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Q9H2R5

- KLK15_HUMAN

UniProt

Q9H2R5 - KLK15_HUMAN

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Protein

Kallikrein-15

Gene

KLK15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Protease whose physiological substrate is not yet known.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Charge relay systemBy similarity
Active sitei106 – 1061Charge relay systemBy similarity
Active sitei209 – 2091Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB
  2. serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.081.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-15 (EC:3.4.21.-)
Alternative name(s):
ACO protease
Gene namesi
Name:KLK15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20453. KLK15.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Propeptidei17 – 215Activation peptideSequence AnalysisPRO_0000027960
Chaini22 – 256235Kallikrein-15PRO_0000027961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi138 ↔ 215PROSITE-ProRule annotation
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi180 ↔ 194PROSITE-ProRule annotation
Disulfide bondi205 ↔ 230PROSITE-ProRule annotation
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9H2R5.
PRIDEiQ9H2R5.

PTM databases

PhosphoSiteiQ9H2R5.

Expressioni

Tissue specificityi

Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.1 Publication

Gene expression databases

BgeeiQ9H2R5.
CleanExiHS_KLK15.
ExpressionAtlasiQ9H2R5. baseline and differential.
GenevestigatoriQ9H2R5.

Organism-specific databases

HPAiHPA019802.

Interactioni

Protein-protein interaction databases

BioGridi120715. 6 interactions.
IntActiQ9H2R5. 1 interaction.
STRINGi9606.ENSP00000314783.

Structurei

3D structure databases

ProteinModelPortaliQ9H2R5.
SMRiQ9H2R5. Positions 22-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 254233Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOVERGENiHBG013304.
InParanoidiQ9H2R5.
KOiK09623.
OMAiRYEARSH.
OrthoDBiEOG75B84T.
PhylomeDBiQ9H2R5.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H2R5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS
60 70 80 90 100
LISPHWVLSA AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA
110 120 130 140 150
RSHRNDIMLL RLVQPARLNP QVRPAVLPTR CPHPGEACVV SGWGLVSHNE
160 170 180 190 200
PGTAGSPRSQ VSLPDTLHCA NISIISDTSC DKSYPGRLTN TMVCAGAEGR
210 220 230 240 250
GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT KVCHYLEWIR

ETMKRN
Length:256
Mass (Da):28,087
Last modified:March 1, 2001 - v1
Checksum:iB5EBF8D6022786B5
GO
Isoform 2 (identifier: Q9H2R5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-256: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:121
Mass (Da):13,907
Checksum:i43BD650A394BF369
GO
Isoform 3 (identifier: Q9H2R5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: V → G
     162-256: Missing.

Show »
Length:161
Mass (Da):17,954
Checksum:i539D5C6163B16285
GO
Isoform 4 (identifier: Q9H2R5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-206: Missing.

Show »
Length:171
Mass (Da):19,341
Checksum:i20CDE27B3E7B89E4
GO
Isoform 5 (identifier: Q9H2R5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: Missing.

Note: No experimental confirmation available.

Show »
Length:255
Mass (Da):28,016
Checksum:i1581B784D4A39C4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 16014SHNEP…SPRSQ → PLSSP(PubMed:11054574)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341P → L.
Corresponds to variant rs3212805 [ dbSNP | Ensembl ].
VAR_020179
Natural varianti137 – 1371A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036298

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 151Missing in isoform 5. 1 PublicationVSP_054621
Alternative sequencei122 – 256135Missing in isoform 2. CuratedVSP_005405Add
BLAST
Alternative sequencei122 – 20685Missing in isoform 4. CuratedVSP_005404Add
BLAST
Alternative sequencei161 – 1611V → G in isoform 3. CuratedVSP_005406
Alternative sequencei162 – 25695Missing in isoform 3. CuratedVSP_005407Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242195 Genomic DNA. Translation: AAG09469.1.
AF242195 Genomic DNA. Translation: AAG09470.1.
AF242195 Genomic DNA. Translation: AAG09471.1.
AF242195 Genomic DNA. Translation: AAG09472.1.
AF243527 Genomic DNA. Translation: AAG33354.1.
X75363 mRNA. Translation: CAA53145.1. Sequence problems.
CH471135 Genomic DNA. Translation: EAW71918.1.
BC069480 mRNA. Translation: AAH69480.1.
BC069507 mRNA. Translation: AAH69507.1.
BC069518 mRNA. Translation: AAH69518.1.
BC126137 mRNA. Translation: AAI26138.1.
BC144046 mRNA. Translation: AAI44047.1.
CCDSiCCDS12805.1. [Q9H2R5-1]
CCDS62766.1. [Q9H2R5-5]
PIRiS45356.
RefSeqiNP_001264010.1. NM_001277081.1. [Q9H2R5-5]
NP_001264011.1. NM_001277082.1.
NP_059979.2. NM_017509.3. [Q9H2R5-1]
XP_006723328.1. XM_006723265.1. [Q9H2R5-1]
UniGeneiHs.567535.

