Q9H2U1 (DHX36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ATP-dependent RNA helicase DHX36
EC=3.6.4.13

Alternative name(s):
DEAH box protein 36
MLE-like protein 1
RNA helicase associated with AU-rich element ARE

Gene names

Name:	DHX36
Synonyms:	DDX36, KIAA1488, MLEL1, RHAU

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1008 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Ref.1 Ref.2
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Interacts with EIF2C1, EIF2C2, PARN, EXOSC3 and EXOSC10. Ref.2 Ref.8
Subcellular location	Nucleus. Cytoplasm. Note: Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Ref.2
Tissue specificity	Highly expressed in testis. Ref.1 Ref.2
Sequence similarities	Belongs to the DEAD box helicase family. DEAH subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to exogenous dsRNA Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro double-stranded RNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H2U1-1)

Also known as: Nuclear isoform;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H2U1-2)

Also known as: Cytoplasmic isoform; RHAU-delta 14;

The sequence of this isoform differs from the canonical sequence as follows:
     517-530: Missing.

Isoform 3 (identifier: Q9H2U1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     737-765: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1008	1008	Probable ATP-dependent RNA helicase DHX36		PRO_0000247530
Regions
	Domain	217 – 387	171	Helicase ATP-binding
	Domain	477 – 647	171	Helicase C-terminal
	Nucleotide binding	230 – 237	8	ATP By similarity
	Coiled coil	72 – 157	86	Potential
	Motif	334 – 337	4	DEAH box
	Motif	517 – 528	12	Nuclear localization signal
	Compositional bias	10 – 63	54	Gly-rich
Amino acid modifications
	Modified residue	947	1	N6-acetyllysine Ref.11
Natural variations
	Alternative sequence	517 – 530	14	Missing in isoform 2.		VSP_020006
	Alternative sequence	737 – 765	29	Missing in isoform 3.		VSP_020007
	Natural variant	151	1	E → K. Corresponds to variant rs1058299 [ dbSNP | Ensembl ].		VAR_027140
	Natural variant	416	1	S → C. Ref.1 Ref.2 Ref.6 Corresponds to variant rs9438 [ dbSNP | Ensembl ].		VAR_027141
	Natural variant	583	1	I → N. Ref.6 Corresponds to variant rs17853513 [ dbSNP | Ensembl ].		VAR_027142
Experimental info
	Mutagenesis	335	1	E → A: Loss of ATPase activity resulting in loss of mRNA deadenylation and decay. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Nuclear isoform) [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 66A28A1FE93C62AE	FASTA	1,008	114,760
	10 20 30 40 50 60 MSYDYHQNWG RDGGPRSSGG GYGGGPAGGH GGNRGSGGGG GGGGGGRGGR GRHPGHLKGR 70 80 90 100 110 120 EIGMWYAKKQ GQKNKEAERQ ERAVVHMDER REEQIVQLLN SVQAKNDKES EAQISWFAPE 130 140 150 160 170 180 DHGYGTEVST KNTPCSENKL DIQEKKLINQ EKKMFRIRNR SYIDRDSEYL LQENEPDGTL 190 200 210 220 230 240 DQKLLEDLQK KKNDLRYIEM QHFREKLPSY GMQKELVNLI DNHQVTVISG ETGCGKTTQV 250 260 270 280 290 300 TQFILDNYIE RGKGSACRIV CTQPRRISAI SVAERVAAER AESCGSGNST GYQIRLQSRL 310 320 330 340 350 360 PRKQGSILYC TTGIILQWLQ SDPYLSSVSH IVLDEIHERN LQSDVLMTVV KDLLNFRSDL 370 380 390 400 410 420 KVILMSATLN AEKFSEYFGN CPMIHIPGFT FPVVEYLLED VIEKIRYVPE QKEHRSQFKR 430 440 450 460 470 480 GFMQGHVNRQ EKEEKEAIYK ERWPDYVREL RRRYSASTVD VIEMMEDDKV DLNLIVALIR 490 500 510 520 530 540 YIVLEEEDGA ILVFLPGWDN ISTLHDLLMS QVMFKSDKFL IIPLHSLMPT VNQTQVFKRT 550 560 570 580 590 600 PPGVRKIVIA TNIAETSITI DDVVYVIDGG KIKETHFDTQ NNISTMSAEW VSKANAKQRK 610 620 630 640 