Q9H2I8 (CJ011_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein C10orf11

Gene names

Name:	C10orf11
ORF Names:	CDA017

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Leucine-rich repeat-containing protein C10orf11		PRO_0000089781
Regions
	Repeat	2 – 22	21	LRR 1
	Repeat	26 – 47	22	LRR 2
	Repeat	48 – 69	22	LRR 3
	Repeat	75 – 95	21	LRR 4
	Domain	96 – 134	39	LRRCT
Natural variations
	Natural variant	153	1	S → F. Corresponds to variant rs35349706 [ dbSNP | Ensembl ].		VAR_033686

Sequences

	Sequence		Length	Mass (Da)
	Q9H2I8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 46C5A791B179AEDF	FASTA	198	22,568
	10 20 30 40 50 60 MEKYLSLSGN HSSNKRSLEG LSAFRSLEEL ILDNNQLGDD LVLPGLPRLH TLTLNKNRIT 70 80 90 100 110 120 DLENLLDHLA EVTPALEYLS LLGNVACPNE LVSLEKDEED YKRYRCFVLY KLPNLKFLDA 130 140 150 160 170 180 QKVTRQEREE ALVRGVFMKV VKPKASSEDV ASSPERHYTP LPSASRELTS HQGVLGKCRY 190 VYYGKNSEGN RFIRDDQL

References

[1]	"A novel gene expressed in human pheochromocytoma." Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pheochromocytoma.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF267860 mRNA. Translation: AAG44729.1. AL731568 , AC012047, AC013286, AC024603 Genomic DNA. Translation: CAH73047.1. CH471083 Genomic DNA. Translation: EAW54585.1.
IPI	IPI00012461.
RefSeq	NP_114413.1. NM_032024.3.
UniGene	Hs.118161.
3D structure databases
ProteinModelPortal	Q9H2I8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361577.
PTM databases
PhosphoSite	Q9H2I8.
Polymorphism databases
DMDM	46576650.
Proteomic databases
PaxDb	Q9H2I8.
PRIDE	Q9H2I8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372499; ENSP00000361577; ENSG00000148655.
GeneID	83938.
KEGG	hsa:83938.
UCSC	uc001jxi.3. human.
Organism-specific databases
CTD	83938.
GeneCards	GC10P077192.
H-InvDB	HIX0020866.
HGNC	HGNC:23405. C10orf11.
HPA	HPA047446. HPA050419.
MIM	614537. gene.
neXtProt	NX_Q9H2I8.
PharmGKB	PA134899373.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG121670.
HOGENOM	HOG000293232.
HOVERGEN	HBG050965.
PhylomeDB	Q9H2I8.
Gene expression databases
ArrayExpress	Q9H2I8.
Bgee	Q9H2I8.
CleanEx	HS_C10orf11.
Genevestigator	Q9H2I8.
GermOnline	ENSG00000148655. Homo sapiens.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. [Graphical view]
PROSITE	PS51450. LRR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C10orf11. human.
GenomeRNAi	83938.
NextBio	73065.
SOURCE	Search...

Entry information

Entry name

CJ011_HUMAN

Accession

Primary (citable) accession number: Q9H2I8
Secondary accession number(s): B1AVW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.