Genome annotation databases

EnsembliENST00000326856; ENSP00000314783; ENSG00000174562. [Q9H2R5-5]
ENST00000598239; ENSP00000469315; ENSG00000174562. [Q9H2R5-1]
GeneIDi55554.
KEGGihsa:55554.
UCSCiuc002ptl.3. human. [Q9H2R5-1]
uc002ptn.3. human. [Q9H2R5-3]
uc002pto.3. human.

Polymorphism databases

DMDMi18202940.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242195 Genomic DNA. Translation: AAG09469.1 .
AF242195 Genomic DNA. Translation: AAG09470.1 .
AF242195 Genomic DNA. Translation: AAG09471.1 .
AF242195 Genomic DNA. Translation: AAG09472.1 .
AF243527 Genomic DNA. Translation: AAG33354.1 .
X75363 mRNA. Translation: CAA53145.1 . Sequence problems.
CH471135 Genomic DNA. Translation: EAW71918.1 .
BC069480 mRNA. Translation: AAH69480.1 .
BC069507 mRNA. Translation: AAH69507.1 .
BC069518 mRNA. Translation: AAH69518.1 .
BC126137 mRNA. Translation: AAI26138.1 .
BC144046 mRNA. Translation: AAI44047.1 .
CCDSi CCDS12805.1. [Q9H2R5-1 ]
CCDS62766.1. [Q9H2R5-5 ]
PIRi S45356.
RefSeqi NP_001264010.1. NM_001277081.1. [Q9H2R5-5 ]
NP_001264011.1. NM_001277082.1.
NP_059979.2. NM_017509.3. [Q9H2R5-1 ]
XP_006723328.1. XM_006723265.1. [Q9H2R5-1 ]
UniGenei Hs.567535.

3D structure databases

ProteinModelPortali Q9H2R5.
SMRi Q9H2R5. Positions 22-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120715. 6 interactions.
IntActi Q9H2R5. 1 interaction.
STRINGi 9606.ENSP00000314783.

Chemistry

BindingDBi Q9H2R5.

Protein family/group databases

MEROPSi S01.081.

PTM databases

PhosphoSitei Q9H2R5.

Polymorphism databases

DMDMi 18202940.

Proteomic databases

PaxDbi Q9H2R5.
PRIDEi Q9H2R5.

Protocols and materials databases

DNASUi 55554.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326856 ; ENSP00000314783 ; ENSG00000174562 . [Q9H2R5-5 ]
ENST00000598239 ; ENSP00000469315 ; ENSG00000174562 . [Q9H2R5-1 ]
GeneIDi 55554.
KEGGi hsa:55554.
UCSCi uc002ptl.3. human. [Q9H2R5-1 ]
uc002ptn.3. human. [Q9H2R5-3 ]
uc002pto.3. human.

Organism-specific databases

CTDi 55554.
GeneCardsi GC19M051328.
HGNCi HGNC:20453. KLK15.
HPAi HPA019802.
MIMi 610601. gene.
neXtProti NX_Q9H2R5.
PharmGKBi PA134977502.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOVERGENi HBG013304.
InParanoidi Q9H2R5.
KOi K09623.
OMAi RYEARSH.
OrthoDBi EOG75B84T.
PhylomeDBi Q9H2R5.
TreeFami TF331065.

Miscellaneous databases

GeneWikii KLK15.
GenomeRNAii 55554.
NextBioi 60018.
PROi Q9H2R5.
SOURCEi Search...

Gene expression databases

Bgeei Q9H2R5.
CleanExi HS_KLK15.
ExpressionAtlasi Q9H2R5. baseline and differential.
Genevestigatori Q9H2R5.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer."
    Yousef G.M., Scorilas A., Jung K., Ashworth L.K., Diamandis E.P.
    J. Biol. Chem. 276:53-61(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  2. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "A novel serine proteinase-like sequence from human brain."
    Dihanich M.E., Spiess M.
    Biochim. Biophys. Acta 1218:225-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
  6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-137.

Entry informationi

Entry nameiKLK15_HUMAN
AccessioniPrimary (citable) accession number: Q9H2R5
Secondary accession number(s): A0AUY8
, Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3