Reviewed, UniProtKB/Swiss-Prot Q9H2H0 (CXXC4_HUMAN)

Names and origin

Protein names

Recommended name:
    CXXC-type zinc finger protein 4
Alternative name(s):
    Inhibition of the Dvl and axin complex protein

Gene names

Name:	CXXC4
Synonyms:	IDAX

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 By similarity.
Subunit structure	Interacts with the PDZ domain of DVL1 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 CXXC-type zinc finger.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of Wnt receptor signaling pathway Ref.1 Inferred from direct assay. Source: UniProtKB zygotic specification of dorsal/ventral axis Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro PDZ domain binding Ref.1 Inferred from physical interaction. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	CXXC-type zinc finger protein 4		PRO_0000317542
Regions
	Zinc finger	132 – 173	42	CXXC-type
	Region	161 – 166	6	Interaction with DVL1 By similarity
	Compositional bias	116 – 123	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q9H2H0-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 9D9F7FAD11A9B759	FASTA	198	20,978
	10 20 30 40 50 60 MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC GAAEAEIMNL 70 80 90 100 110 120 PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD SAFQIANLAD CPQNHSSSSS 130 140 150 160 170 180 SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG 190 TSLERTPVPS AEAFRWFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein." Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. Mol. Cell. Biol. 21:330-342(2001) [PubMed: 11113207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF272159 mRNA. Translation: AAG42072.1. AC093628 Genomic DNA. Translation: AAY40933.1. CH471057 Genomic DNA. Translation: EAX06175.1. BC119751 mRNA. Translation: AAI19752.1. BC119752 mRNA. Translation: AAI19753.1.
IPI	IPI00018828.
RefSeq	NP_079488.1.
UniGene	Hs.12248
3D structure databases
SMR	Q9H2H0. Positions 127-181.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H2H0.
Proteomic databases
PRIDE	Q9H2H0.
Genome annotation databases
Ensembl	ENST00000305749; ENSP00000307051; ENSG00000168772; Homo sapiens. [Genome view] ENST00000394767; ENSP00000378248; ENSG00000168772; Homo sapiens. [Genome view] ENST00000426831; ENSP00000412267; ENSG00000168772; Homo sapiens. [Genome view]
GeneID	80319.
KEGG	hsa:80319.
UCSC	uc003hxg.1. human.
Organism-specific databases
CTD	80319.
GeneCards	GC04M105609.
HGNC	HGNC:24593. CXXC4.
MIM	611645. gene.
PharmGKB	PA134992016.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19337.
HOGENOM	HBG445020.
HOVERGEN	Q9H2H0.
InParanoid	Q9H2H0.
OrthoDB	EOG9P5NW3.
PhylomeDB	Q9H2H0.
Gene expression databases
ArrayExpress	Q9H2H0.
Bgee	Q9H2H0.
CleanEx	HS_CXXC4.
Genevestigator	Q9H2H0.
Family and domain databases
InterPro	IPR002857. Znf_CXXC. [Graphical view]
Pfam	PF02008. zf-CXXC. 1 hit. [Graphical view]
PROSITE	PS51058. ZF_CXXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	70831.
SOURCE	Search...

Entry information

Entry name

CXXC4_HUMAN

Accession

Primary (citable) accession number: Q9H2H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2001
Last modified:	January 19, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.