Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

STE20-like serine/threonine-protein kinase

Gene

SLK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates apoptosis and actin stress fiber dissolution.HMP:

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPIEP:1
Active sitei155Proton acceptorIEP:1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPIEP:9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9H2G2.
SIGNORiQ9H2G2.

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-like serine/threonine-protein kinase (EC:2.7.11.1)
Short name:
STE20-like kinase
Short name:
hSLK
Alternative name(s):
CTCL tumor antigen se20-9
STE20-related serine/threonine-protein kinase
Short name:
STE20-related kinase
Serine/threonine-protein kinase 2
Gene namesi
Name:SLK
Synonyms:KIAA0204, STK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000065613.13.
HGNCiHGNC:11088. SLK.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63K → R: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi9748.
OpenTargetsiENSG00000065613.
PharmGKBiPA35941.

Chemistry databases

ChEMBLiCHEMBL4202.
GuidetoPHARMACOLOGYi2200.

Polymorphism and mutation databases

BioMutaiSLK.
DMDMi74762732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332391 – 1235STE20-like serine/threonine-protein kinaseAdd BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineND:1
Modified residuei183PhosphothreonineHMP:1
Modified residuei189PhosphoserineND:1
Modified residuei330PhosphoserineND:1
Modified residuei340PhosphoserineHMP:1
Modified residuei341PhosphoserineND:1
Modified residuei344PhosphoserineND:1
Modified residuei347PhosphoserineND:1
Modified residuei348PhosphoserineND:1
Modified residuei354PhosphoserineHMP:1
Modified residuei372PhosphoserineND:1
Modified residuei518PhosphoserineND:1
Modified residuei565PhosphoserineND:1
Modified residuei569PhosphothreonineND:1
Modified residuei571PhosphoserineND:1
Modified residuei647PhosphoserineHMP:1
Modified residuei655PhosphoserineND:1
Modified residuei667PhosphoserineHMP:1
Modified residuei777PhosphoserineND:1
Modified residuei779PhosphoserineND:1
Modified residuei814PhosphothreonineND:1
Modified residuei818PhosphoserineND:1
Modified residuei1097PhosphothreonineND:1

Post-translational modificationi

Proteolytically cleaved by caspase-3.
Autophosphorylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei438 – 439Cleavage; by caspase-3HMP:2

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H2G2.
MaxQBiQ9H2G2.
PaxDbiQ9H2G2.
PeptideAtlasiQ9H2G2.
PRIDEiQ9H2G2.

PTM databases

iPTMnetiQ9H2G2.
PhosphoSitePlusiQ9H2G2.

Miscellaneous databases

PMAP-CutDBiQ9H2G2.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000065613.
CleanExiHS_SLK.
GenevisibleiQ9H2G2. HS.

Organism-specific databases

HPAiHPA015757.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1022272,EBI-1022272

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115096. 26 interactors.
IntActiQ9H2G2. 5 interactors.
MINTiMINT-4539212.
STRINGi9606.ENSP00000358770.

Chemistry databases

BindingDBiQ9H2G2.

Structurei

Secondary structure

11235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 28ND:3
Helixi30 – 32ND:3
Beta strandi34 – 40ND:7
Helixi41 – 43ND:3
Beta strandi46 – 53ND:8
Turni54 – 56ND:3
Beta strandi59 – 66ND:8
Helixi70 – 85ND:16
Beta strandi94 – 100ND:7
Beta strandi103 – 109ND:7
Helixi116 – 123ND:8
Helixi129 – 148ND:20
Helixi158 – 160ND:3
Beta strandi161 – 163ND:3
Beta strandi169 – 171ND:3
Helixi181 – 187ND:7
Helixi199 – 203ND:5
Helixi207 – 209ND:3
Helixi214 – 230ND:17
Turni234 – 237ND:4
Helixi240 – 242ND:3
Helixi243 – 249ND:7
Helixi258 – 260ND:3
Helixi263 – 272ND:10
Turni277 – 279ND:3
Helixi283 – 286ND:4
Helixi290 – 292ND:3
Helixi298 – 308ND:11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J51X-ray2.10A19-320[»]
2JFLX-ray2.20A19-320[»]
2JFMX-ray2.85A19-320[»]
2UV2X-ray2.30A19-320[»]
4USFX-ray1.75A/B19-320[»]
ProteinModelPortaliQ9H2G2.
SMRiQ9H2G2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H2G2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 292Protein kinaseIEP:Add BLAST259
Domaini875 – 910UVRIEP:Add BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili826 – 1069IEP:Add BLAST244
Coiled coili1109 – 1183IEP:Add BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 19Poly-Lys4
Compositional biasi302 – 652Glu-richAdd BLAST351

