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Q9H2M1

- Q9H2M1_HUMAN

UniProt

Q9H2M1 - Q9H2M1_HUMAN

Protein
Submitted name:

Estrogen receptor

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. estrogen receptor activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. steroid binding Source: InterPro
    5. steroid hormone receptor activity Source: UniProtKB

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Estrogen receptorImported
    Submitted name:
    Estrogen receptor alphaImported
    Gene namesi
    Name:ESR1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:3467. ESR1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000152618.
    HOVERGENiHBG108344.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001292. Oestr_rcpt.
    IPR024736. Oestrogen-typ_rcpt_final_C_dom.
    IPR001723. Str_hrmn_rcpt.
    [Graphical view]
    PfamiPF12743. ESR1_C. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF02159. Oest_recep. 1 hit.
    [Graphical view]
    PRINTSiPR00543. OESTROGENR.
    PR00398. STRDHORMONER.
    SMARTiSM00430. HOLI. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9H2M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA    50
    VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL 100
    NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY 150
    RNQGKCVEGM VEIFDMLLAT SSRFRMMNLQ GEEFVCLKSI ILLNSGVYTF 200
    LSSTLKSLEE KDHIHRVLDK ITDTLIHLMA KAGLTLQQQH QRLAQLLLIL 250
    SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL EMLDAHRLHA PTSRGGASVE 300
    ETDQSHLATA GSTSSHSLQK YYITGEAEGF PATV 334
    Length:334
    Mass (Da):36,685
    Last modified:March 1, 2001 - v1
    Checksum:i135763A473757216
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035695 Genomic DNA. No translation available.
    AL049821 Genomic DNA. No translation available.
    AL078582 Genomic DNA. No translation available.
    AL356311 Genomic DNA. No translation available.
    AL590993 Genomic DNA. No translation available.
    KF454881 Genomic DNA. No translation available.
    KF458326 Genomic DNA. No translation available.
    KF458327 Genomic DNA. No translation available.
    AF258450 mRNA. Translation: AAG41359.1.
    UniGeneiHs.208124.
    Hs.744830.

    Genome annotation databases

    EnsembliENST00000406599; ENSP00000384064; ENSG00000091831.
    UCSCiuc010kiq.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035695 Genomic DNA. No translation available.
    AL049821 Genomic DNA. No translation available.
    AL078582 Genomic DNA. No translation available.
    AL356311 Genomic DNA. No translation available.
    AL590993 Genomic DNA. No translation available.
    KF454881 Genomic DNA. No translation available.
    KF458326 Genomic DNA. No translation available.
    KF458327 Genomic DNA. No translation available.
    AF258450 mRNA. Translation: AAG41359.1 .
    UniGenei Hs.208124.
    Hs.744830.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000406599 ; ENSP00000384064 ; ENSG00000091831 .
    UCSCi uc010kiq.3. human.

    Organism-specific databases

    HGNCi HGNC:3467. ESR1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000152618.
    HOVERGENi HBG108344.

    Miscellaneous databases

    ChiTaRSi ESR1. human.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001292. Oestr_rcpt.
    IPR024736. Oestrogen-typ_rcpt_final_C_dom.
    IPR001723. Str_hrmn_rcpt.
    [Graphical view ]
    Pfami PF12743. ESR1_C. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF02159. Oest_recep. 1 hit.
    [Graphical view ]
    PRINTSi PR00543. OESTROGENR.
    PR00398. STRDHORMONER.
    SMARTi SM00430. HOLI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Variant estrogen receptor alpha mRNAs in human breast cancer specimens."
      Anandappa S.Y., Sibson R., Platt-Higgins A., Winstanley J.H., Rudland P.S., Barraclough R.
      Int. J. Cancer 88:209-216(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BreastImported.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ9H2M1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2M1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3