Disintegrin and metalloproteinase domain-containing protein 7 precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9H2U9 (ADAM7_HUMAN)

Last modified November 24, 2009. Version 71. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
      Short name=ADAM 7
Alternative name(s):
    Sperm maturation-related glycoprotein GP-83

Gene names

Name:	ADAM7
Synonyms:	GP83

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	754 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

18

Potential

Propeptide

158

By similarity

PRO_0000029052

Chain

578

Disintegrin and metalloproteinase domain-containing protein 7

PRO_0000029053

Regions

Topological domain

650

Extracellular Potential

Transmembrane

21

Potential

Topological domain

65

Cytoplasmic Potential

Domain

196

Peptidase M12B

Domain

87

Disintegrin

Compositional bias

180

Cys-rich

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Disulfide bond

By similarity

Natural variations

Natural variant

1

E → Q: dbSNP rs34852692.

VAR_046728

Natural variant

1

I → V: dbSNP rs7829386.

VAR_046729

Natural variant

1

V → M: dbSNP rs13255694.

VAR_046730

Natural variant

1

I → T: dbSNP rs3736281.

VAR_046731

Natural variant

1

L → V: dbSNP rs2307044.

VAR_046732

Natural variant

1

N → H: dbSNP rs13259668.

VAR_046733

Natural variant

1

L → P: dbSNP rs6980829.

VAR_046734

Experimental info

Sequence conflict

1

E → G in AAG43987. Ref.1

Sequence conflict

2

KF → DL in AAC36742. Ref.3

Sequence conflict

1

S → R in AAC36742. Ref.3

Sequence conflict

1

D → E in BAF85181. Ref.2

Sequence conflict

1

D → E in AAC36742. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q9H2U9-1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: FE32B22D832F137D
Show »

754

85,655

        10         20         30         40         50         60 
MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL 

        70         80         90        100        110        120 
YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH PQIMDHCFYQ GSIVHEYDSA 

       130        140        150        160        170        180 
ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV 

       190        200        210        220        230        240 
PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL 

       250        260        270        280        290        300 
NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV 

       310        320        330        340        350        360 
QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD 

       370        380        390        400        410        420 
SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP 

       430        440        450        460        470        480 
AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC 

       490        500        510        520        530        540 
PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDDAI ESHDICYKMN TKGNKFGYCK 

       550        560        570        580        590        600 
NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD 

       610        620        630        640        650        660 
IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC 

       670        680        690        700        710        720 
EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE 

       730        740        750 
QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of human ADAM7 (GP-83)." Lin Y.C., Lee Y.M., Sun G.H., Liu H.W. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"A ADAM-like cDNA sequence identified in cDNA library of human epididymis." Liu H.W., Lin Y.C., Sun G.H. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-754. Tissue: Epididymis.

Cross-references

Sequence databases
	AF215824 mRNA. Translation: AAG43987.1. AK292492 mRNA. Translation: BAF85181.1. AF090327 mRNA. Translation: AAC36742.1.
IPI	IPI00023134.
RefSeq	NP_003808.2.
UniGene	Hs.116147
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H2U9.
Genome annotation databases
Ensembl	ENST00000175238; ENSP00000175238; ENSG00000069206; Homo sapiens. [Genome view]
GeneID	8756.
KEGG	hsa:8756.
Organism-specific databases
CTD	8756.
GeneCards	GC08P024354.
HGNC	HGNC:214. ADAM7.
MIM	607310. gene.
PharmGKB	PA24532.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H2U9.
Gene expression databases
ArrayExpress	Q9H2U9.
Bgee	Q9H2U9.
CleanEx	HS_ADAM7.
Genevestigator	Q9H2U9.
GermOnline	ENSG00000069206. Homo sapiens.
Family and domain databases
InterPro	IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
SMART	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32854.
SOURCE	Search...

Entry information

Entry name

ADAM7_HUMAN

Accession

Primary (citable) accession number: Q9H2U9
Secondary accession number(s): A8K8X7, O75959

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 14, 2008
Last modified:	November 24, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents