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Q9H2U1

- DHX36_HUMAN

UniProt

Q9H2U1 - DHX36_HUMAN

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Protein

ATP-dependent RNA helicase DHX36

Gene

DHX36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.9 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi230 – 2378ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. core promoter binding Source: UniProtKB
  4. DNA-dependent ATPase activity Source: UniProtKB
  5. double-stranded RNA binding Source: MGI
  6. G-quadruplex DNA binding Source: UniProtKB
  7. G-quadruplex RNA binding Source: UniProtKB
  8. histone deacetylase binding Source: UniProtKB
  9. poly(A) RNA binding Source: UniProtKB
  10. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. innate immune response Source: Reactome
  3. ossification Source: UniProtKB
  4. positive regulation of telomere maintenance Source: UniProtKB
  5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  6. positive regulation of type I interferon production Source: Reactome
  7. response to exogenous dsRNA Source: Ensembl
  8. response to virus Source: Ensembl
  9. RNA secondary structure unwinding Source: UniProtKB
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DHX36 (EC:3.6.4.12, EC:3.6.4.13)
Alternative name(s):
DEAH box protein 36
G4-resolvase 1
Short name:
G4R1
MLE-like protein 1
RNA helicase associated with AU-rich element ARE
Gene namesi
Name:DHX36
Synonyms:DDX36, KIAA1488, MLEL1, RHAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14410. DHX36.

Subcellular locationi

Nucleus. Cytoplasm. Chromosometelomere Curated
Note: Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules.

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB-KW
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541P → G: Reduces G4-RNA binding; when associated with A-57, A-59, A-62 and A-63. 1 Publication
Mutagenesisi57 – 571L → A: Reduces G4-RNA binding; when associated with G-54, A-59, A-62 and A-63. 1 Publication
Mutagenesisi59 – 591G → A: Reduces G4-RNA binding; when associated with G-54, A-57, A-62 and A-63. 1 Publication
Mutagenesisi59 – 591G → P: Greatly reduces G4-RNA binding; when associated with P-63. 1 Publication
Mutagenesisi62 – 621I → A: Reduces G4-RNA binding; when associated with G-54, A-57, A-59 and A-63. 1 Publication
Mutagenesisi63 – 631G → A: Reduces G4-RNA binding; when associated with G-54, A-57, A-59 and A-62. 1 Publication
Mutagenesisi63 – 631G → P: Greatly reduces G4-RNA binding; when associated with P-59. 1 Publication
Mutagenesisi335 – 3351E → A: Loss of ATPase activity resulting in loss of mRNA deadenylation and decay. 1 Publication

Organism-specific databases

PharmGKBiPA27223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10081008ATP-dependent RNA helicase DHX36PRO_0000247530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei947 – 9471N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H2U1.
PaxDbiQ9H2U1.
PRIDEiQ9H2U1.

PTM databases

PhosphoSiteiQ9H2U1.

Expressioni

Tissue specificityi

Highly expressed in testis.2 Publications

Gene expression databases

BgeeiQ9H2U1.
CleanExiHS_DHX36.
ExpressionAtlasiQ9H2U1. baseline and differential.
GenevestigatoriQ9H2U1.

Organism-specific databases

HPAiHPA035399.

Interactioni

Subunit structurei

Interacts with AGO1, AGO2, PARN, EXOSC3, EXOSC10, HDAC1 and HDAC4.4 Publications

Protein-protein interaction databases

BioGridi128022. 38 interactions.
IntActiQ9H2U1. 7 interactions.
MINTiMINT-3066797.
STRINGi9606.ENSP00000417078.

Structurei

3D structure databases

ProteinModelPortaliQ9H2U1.
SMRiQ9H2U1. Positions 192-911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 387171Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini477 – 647171Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 105105RNA-binding; sufficient and required for recruitment to cytoplasmic stress granulesAdd
BLAST
Regioni53 – 10553Sufficient and required for interaction with TERC 5'-endAdd
BLAST
Regioni54 – 6613RSMAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili72 – 15786Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi334 – 3374DEAH box
Motifi517 – 52812Nuclear localization signalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 6354Gly-richAdd
BLAST

Domaini

The RHAU-specific motif (RSM) is required for quadruplex G4-DNA/RNA structure recognition and resolution.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00760000119189.
HOGENOMiHOG000247063.
HOVERGENiHBG081438.
InParanoidiQ9H2U1.
KOiK14442.
OMAiNVEQTEF.
OrthoDBiEOG7SV0TS.
PhylomeDBiQ9H2U1.
TreeFamiTF324744.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H2U1-1) [UniParc]FASTAAdd to Basket

Also known as: Nuclear isoform

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYDYHQNWG RDGGPRSSGG GYGGGPAGGH GGNRGSGGGG GGGGGGRGGR
60 70 80 90 100
GRHPGHLKGR EIGMWYAKKQ GQKNKEAERQ ERAVVHMDER REEQIVQLLN
110 120 130 140 150
SVQAKNDKES EAQISWFAPE DHGYGTEVST KNTPCSENKL DIQEKKLINQ
160 170 180 190 200
EKKMFRIRNR SYIDRDSEYL LQENEPDGTL DQKLLEDLQK KKNDLRYIEM
210 220 230 240 250
QHFREKLPSY GMQKELVNLI DNHQVTVISG ETGCGKTTQV TQFILDNYIE
260 270 280 290 300
RGKGSACRIV CTQPRRISAI SVAERVAAER AESCGSGNST GYQIRLQSRL
310 320 330 340 350
PRKQGSILYC TTGIILQWLQ SDPYLSSVSH IVLDEIHERN LQSDVLMTVV
360 370 380 390 400
KDLLNFRSDL KVILMSATLN AEKFSEYFGN CPMIHIPGFT FPVVEYLLED
410 420 430 440 450
VIEKIRYVPE QKEHRSQFKR GFMQGHVNRQ EKEEKEAIYK ERWPDYVREL
460 470 480 490 500
RRRYSASTVD VIEMMEDDKV DLNLIVALIR YIVLEEEDGA ILVFLPGWDN
510 520 530 540 550
ISTLHDLLMS QVMFKSDKFL IIPLHSLMPT VNQTQVFKRT PPGVRKIVIA
560 570 580 590 600
TNIAETSITI DDVVYVIDGG KIKETHFDTQ NNISTMSAEW VSKANAKQRK
610 620 630 640 650
GRAGRVQPGH CYHLYNGLRA SLLDDYQLPE ILRTPLEELC LQIKILRLGG
660 670 680 690 700
IAYFLSRLMD PPSNEAVLLS IRHLMELNAL DKQEELTPLG VHLARLPVEP
710 720 730 740 750
HIGKMILFGA LFCCLDPVLT IAASLSFKDP FVIPLGKEKI ADARRKELAK
760 770 780 790 800
DTRSDHLTVV NAFEGWEEAR RRGFRYEKDY CWEYFLSSNT LQMLHNMKGQ
810 820 830 840 850
FAEHLLGAGF VSSRNPKDPE SNINSDNEKI IKAVICAGLY PKVAKIRLNL
860 870 880 890 900
GKKRKMVKVY TKTDGLVAVH PKSVNVEQTD FHYNWLIYHL KMRTSSIYLY
910 920 930 940 950
DCTEVSPYCL LFFGGDISIQ KDNDQETIAV DEWIVFQSPA RIAHLVKELR
960 970 980 990 1000
KELDILLQEK IESPHPVDWN DTKSRDCAVL SAIIDLIKTQ EKATPRNFPP

RFQDGYYS
Length:1,008
Mass (Da):114,760
Last modified:November 30, 2010 - v2
Checksum:i66A28A1FE93C62AE
GO
Isoform 2 (identifier: Q9H2U1-2) [UniParc]FASTAAdd to Basket

Also known as: Cytoplasmic isoform, RHAU-delta 14

The sequence of this isoform differs from the canonical sequence as follows:
     517-530: Missing.

