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Q9H2S1

- KCNN2_HUMAN

UniProt

Q9H2S1 - KCNN2_HUMAN

Protein

Small conductance calcium-activated potassium channel protein 2

Gene

KCNN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

    GO - Molecular functioni

    1. alpha-actinin binding Source: BHF-UCL
    2. calcium-activated potassium channel activity Source: BHF-UCL
    3. calmodulin binding Source: RefGenome
    4. protein homodimerization activity Source: BHF-UCL
    5. small conductance calcium-activated potassium channel activity Source: UniProtKB

    GO - Biological processi

    1. potassium ion transmembrane transport Source: BHF-UCL
    2. potassium ion transport Source: UniProtKB
    3. regulation of potassium ion transmembrane transport Source: BHF-UCL
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calmodulin-binding

    Enzyme and pathway databases

    ReactomeiREACT_75896. Ca2+ activated K+ channels.

    Protein family/group databases

    TCDBi1.A.1.16.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small conductance calcium-activated potassium channel protein 2
    Short name:
    SK2
    Short name:
    SKCa 2
    Short name:
    SKCa2
    Alternative name(s):
    KCa2.2
    Gene namesi
    Name:KCNN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6291. KCNN2.

    Subcellular locationi

    GO - Cellular componenti

    1. dendritic spine Source: RefGenome
    2. integral component of membrane Source: UniProtKB
    3. neuronal cell body Source: RefGenome
    4. plasma membrane Source: RefGenome
    5. smooth endoplasmic reticulum Source: Ensembl
    6. T-tubule Source: Ensembl
    7. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30071.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Small conductance calcium-activated potassium channel protein 2PRO_0000155010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei160 – 1601PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H2S1.
    PaxDbiQ9H2S1.
    PRIDEiQ9H2S1.

    PTM databases

    PhosphoSiteiQ9H2S1.

    Expressioni

    Tissue specificityi

    Expressed in atrial myocytes (at protein level). Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9H2S1.
    BgeeiQ9H2S1.
    CleanExiHS_KCNN2.
    GenevestigatoriQ9H2S1.

    Organism-specific databases

    HPAiHPA038221.

    Interactioni

    Subunit structurei

    Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109982. 6 interactions.
    DIPiDIP-48997N.
    IntActiQ9H2S1. 2 interactions.
    STRINGi9606.ENSP00000264773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2S1.
    SMRiQ9H2S1. Positions 322-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei345 – 36521Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei138 – 15821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni412 – 48877Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 455Poly-Gly
    Compositional biasi51 – 588Poly-Ala
    Compositional biasi83 – 886Poly-Gly
    Compositional biasi91 – 10212Poly-GlyAdd
    BLAST
    Compositional biasi563 – 5664Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320393.
    HOVERGENiHBG052241.
    InParanoidiQ9H2S1.
    KOiK04943.
    OMAiAQMESYD.
    PhylomeDBiQ9H2S1.
    TreeFamiTF315015.

