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Protein

Ran-binding protein 17

Gene

RANBP17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a nuclear transport receptor.By similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB
  • nuclear export signal receptor activity Source: GO_Central
  • Ran GTPase binding Source: GO_Central

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • protein export from nucleus Source: GO_Central
  • protein import into nucleus Source: UniProtKB

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

SIGNORiQ9H2T7

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 17
Gene namesi
Name:RANBP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000204764.12
HGNCiHGNC:14428 RANBP17
MIMi606141 gene
neXtProtiNX_Q9H2T7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64901
OpenTargetsiENSG00000204764
PharmGKBiPA34208

Polymorphism and mutation databases

BioMutaiRANBP17
DMDMi17368945

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002047182 – 1088Ran-binding protein 17Add BLAST1087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei569PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H2T7
MaxQBiQ9H2T7
PaxDbiQ9H2T7
PeptideAtlasiQ9H2T7
PRIDEiQ9H2T7

PTM databases

iPTMnetiQ9H2T7
PhosphoSitePlusiQ9H2T7

Expressioni

Tissue specificityi

Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.1 Publication

Gene expression databases

BgeeiENSG00000204764
CleanExiHS_RANBP17
ExpressionAtlasiQ9H2T7 baseline and differential
GenevisibleiQ9H2T7 HS

Organism-specific databases

HPAiHPA029568
HPA029569

Interactioni

Subunit structurei

Binds to nucleoporins and the GTP-bound form of Ran.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122341, 8 interactors
STRINGi9606.ENSP00000427975

Structurei

3D structure databases

ProteinModelPortaliQ9H2T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG1410 Eukaryota
ENOG410XRPR LUCA
GeneTreeiENSGT00730000110927
HOGENOMiHOG000139593
HOVERGENiHBG018869
InParanoidiQ9H2T7
OMAiQEVLAQC
OrthoDBiEOG091G0ONG
PhylomeDBiQ9H2T7
TreeFamiTF314248

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALHFQSLAE LEVLCTHLYI GTDLTQRIEA EKALLELIDS PECLSKCQLL
60 70 80 90 100
LEQGTTSYAQ LLAATCLSKL VSRVSPLPVE QRMDIRNYIL NYVASQPKLA
110 120 130 140 150
PFVIQALIQV IAKITKLGWF EVQKDQFVFR EIIADVKKFL QGTVEHCIIG
160 170 180 190 200
VIILSELTQE MNLVDYSRPS AKHRKIATSF RDTSLKDVLV LACSLLKEVF
210 220 230 240 250
AKPLNLQDQC QQNLVMQVLK LVLNCLNFDF IGSSADESAD DLCTVQIPTT
260 270 280 290 300
WRTIFLEPET LDLFFNLYHS LPPLLSQLAL SCLVQFASTR RSLFNSPERA
310 320 330 340 350
KYLGNLIKGV KRILENPQGL SDPGNYHEFC RFLARLKTNY QLGELVMVKE
360 370 380 390 400
YPEVIRLIAN FTITSLQHWE FAPNSVHYLL TLWQRMVASV PFVKSTEPHL
410 420 430 440 450
LDTYAPEITK AFITSRLDSV AIVVRDHLDD PLDDTATVFQ QLEQLCTVSR
460 470 480 490 500
CEYEKTCALL VQLFDQNAQN YQKLLHPYSG VTVDITIQEG RLAWLVYLVG
510 520 530 540 550
TVVGGRLTYT STDEHDAMDG ELSCRVFQLI SLMDTGLPRC CNEKIELAIL
560 570 580 590 600
WFLDQFRKTY VGDQLQRTSK VYARMSEVLG ITDDNHVLET FMTKIVTNLK
610 620 630 640 650
YWGRYEPVIS RTLQFLNDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL
660 670 680 690 700
GISDNHSLSD FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVAFETV
710 720 730 740 750
LQIFNNNFKQ EDVKRMLIGL ARDLRGIAFA LNTKTSYTML FDWMYPTYLP
760 770 780 790 800
LLQNAVERWY GEPTCTTPIL KLMAELMQNR SQRLNFDVSS PNGILLFREA
810 820 830 840 850
SKMVCTYGNQ ILSLGSLSKD QIYPMKLKGI SICYSALKSA LCGNYVSFGV
860 870 880 890 900
FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
910 920 930 940 950
SFIINLEPPV LMYVLTSISE GLTTLDTVVS SSCCTSLDYI VTYLFKHIAK
960 970 980 990 1000
EGKKPLRCRE ATQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS
1010 1020 1030 1040 1050
VSRPLLGLIL LNEKYFSELR ASLINSQPLP KQEVLAQCFR NLMEGVEQNL
1060 1070 1080
SVKNRDRFTQ NLSVFRRDVA EALRSDGNTE PCSLDMMS
Length:1,088
Mass (Da):124,375
Last modified:March 1, 2001 - v1
Checksum:iA95D5599388EAEFB
GO
Isoform 2 (identifier: Q9H2T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     571-576: VYARMS → KTDIFL
     577-1088: Missing.

Show »
Length:576
Mass (Da):65,567
Checksum:i9483A1664A8307E3
GO

Sequence cautioni

The sequence BAB55427 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107L → H in BAB55427 (PubMed:14702039).Curated1
Sequence conflicti199V → A in BAB55427 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056669571 – 576VYARMS → KTDIFL in isoform 2. 1 Publication6
Alternative sequenceiVSP_056670577 – 1088Missing in isoform 2. 1 PublicationAdd BLAST512

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222747 mRNA Translation: AAG44255.1
AJ288952 mRNA Translation: CAC81806.1
AJ288953 mRNA Translation: CAC81807.1
AJ288955 mRNA Translation: CAC81809.1
AC008514 Genomic DNA No translation available.
AC010306 Genomic DNA No translation available.
AC016574 Genomic DNA No translation available.
AC018753 Genomic DNA No translation available.
AC021077 Genomic DNA No translation available.
AC091980 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61456.1
CH471062 Genomic DNA Translation: EAW61457.1
CH471062 Genomic DNA Translation: EAW61461.1
CH471062 Genomic DNA Translation: EAW61463.1
AK027880 mRNA Translation: BAB55427.1 Different initiation.
CCDSiCCDS34287.1 [Q9H2T7-1]
RefSeqiNP_075048.1, NM_022897.4 [Q9H2T7-1]
UniGeneiHs.410810

Genome annotation databases

EnsembliENST00000389118; ENSP00000373770; ENSG00000204764 [Q9H2T7-2]
ENST00000519256; ENSP00000429298; ENSG00000204764 [Q9H2T7-2]
ENST00000519949; ENSP00000430444; ENSG00000204764 [Q9H2T7-2]
ENST00000522533; ENSP00000430599; ENSG00000204764 [Q9H2T7-2]
ENST00000523189; ENSP00000427975; ENSG00000204764 [Q9H2T7-1]
GeneIDi64901
KEGGihsa:64901
UCSCiuc003mba.4 human [Q9H2T7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBP17_HUMAN
AccessioniPrimary (citable) accession number: Q9H2T7
Secondary accession number(s): Q8IU74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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