Show »
Length:994
Mass (Da):113,153
Checksum:i47809C3BDA49B709
GO
Isoform 3 (identifier: Q9H2U1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-765: Missing.

Note: No experimental confirmation available.

Show »
Length:979
Mass (Da):111,479
Checksum:iE8F39FA84E4DA91D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511E → K.
Corresponds to variant rs1058299 [ dbSNP | Ensembl ].
VAR_027140
Natural varianti416 – 4161S → C.3 Publications
Corresponds to variant rs9438 [ dbSNP | Ensembl ].
VAR_027141
Natural varianti583 – 5831I → N.1 Publication
Corresponds to variant rs17853513 [ dbSNP | Ensembl ].
VAR_027142

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei517 – 53014Missing in isoform 2. 1 PublicationVSP_020006Add
BLAST
Alternative sequencei737 – 76529Missing in isoform 3. 1 PublicationVSP_020007Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217190 mRNA. Translation: AAG36783.1.
AJ577133 mRNA. Translation: CAE11802.1.
AJ577134 mRNA. Translation: CAE11803.1.
AK314435 mRNA. Translation: BAG37047.1.
AC018452 Genomic DNA. No translation available.
AC134026 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78761.1.
BC036035 mRNA. Translation: AAH36035.1.
AB040921 mRNA. Translation: BAA96012.1.
CCDSiCCDS3171.1. [Q9H2U1-1]
CCDS54657.1. [Q9H2U1-2]
PIRiD56236.
RefSeqiNP_001107869.1. NM_001114397.1. [Q9H2U1-2]
NP_065916.2. NM_020865.2. [Q9H2U1-1]
UniGeneiHs.446270.

Genome annotation databases

EnsembliENST00000308361; ENSP00000309296; ENSG00000174953. [Q9H2U1-3]
ENST00000329463; ENSP00000330113; ENSG00000174953. [Q9H2U1-2]
ENST00000496811; ENSP00000417078; ENSG00000174953. [Q9H2U1-1]
GeneIDi170506.
KEGGihsa:170506.
UCSCiuc003ezy.4. human. [Q9H2U1-1]
uc003ezz.4. human. [Q9H2U1-3]
uc010hvq.3. human. [Q9H2U1-2]

Polymorphism databases

DMDMi313104099.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217190 mRNA. Translation: AAG36783.1 .
AJ577133 mRNA. Translation: CAE11802.1 .
AJ577134 mRNA. Translation: CAE11803.1 .
AK314435 mRNA. Translation: BAG37047.1 .
AC018452 Genomic DNA. No translation available.
AC134026 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78761.1 .
BC036035 mRNA. Translation: AAH36035.1 .
AB040921 mRNA. Translation: BAA96012.1 .
CCDSi CCDS3171.1. [Q9H2U1-1 ]
CCDS54657.1. [Q9H2U1-2 ]
PIRi D56236.
RefSeqi NP_001107869.1. NM_001114397.1. [Q9H2U1-2 ]
NP_065916.2. NM_020865.2. [Q9H2U1-1 ]
UniGenei Hs.446270.

3D structure databases

ProteinModelPortali Q9H2U1.
SMRi Q9H2U1. Positions 192-911.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128022. 38 interactions.
IntActi Q9H2U1. 7 interactions.
MINTi MINT-3066797.
STRINGi 9606.ENSP00000417078.

Chemistry

ChEMBLi CHEMBL2040704.

PTM databases

PhosphoSitei Q9H2U1.

Polymorphism databases

DMDMi 313104099.

Proteomic databases

MaxQBi Q9H2U1.
PaxDbi Q9H2U1.
PRIDEi Q9H2U1.

