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Protein

STE20-like serine/threonine-protein kinase

Gene

SLK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates apoptosis and actin stress fiber dissolution.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPPROSITE-ProRule annotation1
Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cytoplasmic microtubule organization Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of cell migration Source: UniProtKB
  • regulation of focal adhesion assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00848-MONOMER.
SignaLinkiQ9H2G2.
SIGNORiQ9H2G2.

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-like serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
STE20-like kinase
Short name:
hSLK
Alternative name(s):
CTCL tumor antigen se20-9
STE20-related serine/threonine-protein kinase
Short name:
STE20-related kinase
Serine/threonine-protein kinase 2
Gene namesi
Name:SLK
Synonyms:KIAA0204, STK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11088. SLK.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cell leading edge Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63K → R: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi9748.
OpenTargetsiENSG00000065613.
PharmGKBiPA35941.

Chemistry databases

ChEMBLiCHEMBL4202.
GuidetoPHARMACOLOGYi2200.

Polymorphism and mutation databases

BioMutaiSLK.
DMDMi74762732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332391 – 1235STE20-like serine/threonine-protein kinaseAdd BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei183PhosphothreonineBy similarity1
Modified residuei189PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei340PhosphoserineBy similarity1
Modified residuei341PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei354PhosphoserineBy similarity1
Modified residuei372PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei569PhosphothreonineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei647PhosphoserineBy similarity1
Modified residuei655PhosphoserineCombined sources1
Modified residuei667PhosphoserineBy similarity1
Modified residuei777PhosphoserineCombined sources1
Modified residuei779PhosphoserineCombined sources1
Modified residuei814PhosphothreonineCombined sources1
Modified residuei818PhosphoserineCombined sources1
Modified residuei1097PhosphothreonineCombined sources1

Post-translational modificationi

Proteolytically cleaved by caspase-3.
Autophosphorylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei438 – 439Cleavage; by caspase-3By similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H2G2.
MaxQBiQ9H2G2.
PaxDbiQ9H2G2.
PeptideAtlasiQ9H2G2.
PRIDEiQ9H2G2.

PTM databases

iPTMnetiQ9H2G2.
PhosphoSitePlusiQ9H2G2.

Miscellaneous databases

PMAP-CutDBQ9H2G2.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000065613.
CleanExiHS_SLK.
GenevisibleiQ9H2G2. HS.

Organism-specific databases

HPAiHPA015757.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1022272,EBI-1022272

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115096. 23 interactors.
IntActiQ9H2G2. 5 interactors.
MINTiMINT-4539212.
STRINGi9606.ENSP00000358770.

Chemistry databases

BindingDBiQ9H2G2.

Structurei

Secondary structure

11235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 28Combined sources3
Helixi30 – 32Combined sources3
Beta strandi34 – 40Combined sources7
Helixi41 – 43Combined sources3
Beta strandi46 – 53Combined sources8
Turni54 – 56Combined sources3
Beta strandi59 – 66Combined sources8
Helixi70 – 85Combined sources16
Beta strandi94 – 100Combined sources7
Beta strandi103 – 109Combined sources7
Helixi116 – 123Combined sources8
Helixi129 – 148Combined sources20
Helixi158 – 160Combined sources3
Beta strandi161 – 163Combined sources3
Beta strandi169 – 171Combined sources3
Helixi181 – 187Combined sources7
Helixi199 – 203Combined sources5
Helixi207 – 209Combined sources3
Helixi214 – 230Combined sources17
Turni234 – 237Combined sources4
Helixi240 – 242Combined sources3
Helixi243 – 249Combined sources7
Helixi258 – 260Combined sources3
Helixi263 – 272Combined sources10
Turni277 – 279Combined sources3
Helixi283 – 286Combined sources4
Helixi290 – 292Combined sources3
Helixi298 – 308Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J51X-ray2.10A19-320[»]
2JFLX-ray2.20A19-320[»]
2JFMX-ray2.85A19-320[»]
2UV2X-ray2.30A19-320[»]
4USFX-ray1.75A/B19-320[»]
ProteinModelPortaliQ9H2G2.
SMRiQ9H2G2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H2G2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 292Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini875 – 910UVRPROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili826 – 1069Sequence analysisAdd BLAST244
Coiled coili1109 – 1183Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 19Poly-Lys4
Compositional biasi302 – 652Glu-richAdd BLAST351

