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Protein

RING finger protein 39

Gene

RNF39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in prolonged long term-potentiation (LTP) maintenance.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 13548RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 39
Alternative name(s):
Protein HZFw
Gene namesi
Name:RNF39
Synonyms:HZFW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18064. RNF39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949953.

Polymorphism and mutation databases

BioMutaiRNF39.
DMDMi68053317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420RING finger protein 39PRO_0000056080Add
BLAST

Proteomic databases

EPDiQ9H2S5.
PaxDbiQ9H2S5.
PRIDEiQ9H2S5.

PTM databases

iPTMnetiQ9H2S5.
PhosphoSiteiQ9H2S5.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiQ9H2S5.
ExpressionAtlasiQ9H2S5. baseline and differential.
GenevisibleiQ9H2S5. HS.

Organism-specific databases

HPAiCAB019278.
HPA047115.

Interactioni

Protein-protein interaction databases

BioGridi123258. 1 interaction.
STRINGi9606.ENSP00000244360.

Structurei

3D structure databases

ProteinModelPortaliQ9H2S5.
SMRiQ9H2S5. Positions 78-156, 220-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 420211B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri88 – 13548RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOVERGENiHBG057890.
InParanoidiQ9H2S5.
OMAiTCLEERE.
OrthoDBiEOG7ZPNK8.
PhylomeDBiQ9H2S5.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2S5-1) [UniParc]FASTAAdd to basket

Also known as: HZFW1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWWRDLTRLR LWLKREAIPG EGRKAAKVNA GVGEKGIYTA SSRGGPPSAR
60 70 80 90 100
SKAVTVVAEG AASRSWLSMD APELGPGLVE RLEQLATCPL CGGSFEDPVL
110 120 130 140 150
LACEHSFCRA CLARRWGTPP ATGTEASPTA CPCCGLPCPR RSLRSNVRLA
160 170 180 190 200
VEVRISRELR EKLAEPGARA GRRRGGRIPT MGCLDLPGED MRKTWRRFEV
210 220 230 240 250
PTSKSSNSED DLPEDYPVVK KMLHRLTADL TLDPGTAHRR LLISADRRSV
260 270 280 290 300
QLAPPGTPAP PDGPKRFDQL PAVLGAQGFG AGRHCWEVET ADAASCRDSS
310 320 330 340 350
GEDADDEESH YAVGAAGESV QRKGCVRLCP AGAVWAVEGR GGRLWALTAP
360 370 380 390 400
EPTLLGGVEP PPRRIRVDLD WERGRVAFYD GRSLDLLYAF QAPGPLGERI
410 420
FPLFCTCDPR APLRIVPAES
Length:420
Mass (Da):45,525
Last modified:June 21, 2005 - v2
Checksum:iCE9C7869D93016EC
GO
Isoform 2 (identifier: Q9H2S5-2) [UniParc]FASTAAdd to basket

Also known as: HZFW2

The sequence of this isoform differs from the canonical sequence as follows:
     326-391: Missing.

Show »
Length:354
Mass (Da):38,179
Checksum:i26F8CA120301D406
GO
Isoform 3 (identifier: Q9H2S5-3) [UniParc]FASTAAdd to basket

Also known as: HZFW3

The sequence of this isoform differs from the canonical sequence as follows:
     160-251: REKLAEPGAR...LISADRRSVQ → LFGGGIPHSF...NRPSPSVLVK
     252-420: Missing.