    Family and domain databases

    InterProiIPR013099. 2pore_dom_K_chnl_dom.
    IPR004178. CaM-bd_dom.
    IPR015449. K_chnl_Ca-activ_SK.
    [Graphical view]
    PANTHERiPTHR10153. PTHR10153. 1 hit.
    PfamiPF02888. CaMBD. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    PF03530. SK_channel. 1 hit.
    [Graphical view]
    PRINTSiPR01451. SKCHANNEL.
    SMARTiSM01053. CaMBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF81327. SSF81327. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H2S1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSCRYNGGV MRPLSNLSAS RRNLHEMDSE AQPLQPPASV GGGGGASSPS    50
    AAAAAAAAVS SSAPEIVVSK PEHNNSNNLA LYGTGGGGST GGGGGGGGSG 100
    HGSSSGTKSS KKKNQNIGYK LGHRRALFEK RKRLSDYALI FGMFGIVVMV 150
    IETELSWGAY DKASLYSLAL KCLISLSTII LLGLIIVYHA REIQLFMVDN 200
    GADDWRIAMT YERIFFICLE ILVCAIHPIP GNYTFTWTAR LAFSYAPSTT 250
    TADVDIILSI PMFLRLYLIA RVMLLHSKLF TDASSRSIGA LNKINFNTRF 300
    VMKTLMTICP GTVLLVFSIS LWIIAAWTVR ACERYHDQQD VTSNFLGAMW 350
    LISITFLSIG YGDMVPNTYC GKGVCLLTGI MGAGCTALVV AVVARKLELT 400
    KAEKHVHNFM MDTQLTKRVK NAAANVLRET WLIYKNTKLV KKIDHAKVRK 450
    HQRKFLQAIH QLRSVKMEQR KLNDQANTLV DLAKTQNIMY DMISDLNERS 500
    EDFEKRIVTL ETKLETLIGS IHALPGLISQ TIRQQQRDFI EAQMESYDKH 550
    VTYNAERSRS SSRRRRSSST APPTSSESS 579
    Length:579
    Mass (Da):63,760
    Last modified:October 14, 2008 - v2
    Checksum:i2ED87FE13C106183
    GO
    Isoform 2 (identifier: Q9H2S1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-348: Missing.

    Show »
    Length:231
    Mass (Da):26,341
    Checksum:i89BD2ED1EAD6E54B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501S → SA in AAK84039. 1 PublicationCurated
    Sequence conflicti52 – 521A → D in AAG16728. (PubMed:10991935)Curated
    Sequence conflicti58 – 581A → AA in AAP45946. (PubMed:13679367)Curated
    Sequence conflicti323 – 3231I → T in AAK84039. 1 PublicationCurated
    Sequence conflicti530 – 5301Q → R in AAP45946. (PubMed:13679367)Curated
    Sequence conflicti530 – 5301Q → R in AAK84039. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 348348Missing in isoform 2. 1 PublicationVSP_044584Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239613 mRNA. Translation: AAG16728.1.
    AY258141 mRNA. Translation: AAP45946.1.
    AF397175 mRNA. Translation: AAK84039.1.
    AK289948 mRNA. Translation: BAF82637.1.
    AC025761 Genomic DNA. No translation available.
    AC109482 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48975.1.
    CH471086 Genomic DNA. Translation: EAW48976.1.
    BC015371 mRNA. Translation: AAH15371.1.
    BC117454 mRNA. Translation: AAI17455.1.
    BC117456 mRNA. Translation: AAI17457.1.
    CCDSiCCDS4114.1. [Q9H2S1-1]
    CCDS43352.1. [Q9H2S1-2]
    RefSeqiNP_001265133.1. NM_001278204.1. [Q9H2S1-2]
    NP_067627.2. NM_021614.3. [Q9H2S1-1]
    NP_740721.1. NM_170775.2. [Q9H2S1-2]
    UniGeneiHs.98280.

    Genome annotation databases

    EnsembliENST00000264773; ENSP00000264773; ENSG00000080709. [Q9H2S1-1]
    ENST00000503706; ENSP00000421439; ENSG00000080709. [Q9H2S1-2]
    ENST00000512097; ENSP00000427120; ENSG00000080709. [Q9H2S1-1]
    GeneIDi3781.
    KEGGihsa:3781.
    UCSCiuc003kqo.3. human. [Q9H2S1-1]
    uc003kqp.3. human.

    Polymorphism databases

    DMDMi209572638.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239613 mRNA. Translation: AAG16728.1 .
    AY258141 mRNA. Translation: AAP45946.1 .
    AF397175 mRNA. Translation: AAK84039.1 .
    AK289948 mRNA. Translation: BAF82637.1 .
    AC025761 Genomic DNA. No translation available.
    AC109482 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48975.1 .
    CH471086 Genomic DNA. Translation: EAW48976.1 .
    BC015371 mRNA. Translation: AAH15371.1 .
    BC117454 mRNA. Translation: AAI17455.1 .
    BC117456 mRNA. Translation: AAI17457.1 .
    CCDSi CCDS4114.1. [Q9H2S1-1 ]
    CCDS43352.1. [Q9H2S1-2 ]
    RefSeqi NP_001265133.1. NM_001278204.1. [Q9H2S1-2 ]
    NP_067627.2. NM_021614.3. [Q9H2S1-1 ]
    NP_740721.1. NM_170775.2. [Q9H2S1-2 ]
    UniGenei Hs.98280.