Protocols and materials databases

DNASUi 170506.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308361 ; ENSP00000309296 ; ENSG00000174953 . [Q9H2U1-3 ]
ENST00000329463 ; ENSP00000330113 ; ENSG00000174953 . [Q9H2U1-2 ]
ENST00000496811 ; ENSP00000417078 ; ENSG00000174953 . [Q9H2U1-1 ]
GeneIDi 170506.
KEGGi hsa:170506.
UCSCi uc003ezy.4. human. [Q9H2U1-1 ]
uc003ezz.4. human. [Q9H2U1-3 ]
uc010hvq.3. human. [Q9H2U1-2 ]

Organism-specific databases

CTDi 170506.
GeneCardsi GC03M153990.
HGNCi HGNC:14410. DHX36.
HPAi HPA035399.
MIMi 612767. gene.
neXtProti NX_Q9H2U1.
PharmGKBi PA27223.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1643.
GeneTreei ENSGT00760000119189.
HOGENOMi HOG000247063.
HOVERGENi HBG081438.
InParanoidi Q9H2U1.
KOi K14442.
OMAi NVEQTEF.
OrthoDBi EOG7SV0TS.
PhylomeDBi Q9H2U1.
TreeFami TF324744.

Enzyme and pathway databases

Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.

Miscellaneous databases

ChiTaRSi DHX36. human.
GeneWikii DHX36.
GenomeRNAii 170506.
NextBioi 88959.
PROi Q9H2U1.
SOURCEi Search...

Gene expression databases

Bgeei Q9H2U1.
CleanExi HS_DHX36.
ExpressionAtlasi Q9H2U1. baseline and differential.
Genevestigatori Q9H2U1.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily."
    Fu J.-J., Li L.-Y., Lu G.-X.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:655-661(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT CYS-416.
    Tissue: Brain.
  2. "Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU."
    Tran H., Schilling M., Wirbelauer C., Hess D., Nagamine Y.
    Mol. Cell 13:101-111(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH PARN; EXOSC3 AND EXOSC10, MUTAGENESIS OF GLU-335, VARIANT CYS-416.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS CYS-416 AND ASN-583.
    Tissue: Testis.
  7. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-1008 (ISOFORM 1).
    Tissue: Brain.
  8. "The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates."
    Vaughn J.P., Creacy S.D., Routh E.D., Joyner-Butt C., Jenkins G.S., Pauli S., Nagamine Y., Akman S.A.
    J. Biol. Chem. 280:38117-38120(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
    Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G.
    EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AGO1 AND AGO2.
  10. "G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates."
    Creacy S.D., Routh E.D., Iwamoto F., Nagamine Y., Akman S.A., Vaughn J.P.
    J. Biol. Chem. 283:34626-34634(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BINDING TO RNA/DNA QUADRUPLEX STRUCTURES.
  11. "Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain."
    Chalupnikova K., Lattmann S., Selak N., Iwamoto F., Fujiki Y., Nagamine Y.
    J. Biol. Chem. 283:35186-35198(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, RNA-BINDING.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-947, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU."
    Lattmann S., Giri B., Vaughn J.P., Akman S.A., Nagamine Y.
    Nucleic Acids Res. 38:6219-6233(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF PRO-54; LEU-57; GLY-59; ILE-62 AND GLY-63.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation."
    Sexton A.N., Collins K.
    Mol. Cell. Biol. 31:736-743(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TERC.
  18. Cited for: FUNCTION AND CATALYTIC ACTIVITY.
  19. "Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1."
    Huang W., Smaldino P.J., Zhang Q., Miller L.D., Cao P., Stadelman K., Wan M., Giri B., Lei M., Nagamine Y., Vaughn J.P., Akman S.A., Sui G.
    Nucleic Acids Res. 40:1033-1049(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary."
    Booy E.P., Meier M., Okun N., Novakowski S.K., Xiong S., Stetefeld J., McKenna S.A.
    Nucleic Acids Res. 40:4110-4124(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TERC.

Entry informationi

Entry nameiDHX36_HUMAN
AccessioniPrimary (citable) accession number: Q9H2U1
Secondary accession number(s): B2RB00
, Q70JU3, Q8IYE5, Q9P240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3