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Protein

CXXC-type zinc finger protein 4

Gene

CXXC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri132 – 17342CXXC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: InterPro
  • PDZ domain binding Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5368598. Negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 4
Alternative name(s):
Inhibition of the Dvl and axin complex protein
Gene namesi
Name:CXXC4
Synonyms:IDAX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24593. CXXC4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytoplasmic vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992016.

Polymorphism and mutation databases

DMDMi74752605.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198CXXC-type zinc finger protein 4PRO_0000317542Add
BLAST

Proteomic databases

PaxDbiQ9H2H0.
PRIDEiQ9H2H0.

PTM databases

iPTMnetiQ9H2H0.

Expressioni

Gene expression databases

BgeeiQ9H2H0.
CleanExiHS_CXXC4.

Organism-specific databases

HPAiHPA036600.

Interactioni

Subunit structurei

Interacts with the PDZ domain of DVL1.By similarity

GO - Molecular functioni

  • PDZ domain binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ9H2H0. 6 interactions.
STRINGi9606.ENSP00000412267.

Structurei

3D structure databases

ProteinModelPortaliQ9H2H0.
SMRiQ9H2H0. Positions 135-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1666Interaction with DVL1By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi116 – 1238Poly-Ser

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri132 – 17342CXXC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEZT. Eukaryota.
ENOG4111BB0. LUCA.
HOGENOMiHOG000112118.
HOVERGENiHBG107791.
InParanoidiQ9H2H0.
PhylomeDBiQ9H2H0.
TreeFamiTF326617.

Family and domain databases

InterProiIPR002857. Znf_CXXC.
[Graphical view]
PfamiPF02008. zf-CXXC. 1 hit.
[Graphical view]
PROSITEiPS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHRNDSQRL GKAGCPPEPS LQMANTNFLS TLSPEHCRPL AGECMNKLKC
60 70 80 90 100
GAAEAEIMNL PERVGTFSAI PALGGISLPP GVIVMTALHS PAAASAAVTD
110 120 130 140 150
SAFQIANLAD CPQNHSSSSS SSSGGAGGAN PAKKKRKRCG VCVPCKRLIN
160 170 180 190
CGVCSSCRNR KTGHQICKFR KCEELKKKPG TSLERTPVPS AEAFRWFF
Length:198
Mass (Da):20,978
Last modified:March 1, 2001 - v1
Checksum:i9D9F7FAD11A9B759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272159 mRNA. Translation: AAG42072.1.
AC093628 Genomic DNA. Translation: AAY40933.1.
CH471057 Genomic DNA. Translation: EAX06175.1.
BC119751 mRNA. Translation: AAI19752.1.
BC119752 mRNA. Translation: AAI19753.1.
UniGeneiHs.12248.
Hs.624057.

Genome annotation databases

EnsembliENST00000426831; ENSP00000412267; ENSG00000168772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272159 mRNA. Translation: AAG42072.1.
AC093628 Genomic DNA. Translation: AAY40933.1.
CH471057 Genomic DNA. Translation: EAX06175.1.
BC119751 mRNA. Translation: AAI19752.1.
BC119752 mRNA. Translation: AAI19753.1.
UniGeneiHs.12248.
Hs.624057.

3D structure databases

ProteinModelPortaliQ9H2H0.
SMRiQ9H2H0. Positions 135-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H2H0. 6 interactions.
STRINGi9606.ENSP00000412267.

PTM databases

iPTMnetiQ9H2H0.

Polymorphism and mutation databases

DMDMi74752605.

Proteomic databases

PaxDbiQ9H2H0.
PRIDEiQ9H2H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426831; ENSP00000412267; ENSG00000168772.

Organism-specific databases

GeneCardsiCXXC4.
HGNCiHGNC:24593. CXXC4.
HPAiHPA036600.
MIMi611645. gene.
neXtProtiNX_Q9H2H0.
PharmGKBiPA134992016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEZT. Eukaryota.
ENOG4111BB0. LUCA.
HOGENOMiHOG000112118.
HOVERGENiHBG107791.
InParanoidiQ9H2H0.
PhylomeDBiQ9H2H0.
TreeFamiTF326617.

Enzyme and pathway databases

ReactomeiR-HSA-5368598. Negative regulation of TCF-dependent signaling by DVL-interacting proteins.

Miscellaneous databases

PROiQ9H2H0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2H0.
CleanExiHS_CXXC4.

Family and domain databases

InterProiIPR002857. Znf_CXXC.
[Graphical view]
PfamiPF02008. zf-CXXC. 1 hit.
[Graphical view]
PROSITEiPS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein."
    Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A.
    Mol. Cell. Biol. 21:330-342(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCXXC4_HUMAN
AccessioniPrimary (citable) accession number: Q9H2H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.