Show »
Length:251
Mass (Da):27,081
Checksum:i81BFF50746712554
GO

Sequence cautioni

Isoform 3 : The sequence AAG40630.1 differs from that shown. Reason: Frameshift at position 237. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti203 – 2031S → P.1 Publication
Corresponds to variant rs2074479 [ dbSNP | Ensembl ].
VAR_022723
Natural varianti245 – 2451A → T.1 Publication
Corresponds to variant rs2301752 [ dbSNP | Ensembl ].
VAR_022724
Natural varianti268 – 2681D → N.2 Publications
Corresponds to variant rs1057539 [ dbSNP | Ensembl ].
VAR_022725
Natural varianti304 – 3041A → E.1 Publication
Corresponds to variant rs2301753 [ dbSNP | Ensembl ].
VAR_022726

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 25192REKLA…RRSVQ → LFGGGIPHSFLGTHSHAHCR SINSNPHFRPKIMRPHLVST FPRPCSKPNPFLPSGSQNLL SPTATTVLPDFSHSNHSRPA MGNRPSPSVLVK in isoform 3. 1 PublicationVSP_014240Add
BLAST
Alternative sequencei252 – 420169Missing in isoform 3. 1 PublicationVSP_014241Add
BLAST
Alternative sequencei326 – 39166Missing in isoform 2. 1 PublicationVSP_014242Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238315 mRNA. Translation: AAG40628.1.
AF238316 mRNA. Translation: AAG40629.1.
AF238317 mRNA. Translation: AAG40630.1. Frameshift.
AL671859 Genomic DNA. Translation: CAI17580.1.
AL669914 Genomic DNA. Translation: CAI18179.1.
AL845439 Genomic DNA. Translation: CAI18543.1.
AL845439 Genomic DNA. Translation: CAI18544.1.
BX088647 Genomic DNA. Translation: CAM26286.1.
CR388205, CR933538 Genomic DNA. Translation: CAQ06743.1.
CR759763 Genomic DNA. Translation: CAQ08162.1.
CR759960 Genomic DNA. Translation: CAQ09123.1.
CR933538, CR388205 Genomic DNA. Translation: CAQ10228.1.
BX927229 Genomic DNA. Translation: CAQ10496.1.
CH471081 Genomic DNA. Translation: EAX03256.1.
CCDSiCCDS4673.1. [Q9H2S5-1]
CCDS4674.1. [Q9H2S5-2]
RefSeqiNP_079512.2. NM_025236.3. [Q9H2S5-1]
NP_739575.2. NM_170769.2. [Q9H2S5-2]
UniGeneiHs.121178.

Genome annotation databases

EnsembliENST00000244360; ENSP00000244360; ENSG00000204618. [Q9H2S5-1]
ENST00000376750; ENSP00000365941; ENSG00000206500.
ENST00000376751; ENSP00000365942; ENSG00000204618. [Q9H2S5-2]
ENST00000417541; ENSP00000407248; ENSG00000237733.
ENST00000425956; ENSP00000393560; ENSG00000227171. [Q9H2S5-1]
ENST00000432647; ENSP00000398512; ENSG00000230332. [Q9H2S5-1]
ENST00000441449; ENSP00000392508; ENSG00000236967. [Q9H2S5-2]
ENST00000442063; ENSP00000415281; ENSG00000235022. [Q9H2S5-2]
ENST00000442378; ENSP00000401131; ENSG00000227171. [Q9H2S5-2]
ENST00000449145; ENSP00000408539; ENSG00000237733.
ENST00000450015; ENSP00000407291; ENSG00000236967. [Q9H2S5-1]
ENST00000451425; ENSP00000391822; ENSG00000230332. [Q9H2S5-2]
ENST00000456156; ENSP00000395696; ENSG00000235022. [Q9H2S5-1]
ENST00000457092; ENSP00000405340; ENSG00000230467. [Q9H2S5-2]
GeneIDi80352.
KEGGihsa:80352.
UCSCiuc003npd.4. human. [Q9H2S5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238315 mRNA. Translation: AAG40628.1.
AF238316 mRNA. Translation: AAG40629.1.
AF238317 mRNA. Translation: AAG40630.1. Frameshift.
AL671859 Genomic DNA. Translation: CAI17580.1.
AL669914 Genomic DNA. Translation: CAI18179.1.
AL845439 Genomic DNA. Translation: CAI18543.1.
AL845439 Genomic DNA. Translation: CAI18544.1.
BX088647 Genomic DNA. Translation: CAM26286.1.
CR388205, CR933538 Genomic DNA. Translation: CAQ06743.1.
CR759763 Genomic DNA. Translation: CAQ08162.1.
CR759960 Genomic DNA. Translation: CAQ09123.1.
CR933538, CR388205 Genomic DNA. Translation: CAQ10228.1.
BX927229 Genomic DNA. Translation: CAQ10496.1.
CH471081 Genomic DNA. Translation: EAX03256.1.
CCDSiCCDS4673.1. [Q9H2S5-1]
CCDS4674.1. [Q9H2S5-2]
RefSeqiNP_079512.2. NM_025236.3. [Q9H2S5-1]
NP_739575.2. NM_170769.2. [Q9H2S5-2]
UniGeneiHs.121178.

3D structure databases

ProteinModelPortaliQ9H2S5.
SMRiQ9H2S5. Positions 78-156, 220-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123258. 1 interaction.
STRINGi9606.ENSP00000244360.

PTM databases

iPTMnetiQ9H2S5.
PhosphoSiteiQ9H2S5.

Polymorphism and mutation databases

BioMutaiRNF39.
DMDMi68053317.

Proteomic databases

EPDiQ9H2S5.
PaxDbiQ9H2S5.
PRIDEiQ9H2S5.

Protocols and materials databases

DNASUi80352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244360; ENSP00000244360; ENSG00000204618. [Q9H2S5-1]
ENST00000376750; ENSP00000365941; ENSG00000206500.
ENST00000376751; ENSP00000365942; ENSG00000204618. [Q9H2S5-2]
ENST00000417541; ENSP00000407248; ENSG00000237733.
ENST00000425956; ENSP00000393560; ENSG00000227171. [Q9H2S5-1]
ENST00000432647; ENSP00000398512; ENSG00000230332. [Q9H2S5-1]
ENST00000441449; ENSP00000392508; ENSG00000236967. [Q9H2S5-2]
ENST00000442063; ENSP00000415281; ENSG00000235022. [Q9H2S5-2]
ENST00000442378; ENSP00000401131; ENSG00000227171. [Q9H2S5-2]
ENST00000449145; ENSP00000408539; ENSG00000237733.
ENST00000450015; ENSP00000407291; ENSG00000236967. [Q9H2S5-1]
ENST00000451425; ENSP00000391822; ENSG00000230332. [Q9H2S5-2]
ENST00000456156; ENSP00000395696; ENSG00000235022. [Q9H2S5-1]
ENST00000457092; ENSP00000405340; ENSG00000230467. [Q9H2S5-2]
GeneIDi80352.
KEGGihsa:80352.
UCSCiuc003npd.4. human. [Q9H2S5-1]

Organism-specific databases

CTDi80352.
GeneCardsiRNF39.
H-InvDBHIX0032789.
HIX0165952.
HIX0166425.
HIX0166948.
HIX0167433.
HIX0184216.
HGNCiHGNC:18064. RNF39.
HPAiCAB019278.
HPA047115.
MIMi607524. gene.
neXtProtiNX_Q9H2S5.
PharmGKBiPA134949953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOVERGENiHBG057890.
InParanoidiQ9H2S5.
OMAiTCLEERE.
OrthoDBiEOG7ZPNK8.
PhylomeDBiQ9H2S5.
TreeFamiTF317532.

Miscellaneous databases

GeneWikiiRNF39.
GenomeRNAii80352.
PROiQ9H2S5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2S5.
ExpressionAtlasiQ9H2S5. baseline and differential.
GenevisibleiQ9H2S5. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes."
    Coriton O., Lepourcelet M., Hampe A., Galibert F., Mosser J.
    Mamm. Genome 11:1127-1131(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ASN-268, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PRO-203; THR-245; ASN-268 AND GLU-304.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRNF39_HUMAN
AccessioniPrimary (citable) accession number: Q9H2S5
Secondary accession number(s): A2BEK3
, A6NCD6, B0S858, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: June 8, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.