Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosducin-like protein 3

Gene

PDCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.2 Publications

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • apoptotic process Source: UniProtKB-KW
  • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • queuosine biosynthetic process Source: GO_Central
  • regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processAngiogenesis, Apoptosis, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Alternative name(s):
HTPHLP
PhPL3
Viral IAP-associated factor 1
Short name:
VIAF-1
Gene namesi
Name:PDCL3
Synonyms:PhLP2A, VIAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115539.13.
HGNCiHGNC:28860. PDCL3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115539.
PharmGKBiPA134979849.

Polymorphism and mutation databases

BioMutaiPDCL3.
DMDMi50401164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637581 – 239Phosducin-like protein 3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H2J4.
MaxQBiQ9H2J4.
PaxDbiQ9H2J4.
PeptideAtlasiQ9H2J4.
PRIDEiQ9H2J4.
TopDownProteomicsiQ9H2J4.

PTM databases

iPTMnetiQ9H2J4.
PhosphoSitePlusiQ9H2J4.

Expressioni

Tissue specificityi

Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000115539.
CleanExiHS_PDCL3.
ExpressionAtlasiQ9H2J4. baseline and differential.
GenevisibleiQ9H2J4. HS.

Organism-specific databases

HPAiHPA018469.
HPA027094.

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain). Interacts with OpMNPV IAP3.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122497. 52 interactors.
IntActiQ9H2J4. 11 interactors.
STRINGi9606.ENSP00000264254.

Chemistry databases

BindingDBiQ9H2J4.

Structurei

3D structure databases

ProteinModelPortaliQ9H2J4.
SMRiQ9H2J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 239Thioredoxin foldBy similarityAdd BLAST149

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ9H2J4.
OMAiHENRLEG.
OrthoDBiEOG091G0QP8.
PhylomeDBiQ9H2J4.
TreeFamiTF315179.

Family and domain databases

InterProiView protein in InterPro
IPR024253. Phosducin_thioredoxin-like_dom.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF02114. Phosducin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H2J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEAEEEQRIL QQSVVKTYED
60 70 80 90 100
MTLEELEDHE DEFNEEDERA IEMYRRRRLA EWKATKLKNK FGEVLEISGK
110 120 130 140 150
DYVQEVTKAG EGLWVILHLY KQGIPLCALI NQHLSGLARK FPDVKFIKAI
160 170 180 190 200
STTCIPNYPD RNLPTIFVYL EGDIKAQFIG PLVFGGMNLT RDELEWKLSE
210 220 230
SGAIMTDLEE NPKKPIEDVL LSSVRRSVLM KRDSDSEGD
Length:239
Mass (Da):27,614
Last modified:March 1, 2001 - v1
Checksum:iD54900B9EEE3A1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110511 mRNA. Translation: AAG21887.1.
AF267853 mRNA. Translation: AAG44722.1.
AK313985 mRNA. Translation: BAG36697.1.
AC068538 Genomic DNA. Translation: AAX93227.1.
CH471127 Genomic DNA. Translation: EAX01838.1.
BC001021 mRNA. Translation: AAH01021.1.
CCDSiCCDS33261.1.
RefSeqiNP_076970.1. NM_024065.4.
UniGeneiHs.469459.

Genome annotation databases

EnsembliENST00000264254; ENSP00000264254; ENSG00000115539.
GeneIDi79031.
KEGGihsa:79031.
UCSCiuc002tao.3. human.

Similar proteinsi

Entry informationi

Entry nameiPDCL3_HUMAN
AccessioniPrimary (citable) accession number: Q9H2J4
Secondary accession number(s): B2RA00, Q53S68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families