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Q9H2P0

- ADNP_HUMAN

UniProt

Q9H2P0 - ADNP_HUMAN

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Protein

Activity-dependent neuroprotector homeobox protein

Gene
ADNP, ADNP1, KIAA0784
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9724C2H2-type 1Add
BLAST
Zinc fingeri107 – 12923C2H2-type 2; atypicalAdd
BLAST
Zinc fingeri165 – 18824C2H2-type 3Add
BLAST
Zinc fingeri221 – 24424C2H2-type 4Add
BLAST
Zinc fingeri447 – 46923C2H2-type 5; atypicalAdd
BLAST
Zinc fingeri489 – 51022C2H2-type 6; atypicalAdd
BLAST
Zinc fingeri512 – 53524C2H2-type 7Add
BLAST
Zinc fingeri622 – 64726C2H2-type 8; atypicalAdd
BLAST
Zinc fingeri662 – 68625C2H2-type 9; atypicalAdd
BLAST
DNA bindingi754 – 81461HomeoboxAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. negative regulation of neuron apoptotic process Source: Ensembl
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein
Alternative name(s):
Activity-dependent neuroprotective protein
Gene namesi
Name:ADNP
Synonyms:ADNP1, KIAA0784
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15766. ADNP.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11021102Activity-dependent neuroprotector homeobox proteinPRO_0000048807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei98 – 981Phosphoserine3 Publications
Modified residuei409 – 4091Phosphoserine2 Publications
Modified residuei413 – 4131Phosphoserine1 Publication
Modified residuei709 – 7091Phosphoserine2 Publications
Modified residuei736 – 7361Phosphoserine2 Publications
Modified residuei805 – 8051Phosphoserine1 Publication
Modified residuei876 – 8761Phosphoserine1 Publication
Modified residuei878 – 8781Phosphoserine1 Publication
Modified residuei921 – 9211Phosphoserine1 Publication
Modified residuei953 – 9531Phosphoserine4 Publications
Modified residuei955 – 9551Phosphoserine3 Publications
Modified residuei1035 – 10351N6-acetyllysine1 Publication
Modified residuei1042 – 10421N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9H2P0.
PaxDbiQ9H2P0.
PeptideAtlasiQ9H2P0.
PRIDEiQ9H2P0.

PTM databases

PhosphoSiteiQ9H2P0.

Expressioni

Tissue specificityi

Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues.

Gene expression databases

ArrayExpressiQ9H2P0.
BgeeiQ9H2P0.
CleanExiHS_ADNP.
GenevestigatoriQ9H2P0.

Organism-specific databases

HPAiHPA006371.
HPA050560.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX1P839162EBI-1764854,EBI-78129
CBX3Q131852EBI-1764854,EBI-78176
CBX5P459732EBI-1764854,EBI-78219

Protein-protein interaction databases

BioGridi116967. 24 interactions.
DIPiDIP-47288N.
IntActiQ9H2P0. 14 interactions.
MINTiMINT-1626775.
STRINGi9606.ENSP00000342905.

Structurei

3D structure databases

ProteinModelPortaliQ9H2P0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni354 – 3618Neuroprotective peptide (NAP)

Sequence similaritiesi

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG41028.
HOGENOMiHOG000232088.
HOVERGENiHBG024319.
InParanoidiQ9H2P0.
OMAiKCVRDCE.
OrthoDBiEOG7GJ6C7.
PhylomeDBiQ9H2P0.
TreeFamiTF328818.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2P0-1 [UniParc]FASTAAdd to Basket

« Hide

MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN     50
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED 100
FENRILLNCP YCTFNADKKT LETHIKIFHA PNASAPSSSL STFKDKNKND 150
GLKPKQADSV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA 200
GEKSLNGAVP LGSNAREESS IHCKRCLFMP KSYEALVQHV IEDHERIGYQ 250
VTAMIGHTNV VVPRSKPLML IAPKPQDKKS MGLPPRIGSL ASGNVRSLPS 300
QQMVNRLSIP KPNLNSTGVN MMSSVHLQQN NYGVKSVGQG YSVGQSMRLG 350
LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GSEQRSQAPA RYSLQSANAS 400
SLSSGQLKSP SLSQSQASRV LGQSSSKPAA AATGPPPGNT SSTQKWKICT 450
ICNELFPENV YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLPT 500
DTLLNHMLIH GLSCPYCRST FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF 550
DLTLQQGSHT NIHLLVTTYN LRDAPAESVA YHAQNNPPVP PKPQPKVQEK 600
ADIPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA HHLRERHQVI 650
QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT 700
NAPSRLNQSP SLAPVKRTYE QMEFPLLKKR KLDDDSDSPS FFEEKPEEPV 750
VLALDPKGHE DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI 800
ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF DAEWLFENHD 850
EKDSRVNASK TADKKLNLGK EDDSSSDSFE NLEEESNESG SPFDPVFEVE 900
PKISNDNPEE HVLKVIPEDA SESEEKLDQK EDGSKYETIH LTEEPTKLMH 950
NASDSEVDQD DVVEWKDGAS PSESGPGSQQ VSDFEDNTCE MKPGTWSDES 1000
SQSEDARSSK PAAKKKATMQ GDREQLKWKN SSYGKVEGFW SKDQSQWKNA 1050
SENDERLSNP QIEWQNSTID SEDGEQFDNM TDGVAEPMHG SLAGVKLSSQ 1100
QA 1102
Length:1,102
Mass (Da):123,563
Last modified:March 1, 2001 - v1
Checksum:i4132E3EF814AF43B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF250860 mRNA. Translation: AAG47651.1.
AL034553 Genomic DNA. Translation: CAB53748.2.
CH471077 Genomic DNA. Translation: EAW75611.1.
CH471077 Genomic DNA. Translation: EAW75612.1.
BC090933 mRNA. Translation: AAH90933.1.
AB018327 mRNA. Translation: BAA34504.1.
AL080163 mRNA. Translation: CAB45752.1.
CCDSiCCDS13433.1.
PIRiT12546.
RefSeqiNP_001269460.1. NM_001282531.1.
NP_001269461.1. NM_001282532.1.
NP_056154.1. NM_015339.3.
NP_852107.1. NM_181442.2.
UniGeneiHs.293736.
Hs.570355.

