – 754578Disintegrin and metalloproteinase domain-containing protein 7PRO_0000029053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi310 ↔ 389By similarity
    Disulfide bondi350 ↔ 373By similarity
    Disulfide bondi352 ↔ 357By similarity
    Disulfide bondi460 ↔ 480By similarity
    Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi668 – 6681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H2U9.
    PRIDEiQ9H2U9.

    PTM databases

    PhosphoSiteiQ9H2U9.

    Expressioni

    Tissue specificityi

    Not detected in healthy melanocytes. Expressed in melanoma cells.1 Publication

    Gene expression databases

    ArrayExpressiQ9H2U9.
    BgeeiQ9H2U9.
    CleanExiHS_ADAM7.
    GenevestigatoriQ9H2U9.

    Organism-specific databases

    HPAiHPA008879.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000175238.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2U9.
    SMRiQ9H2U9. Positions 195-628, 634-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 668650ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini690 – 75465CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei669 – 68921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini199 – 394196Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini402 – 48887DisintegrinPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi489 – 668180Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277164.
    HOGENOMiHOG000230883.
    HOVERGENiHBG006978.
    KOiK16071.
    OrthoDBiEOG7X0VGD.
    PhylomeDBiQ9H2U9.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H2U9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD    50
    ILKTYEEELL YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH 100
    PQIMDHCFYQ GSIVHEYDSA ASISTCNGLR GFFRINDQRY LIEPVKYSDE 150
    GEHLVFKYNL RVPYGANYSC TELNFTRKTV PGDNESEEDS KIKGIHDEKY 200
    VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL NIHVTLVGIE 250
    IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV 300
    QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC 350
    TCPSGKCVMD SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH 400
    DFQFCGNKKL DEGEECDCGP AQECTNPCCD AHTCVLKPGF TCAEGECCES 450
    CQIKKAGSIC RPAKDECDFP EMCTGHSPAC PKDQFRVNGF PCKNSEGYCF 500
    MGKCPTREDQ CSELFDDEAI ESHDICYKMN TKGNKFGYCK NKENRFLPCE 550
    EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD 600
    IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH 650
    CEEGQAPVAC EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ 700
    VQSPPTETLG VENKGYFGDE QQIRTEPILP EIHFLNKPAS KDSRGIADPN 750
    QSAK 754
    Length:754
    Mass (Da):85,669
    Last modified:May 18, 2010 - v3
    Checksum:iD9E9DF9B5812B0A7
    GO
    Isoform 2 (identifier: Q9H2U9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         194-210: GIHDEKYVELFIVADDT → VSTLLLSLPQMKHLLFS
         211-754: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:210
    Mass (Da):24,414
    Checksum:i9DA98150EA3F0499
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951E → G in AAG43987. 1 PublicationCurated
    Sequence conflicti369 – 3702KF → DL in AAC36742. 1 PublicationCurated
    Sequence conflicti374 – 3741S → R in AAC36742. 1 PublicationCurated
    Sequence conflicti518 – 5181E → D in AAG43987. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141P → S in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066296
    Natural varianti25 – 251E → Q.
    Corresponds to variant rs34852692 [ dbSNP | Ensembl ].
    VAR_046728
    Natural varianti31 – 311R → C in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066297
    Natural varianti36 – 361P → S in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066298
    Natural varianti106 – 1061H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066299
    Natural varianti173 – 1731L → P Detected in a melanoma cell line. 1 Publication
    VAR_066300
    Natural varianti180 – 1801V → A in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066301
    Natural varianti205 – 2051I → V.
    Corresponds to variant rs7829386 [ dbSNP | Ensembl ].
    VAR_046729
    Natural varianti243 – 2431H → Y in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to laminin-1. 1 Publication
    VAR_066302
    Natural varianti244 – 2441V → M.
    Corresponds to variant rs13255694 [ dbSNP | Ensembl ].
    VAR_046730
    Natural varianti302 – 3021G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066303
    Natural varianti359 – 3591M → I in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to collagen IV. 1 Publication
    VAR_066304
    Natural varianti453 – 4531I → T.
    Corresponds to variant rs3736281 [ dbSNP | Ensembl ].
    VAR_046731
    Natural varianti533 – 5331G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066305
    Natural varianti570 – 5701L → V.
    Corresponds to variant rs2307044 [ dbSNP | Ensembl ].
    VAR_046732
    Natural varianti593 – 5931F → L Detected in a melanoma cell line. 1 Publication
    VAR_066306
    Natural varianti638 – 6381N → H.
    Corresponds to variant rs13259668 [ dbSNP | Ensembl ].
    VAR_046733
    Natural varianti639 – 6391E → K in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to collagen IV and laminin-1; increases cell migration capabilities compared to wild-type. 1 Publication
    VAR_066307
    Natural varianti703 – 7031S → N in a cutaneous metastatic melanoma sample; somatic mutation; does not affect cell growth but conferes reduced cell adhesion to collagen IV and laminin-1; increases cell migration capabilities compared to wild-type. 1 Publication
    VAR_066308
    Natural varianti735 – 7351L → P.
    Corresponds to variant rs6980829 [ dbSNP | Ensembl ].
    VAR_046734