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UVR domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0579. Eukaryota.
ENOG410XPQN. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG052712.
InParanoidiQ9H2G2.
KOiK08836.
OMAiDQEKQQM.
OrthoDBiEOG091G01Y1.
PhylomeDBiQ9H2G2.
TreeFamiTF351445.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR022165. PKK.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF12474. PKK. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVYK
60 70 80 90 100
AQNKETSVLA AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY
110 120 130 140 150
ENNLWILIEF CAGGAVDAVM LELERPLTES QIQVVCKQTL DALNYLHDNK
160 170 180 190 200
IIHRDLKAGN ILFTLDGDIK LADFGVSAKN TRTIQRRDSF IGTPYWMAPE
210 220 230 240 250
VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP MRVLLKIAKS
260 270 280 290 300
EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI
310 320 330 340 350
RELIAEAKAE VTEEVEDGKE EDEEEETENS LPIPASKRAS SDLSIASSEE
360 370 380 390 400
DKLSQNACIL ESVSEKTERS NSEDKLNSKI LNEKPTTDEP EKAVEDINEH
410 420 430 440 450
ITDAQLEAMT ELHDRTAVIK ENEREKRPKL ENLPDTEDQE TVDINSVSEG
460 470 480 490 500
KENNIMITLE TNIEHNLKSE EEKDQEKQQM FENKLIKSEE IKDTILQTVD
510 520 530 540 550
LVSQETGEKE ANIQAVDSEV GLTKEDTQEK LGEDDKTQKD VISNTSDVIG
560 570 580 590 600
TCEAADVAQK VDEDSAEDTQ SNDGKEVVEV GQKLINKPMV GPEAGGTKEV
610 620 630 640 650
PIKEIVEMNE IEEGKNKEQA INSSENIMDI NEEPGTTEGE EITESSSTEE
660 670 680 690 700
MEVRSVVADT DQKALGSEVQ DASKVTTQID KEKKEIPVSI KKEPEVTVVS
710 720 730 740 750
QPTEPQPVLI PSININSDSG ENKEEIGSLS KTETILPPES ENPKENDNDS
760 770 780 790 800
GTGSTADTSS IDLNLSISSF LSKTKDSGSI SLQETRRQKK TLKKTRKFIV
810 820 830 840 850
DGVEVSVTTS KIVTDSDSKT EELRFLRRQE LRELRFLQKE EQRAQQQLNS
860 870 880 890 900
KLQQQREQIF RRFEQEMMSK KRQYDQEIEN LEKQQKQTIE RLEQEHTNRL
910 920 930 940 950
RDEAKRIKGE QEKELSKFQN MLKNRKKEVI NEVEKAPKEL RKELMKRRKE
960 970 980 990 1000
ELAQSQHAQE QEFVQKQQQE LDGSLKKIIQ QQKAELANIE RECLNNKQQL
1010 1020 1030 1040 1050
MRAREAAIWE LEERHLQEKH QLLKQQLKDQ YFMQRHQLLK RHEKETEQMQ
1060 1070 1080 1090 1100
RYNQRLIEEL KNRQTQERAR LPKIQRSEAK TRMAMFKKSL RINSTATPDQ
1110 1120 1130 1140 1150
DRDKIKQFAA QEEKRQKNER MAQHQKHENQ MRDLQLQCEA NVRELHQLQN
1160 1170 1180 1190 1200
EKCHLLVEHE TQKLKELDEE HSQELKEWRE KLRPRKKTLE EEFARKLQEQ
1210 1220 1230
EVFFKMTGES ECLNPSTQSR ISKFYPIPSL HSTGS
Length:1,235
Mass (Da):142,695
Last modified:March 1, 2001 - v1
Checksum:i53A43E7CA29B0ED3
GO
Isoform 2 (identifier: Q9H2G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-959: Missing.

Show »
Length:1,204
Mass (Da):138,996
Checksum:i2CA08AF0591C9AD6
GO

Sequence cautioni

The sequence AAH47762 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 611.Curated
The sequence AAH47885 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 422.Curated
The sequence AAH64804 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 614.Curated
The sequence BAA13195 differs from that shown. Reason: Frameshift at position 1172.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5N → S in BAA13195 (PubMed:9039502).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041080405Q → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041081552C → Y.1 PublicationCorresponds to variant rs805657dbSNPEnsembl.1
Natural variantiVAR_041082604E → Q in an ovarian serous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs190220654dbSNPEnsembl.1
Natural variantiVAR_041083658A → G.1 PublicationCorresponds to variant rs56400929dbSNPEnsembl.1
Natural variantiVAR_051666666G → E.Corresponds to variant rs7071400dbSNPEnsembl.1
Natural variantiVAR_041084679I → T.1 PublicationCorresponds to variant rs34326537dbSNPEnsembl.1
Natural variantiVAR_041085683K → N.1 PublicationCorresponds to variant rs35389916dbSNPEnsembl.1
Natural variantiVAR_041086697T → I.1 PublicationCorresponds to variant rs3740469dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018100929 – 959Missing in isoform 2. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002804 mRNA. Translation: BAA19655.1.
AF273048 mRNA. Translation: AAG34908.1.
D86959 mRNA. Translation: BAA13195.2. Sequence problems.
AL360170, AL138761 Genomic DNA. Translation: CAH70403.1.
AL360170, AL138761 Genomic DNA. Translation: CAH70404.1.
AL138761, AL360170 Genomic DNA. Translation: CAI12395.1.
AL138761, AL360170 Genomic DNA. Translation: CAI12396.1.
CH471066 Genomic DNA. Translation: EAW49615.1.
CH471066 Genomic DNA. Translation: EAW49616.1.
CH471066 Genomic DNA. Translation: EAW49617.1.
CH471066 Genomic DNA. Translation: EAW49618.1.
BC047762 mRNA. Translation: AAH47762.1. Sequence problems.
BC047885 mRNA. Translation: AAH47885.1. Sequence problems.
BC064804 mRNA. Translation: AAH64804.1. Sequence problems.
BC111565 mRNA. Translation: AAI11566.1.
CCDSiCCDS7553.1. [Q9H2G2-1]
CCDS76334.1. [Q9H2G2-2]
RefSeqiNP_001291672.1. NM_001304743.1. [Q9H2G2-2]
NP_055535.2. NM_014720.3. [Q9H2G2-1]
UniGeneiHs.591922.

