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Q9H2R5

- KLK15_HUMAN

UniProt

Q9H2R5 - KLK15_HUMAN

Protein

Kallikrein-15

Gene

KLK15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Protease whose physiological substrate is not yet known.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Charge relay systemBy similarity
    Active sitei106 – 1061Charge relay systemBy similarity
    Active sitei209 – 2091Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB
    2. serine-type peptidase activity Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.081.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-15 (EC:3.4.21.-)
    Alternative name(s):
    ACO protease
    Gene namesi
    Name:KLK15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20453. KLK15.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 215Activation peptideSequence AnalysisPRO_0000027960
    Chaini22 – 256235Kallikrein-15PRO_0000027961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
    Disulfide bondi138 ↔ 215PROSITE-ProRule annotation
    Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 194PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 230PROSITE-ProRule annotation
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9H2R5.
    PRIDEiQ9H2R5.

    PTM databases

    PhosphoSiteiQ9H2R5.

    Expressioni

    Tissue specificityi

    Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ9H2R5.
    BgeeiQ9H2R5.
    CleanExiHS_KLK15.
    GenevestigatoriQ9H2R5.

    Organism-specific databases

    HPAiHPA019802.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9H2R5. 1 interaction.
    STRINGi9606.ENSP00000314783.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2R5.
    SMRiQ9H2R5. Positions 22-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 254233Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOVERGENiHBG013304.
    InParanoidiQ9H2R5.
    KOiK09623.
    OMAiRYEARSH.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ9H2R5.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H2R5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS    50
    LISPHWVLSA AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA 100
    RSHRNDIMLL RLVQPARLNP QVRPAVLPTR CPHPGEACVV SGWGLVSHNE 150
    PGTAGSPRSQ VSLPDTLHCA NISIISDTSC DKSYPGRLTN TMVCAGAEGR 200
    GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT KVCHYLEWIR 250
    ETMKRN 256
    Length:256
    Mass (Da):28,087
    Last modified:March 1, 2001 - v1
    Checksum:iB5EBF8D6022786B5
    GO
    Isoform 2 (identifier: Q9H2R5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-256: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:121
    Mass (Da):13,907
    Checksum:i43BD650A394BF369
    GO
    Isoform 3 (identifier: Q9H2R5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         161-161: V → G
         162-256: Missing.

    Show »
    Length:161
    Mass (Da):17,954
    Checksum:i539D5C6163B16285
    GO
    Isoform 4 (identifier: Q9H2R5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-206: Missing.

    Show »
    Length:171
    Mass (Da):19,341
    Checksum:i20CDE27B3E7B89E4
    GO
    Isoform 5 (identifier: Q9H2R5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         15-15: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:255
    Mass (Da):28,016
    Checksum:i1581B784D4A39C4F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 16014SHNEP…SPRSQ → PLSSP(PubMed:11054574)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341P → L.
    Corresponds to variant rs3212805 [ dbSNP | Ensembl ].
    VAR_020179
    Natural varianti137 – 1371A → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036298

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei15 – 151Missing in isoform 5. 1 PublicationVSP_054621
    Alternative sequencei122 – 256135Missing in isoform 2. CuratedVSP_005405Add
    BLAST
    Alternative sequencei122 – 20685Missing in isoform 4. CuratedVSP_005404Add
    BLAST
    Alternative sequencei161 – 1611V → G in isoform 3. CuratedVSP_005406
    Alternative sequencei162 – 25695Missing in isoform 3. CuratedVSP_005407Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242195 Genomic DNA. Translation: AAG09469.1.
    AF242195 Genomic DNA. Translation: AAG09470.1.
    AF242195 Genomic DNA. Translation: AAG09471.1.
    AF242195 Genomic DNA. Translation: AAG09472.1.
    AF243527 Genomic DNA. Translation: AAG33354.1.
    X75363 mRNA. Translation: CAA53145.1. Sequence problems.
    CH471135 Genomic DNA. Translation: EAW71918.1.
    BC069480 mRNA. Translation: AAH69480.1.
    BC069507 mRNA. Translation: AAH69507.1.
    BC069518 mRNA. Translation: AAH69518.1.
    BC126137 mRNA. Translation: AAI26138.1.
    BC144046 mRNA. Translation: AAI44047.1.
    CCDSiCCDS12805.1. [Q9H2R5-1]
    CCDS62766.1. [Q9H2R5-5]
    PIRiS45356.
    RefSeqiNP_001264010.1. NM_001277081.1. [Q9H2R5-5]
    NP_001264011.1. NM_001277082.1.
    NP_059979.2. NM_017509.3. [Q9H2R5-1]
    XP_006723328.1. XM_006723265.1. [Q9H2R5-1]
    UniGeneiHs.567535.

