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Protein

Kallikrein-15

Gene

KLK15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protease whose physiological substrate is not yet known.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Charge relay systemBy similarity1
Active sitei106Charge relay systemBy similarity1
Active sitei209Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174562-MONOMER.

Protein family/group databases

MEROPSiS01.081.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-15 (EC:3.4.21.-)
Alternative name(s):
ACO protease
Gene namesi
Name:KLK15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20453. KLK15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55554.
OpenTargetsiENSG00000174562.
PharmGKBiPA134977502.

Polymorphism and mutation databases

DMDMi18202940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002796017 – 21Activation peptideSequence analysis5
ChainiPRO_000002796122 – 256Kallikrein-15Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 63PROSITE-ProRule annotation
Disulfide bondi138 ↔ 215PROSITE-ProRule annotation
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi180 ↔ 194PROSITE-ProRule annotation
Disulfide bondi205 ↔ 230PROSITE-ProRule annotation
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9H2R5.
PeptideAtlasiQ9H2R5.
PRIDEiQ9H2R5.

PTM databases

iPTMnetiQ9H2R5.
PhosphoSitePlusiQ9H2R5.

Expressioni

Tissue specificityi

Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney.1 Publication

Gene expression databases

BgeeiENSG00000174562.
CleanExiHS_KLK15.
ExpressionAtlasiQ9H2R5. baseline and differential.
GenevisibleiQ9H2R5. HS.

Organism-specific databases

HPAiHPA019802.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP6Q156543EBI-8645371,EBI-742327

Protein-protein interaction databases

BioGridi120715. 10 interactors.
IntActiQ9H2R5. 3 interactors.
STRINGi9606.ENSP00000469315.

Structurei

3D structure databases

ProteinModelPortaliQ9H2R5.
SMRiQ9H2R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 254Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOVERGENiHBG013304.
InParanoidiQ9H2R5.
KOiK09623.
OMAiRYEARSH.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9H2R5.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS
60 70 80 90 100
LISPHWVLSA AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA
110 120 130 140 150
RSHRNDIMLL RLVQPARLNP QVRPAVLPTR CPHPGEACVV SGWGLVSHNE
160 170 180 190 200
PGTAGSPRSQ VSLPDTLHCA NISIISDTSC DKSYPGRLTN TMVCAGAEGR
210 220 230 240 250
GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT KVCHYLEWIR

ETMKRN
Length:256
Mass (Da):28,087
Last modified:March 1, 2001 - v1
Checksum:iB5EBF8D6022786B5
GO
Isoform 2 (identifier: Q9H2R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-256: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:121
Mass (Da):13,907
Checksum:i43BD650A394BF369
GO
Isoform 3 (identifier: Q9H2R5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: V → G
     162-256: Missing.

Show »
Length:161
Mass (Da):17,954
Checksum:i539D5C6163B16285
GO
Isoform 4 (identifier: Q9H2R5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-206: Missing.

Show »
Length:171
Mass (Da):19,341
Checksum:i20CDE27B3E7B89E4
GO
Isoform 5 (identifier: Q9H2R5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):28,016
Checksum:i1581B784D4A39C4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147 – 160SHNEP…SPRSQ → PLSSP (PubMed:11054574).CuratedAdd BLAST14

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020179134P → L.Corresponds to variant rs3212805dbSNPEnsembl.1
Natural variantiVAR_036298137A → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05462115Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_005405122 – 256Missing in isoform 2. CuratedAdd BLAST135
Alternative sequenceiVSP_005404122 – 206Missing in isoform 4. CuratedAdd BLAST85
Alternative sequenceiVSP_005406161V → G in isoform 3. Curated1
Alternative sequenceiVSP_005407162 – 256Missing in isoform 3. CuratedAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242195 Genomic DNA. Translation: AAG09469.1.
AF242195 Genomic DNA. Translation: AAG09470.1.
AF242195 Genomic DNA. Translation: AAG09471.1.
AF242195 Genomic DNA. Translation: AAG09472.1.
AF243527 Genomic DNA. Translation: AAG33354.1.
X75363 mRNA. Translation: CAA53145.1. Sequence problems.
CH471135 Genomic DNA. Translation: EAW71918.1.
BC069480 mRNA. Translation: AAH69480.1.
BC069507 mRNA. Translation: AAH69507.1.
BC069518 mRNA. Translation: AAH69518.1.
BC126137 mRNA. Translation: AAI26138.1.
BC144046 mRNA. Translation: AAI44047.1.
CCDSiCCDS12805.1. [Q9H2R5-1]
CCDS62766.1. [Q9H2R5-5]
PIRiS45356.
RefSeqiNP_001264010.1. NM_001277081.1. [Q9H2R5-5]
NP_001264011.1. NM_001277082.1.
NP_059979.2. NM_017509.3. [Q9H2R5-1]
XP_006723328.1. XM_006723265.3. [Q9H2R5-1]
XP_011525387.1. XM_011527085.2. [Q9H2R5-5]
XP_011525389.1. XM_011527087.2. [Q9H2R5-4]
XP_011525390.1. XM_011527088.2. [Q9H2R5-3]
XP_016882432.1. XM_017026943.1. [Q9H2R5-2]
UniGeneiHs.567535.