Genome annotation databases

EnsembliENST00000335753; ENSP00000336824; ENSG00000065613. [Q9H2G2-2]
ENST00000369755; ENSP00000358770; ENSG00000065613. [Q9H2G2-1]
GeneIDi9748.
KEGGihsa:9748.
UCSCiuc001kxo.2. human. [Q9H2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002804 mRNA. Translation: BAA19655.1.
AF273048 mRNA. Translation: AAG34908.1.
D86959 mRNA. Translation: BAA13195.2. Sequence problems.
AL360170, AL138761 Genomic DNA. Translation: CAH70403.1.
AL360170, AL138761 Genomic DNA. Translation: CAH70404.1.
AL138761, AL360170 Genomic DNA. Translation: CAI12395.1.
AL138761, AL360170 Genomic DNA. Translation: CAI12396.1.
CH471066 Genomic DNA. Translation: EAW49615.1.
CH471066 Genomic DNA. Translation: EAW49616.1.
CH471066 Genomic DNA. Translation: EAW49617.1.
CH471066 Genomic DNA. Translation: EAW49618.1.
BC047762 mRNA. Translation: AAH47762.1. Sequence problems.
BC047885 mRNA. Translation: AAH47885.1. Sequence problems.
BC064804 mRNA. Translation: AAH64804.1. Sequence problems.
BC111565 mRNA. Translation: AAI11566.1.
CCDSiCCDS7553.1. [Q9H2G2-1]
CCDS76334.1. [Q9H2G2-2]
RefSeqiNP_001291672.1. NM_001304743.1. [Q9H2G2-2]
NP_055535.2. NM_014720.3. [Q9H2G2-1]
UniGeneiHs.591922.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J51X-ray2.10A19-320[»]
2JFLX-ray2.20A19-320[»]
2JFMX-ray2.85A19-320[»]
2UV2X-ray2.30A19-320[»]
4USFX-ray1.75A/B19-320[»]
ProteinModelPortaliQ9H2G2.
SMRiQ9H2G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115096. 23 interactors.
IntActiQ9H2G2. 5 interactors.
MINTiMINT-4539212.
STRINGi9606.ENSP00000358770.

Chemistry databases

BindingDBiQ9H2G2.
ChEMBLiCHEMBL4202.
GuidetoPHARMACOLOGYi2200.

PTM databases

iPTMnetiQ9H2G2.
PhosphoSitePlusiQ9H2G2.

Polymorphism and mutation databases

BioMutaiSLK.
DMDMi74762732.

Proteomic databases

EPDiQ9H2G2.
MaxQBiQ9H2G2.
PaxDbiQ9H2G2.
PeptideAtlasiQ9H2G2.
PRIDEiQ9H2G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335753; ENSP00000336824; ENSG00000065613. [Q9H2G2-2]
ENST00000369755; ENSP00000358770; ENSG00000065613. [Q9H2G2-1]
GeneIDi9748.
KEGGihsa:9748.
UCSCiuc001kxo.2. human. [Q9H2G2-1]

Organism-specific databases

CTDi9748.
DisGeNETi9748.
GeneCardsiSLK.
HGNCiHGNC:11088. SLK.
HPAiHPA015757.
MIMi616563. gene.
neXtProtiNX_Q9H2G2.
OpenTargetsiENSG00000065613.
PharmGKBiPA35941.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0579. Eukaryota.
ENOG410XPQN. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG052712.
InParanoidiQ9H2G2.
KOiK08836.
OMAiDQEKQQM.
OrthoDBiEOG091G01Y1.
PhylomeDBiQ9H2G2.
TreeFamiTF351445.

Enzyme and pathway databases

BioCyciZFISH:HS00848-MONOMER.
SignaLinkiQ9H2G2.
SIGNORiQ9H2G2.

Miscellaneous databases

EvolutionaryTraceiQ9H2G2.
GeneWikiiSLK_(gene).
GenomeRNAii9748.
PMAP-CutDBQ9H2G2.
PROiQ9H2G2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065613.
CleanExiHS_SLK.
GenevisibleiQ9H2G2. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR022165. PKK.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001943. UVR_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF12474. PKK. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLK_HUMAN
AccessioniPrimary (citable) accession number: Q9H2G2
Secondary accession number(s): D3DRA0
, D3DRA1, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.