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Protein

Ran-binding protein 17

Gene

RANBP17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a nuclear transport receptor.By similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB
  • nuclear export signal receptor activity Source: GO_Central
  • Ran GTPase binding Source: GO_Central

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • protein export from nucleus Source: GO_Central
  • protein import into nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 17
Gene namesi
Name:RANBP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14428. RANBP17.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nuclear pore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34208.

Polymorphism and mutation databases

BioMutaiRANBP17.
DMDMi17368945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10881088Ran-binding protein 17PRO_0000204718Add
BLAST

Proteomic databases

MaxQBiQ9H2T7.
PaxDbiQ9H2T7.
PRIDEiQ9H2T7.

PTM databases

iPTMnetiQ9H2T7.
PhosphoSiteiQ9H2T7.

Expressioni

Tissue specificityi

Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.1 Publication

Gene expression databases

BgeeiQ9H2T7.
CleanExiHS_RANBP17.
ExpressionAtlasiQ9H2T7. baseline and differential.
GenevisibleiQ9H2T7. HS.

Organism-specific databases

HPAiHPA029568.
HPA029569.

Interactioni

Subunit structurei

Binds to nucleoporins and the GTP-bound form of Ran.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122341. 8 interactions.
STRINGi9606.ENSP00000427975.

Structurei

3D structure databases

ProteinModelPortaliQ9H2T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG1410. Eukaryota.
ENOG410XRPR. LUCA.
GeneTreeiENSGT00730000110927.
HOGENOMiHOG000139593.
HOVERGENiHBG018869.
InParanoidiQ9H2T7.
OMAiQEVLAQC.
OrthoDBiEOG7HXCQ0.
PhylomeDBiQ9H2T7.
TreeFamiTF314248.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALHFQSLAE LEVLCTHLYI GTDLTQRIEA EKALLELIDS PECLSKCQLL
60 70 80 90 100
LEQGTTSYAQ LLAATCLSKL VSRVSPLPVE QRMDIRNYIL NYVASQPKLA
110 120 130 140 150
PFVIQALIQV IAKITKLGWF EVQKDQFVFR EIIADVKKFL QGTVEHCIIG
160 170 180 190 200
VIILSELTQE MNLVDYSRPS AKHRKIATSF RDTSLKDVLV LACSLLKEVF
210 220 230 240 250
AKPLNLQDQC QQNLVMQVLK LVLNCLNFDF IGSSADESAD DLCTVQIPTT
260 270 280 290 300
WRTIFLEPET LDLFFNLYHS LPPLLSQLAL SCLVQFASTR RSLFNSPERA
310 320 330 340 350
KYLGNLIKGV KRILENPQGL SDPGNYHEFC RFLARLKTNY QLGELVMVKE
360 370 380 390 400
YPEVIRLIAN FTITSLQHWE FAPNSVHYLL TLWQRMVASV PFVKSTEPHL
410 420 430 440 450
LDTYAPEITK AFITSRLDSV AIVVRDHLDD PLDDTATVFQ QLEQLCTVSR
460 470 480 490 500
CEYEKTCALL VQLFDQNAQN YQKLLHPYSG VTVDITIQEG RLAWLVYLVG
510 520 530 540 550
TVVGGRLTYT STDEHDAMDG ELSCRVFQLI SLMDTGLPRC CNEKIELAIL
560 570 580 590 600
WFLDQFRKTY VGDQLQRTSK VYARMSEVLG ITDDNHVLET FMTKIVTNLK
610 620 630 640 650
YWGRYEPVIS RTLQFLNDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL
660 670 680 690 700
GISDNHSLSD FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVAFETV
710 720 730 740 750
LQIFNNNFKQ EDVKRMLIGL ARDLRGIAFA LNTKTSYTML FDWMYPTYLP
760 770 780 790 800
LLQNAVERWY GEPTCTTPIL KLMAELMQNR SQRLNFDVSS PNGILLFREA
810 820 830 840 850
SKMVCTYGNQ ILSLGSLSKD QIYPMKLKGI SICYSALKSA LCGNYVSFGV
860 870 880 890 900
FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
910 920 930 940 950
SFIINLEPPV LMYVLTSISE GLTTLDTVVS SSCCTSLDYI VTYLFKHIAK
960 970 980 990 1000
EGKKPLRCRE ATQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS
1010 1020 1030 1040 1050
VSRPLLGLIL LNEKYFSELR ASLINSQPLP KQEVLAQCFR NLMEGVEQNL
1060 1070 1080
SVKNRDRFTQ NLSVFRRDVA EALRSDGNTE PCSLDMMS
Length:1,088
Mass (Da):124,375
Last modified:March 1, 2001 - v1
Checksum:iA95D5599388EAEFB
GO
Isoform 2 (identifier: Q9H2T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     571-576: VYARMS → KTDIFL
     577-1088: Missing.