Genome annotation databases

EnsembliENST00000326856; ENSP00000314783; ENSG00000174562. [Q9H2R5-5]
ENST00000598239; ENSP00000469315; ENSG00000174562. [Q9H2R5-1]
GeneIDi55554.
KEGGihsa:55554.
UCSCiuc002ptl.4. human. [Q9H2R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242195 Genomic DNA. Translation: AAG09469.1.
AF242195 Genomic DNA. Translation: AAG09470.1.
AF242195 Genomic DNA. Translation: AAG09471.1.
AF242195 Genomic DNA. Translation: AAG09472.1.
AF243527 Genomic DNA. Translation: AAG33354.1.
X75363 mRNA. Translation: CAA53145.1. Sequence problems.
CH471135 Genomic DNA. Translation: EAW71918.1.
BC069480 mRNA. Translation: AAH69480.1.
BC069507 mRNA. Translation: AAH69507.1.
BC069518 mRNA. Translation: AAH69518.1.
BC126137 mRNA. Translation: AAI26138.1.
BC144046 mRNA. Translation: AAI44047.1.
CCDSiCCDS12805.1. [Q9H2R5-1]
CCDS62766.1. [Q9H2R5-5]
PIRiS45356.
RefSeqiNP_001264010.1. NM_001277081.1. [Q9H2R5-5]
NP_001264011.1. NM_001277082.1.
NP_059979.2. NM_017509.3. [Q9H2R5-1]
XP_006723328.1. XM_006723265.3. [Q9H2R5-1]
XP_011525387.1. XM_011527085.2. [Q9H2R5-5]
XP_011525389.1. XM_011527087.2. [Q9H2R5-4]
XP_011525390.1. XM_011527088.2. [Q9H2R5-3]
XP_016882432.1. XM_017026943.1. [Q9H2R5-2]
UniGeneiHs.567535.

3D structure databases

ProteinModelPortaliQ9H2R5.
SMRiQ9H2R5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120715. 10 interactors.
IntActiQ9H2R5. 3 interactors.
STRINGi9606.ENSP00000469315.

Protein family/group databases

MEROPSiS01.081.

PTM databases

iPTMnetiQ9H2R5.
PhosphoSitePlusiQ9H2R5.

Polymorphism and mutation databases

DMDMi18202940.

Proteomic databases

PaxDbiQ9H2R5.
PeptideAtlasiQ9H2R5.
PRIDEiQ9H2R5.

Protocols and materials databases

DNASUi55554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326856; ENSP00000314783; ENSG00000174562. [Q9H2R5-5]
ENST00000598239; ENSP00000469315; ENSG00000174562. [Q9H2R5-1]
GeneIDi55554.
KEGGihsa:55554.
UCSCiuc002ptl.4. human. [Q9H2R5-1]

Organism-specific databases

CTDi55554.
DisGeNETi55554.
GeneCardsiKLK15.
HGNCiHGNC:20453. KLK15.
HPAiHPA019802.
MIMi610601. gene.
neXtProtiNX_Q9H2R5.
OpenTargetsiENSG00000174562.
PharmGKBiPA134977502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOVERGENiHBG013304.
InParanoidiQ9H2R5.
KOiK09623.
OMAiRYEARSH.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9H2R5.
TreeFamiTF331065.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174562-MONOMER.

Miscellaneous databases

GeneWikiiKLK15.
GenomeRNAii55554.
PROiQ9H2R5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174562.
CleanExiHS_KLK15.
ExpressionAtlasiQ9H2R5. baseline and differential.
GenevisibleiQ9H2R5. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK15_HUMAN
AccessioniPrimary (citable) accession number: Q9H2R5
Secondary accession number(s): A0AUY8
, Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.