650 660 GRAGRVQPGH CYHLYNGLRA SLLDDYQLPE ILRTPLEELC LQIKILRLGG IAYFLSRLMD 670 680 690 700 710 720 PPSNEAVLLS IRHLMELNAL DKQEELTPLG VHLARLPVEP HIGKMILFGA LFCCLDPVLT 730 740 750 760 770 780 IAASLSFKDP FVIPLGKEKI ADARRKELAK DTRSDHLTVV NAFEGWEEAR RRGFRYEKDY 790 800 810 820 830 840 CWEYFLSSNT LQMLHNMKGQ FAEHLLGAGF VSSRNPKDPE SNINSDNEKI IKAVICAGLY 850 860 870 880 890 900 PKVAKIRLNL GKKRKMVKVY TKTDGLVAVH PKSVNVEQTD FHYNWLIYHL KMRTSSIYLY 910 920 930 940 950 960 DCTEVSPYCL LFFGGDISIQ KDNDQETIAV DEWIVFQSPA RIAHLVKELR KELDILLQEK 970 980 990 1000 IESPHPVDWN DTKSRDCAVL SAIIDLIKTQ EKATPRNFPP RFQDGYYS
	Isoform 2 (Cytoplasmic isoform) (RHAU-delta 14) [UniParc]. Checksum: 47809C3BDA49B709	FASTA	994	113,153
	10 20 30 40 50 60 MSYDYHQNWG RDGGPRSSGG GYGGGPAGGH GGNRGSGGGG GGGGGGRGGR GRHPGHLKGR 70 80 90 100 110 120 EIGMWYAKKQ GQKNKEAERQ ERAVVHMDER REEQIVQLLN SVQAKNDKES EAQISWFAPE 130 140 150 160 170 180 DHGYGTEVST KNTPCSENKL DIQEKKLINQ EKKMFRIRNR SYIDRDSEYL LQENEPDGTL 190 200 210 220 230 240 DQKLLEDLQK KKNDLRYIEM QHFREKLPSY GMQKELVNLI DNHQVTVISG ETGCGKTTQV 250 260 270 280 290 300 TQFILDNYIE RGKGSACRIV CTQPRRISAI SVAERVAAER AESCGSGNST GYQIRLQSRL 310 320 330 340 350 360 PRKQGSILYC TTGIILQWLQ SDPYLSSVSH IVLDEIHERN LQSDVLMTVV KDLLNFRSDL 370 380 390 400 410 420 KVILMSATLN AEKFSEYFGN CPMIHIPGFT FPVVEYLLED VIEKIRYVPE QKEHRSQFKR 430 440 450 460 470 480 GFMQGHVNRQ EKEEKEAIYK ERWPDYVREL RRRYSASTVD VIEMMEDDKV DLNLIVALIR 490 500 510 520 530 540 YIVLEEEDGA ILVFLPGWDN ISTLHDLLMS QVMFKSVNQT QVFKRTPPGV RKIVIATNIA 550 560 570 580 590 600 ETSITIDDVV YVIDGGKIKE THFDTQNNIS TMSAEWVSKA NAKQRKGRAG RVQPGHCYHL 610 620 630 640 650 660 YNGLRASLLD DYQLPEILRT PLEELCLQIK ILRLGGIAYF LSRLMDPPSN EAVLLSIRHL 670 680 690 700 710 720 MELNALDKQE ELTPLGVHLA RLPVEPHIGK MILFGALFCC LDPVLTIAAS LSFKDPFVIP 730 740 750 760 770 780 LGKEKIADAR RKELAKDTRS DHLTVVNAFE GWEEARRRGF RYEKDYCWEY FLSSNTLQML 790 800 810 820 830 840 HNMKGQFAEH LLGAGFVSSR NPKDPESNIN SDNEKIIKAV ICAGLYPKVA KIRLNLGKKR 850 860 870 880 890 900 KMVKVYTKTD GLVAVHPKSV NVEQTDFHYN WLIYHLKMRT SSIYLYDCTE VSPYCLLFFG 910 920 930 940 950 960 GDISIQKDND QETIAVDEWI VFQSPARIAH LVKELRKELD ILLQEKIESP HPVDWNDTKS 970 980 990 RDCAVLSAII DLIKTQEKAT PRNFPPRFQD GYYS
	Isoform 3 [UniParc]. Checksum: E8F39FA84E4DA91D	FASTA	979	111,479
	10 20 30 40 50 60 MSYDYHQNWG RDGGPRSSGG GYGGGPAGGH GGNRGSGGGG GGGGGGRGGR GRHPGHLKGR 70 80 90 100 110 120 EIGMWYAKKQ GQKNKEAERQ ERAVVHMDER REEQIVQLLN SVQAKNDKES EAQISWFAPE 130 140 150 160 170 180 DHGYGTEVST KNTPCSENKL DIQEKKLINQ EKKMFRIRNR SYIDRDSEYL LQENEPDGTL 190 200 210 220 230 240 DQKLLEDLQK KKNDLRYIEM QHFREKLPSY GMQKELVNLI DNHQVTVISG ETGCGKTTQV 250 260 270 280 290 300 TQFILDNYIE RGKGSACRIV CTQPRRISAI SVAERVAAER AESCGSGNST GYQIRLQSRL 310 320 330 340 350 360 PRKQGSILYC TTGIILQWLQ SDPYLSSVSH IVLDEIHERN LQSDVLMTVV KDLLNFRSDL 370 380 390 400 410 420 KVILMSATLN AEKFSEYFGN CPMIHIPGFT FPVVEYLLED VIEKIRYVPE QKEHRSQFKR 430 440 450 460 470 480 GFMQGHVNRQ EKEEKEAIYK ERWPDYVREL RRRYSASTVD VIEMMEDDKV DLNLIVALIR 490 500 510 520 530 540 YIVLEEEDGA ILVFLPGWDN ISTLHDLLMS QVMFKSDKFL IIPLHSLMPT VNQTQVFKRT 550 560 570 580 590 600 PPGVRKIVIA TNIAETSITI DDVVYVIDGG KIKETHFDTQ NNISTMSAEW VSKANAKQRK 610 620 630 640 650 660 GRAGRVQPGH CYHLYNGLRA SLLDDYQLPE ILRTPLEELC LQIKILRLGG IAYFLSRLMD 670 680 690 700 710 720 PPSNEAVLLS IRHLMELNAL DKQEELTPLG VHLARLPVEP HIGKMILFGA LFCCLDPVLT 730 740 750 760 770 780 IAASLSFKDP FVIPLGWEEA RRRGFRYEKD YCWEYFLSSN TLQMLHNMKG QFAEHLLGAG 790 800 810 820 830 840 FVSSRNPKDP ESNINSDNEK IIKAVICAGL YPKVAKIRLN LGKKRKMVKV YTKTDGLVAV 850 860 870 880 890 900 HPKSVNVEQT DFHYNWLIYH LKMRTSSIYL YDCTEVSPYC LLFFGGDISI QKDNDQETIA 910 920 930 940 950 960 VDEWIVFQSP ARIAHLVKEL RKELDILLQE KIESPHPVDW NDTKSRDCAV LSAIIDLIKT 970 QEKATPRNFP PRFQDGYYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily." Fu J.-J., Li L.-Y., Lu G.-X. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:655-661(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT CYS-416. Tissue: Brain.