    3D structure databases

    ProteinModelPortali Q9H2S1.
    SMRi Q9H2S1. Positions 322-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109982. 6 interactions.
    DIPi DIP-48997N.
    IntActi Q9H2S1. 2 interactions.
    STRINGi 9606.ENSP00000264773.

    Chemistry

    BindingDBi Q9H2S1.
    ChEMBLi CHEMBL4469.
    GuidetoPHARMACOLOGYi 382.

    Protein family/group databases

    TCDBi 1.A.1.16.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q9H2S1.

    Polymorphism databases

    DMDMi 209572638.

    Proteomic databases

    MaxQBi Q9H2S1.
    PaxDbi Q9H2S1.
    PRIDEi Q9H2S1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264773 ; ENSP00000264773 ; ENSG00000080709 . [Q9H2S1-1 ]
    ENST00000503706 ; ENSP00000421439 ; ENSG00000080709 . [Q9H2S1-2 ]
    ENST00000512097 ; ENSP00000427120 ; ENSG00000080709 . [Q9H2S1-1 ]
    GeneIDi 3781.
    KEGGi hsa:3781.
    UCSCi uc003kqo.3. human. [Q9H2S1-1 ]
    uc003kqp.3. human.

    Organism-specific databases

    CTDi 3781.
    GeneCardsi GC05P113725.
    HGNCi HGNC:6291. KCNN2.
    HPAi HPA038221.
    MIMi 605879. gene.
    neXtProti NX_Q9H2S1.
    PharmGKBi PA30071.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320393.
    HOVERGENi HBG052241.
    InParanoidi Q9H2S1.
    KOi K04943.
    OMAi AQMESYD.
    PhylomeDBi Q9H2S1.
    TreeFami TF315015.

    Enzyme and pathway databases

    Reactomei REACT_75896. Ca2+ activated K+ channels.

    Miscellaneous databases

    GeneWikii KCNN2.
    GenomeRNAii 3781.
    NextBioi 14837.
    PROi Q9H2S1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H2S1.
    Bgeei Q9H2S1.
    CleanExi HS_KCNN2.
    Genevestigatori Q9H2S1.

    Family and domain databases

    InterProi IPR013099. 2pore_dom_K_chnl_dom.
    IPR004178. CaM-bd_dom.
    IPR015449. K_chnl_Ca-activ_SK.
    [Graphical view ]
    PANTHERi PTHR10153. PTHR10153. 1 hit.
    Pfami PF02888. CaMBD. 1 hit.
    PF07885. Ion_trans_2. 1 hit.
    PF03530. SK_channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01451. SKCHANNEL.
    SMARTi SM01053. CaMBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81327. SSF81327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization."
      Desai R., Peretz A., Idelson H., Lazarovici P., Attali B.
      J. Biol. Chem. 275:39954-39963(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts."
      Xu Y., Tuteja D., Zhang Z., Xu D., Zhang Y., Rodriguez J., Nie L., Tuxson H.R., Young J.N., Glatter K.A., Vazquez A.E., Yamoah E.N., Chiamvimonvat N.
      J. Biol. Chem. 278:49085-49094(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Heart.
    3. "Characterization of calcium-activated potassium channels in human myometrium."
      Mazzone J.N., Kaiser R.A., Buxton I.L.O.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Myometrium.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Skin.

    Entry informationi

    Entry nameiKCNN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2S1
    Secondary accession number(s): A6NF94
    , Q0VFZ4, Q6PJI0, Q6X2Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3