Show »
Length:576
Mass (Da):65,567
Checksum:i9483A1664A8307E3
GO

Sequence cautioni

The sequence BAB55427.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071L → H in BAB55427 (PubMed:14702039).Curated
Sequence conflicti199 – 1991V → A in BAB55427 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei571 – 5766VYARMS → KTDIFL in isoform 2. 1 PublicationVSP_056669
Alternative sequencei577 – 1088512Missing in isoform 2. 1 PublicationVSP_056670Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222747 mRNA. Translation: AAG44255.1.
AJ288952 mRNA. Translation: CAC81806.1.
AJ288953 mRNA. Translation: CAC81807.1.
AJ288955 mRNA. Translation: CAC81809.1.
AC008514 Genomic DNA. No translation available.
AC010306 Genomic DNA. No translation available.
AC016574 Genomic DNA. No translation available.
AC018753 Genomic DNA. No translation available.
AC021077 Genomic DNA. No translation available.
AC091980 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61456.1.
CH471062 Genomic DNA. Translation: EAW61457.1.
CH471062 Genomic DNA. Translation: EAW61461.1.
CH471062 Genomic DNA. Translation: EAW61463.1.
AK027880 mRNA. Translation: BAB55427.1. Different initiation.
CCDSiCCDS34287.1. [Q9H2T7-1]
RefSeqiNP_075048.1. NM_022897.4. [Q9H2T7-1]
UniGeneiHs.410810.

Genome annotation databases

EnsembliENST00000389118; ENSP00000373770; ENSG00000204764. [Q9H2T7-2]
ENST00000519256; ENSP00000429298; ENSG00000204764. [Q9H2T7-2]
ENST00000519949; ENSP00000430444; ENSG00000204764. [Q9H2T7-2]
ENST00000522533; ENSP00000430599; ENSG00000204764. [Q9H2T7-2]
ENST00000523189; ENSP00000427975; ENSG00000204764. [Q9H2T7-1]
GeneIDi64901.
KEGGihsa:64901.
UCSCiuc003mba.4. human. [Q9H2T7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222747 mRNA. Translation: AAG44255.1.
AJ288952 mRNA. Translation: CAC81806.1.
AJ288953 mRNA. Translation: CAC81807.1.
AJ288955 mRNA. Translation: CAC81809.1.
AC008514 Genomic DNA. No translation available.
AC010306 Genomic DNA. No translation available.
AC016574 Genomic DNA. No translation available.
AC018753 Genomic DNA. No translation available.
AC021077 Genomic DNA. No translation available.
AC091980 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61456.1.
CH471062 Genomic DNA. Translation: EAW61457.1.
CH471062 Genomic DNA. Translation: EAW61461.1.
CH471062 Genomic DNA. Translation: EAW61463.1.
AK027880 mRNA. Translation: BAB55427.1. Different initiation.
CCDSiCCDS34287.1. [Q9H2T7-1]
RefSeqiNP_075048.1. NM_022897.4. [Q9H2T7-1]
UniGeneiHs.410810.

3D structure databases

ProteinModelPortaliQ9H2T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122341. 8 interactions.
STRINGi9606.ENSP00000427975.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ9H2T7.
PhosphoSiteiQ9H2T7.

Polymorphism and mutation databases

BioMutaiRANBP17.
DMDMi17368945.

Proteomic databases

MaxQBiQ9H2T7.
PaxDbiQ9H2T7.
PRIDEiQ9H2T7.

Protocols and materials databases

DNASUi64901.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389118; ENSP00000373770; ENSG00000204764. [Q9H2T7-2]
ENST00000519256; ENSP00000429298; ENSG00000204764. [Q9H2T7-2]
ENST00000519949; ENSP00000430444; ENSG00000204764. [Q9H2T7-2]
ENST00000522533; ENSP00000430599; ENSG00000204764. [Q9H2T7-2]
ENST00000523189; ENSP00000427975; ENSG00000204764. [Q9H2T7-1]
GeneIDi64901.
KEGGihsa:64901.
UCSCiuc003mba.4. human. [Q9H2T7-1]

Organism-specific databases

CTDi64901.
GeneCardsiRANBP17.
HGNCiHGNC:14428. RANBP17.
HPAiHPA029568.
HPA029569.
MIMi606141. gene.
neXtProtiNX_Q9H2T7.
PharmGKBiPA34208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1410. Eukaryota.
ENOG410XRPR. LUCA.
GeneTreeiENSGT00730000110927.
HOGENOMiHOG000139593.
HOVERGENiHBG018869.
InParanoidiQ9H2T7.
OMAiQEVLAQC.
OrthoDBiEOG7HXCQ0.
PhylomeDBiQ9H2T7.
TreeFamiTF314248.

Miscellaneous databases

ChiTaRSiRANBP17. human.
GenomeRNAii64901.
NextBioi67049.
PROiQ9H2T7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2T7.
CleanExiHS_RANBP17.
ExpressionAtlasiQ9H2T7. baseline and differential.
GenevisibleiQ9H2T7. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily."
    Kutay U., Hartmann E., Treichel N., Calado A., Carmo-Fonseca M., Prehn S., Kraft R., Goerlich D., Bischoff F.R.
    J. Biol. Chem. 275:40163-40168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cervix carcinoma.
  3. "Identification of a gene located at the chromosomal breakpoint t(5;14)(q33-q34;q11), a recurring chromosomal aberration in a subset of human acute leukemias."
    Hansen-Hagge T.E., Schaefer M., Kiyoi H., Bohlmann I., Koch P., Morris S., Bartram C.R., Janssen J.W.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1088 (ISOFORM 1).
    Tissue: Thyroid.

Entry informationi

Entry nameiRBP17_HUMAN
AccessioniPrimary (citable) accession number: Q9H2T7
Secondary accession number(s): Q8IU74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.