[2]	"Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU." Tran H., Schilling M., Wirbelauer C., Hess D., Nagamine Y. Mol. Cell 13:101-111(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PARN; EXOSC3 AND EXOSC10, MUTAGENESIS OF GLU-335, VARIANT CYS-416.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS CYS-416 AND ASN-583. Tissue: Testis.
[7]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-1008 (ISOFORM 1). Tissue: Brain.
[8]	"Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells." Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G. EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EIF2C1 AND EIF2C2.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-947, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217190 mRNA. Translation: AAG36783.1. AJ577133 mRNA. Translation: CAE11802.1. AJ577134 mRNA. Translation: CAE11803.1. AK314435 mRNA. Translation: BAG37047.1. AC018452 Genomic DNA. No translation available. AC134026 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78761.1. BC036035 mRNA. Translation: AAH36035.1. AB040921 mRNA. Translation: BAA96012.1.
IPI	IPI00027415. IPI00217760. IPI00784170.
PIR	D56236.
RefSeq	NP_001107869.1. NM_001114397.1. NP_065916.2. NM_020865.2.
UniGene	Hs.446270.
3D structure databases
ProteinModelPortal	Q9H2U1.
SMR	Q9H2U1. Positions 192-911.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H2U1. 5 interactions.
MINT	MINT-3066797.
STRING	9606.ENSP00000417078.
PTM databases
PhosphoSite	Q9H2U1.
Polymorphism databases
DMDM	74762733.
Proteomic databases
PaxDb	Q9H2U1.
PRIDE	Q9H2U1.
Protocols and materials databases
DNASU	170506.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308361; ENSP00000309296; ENSG00000174953. ENST00000329463; ENSP00000330113; ENSG00000174953. ENST00000496811; ENSP00000417078; ENSG00000174953.
GeneID	170506.
KEGG	hsa:170506.
UCSC	uc003ezy.4. human. uc003ezz.4. human. uc010hvq.3. human.
Organism-specific databases
CTD	170506.
GeneCards	GC03M153990.
HGNC	HGNC:14410. DHX36.
HPA	HPA035399.
MIM	612767. gene.
neXtProt	NX_Q9H2U1.
PharmGKB	PA27223.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1643.
HOGENOM	HOG000247063.
HOVERGEN	HBG081438.
InParanoid	Q9H2U1.
KO	K14442.
OMA	RIRNRSY.
OrthoDB	EOG4K6G3J.
PhylomeDB	Q9H2U1.
Gene expression databases
ArrayExpress	Q9H2U1.
Bgee	Q9H2U1.
CleanEx	HS_DHX36.
Genevestigator	Q9H2U1.
GermOnline	ENSG00000174953. Homo sapiens.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR011709. DUF1605. IPR007502. Helicase-assoc_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF04408. HA2. 1 hit. PF00271. Helicase_C. 1 hit. PF07717. OB_NTP_bind. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00847. HA2. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	170506.
NextBio	88959.
SOURCE	Search...

Entry information

Entry name

DHX36_HUMAN

Accession

Primary (citable) accession number: Q9H2U1
Secondary accession number(s): B2RB00 , Q70JU3, Q8IYE5, Q9P240

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.