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Q9H2R5 (KLK15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein-15

EC=3.4.21.-
Alternative name(s):
ACO protease
Gene names
Name:KLK15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protease whose physiological substrate is not yet known.

Subcellular location

Secreted Probable.

Tissue specificity

Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney. Ref.1

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Non-traceable author statement Ref.1. Source: UniProtKB

serine-type peptidase activity

Traceable author statement Ref.3. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H2R5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H2R5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     122-256: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 3 (identifier: Q9H2R5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     161-161: V → G
     162-256: Missing.
Isoform 4 (identifier: Q9H2R5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     122-206: Missing.
Isoform 5 (identifier: Q9H2R5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     15-15: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 215Activation peptide Potential
PRO_0000027960
Chain22 – 256235Kallikrein-15
PRO_0000027961

Regions

Domain22 – 254233Peptidase S1

Sites

Active site621Charge relay system By similarity
Active site1061Charge relay system By similarity
Active site2091Charge relay system By similarity

Amino acid modifications

Glycosylation1711N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 63 By similarity
Disulfide bond138 ↔ 215 By similarity
Disulfide bond180 ↔ 194 By similarity
Disulfide bond205 ↔ 230 By similarity

Natural variations

Alternative sequence151Missing in isoform 5.
VSP_054621
Alternative sequence122 – 256135Missing in isoform 2.
VSP_005405
Alternative sequence122 – 20685Missing in isoform 4.
VSP_005404
Alternative sequence1611V → G in isoform 3.
VSP_005406
Alternative sequence162 – 25695Missing in isoform 3.
VSP_005407
Natural variant1341P → L.
Corresponds to variant rs3212805 [ dbSNP | Ensembl ].
VAR_020179
Natural variant1371A → T in a breast cancer sample; somatic mutation. Ref.7
VAR_036298

Experimental info

Sequence conflict147 – 16014SHNEP…SPRSQ → PLSSP Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B5EBF8D6022786B5

FASTA25628,087
        10         20         30         40         50         60 
MWLLLTLSFL LASTAAQDGD KLLEGDECAP HSQPWQVALY ERGRFNCGAS LISPHWVLSA 

        70         80         90        100        110        120 
AHCQSRFMRV RLGEHNLRKR DGPEQLRTTS RVIPHPRYEA RSHRNDIMLL RLVQPARLNP 

       130        140        150        160        170        180 
QVRPAVLPTR CPHPGEACVV SGWGLVSHNE PGTAGSPRSQ VSLPDTLHCA NISIISDTSC 

       190        200        210        220        230        240 
DKSYPGRLTN TMVCAGAEGR GAESCEGDSG GPLVCGGILQ GIVSWGDVPC DNTTKPGVYT 

       250 
KVCHYLEWIR ETMKRN 

« Hide

Isoform 2 [UniParc].

Checksum: 43BD650A394BF369
Show »

FASTA12113,907
Isoform 3 [UniParc].

Checksum: 539D5C6163B16285
Show »

FASTA16117,954
Isoform 4 [UniParc].

Checksum: 20CDE27B3E7B89E4
Show »

FASTA17119,341
Isoform 5 [UniParc].

Checksum: 1581B784D4A39C4F
Show »

FASTA25528,016

References

« Hide 'large scale' references
[1]"Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer."
Yousef G.M., Scorilas A., Jung K., Ashworth L.K., Diamandis E.P.
J. Biol. Chem. 276:53-61(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A novel serine proteinase-like sequence from human brain."
Dihanich M.E., Spiess M.
Biochim. Biophys. Acta 1218:225-228(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
[6]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-137.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF242195 Genomic DNA. Translation: AAG09469.1.
AF242195 Genomic DNA. Translation: AAG09470.1.
AF242195 Genomic DNA. Translation: AAG09471.1.
AF242195 Genomic DNA. Translation: AAG09472.1.
AF243527 Genomic DNA. Translation: AAG33354.1.
X75363 mRNA. Translation: CAA53145.1. Sequence problems.
CH471135 Genomic DNA. Translation: EAW71918.1.
BC069480 mRNA. Translation: AAH69480.1.
BC069507 mRNA. Translation: AAH69507.1.
BC069518 mRNA. Translation: AAH69518.1.
BC126137 mRNA. Translation: AAI26138.1.
BC144046 mRNA. Translation: AAI44047.1.
CCDSCCDS12805.1. [Q9H2R5-1]
PIRS45356.
RefSeqNP_001264010.1. NM_001277081.1. [Q9H2R5-5]
NP_001264011.1. NM_001277082.1.
NP_059979.2. NM_017509.3. [Q9H2R5-1]
XP_006723328.1. XM_006723265.1. [Q9H2R5-1]
UniGeneHs.567535.

3D structure databases

ProteinModelPortalQ9H2R5.
SMRQ9H2R5. Positions 22-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9H2R5. 1 interaction.
STRING9606.ENSP00000314783.

Chemistry

BindingDBQ9H2R5.

Protein family/group databases

MEROPSS01.081.

PTM databases

PhosphoSiteQ9H2R5.

Polymorphism databases

DMDM18202940.

Proteomic databases

PaxDbQ9H2R5.
PRIDEQ9H2R5.

Protocols and materials databases

DNASU55554.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301421; ENSP00000301421; ENSG00000174562. [Q9H2R5-3]
ENST00000416184; ENSP00000415136; ENSG00000174562. [Q9H2R5-4]
ENST00000598239; ENSP00000469315; ENSG00000174562. [Q9H2R5-1]
GeneID55554.
KEGGhsa:55554.
UCSCuc002ptl.3. human. [Q9H2R5-1]
uc002ptn.3. human. [Q9H2R5-3]

Organism-specific databases

CTD55554.
GeneCardsGC19M051328.
HGNCHGNC:20453. KLK15.
HPAHPA019802.
MIM610601. gene.
neXtProtNX_Q9H2R5.
PharmGKBPA134977502.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOVERGENHBG013304.
InParanoidQ9H2R5.
KOK09623.
OMARYEARSH.
OrthoDBEOG75B84T.
PhylomeDBQ9H2R5.
TreeFamTF331065.

Gene expression databases

ArrayExpressQ9H2R5.
BgeeQ9H2R5.
CleanExHS_KLK15.
GenevestigatorQ9H2R5.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKLK15.
GenomeRNAi55554.
NextBio60018.
PROQ9H2R5.
SOURCESearch...

Entry information

Entry nameKLK15_HUMAN
AccessionPrimary (citable) accession number: Q9H2R5
Secondary accession number(s): A0AUY8 expand/collapse secondary AC list , Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R6, Q9HBG9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM