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Protein

Phosducin-like protein 3

Gene

PDCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.2 Publications

GO - Molecular functioni

  • protein binding involved in protein folding Source: MGI

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • apoptotic process Source: UniProtKB-KW
  • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • queuosine biosynthetic process Source: GO_Central
  • regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Apoptosis, Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin-like protein 3
Alternative name(s):
HTPHLP
PhPL3
Viral IAP-associated factor 1
Short name:
VIAF-1
Gene namesi
Name:PDCL3
Synonyms:PhLP2A, VIAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28860. PDCL3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi79031.
OpenTargetsiENSG00000115539.
PharmGKBiPA134979849.

Polymorphism and mutation databases

BioMutaiPDCL3.
DMDMi50401164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637581 – 239Phosducin-like protein 3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H2J4.
MaxQBiQ9H2J4.
PaxDbiQ9H2J4.
PeptideAtlasiQ9H2J4.
PRIDEiQ9H2J4.
TopDownProteomicsiQ9H2J4.

PTM databases

iPTMnetiQ9H2J4.
PhosphoSitePlusiQ9H2J4.

Expressioni

Tissue specificityi

Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000115539.
CleanExiHS_PDCL3.
ExpressionAtlasiQ9H2J4. baseline and differential.
GenevisibleiQ9H2J4. HS.

Organism-specific databases

HPAiHPA018469.
HPA027094.

Interactioni

Subunit structurei

Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain). Interacts with OpMNPV IAP3.2 Publications

GO - Molecular functioni

  • protein binding involved in protein folding Source: MGI

Protein-protein interaction databases

BioGridi122497. 24 interactors.
IntActiQ9H2J4. 11 interactors.
STRINGi9606.ENSP00000264254.

Chemistry databases

BindingDBiQ9H2J4.

Structurei

3D structure databases

ProteinModelPortaliQ9H2J4.
SMRiQ9H2J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 239Thioredoxin foldBy similarityAdd BLAST149

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ9H2J4.
OMAiPLCSLIN.
OrthoDBiEOG091G0QP8.
PhylomeDBiQ9H2J4.
TreeFamiTF315179.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H2J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDPNADTEW NDILRKKGIL PPKESLKELE EEAEEEQRIL QQSVVKTYED
60 70 80 90 100
MTLEELEDHE DEFNEEDERA IEMYRRRRLA EWKATKLKNK FGEVLEISGK
110 120 130 140 150
DYVQEVTKAG EGLWVILHLY KQGIPLCALI NQHLSGLARK FPDVKFIKAI
160 170 180 190 200
STTCIPNYPD RNLPTIFVYL EGDIKAQFIG PLVFGGMNLT RDELEWKLSE
210 220 230
SGAIMTDLEE NPKKPIEDVL LSSVRRSVLM KRDSDSEGD
Length:239
Mass (Da):27,614
Last modified:March 1, 2001 - v1
Checksum:iD54900B9EEE3A1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110511 mRNA. Translation: AAG21887.1.
AF267853 mRNA. Translation: AAG44722.1.
AK313985 mRNA. Translation: BAG36697.1.
AC068538 Genomic DNA. Translation: AAX93227.1.
CH471127 Genomic DNA. Translation: EAX01838.1.
BC001021 mRNA. Translation: AAH01021.1.
CCDSiCCDS33261.1.
RefSeqiNP_076970.1. NM_024065.4.
UniGeneiHs.469459.

Genome annotation databases

EnsembliENST00000264254; ENSP00000264254; ENSG00000115539.
GeneIDi79031.
KEGGihsa:79031.
UCSCiuc002tao.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110511 mRNA. Translation: AAG21887.1.
AF267853 mRNA. Translation: AAG44722.1.
AK313985 mRNA. Translation: BAG36697.1.
AC068538 Genomic DNA. Translation: AAX93227.1.
CH471127 Genomic DNA. Translation: EAX01838.1.
BC001021 mRNA. Translation: AAH01021.1.
CCDSiCCDS33261.1.
RefSeqiNP_076970.1. NM_024065.4.
UniGeneiHs.469459.

3D structure databases

ProteinModelPortaliQ9H2J4.
SMRiQ9H2J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122497. 24 interactors.
IntActiQ9H2J4. 11 interactors.
STRINGi9606.ENSP00000264254.

Chemistry databases

BindingDBiQ9H2J4.

PTM databases

iPTMnetiQ9H2J4.
PhosphoSitePlusiQ9H2J4.

Polymorphism and mutation databases

BioMutaiPDCL3.
DMDMi50401164.

Proteomic databases

EPDiQ9H2J4.
MaxQBiQ9H2J4.
PaxDbiQ9H2J4.
PeptideAtlasiQ9H2J4.
PRIDEiQ9H2J4.
TopDownProteomicsiQ9H2J4.

Protocols and materials databases

DNASUi79031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264254; ENSP00000264254; ENSG00000115539.
GeneIDi79031.
KEGGihsa:79031.
UCSCiuc002tao.3. human.

Organism-specific databases

CTDi79031.
DisGeNETi79031.
GeneCardsiPDCL3.
HGNCiHGNC:28860. PDCL3.
HPAiHPA018469.
HPA027094.
MIMi611678. gene.
neXtProtiNX_Q9H2J4.
OpenTargetsiENSG00000115539.
PharmGKBiPA134979849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3170. Eukaryota.
ENOG4111H24. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000184445.
HOVERGENiHBG108238.
InParanoidiQ9H2J4.
OMAiPLCSLIN.
OrthoDBiEOG091G0QP8.
PhylomeDBiQ9H2J4.
TreeFamiTF315179.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115539-MONOMER.

Miscellaneous databases

GenomeRNAii79031.
PROiQ9H2J4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115539.
CleanExiHS_PDCL3.
ExpressionAtlasiQ9H2J4. baseline and differential.
GenevisibleiQ9H2J4. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006442. Antitoxin_Phd/YefM.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01552. phd_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDCL3_HUMAN
AccessioniPrimary (citable) accession number: Q9H2J4
Secondary accession number(s): B2RA00, Q53S68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.