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Q9H2I8 (CJ011_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein C10orf11
Gene names
Name:C10orf11
ORF Names:CDA017
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 4 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainLeucine-rich repeat
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Leucine-rich repeat-containing protein C10orf11
PRO_0000089781

Regions

Repeat2 – 2221LRR 1
Repeat26 – 4722LRR 2
Repeat48 – 6922LRR 3
Repeat75 – 9521LRR 4
Domain96 – 13439LRRCT

Amino acid modifications

Modified residue1531Phosphoserine Ref.4 Ref.5

Natural variations

Natural variant1531S → F.
Corresponds to variant rs35349706 [ dbSNP | Ensembl ].
VAR_033686

Sequences

Sequence LengthMass (Da)Tools
Q9H2I8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 46C5A791B179AEDF

FASTA19822,568
        10         20         30         40         50         60 
MEKYLSLSGN HSSNKRSLEG LSAFRSLEEL ILDNNQLGDD LVLPGLPRLH TLTLNKNRIT 

        70         80         90        100        110        120 
DLENLLDHLA EVTPALEYLS LLGNVACPNE LVSLEKDEED YKRYRCFVLY KLPNLKFLDA 

       130        140        150        160        170        180 
QKVTRQEREE ALVRGVFMKV VKPKASSEDV ASSPERHYTP LPSASRELTS HQGVLGKCRY 

       190 
VYYGKNSEGN RFIRDDQL

« Hide

References

[1]"A novel gene expressed in human pheochromocytoma."
Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pheochromocytoma.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[5]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, MASS SPECTROMETRY.
Tissue: Platelet.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF267860 mRNA. Translation: AAG44729.1.
AL731568 expand/collapse EMBL AC list , AC012047, AC013286, AC024603 Genomic DNA. Translation: CAH73047.1.
CH471083 Genomic DNA. Translation: EAW54585.1.
IPIIPI00012461.
RefSeqNP_114413.1. NM_032024.3.
UniGeneHs.118161.

3D structure databases

ProteinModelPortalQ9H2I8.
SMRQ9H2I8. Positions 3-126.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9H2I8.

PTM databases

PhosphoSiteQ9H2I8.

Polymorphism databases

DMDM46576650.

Proteomic databases

PRIDEQ9H2I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372499; ENSP00000361577; ENSG00000148655.
GeneID83938.
KEGGhsa:83938.
UCSCuc001jxi.1. human.

Organism-specific databases

CTD83938.
GeneCardsGC10P077212.
HGNCHGNC:23405. C10orf11.
neXtProtNX_Q9H2I8.
PharmGKBPA134899373.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG16690.
GeneTreeENSGT00390000006581.
HOVERGENHBG050965.
PhylomeDBQ9H2I8.

Gene expression databases

ArrayExpressQ9H2I8.
BgeeQ9H2I8.
CleanExHS_C10orf11.
GenevestigatorQ9H2I8.
GermOnlineENSG00000148655. Homo sapiens.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
[Graphical view]
PROSITEPS51450. LRR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio73065.

Entry information

Entry nameCJ011_HUMAN
AccessionPrimary (citable) accession number: Q9H2I8
Secondary accession number(s): B1AVW6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents