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Q9H2G4

- TSYL2_HUMAN

UniProt

Q9H2G4 - TSYL2_HUMAN

Protein

Testis-specific Y-encoded-like protein 2

Gene

TSPYL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.2 Publications

    GO - Molecular functioni

    1. rDNA binding Source: UniProtKB

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cell cycle Source: UniProtKB-KW
    3. cellular protein metabolic process Source: Reactome
    4. chromatin modification Source: UniProtKB-KW
    5. endoplasmic reticulum unfolded protein response Source: Reactome
    6. negative regulation of cell cycle Source: UniProtKB
    7. negative regulation of cell growth Source: UniProtKB
    8. negative regulation of DNA replication Source: UniProtKB
    9. nucleosome assembly Source: InterPro
    10. regulation of protein kinase activity Source: UniProtKB
    11. regulation of signal transduction Source: UniProtKB
    12. regulation of transcription, DNA-templated Source: UniProtKB-KW
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific Y-encoded-like protein 2
    Short name:
    TSPY-like protein 2
    Alternative name(s):
    Cell division autoantigen 1
    Cutaneous T-cell lymphoma-associated antigen se20-4
    Short name:
    CTCL-associated antigen se20-4
    Differentially-expressed nucleolar TGF-beta1 target protein
    Nuclear protein of 79 kDa
    Short name:
    NP79
    Gene namesi
    Name:TSPYL2
    Synonyms:CDA1, DENTT, TSPX
    ORF Names:HRIHFB2216
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24358. TSPYL2.

    Subcellular locationi

    Nucleus 2 Publications. Cytoplasm By similarity
    Note: Enriched in transcriptionally active regions of chromatin in neurons.By similarity

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. cytoplasm Source: HPA
    3. nucleolus Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProtKB
    6. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi20 – 201S → A: Impairs effect on cell proliferation; when associated with A-340. 1 Publication
    Mutagenesisi340 – 3401T → A: Impairs effect on cell proliferation; when associated with A-20. 1 Publication

    Organism-specific databases

    PharmGKBiPA134930188.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693Testis-specific Y-encoded-like protein 2PRO_0000289100Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphoserine1 Publication
    Modified residuei20 – 201Phosphoserine1 Publication
    Modified residuei340 – 3401Phosphothreonine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H2G4.
    PaxDbiQ9H2G4.
    PRIDEiQ9H2G4.

    PTM databases

    PhosphoSiteiQ9H2G4.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.4 Publications

    Inductioni

    Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung cancer cells (at protein level).3 Publications

    Gene expression databases

    ArrayExpressiQ9H2G4.
    BgeeiQ9H2G4.
    CleanExiHS_TSPYL2.
    GenevestigatoriQ9H2G4.

    Organism-specific databases

    HPAiHPA044133.

    Interactioni

    Subunit structurei

    Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi122034. 13 interactions.
    IntActiQ9H2G4. 8 interactions.
    MINTiMINT-4719361.
    STRINGi9606.ENSP00000364591.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2G4.
    SMRiQ9H2G4. Positions 210-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 7572Pro-richAdd
    BLAST
    Compositional biasi180 – 21132Arg-richAdd
    BLAST
    Compositional biasi473 – 54270Asn-richAdd
    BLAST
    Compositional biasi557 – 675119Asp-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG295286.
    HOGENOMiHOG000154699.
    HOVERGENiHBG014779.
    InParanoidiQ9H2G4.
    KOiK11285.
    OMAiDSESPDH.
    PhylomeDBiQ9H2G4.
    TreeFamiTF313386.

    Family and domain databases

    InterProiIPR002164. NAP_family.
    [Graphical view]
    PANTHERiPTHR11875. PTHR11875. 1 hit.
    PfamiPF00956. NAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H2G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRPDEGPPA KTRRLSSSES PQRDPPPPPP PPPLLRLPLP PPQQRPRLQE    50
    ETEAAQVLAD MRGVGLGPAL PPPPPYVILE EGGIRAYFTL GAECPGWDST 100
    IESGYGEAPP PTESLEALPT PEASGGSLEI DFQVVQSSSF GGEGALETCS 150
    AVGWAPQRLV DPKSKEEAII IVEDEDEDER ESMRSSRRRR RRRRRKQRKV 200
    KRESRERNAE RMESILQALE DIQLDLEAVN IKAGKAFLRL KRKFIQMRRP 250
    FLERRDLIIQ HIPGFWVKAF LNHPRISILI NRRDEDIFRY LTNLQVQDLR 300
    HISMGYKMKL YFQTNPYFTN MVIVKEFQRN RSGRLVSHST PIRWHRGQEP 350
    QARRHGNQDA SHSFFSWFSN HSLPEADRIA EIIKNDLWVN PLRYYLRERG 400
    SRIKRKKQEM KKRKTRGRCE VVIMEDAPDY YAVEDIFSEI SDIDETIHDI 450
    KISDFMETTD YFETTDNEIT DINENICDSE NPDHNEVPNN ETTDNNESAD 500
    DHETTDNNES ADDNNENPED NNKNTDDNEE NPNNNENTYG NNFFKGGFWG 550
    SHGNNQDSSD SDNEADEASD DEDNDGNEGD NEGSDDDGNE GDNEGSDDDD 600
    RDIEYYEKVI EDFDKDQADY EDVIEIISDE SVEEEGIEEG IQQDEDIYEE 650
    GNYEEEGSED VWEEGEDSDD SDLEDVLQVP NGWANPGKRG KTG 693
    Length:693
    Mass (Da):79,435
    Last modified:March 1, 2001 - v1
    Checksum:i726F3BDC10A36165
    GO