Genome annotation databases

EnsembliENST00000349014; ENSP00000342905; ENSG00000101126.
ENST00000371602; ENSP00000360662; ENSG00000101126.
ENST00000396029; ENSP00000379346; ENSG00000101126.
ENST00000396032; ENSP00000379349; ENSG00000101126.
GeneIDi23394.
KEGGihsa:23394.
UCSCiuc002xvt.1. human.

Polymorphism databases

DMDMi24636245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF250860 mRNA. Translation: AAG47651.1 .
AL034553 Genomic DNA. Translation: CAB53748.2 .
CH471077 Genomic DNA. Translation: EAW75611.1 .
CH471077 Genomic DNA. Translation: EAW75612.1 .
BC090933 mRNA. Translation: AAH90933.1 .
AB018327 mRNA. Translation: BAA34504.1 .
AL080163 mRNA. Translation: CAB45752.1 .
CCDSi CCDS13433.1.
PIRi T12546.
RefSeqi NP_001269460.1. NM_001282531.1.
NP_001269461.1. NM_001282532.1.
NP_056154.1. NM_015339.3.
NP_852107.1. NM_181442.2.
UniGenei Hs.293736.
Hs.570355.

3D structure databases

ProteinModelPortali Q9H2P0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116967. 24 interactions.
DIPi DIP-47288N.
IntActi Q9H2P0. 14 interactions.
MINTi MINT-1626775.
STRINGi 9606.ENSP00000342905.

PTM databases

PhosphoSitei Q9H2P0.

Polymorphism databases

DMDMi 24636245.

Proteomic databases

MaxQBi Q9H2P0.
PaxDbi Q9H2P0.
PeptideAtlasi Q9H2P0.
PRIDEi Q9H2P0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000349014 ; ENSP00000342905 ; ENSG00000101126 .
ENST00000371602 ; ENSP00000360662 ; ENSG00000101126 .
ENST00000396029 ; ENSP00000379346 ; ENSG00000101126 .
ENST00000396032 ; ENSP00000379349 ; ENSG00000101126 .
GeneIDi 23394.
KEGGi hsa:23394.
UCSCi uc002xvt.1. human.

Organism-specific databases

CTDi 23394.
GeneCardsi GC20M049505.
HGNCi HGNC:15766. ADNP.
HPAi HPA006371.
HPA050560.
MIMi 611386. gene.
neXtProti NX_Q9H2P0.
PharmGKBi PA24582.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41028.
HOGENOMi HOG000232088.
HOVERGENi HBG024319.
InParanoidi Q9H2P0.
OMAi KCVRDCE.
OrthoDBi EOG7GJ6C7.
PhylomeDBi Q9H2P0.
TreeFami TF328818.

Miscellaneous databases

ChiTaRSi ADNP. human.
GenomeRNAii 23394.
NextBioi 45527.
PROi Q9H2P0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H2P0.
Bgeei Q9H2P0.
CleanExi HS_ADNP.
Genevestigatori Q9H2P0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  5. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-1102.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-1102.
    Tissue: Uterus.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-953 AND SER-955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  9. "NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42)."
    Gozes I., Divinski I., Piltzer I.
    BMC Neurosci. 9:S3-S3(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF NAP PEPTIDE.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409; SER-709; SER-736; SER-876 AND SER-878, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736; SER-953 AND SER-955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1035 AND LYS-1042, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-709; SER-805; SER-953 AND SER-955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-409; SER-921 AND SER-953, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADNP_HUMAN
AccessioniPrimary (citable) accession number: Q9H2P0
Secondary accession number(s): E1P5Y2
, O94881, Q5BKU2, Q9UG34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the beta-amyloid peptide.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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