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Protein

CXXC-type zinc finger protein 4

Gene

CXXC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 173CXXC-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • DNA binding Source: InterPro
  • PDZ domain binding Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5368598. Negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 4
Alternative name(s):
Inhibition of the Dvl and axin complex protein
Gene namesi
Name:CXXC4
Synonyms:IDAX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24593. CXXC4.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80319.
PharmGKBiPA134992016.

Polymorphism and mutation databases

DMDMi74752605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175421 – 198CXXC-type zinc finger protein 4Add BLAST198

Proteomic databases

EPDiQ9H2H0.
PaxDbiQ9H2H0.
PRIDEiQ9H2H0.

PTM databases

iPTMnetiQ9H2H0.
PhosphoSitePlusiQ9H2H0.

Expressioni

Gene expression databases

CleanExiHS_CXXC4.

Organism-specific databases

HPAiHPA036600.

Interactioni

Subunit structurei

Interacts with the PDZ domain of DVL1.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ9H2H0. 6 interactors.
STRINGi9606.ENSP00000412267.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VC9X-ray2.10C/F133-180[»]
ProteinModelPortaliQ9H2H0.
SMRiQ9H2H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 166Interaction with DVL1By similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 123Poly-Ser8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 173CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEZT. Eukaryota.
ENOG4111BB0. LUCA.
HOGENOMiHOG000112118.
HOVERGENiHBG107791.
InParanoidiQ9H2H0.
PhylomeDBiQ9H2H0.
TreeFamiTF326617.

Family and domain databases

InterProiView protein in InterPro
IPR002857. Znf_CXXC.
PfamiView protein in Pfam
PF02008. zf-CXXC. 1 hit.
PROSITEiView protein in PROSITE
PS51058. ZF_CXXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H2H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC
60 70 80 90 100
GAAEAEIMNL PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD
110 120 130 140 150
SAFQIANLAD CPQNHSSSSS SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN
160 170 180 190
CGVCSSCRNR KTGHQICKFR KCEELKKKPG TSLERTPVPS AEAFRWFF
Length:198
Mass (Da):20,978
Last modified:March 1, 2001 - v1
Checksum:i9D9F7FAD11A9B759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272159 mRNA. Translation: AAG42072.1.
AC093628 Genomic DNA. Translation: AAY40933.1.
CH471057 Genomic DNA. Translation: EAX06175.1.
BC119751 mRNA. Translation: AAI19752.1.
BC119752 mRNA. Translation: AAI19753.1.
UniGeneiHs.12248.
Hs.624057.

Genome annotation databases

EnsembliENST00000426831; ENSP00000412267; ENSG00000168772.

Similar proteinsi

Entry informationi

Entry nameiCXXC4_HUMAN
AccessioniPrimary (citable) accession number: Q9H2H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references