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Protein

Sodium-coupled neutral amino acid transporter 1

Gene

SLC38A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.1 Publication

Enzyme regulationi

Inhibited by potassium, choline ions and 2-methylamino-isobutyric acid (MeAIB) (By similarity). Inhibited by lithium and N-methyl-D-glucamine.By similarity1 Publication

Kineticsi

  1. KM=890 µM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.5)1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
    LigandSodium

    Enzyme and pathway databases

    ReactomeiR-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-HSA-352230 Amino acid transport across the plasma membrane

    Protein family/group databases

    TCDBi2.A.18.6.14 the amino acid/auxin permease (aaap) family

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 1
    Alternative name(s):
    Amino acid transporter A1
    N-system amino acid transporter 2
    Solute carrier family 38 member 1
    System A amino acid transporter 1
    System N amino acid transporter 1
    Gene namesi
    Name:SLC38A1
    Synonyms:ATA1, NAT2, SAT1, SNAT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 12

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000111371.15
    HGNCiHGNC:13447 SLC38A1
    MIMi608490 gene
    neXtProtiNX_Q9H2H9

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
    Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
    Topological domaini98 – 112ExtracellularSequence analysisAdd BLAST15
    Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
    Topological domaini134 – 147CytoplasmicSequence analysisAdd BLAST14
    Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
    Topological domaini169 – 188ExtracellularSequence analysisAdd BLAST20
    Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
    Topological domaini212 – 216CytoplasmicSequence analysis5
    Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
    Topological domaini238 – 275ExtracellularSequence analysisAdd BLAST38
    Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
    Topological domaini297 – 312CytoplasmicSequence analysisAdd BLAST16
    Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
    Topological domaini334 – 350ExtracellularSequence analysisAdd BLAST17
    Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
    Topological domaini372 – 393CytoplasmicSequence analysisAdd BLAST22
    Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
    Topological domaini415 – 416ExtracellularSequence analysis2
    Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
    Topological domaini438 – 452CytoplasmicSequence analysisAdd BLAST15
    Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
    Topological domaini474 – 487ExtracellularSequence analysisAdd BLAST14

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi81539
    OpenTargetsiENSG00000111371
    PharmGKBiPA37772

    Polymorphism and mutation databases

    BioMutaiSLC38A1
    DMDMi74733561

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003104751 – 487Sodium-coupled neutral amino acid transporter 1Add BLAST487

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei6PhosphoserineBy similarity1
    Modified residuei11PhosphothreonineBy similarity1
    Modified residuei25PhosphoserineCombined sources1
    Modified residuei28PhosphoserineCombined sources1
    Modified residuei49PhosphoserineCombined sources1
    Modified residuei52PhosphoserineCombined sources1
    Modified residuei54PhosphothreonineCombined sources1
    Modified residuei56PhosphoserineCombined sources1
    Disulfide bondi245 ↔ 264PROSITE-ProRule annotation
    Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H2H9
    PaxDbiQ9H2H9
    PeptideAtlasiQ9H2H9
    PRIDEiQ9H2H9

    PTM databases

    iPTMnetiQ9H2H9
    PhosphoSitePlusiQ9H2H9
    SwissPalmiQ9H2H9

    Expressioni

    Tissue specificityi

    Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.4 Publications

    Inductioni

    Down-regulated by bacterial lipopolysaccharides (LPS) in glial cells. Down-regulated upon hypoxia.2 Publications

    Gene expression databases

    BgeeiENSG00000111371
    CleanExiHS_NAT2
    HS_SAT1
    HS_SLC38A1
    ExpressionAtlasiQ9H2H9 baseline and differential
    GenevisibleiQ9H2H9 HS

    Organism-specific databases

    HPAiHPA039460
    HPA052272

    Interactioni

    Binary interactionsi

    Show more details

    Protein-protein interaction databases

    BioGridi123509, 11 interactors
    IntActiQ9H2H9, 74 interactors
    STRINGi9606.ENSP00000381634

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2H9
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1305 Eukaryota
    COG0814 LUCA
    GeneTreeiENSGT00760000119147
    HOGENOMiHOG000013088
    HOVERGENiHBG059571
    InParanoidiQ9H2H9
    KOiK14990
    PhylomeDBiQ9H2H9
    TreeFamiTF328787

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057 AA_transpt_TM
    PfamiView protein in Pfam
    PF01490 Aa_trans, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9H2H9-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MMHFKSGLEL TELQNMTVPE DDNISNDSND FTEVENGQIN SKFISDRESR
    60 70 80 90 100
    RSLTNSHLEK KKCDEYIPGT TSLGMSVFNL SNAIMGSGIL GLAFALANTG
    110 120 130 140 150
    ILLFLVLLTS VTLLSIYSIN LLLICSKETG CMVYEKLGEQ VFGTTGKFVI
    160 170 180 190 200
    FGATSLQNTG AMLSYLFIVK NELPSAIKFL MGKEETFSAW YVDGRVLVVI
    210 220 230 240 250
    VTFGIILPLC LLKNLGYLGY TSGFSLSCMV FFLIVVIYKK FQIPCIVPEL
    260 270 280 290 300
    NSTISANSTN ADTCTPKYVT FNSKTVYALP TIAFAFVCHP SVLPIYSELK
    310 320 330 340 350
    DRSQKKMQMV SNISFFAMFV MYFLTAIFGY LTFYDNVQSD LLHKYQSKDD
    360 370 380 390 400
    ILILTVRLAV IVAVILTVPV LFFTVRSSLF ELAKKTKFNL CRHTVVTCIL
    410 420 430 440 450
    LVVINLLVIF IPSMKDIFGV VGVTSANMLI FILPSSLYLK ITDQDGDKGT
    460 470 480
    QRIWAALFLG LGVLFSLVSI PLVIYDWACS SSSDEGH
    Length:487
    Mass (Da):54,048
    Last modified:March 1, 2001 - v1
    Checksum:i5CBC96880D7BDE03
    GO

    Sequence cautioni

    The sequence AAG44546 differs from that shown. Reason: Frameshift at position 443.Curated
    The sequence BAC11186 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti107L → P in BAB55394 (PubMed:14702039).Curated1
    Sequence conflicti203F → V in BAC11310 (PubMed:16303743).Curated1
    Sequence conflicti375V → D in AAG44546 (Ref. 2) Curated1
    Sequence conflicti483 – 484SD → NG in AAG44546 (Ref. 2) Curated2

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271070 mRNA Translation: AAG39354.1
    AF247166 mRNA Translation: AAG44546.1 Frameshift.
    AK027825 mRNA Translation: BAB55394.1
    AK074758 mRNA Translation: BAC11186.1 Different initiation.
    AK074949 mRNA Translation: BAC11310.1
    CH471111 Genomic DNA Translation: EAW57895.1
    BC010620 mRNA Translation: AAH10620.1
    CCDSiCCDS41774.1
    PIRiJC7328
    RefSeqiNP_001070952.1, NM_001077484.1
    NP_001265316.1, NM_001278387.1
    NP_001265317.1, NM_001278388.1
    NP_001265318.1, NM_001278389.1
    NP_109599.3, NM_030674.3
    UniGeneiHs.533770

    Genome annotation databases

    EnsembliENST00000398637; ENSP00000381634; ENSG00000111371
    ENST00000439706; ENSP00000398142; ENSG00000111371
    ENST00000546893; ENSP00000447853; ENSG00000111371
    ENST00000549049; ENSP00000449607; ENSG00000111371
    GeneIDi81539
    KEGGihsa:81539
    UCSCiuc001rpb.5 human

    Similar proteinsi

    Entry informationi

    Entry nameiS38A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2H9
    Secondary accession number(s): Q8NC61
    , Q8NCF8, Q96JX2, Q9H2Q2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2001
    Last modified: May 23, 2018
    This is version 133 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

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