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Protein

Tenomodulin

Gene

TNMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be an angiogenesis inhibitor.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tenomodulin
Short name:
TeM
Short name:
hTeM
Alternative name(s):
Chondromodulin-1-like protein
Short name:
ChM1L
Short name:
hChM1L
Chondromodulin-I-like protein
Myodulin
Tendin
Gene namesi
Name:TNMD
Synonyms:CHM1L
ORF Names:UNQ771/PRO1565
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17757. TNMD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030CytoplasmicSequence analysisAdd
BLAST
Transmembranei31 – 5020Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini51 – 317267ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878561.

Polymorphism and mutation databases

BioMutaiTNMD.
DMDMi18202941.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317TenomodulinPRO_0000144308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 178By similarity
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Modified residuei239 – 2391PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9H2S6.
PeptideAtlasiQ9H2S6.
PRIDEiQ9H2S6.

PTM databases

iPTMnetiQ9H2S6.
PhosphoSiteiQ9H2S6.

Expressioni

Tissue specificityi

Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.3 Publications

Gene expression databases

BgeeiQ9H2S6.
CleanExiHS_TNMD.
GenevisibleiQ9H2S6. HS.

Organism-specific databases

HPAiHPA034961.
HPA055634.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM79Q9BSE23EBI-10306119,EBI-8649725

Protein-protein interaction databases

BioGridi122062. 1 interaction.
IntActiQ9H2S6. 1 interaction.
STRINGi9606.ENSP00000362122.

Structurei

3D structure databases

ProteinModelPortaliQ9H2S6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 18694BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chondromodulin-1 family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWK. Eukaryota.
ENOG410YB96. LUCA.
GeneTreeiENSGT00480000042679.
HOGENOMiHOG000234812.
HOVERGENiHBG004387.
InParanoidiQ9H2S6.
OMAiFWPETPK.
OrthoDBiEOG7R832C.
PhylomeDBiQ9H2S6.
TreeFamiTF329712.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2S6-1) [UniParc]FASTAAdd to basket

Also known as: 64kDa, I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKNPPENCE DCHILNAEAF KSKKICKSLK ICGLVFGILA LTLIVLFWGS
60 70 80 90 100
KHFWPEVPKK AYDMEHTFYS NGEKKKIYME IDPVTRTEIF RSGNGTDETL
110 120 130 140 150
EVHDFKNGYT GIYFVGLQKC FIKTQIKVIP EFSEPEEEID ENEEITTTFF
160 170 180 190 200
EQSVIWVPAE KPIENRDFLK NSKILEICDN VTMYWINPTL ISVSELQDFE
210 220 230 240 250
EEGEDLHFPA NEKKGIEQNE QWVVPQVKVE KTRHARQASE EELPINDYTE
260 270 280 290 300
NGIEFDPMLD ERGYCCIYCR RGNRYCRRVC EPLLGYYPYP YCYQGGRVIC
310
RVIMPCNWWV ARMLGRV
Length:317
Mass (Da):37,130
Last modified:March 1, 2001 - v1
Checksum:iD17507D7E2EA0C68
GO
Isoform 2 (identifier: Q9H2S6-2) [UniParc]FASTAAdd to basket

Also known as: 33 kDa, II

The sequence of this isoform differs from the canonical sequence as follows:
     193-207: VSELQDFEEEGEDLH → GMTFLSSSSSYFLRQ
     208-317: Missing.

Show »
Length:207
Mass (Da):23,967
Checksum:iDF69CCCDFDC0A2B1
GO
Isoform 3 (identifier: Q9H2S6-3) [UniParc]FASTAAdd to basket

Also known as: 45kDa, III

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Show »
Length:254
Mass (Da):30,013
Checksum:i3E8E6F4A229CBF3A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401A → T in AAG28395 (Ref. 3) Curated
Sequence conflicti71 – 711N → S in AAG28395 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 3. CuratedVSP_054949Add
BLAST
Alternative sequencei193 – 20715VSELQ…GEDLH → GMTFLSSSSSYFLRQ in isoform 2. CuratedVSP_054950Add
BLAST
Alternative sequencei208 – 317110Missing in isoform 2. CuratedVSP_054951Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055421 mRNA. Translation: BAB21756.1.
AF234259 mRNA. Translation: AAG49144.1.
AF191770 mRNA. Translation: AAG28395.1.
AF291656 mRNA. Translation: AAK83109.1.
AY358706 mRNA. Translation: AAQ89069.1.
AL035608 Genomic DNA. Translation: CAI42846.1.
CCDSiCCDS14469.1. [Q9H2S6-1]
PIRiJC7597.
RefSeqiNP_071427.2. NM_022144.2. [Q9H2S6-1]
XP_005262232.1. XM_005262175.3. [Q9H2S6-3]
XP_011529310.1. XM_011531008.1. [Q9H2S6-3]
XP_011529311.1. XM_011531009.1. [Q9H2S6-3]
XP_011529312.1. XM_011531010.1. [Q9H2S6-3]
UniGeneiHs.132957.

