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Protein
Submitted name:

Estrogen receptor

Gene

ESR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: InterPro
  • estrogen receptor activity Source: InterPro
  • steroid binding Source: InterPro
  • steroid hormone receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotationImported
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptorImported
Submitted name:
Estrogen receptor alphaImported
Gene namesi
Name:ESR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000091831.21
HGNCiHGNC:3467 ESR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091831

Expressioni

Gene expression databases

BgeeiENSG00000091831

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 286NR LBDInterPro annotationAdd BLAST286

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.SAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000152618
HOVERGENiHBG108344

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H2M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80 90 100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL
110 120 130 140 150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY
160 170 180 190 200
RNQGKCVEGM VEIFDMLLAT SSRFRMMNLQ GEEFVCLKSI ILLNSGVYTF
210 220 230 240 250
LSSTLKSLEE KDHIHRVLDK ITDTLIHLMA KAGLTLQQQH QRLAQLLLIL
260 270 280 290 300
SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL EMLDAHRLHA PTSRGGASVE
310 320 330
ETDQSHLATA GSTSSHSLQK YYITGEAEGF PATV
Length:334
Mass (Da):36,685
Last modified:March 1, 2001 - v1
Checksum:i135763A473757216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035695 Genomic DNA No translation available.
AL049821 Genomic DNA No translation available.
AL356311 Genomic DNA No translation available.
AL590993 Genomic DNA No translation available.
KF454881 Genomic DNA No translation available.
KF458326 Genomic DNA No translation available.
KF458327 Genomic DNA No translation available.
AF258450 mRNA Translation: AAG41359.1
UniGeneiHs.208124
Hs.744830

Genome annotation databases

EnsembliENST00000406599; ENSP00000384064; ENSG00000091831
UCSCiuc010kir.4 human

Similar proteinsi

Entry informationi

Entry nameiQ9H2M1_HUMAN
AccessioniPrimary (citable) accession number: Q9H2M1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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