    Genome annotation databases

    EnsembliENST00000326856; ENSP00000314783; ENSG00000174562. [Q9H2R5-5]
    ENST00000598239; ENSP00000469315; ENSG00000174562. [Q9H2R5-1]
    GeneIDi55554.
    KEGGihsa:55554.
    UCSCiuc002ptl.3. human. [Q9H2R5-1]
    uc002ptn.3. human. [Q9H2R5-3]
    uc002pto.3. human.

    Polymorphism databases

    DMDMi18202940.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242195 Genomic DNA. Translation: AAG09469.1 .
    AF242195 Genomic DNA. Translation: AAG09470.1 .
    AF242195 Genomic DNA. Translation: AAG09471.1 .
    AF242195 Genomic DNA. Translation: AAG09472.1 .
    AF243527 Genomic DNA. Translation: AAG33354.1 .
    X75363 mRNA. Translation: CAA53145.1 . Sequence problems.
    CH471135 Genomic DNA. Translation: EAW71918.1 .
    BC069480 mRNA. Translation: AAH69480.1 .
    BC069507 mRNA. Translation: AAH69507.1 .
    BC069518 mRNA. Translation: AAH69518.1 .
    BC126137 mRNA. Translation: AAI26138.1 .
    BC144046 mRNA. Translation: AAI44047.1 .
    CCDSi CCDS12805.1. [Q9H2R5-1 ]
    CCDS62766.1. [Q9H2R5-5 ]
    PIRi S45356.
    RefSeqi NP_001264010.1. NM_001277081.1. [Q9H2R5-5 ]
    NP_001264011.1. NM_001277082.1.
    NP_059979.2. NM_017509.3. [Q9H2R5-1 ]
    XP_006723328.1. XM_006723265.1. [Q9H2R5-1 ]
    UniGenei Hs.567535.

    3D structure databases

    ProteinModelPortali Q9H2R5.
    SMRi Q9H2R5. Positions 22-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9H2R5. 1 interaction.
    STRINGi 9606.ENSP00000314783.

    Chemistry

    BindingDBi Q9H2R5.

    Protein family/group databases

    MEROPSi S01.081.

    PTM databases

    PhosphoSitei Q9H2R5.

    Polymorphism databases

    DMDMi 18202940.

    Proteomic databases

    PaxDbi Q9H2R5.
    PRIDEi Q9H2R5.

    Protocols and materials databases

    DNASUi 55554.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326856 ; ENSP00000314783 ; ENSG00000174562 . [Q9H2R5-5 ]
    ENST00000598239 ; ENSP00000469315 ; ENSG00000174562 . [Q9H2R5-1 ]
    GeneIDi 55554.
    KEGGi hsa:55554.
    UCSCi uc002ptl.3. human. [Q9H2R5-1 ]
    uc002ptn.3. human. [Q9H2R5-3 ]
    uc002pto.3. human.

    Organism-specific databases

    CTDi 55554.
    GeneCardsi GC19M051328.
    HGNCi HGNC:20453. KLK15.
    HPAi HPA019802.
    MIMi 610601. gene.
    neXtProti NX_Q9H2R5.
    PharmGKBi PA134977502.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOVERGENi HBG013304.
    InParanoidi Q9H2R5.
    KOi K09623.
    OMAi RYEARSH.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q9H2R5.
    TreeFami TF331065.

    Miscellaneous databases

    GeneWikii KLK15.
    GenomeRNAii 55554.
    NextBioi 60018.
    PROi Q9H2R5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H2R5.
    Bgeei Q9H2R5.
    CleanExi HS_KLK15.
    Genevestigatori Q9H2R5.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer."
      Yousef G.M., Scorilas A., Jung K., Ashworth L.K., Diamandis E.P.
      J. Biol. Chem. 276:53-61(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    2. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "A novel serine proteinase-like sequence from human brain."
      Dihanich M.E., Spiess M.
      Biochim. Biophys. Acta 1218:225-228(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-137.

    Entry informationi

    Entry nameiKLK15_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2R5
    Secondary accession number(s): A0AUY8
    , Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3