Genome annotation databases

EnsembliENST00000373031; ENSP00000362122; ENSG00000000005. [Q9H2S6-1]
GeneIDi64102.
KEGGihsa:64102.
UCSCiuc004efy.5. human. [Q9H2S6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055421 mRNA. Translation: BAB21756.1.
AF234259 mRNA. Translation: AAG49144.1.
AF191770 mRNA. Translation: AAG28395.1.
AF291656 mRNA. Translation: AAK83109.1.
AY358706 mRNA. Translation: AAQ89069.1.
AL035608 Genomic DNA. Translation: CAI42846.1.
CCDSiCCDS14469.1. [Q9H2S6-1]
PIRiJC7597.
RefSeqiNP_071427.2. NM_022144.2. [Q9H2S6-1]
XP_005262232.1. XM_005262175.3. [Q9H2S6-3]
XP_011529310.1. XM_011531008.1. [Q9H2S6-3]
XP_011529311.1. XM_011531009.1. [Q9H2S6-3]
XP_011529312.1. XM_011531010.1. [Q9H2S6-3]
UniGeneiHs.132957.

3D structure databases

ProteinModelPortaliQ9H2S6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122062. 1 interaction.
IntActiQ9H2S6. 1 interaction.
STRINGi9606.ENSP00000362122.

PTM databases

iPTMnetiQ9H2S6.
PhosphoSiteiQ9H2S6.

Polymorphism and mutation databases

BioMutaiTNMD.
DMDMi18202941.

Proteomic databases

PaxDbiQ9H2S6.
PeptideAtlasiQ9H2S6.
PRIDEiQ9H2S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373031; ENSP00000362122; ENSG00000000005. [Q9H2S6-1]
GeneIDi64102.
KEGGihsa:64102.
UCSCiuc004efy.5. human. [Q9H2S6-1]

Organism-specific databases

CTDi64102.
GeneCardsiTNMD.
HGNCiHGNC:17757. TNMD.
HPAiHPA034961.
HPA055634.
MIMi300459. gene.
neXtProtiNX_Q9H2S6.
PharmGKBiPA134878561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHWK. Eukaryota.
ENOG410YB96. LUCA.
GeneTreeiENSGT00480000042679.
HOGENOMiHOG000234812.
HOVERGENiHBG004387.
InParanoidiQ9H2S6.
OMAiFWPETPK.
OrthoDBiEOG7R832C.
PhylomeDBiQ9H2S6.
TreeFamiTF329712.

Miscellaneous databases

GeneWikiiTNMD.
GenomeRNAii64102.
PROiQ9H2S6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2S6.
CleanExiHS_TNMD.
GenevisibleiQ9H2S6. HS.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of ChM1L, a novel membrane molecule similar to chondromodulin-I."
    Yamana K., Wada H., Takahashi Y., Sato H., Kasahara Y., Kiyoki M.
    Biochem. Biophys. Res. Commun. 280:1101-1106(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of tenomodulin, a novel chondromodulin-I related gene."
    Shukunami C., Oshima Y., Hiraki Y.
    Biochem. Biophys. Res. Commun. 280:1323-1327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Gene expression alterations revealed by suppression subtractive hybridization in rat soleus muscle disuse atrophy."
    Cros N., Tkatchenko A.V., Leclerc L., Leger J.J., Marini J.-F., Dechesne C.A.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  4. "A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I."
    Brandau O., Meindl A., Faessler R., Aszodi A.
    Dev. Dyn. 221:72-80(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss."
    Saiki A., Olsson M., Jernas M., Gummesson A., McTernan P.G., Andersson J., Jacobson P., Sjoholm K., Olsson B., Yamamura S., Walley A., Froguel P., Carlsson B., Sjostrom L., Svensson P.A., Carlsson L.M.
    J. Clin. Endocrinol. Metab. 94:3987-3994(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Tendon-selective genes identified from rat and human musculoskeletal tissues."
    Jelinsky S.A., Archambault J., Li L., Seeherman H.
    J. Orthop. Res. 28:289-297(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin."
    Qi J., Dmochowski J.M., Banes A.N., Tsuzaki M., Bynum D., Patterson M., Creighton A., Gomez S., Tech K., Cederlund A., Banes A.J.
    J. Appl. Physiol. 113:861-871(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTNMD_HUMAN
AccessioniPrimary (citable) accession number: Q9H2S6
Secondary accession number(s): Q9HBX0, Q9UJG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.