    Sequence cautioni

    The sequence AAG53596.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti442 – 4421D → N in AAG53596. (PubMed:11318608)Curated
    Sequence conflicti566 – 5661D → V in AAG53596. (PubMed:11318608)Curated
    Sequence conflicti609 – 6091V → G in BAA34802. (PubMed:9853615)Curated
    Sequence conflicti615 – 6151K → R in BAA34802. (PubMed:9853615)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273046 mRNA. Translation: AAG34906.1.
    AY040871 mRNA. Translation: AAK72407.1.
    AL713652 mRNA. Translation: CAD28461.1.
    BX322635 Genomic DNA. Translation: CAI42531.1.
    BC001566 mRNA. Translation: AAH01566.1.
    BC024270 mRNA. Translation: AAH24270.1.
    AF254794 mRNA. Translation: AAG53596.1. Different initiation.
    AB015345 mRNA. Translation: BAA34802.1.
    CCDSiCCDS14350.1.
    RefSeqiNP_071400.1. NM_022117.3.
    UniGeneiHs.136164.
    Hs.592916.

    Genome annotation databases

    EnsembliENST00000375442; ENSP00000364591; ENSG00000184205.
    GeneIDi64061.
    KEGGihsa:64061.
    UCSCiuc004drw.3. human.

    Polymorphism databases

    DMDMi74752604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF273046 mRNA. Translation: AAG34906.1 .
    AY040871 mRNA. Translation: AAK72407.1 .
    AL713652 mRNA. Translation: CAD28461.1 .
    BX322635 Genomic DNA. Translation: CAI42531.1 .
    BC001566 mRNA. Translation: AAH01566.1 .
    BC024270 mRNA. Translation: AAH24270.1 .
    AF254794 mRNA. Translation: AAG53596.1 . Different initiation.
    AB015345 mRNA. Translation: BAA34802.1 .
    CCDSi CCDS14350.1.
    RefSeqi NP_071400.1. NM_022117.3.
    UniGenei Hs.136164.
    Hs.592916.

    3D structure databases

    ProteinModelPortali Q9H2G4.
    SMRi Q9H2G4. Positions 210-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122034. 13 interactions.
    IntActi Q9H2G4. 8 interactions.
    MINTi MINT-4719361.
    STRINGi 9606.ENSP00000364591.

    PTM databases

    PhosphoSitei Q9H2G4.

    Polymorphism databases

    DMDMi 74752604.

    Proteomic databases

    MaxQBi Q9H2G4.
    PaxDbi Q9H2G4.
    PRIDEi Q9H2G4.

    Protocols and materials databases

    DNASUi 64061.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375442 ; ENSP00000364591 ; ENSG00000184205 .
    GeneIDi 64061.
    KEGGi hsa:64061.
    UCSCi uc004drw.3. human.

    Organism-specific databases

    CTDi 64061.
    GeneCardsi GC0XP053111.
    HGNCi HGNC:24358. TSPYL2.
    HPAi HPA044133.
    MIMi 300564. gene.
    neXtProti NX_Q9H2G4.
    PharmGKBi PA134930188.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295286.
    HOGENOMi HOG000154699.
    HOVERGENi HBG014779.
    InParanoidi Q9H2G4.
    KOi K11285.
    OMAi DSESPDH.
    PhylomeDBi Q9H2G4.
    TreeFami TF313386.

    Enzyme and pathway databases

    Reactomei REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi TSPYL2. human.
    GeneWikii TSPYL2.
    GenomeRNAii 64061.
    NextBioi 65816.
    PROi Q9H2G4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H2G4.
    Bgeei Q9H2G4.
    CleanExi HS_TSPYL2.
    Genevestigatori Q9H2G4.

    Family and domain databases

    InterProi IPR002164. NAP_family.
    [Graphical view ]
    PANTHERi PTHR11875. PTHR11875. 1 hit.
    Pfami PF00956. NAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SET-related cell division autoantigen-1 (CDA1) arrests cell growth."
      Chai Z., Sarcevic B., Mawson A., Toh B.-H.
      J. Biol. Chem. 276:33665-33674(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-20 AND THR-340, MUTAGENESIS OF SER-20 AND THR-340, FUNCTION.
      Tissue: Testis.
    2. "Serological detection of cutaneous T-cell lymphoma-associated antigens."
      Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.
      Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Placenta.
    6. "Identification of Differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily."
      Ozbun L.L., You L., Kiang S., Angdisen J., Martinez A., Jakowlew S.B.
      Genomics 73:179-193(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-693, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION BY TGFB1.
    7. "Selection system for genes encoding nuclear-targeted proteins."
      Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
      Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 208-693.
      Tissue: Fetal brain.
    8. "Isolation of differentially expressed genes in human heart tissues."
      Sun G., Yuen Chan S., Yuan Y., Wang Chan K., Qiu G., Sun K., Ping Leung M.
      Biochim. Biophys. Acta 1588:241-246(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    9. "TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X -- implications for Y chromosome evolution."
      Delbridge M.L., Longepied G., Depetris D., Mattei M.-G., Disteche C.M., Marshall Graves J.A., Mitchell M.J.
      Chromosome Res. 12:345-356(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    10. "A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest."
      Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Mimura J., Lin T.-M., Peterson R.E., Tohyama C., Nohara K.
      J. Biol. Chem. 279:25204-25210(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    11. "Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates."
      Ozbun L.L., Martinez A., Jakowlew S.B.
      Biochim. Biophys. Acta 1728:163-180(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    12. "Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways."
      Tu Y., Wu W., Wu T., Cao Z., Wilkins R., Toh B.-H., Cooper M.E., Chai Z.
      J. Biol. Chem. 282:11722-11731(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTSYL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2G4
    Secondary accession number(s): O94799, Q96DG7, Q9BZW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.By similarity
    Subject to X inactivation.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3