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei194 – 21017GIHDE…VADDT → VSTLLLSLPQMKHLLFS in isoform 2. 1 PublicationVSP_056602Add
    BLAST
    Alternative sequencei211 – 754544Missing in isoform 2. 1 PublicationVSP_056603Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215824 mRNA. Translation: AAG43987.1.
    AK292492 mRNA. Translation: BAF85181.1.
    AC024958 Genomic DNA. No translation available.
    AC120193 Genomic DNA. No translation available.
    BC058037 mRNA. Translation: AAH58037.1.
    AF090327 mRNA. Translation: AAC36742.1.
    CCDSiCCDS6045.1.
    RefSeqiNP_003808.2. NM_003817.3.
    UniGeneiHs.116147.

    Genome annotation databases

    EnsembliENST00000175238; ENSP00000175238; ENSG00000069206.
    ENST00000441335; ENSP00000393073; ENSG00000069206.
    GeneIDi8756.
    KEGGihsa:8756.
    UCSCiuc003xeb.3. human.

    Polymorphism databases

    DMDMi296439449.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215824 mRNA. Translation: AAG43987.1 .
    AK292492 mRNA. Translation: BAF85181.1 .
    AC024958 Genomic DNA. No translation available.
    AC120193 Genomic DNA. No translation available.
    BC058037 mRNA. Translation: AAH58037.1 .
    AF090327 mRNA. Translation: AAC36742.1 .
    CCDSi CCDS6045.1.
    RefSeqi NP_003808.2. NM_003817.3.
    UniGenei Hs.116147.

    3D structure databases

    ProteinModelPortali Q9H2U9.
    SMRi Q9H2U9. Positions 195-628, 634-662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000175238.

    Protein family/group databases

    MEROPSi M12.956.

    PTM databases

    PhosphoSitei Q9H2U9.

    Polymorphism databases

    DMDMi 296439449.

    Proteomic databases

    PaxDbi Q9H2U9.
    PRIDEi Q9H2U9.

    Protocols and materials databases

    DNASUi 8756.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000175238 ; ENSP00000175238 ; ENSG00000069206 .
    ENST00000441335 ; ENSP00000393073 ; ENSG00000069206 .
    GeneIDi 8756.
    KEGGi hsa:8756.
    UCSCi uc003xeb.3. human.

    Organism-specific databases

    CTDi 8756.
    GeneCardsi GC08P024354.
    HGNCi HGNC:214. ADAM7.
    HPAi HPA008879.
    MIMi 607310. gene.
    neXtProti NX_Q9H2U9.
    PharmGKBi PA24532.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277164.
    HOGENOMi HOG000230883.
    HOVERGENi HBG006978.
    KOi K16071.
    OrthoDBi EOG7X0VGD.
    PhylomeDBi Q9H2U9.
    TreeFami TF314733.

    Miscellaneous databases

    GenomeRNAii 8756.
    NextBioi 32854.
    PROi Q9H2U9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H2U9.
    Bgeei Q9H2U9.
    CleanExi HS_ADAM7.
    Genevestigatori Q9H2U9.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of human ADAM7 (GP-83)."
      Lin Y.C., Lee Y.M., Sun G.H., Liu H.W.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Epididymis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    5. "A ADAM-like cDNA sequence identified in cDNA library of human epididymis."
      Liu H.W., Lin Y.C., Sun G.H.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-754 (ISOFORM 1).
      Tissue: Epididymis.
    6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
      Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
      Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INVOLVEMENT IN CUTANEOUS MELANOMA, VARIANTS SER-14; CYS-31; SER-36; TYR-106; PRO-173; ALA-180; TYR-243; GLU-302; ILE-359; GLU-533; LEU-593; LYS-639 AND ASN-703, CHARACTERIZATION OF VARIANTS TYR-243; ILE-359; LYS-639 AND ASN-703.

    Entry informationi

    Entry nameiADAM7_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2U9
    Secondary accession number(s): A8K8X7, O75959, Q6PEJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3