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0579. Eukaryota.
ENOG410XPQN. LUCA.
GeneTreeiENSGT00900000140794.
HOVERGENiHBG052712.
InParanoidiQ9H2G2.
KOiK08836.
OMAiHAQEQEF.
OrthoDBiEOG091G01Y1.
PhylomeDBiQ9H2G2.
TreeFamiTF351445.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR022165. PKK.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001943. UVR_dom.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
PF12474. PKK. 2 hits.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50151. UVR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H2G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVYK
60 70 80 90 100
AQNKETSVLA AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY
110 120 130 140 150
ENNLWILIEF CAGGAVDAVM LELERPLTES QIQVVCKQTL DALNYLHDNK
160 170 180 190 200
IIHRDLKAGN ILFTLDGDIK LADFGVSAKN TRTIQRRDSF IGTPYWMAPE
210 220 230 240 250
VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP MRVLLKIAKS
260 270 280 290 300
EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI
310 320 330 340 350
RELIAEAKAE VTEEVEDGKE EDEEEETENS LPIPASKRAS SDLSIASSEE
360 370 380 390 400
DKLSQNACIL ESVSEKTERS NSEDKLNSKI LNEKPTTDEP EKAVEDINEH
410 420 430 440 450
ITDAQLEAMT ELHDRTAVIK ENEREKRPKL ENLPDTEDQE TVDINSVSEG
460 470 480 490 500
KENNIMITLE TNIEHNLKSE EEKDQEKQQM FENKLIKSEE IKDTILQTVD
510 520 530 540 550
LVSQETGEKE ANIQAVDSEV GLTKEDTQEK LGEDDKTQKD VISNTSDVIG
560 570 580 590 600
TCEAADVAQK VDEDSAEDTQ SNDGKEVVEV GQKLINKPMV GPEAGGTKEV
610 620 630 640 650
PIKEIVEMNE IEEGKNKEQA INSSENIMDI NEEPGTTEGE EITESSSTEE
660 670 680 690 700
MEVRSVVADT DQKALGSEVQ DASKVTTQID KEKKEIPVSI KKEPEVTVVS
710 720 730 740 750
QPTEPQPVLI PSININSDSG ENKEEIGSLS KTETILPPES ENPKENDNDS
760 770 780 790 800
GTGSTADTSS IDLNLSISSF LSKTKDSGSI SLQETRRQKK TLKKTRKFIV
810 820 830 840 850
DGVEVSVTTS KIVTDSDSKT EELRFLRRQE LRELRFLQKE EQRAQQQLNS
860 870 880 890 900
KLQQQREQIF RRFEQEMMSK KRQYDQEIEN LEKQQKQTIE RLEQEHTNRL
910 920 930 940 950
RDEAKRIKGE QEKELSKFQN MLKNRKKEVI NEVEKAPKEL RKELMKRRKE
960 970 980 990 1000
ELAQSQHAQE QEFVQKQQQE LDGSLKKIIQ QQKAELANIE RECLNNKQQL
1010 1020 1030 1040 1050
MRAREAAIWE LEERHLQEKH QLLKQQLKDQ YFMQRHQLLK RHEKETEQMQ
1060 1070 1080 1090 1100
RYNQRLIEEL KNRQTQERAR LPKIQRSEAK TRMAMFKKSL RINSTATPDQ
1110 1120 1130 1140 1150
DRDKIKQFAA QEEKRQKNER MAQHQKHENQ MRDLQLQCEA NVRELHQLQN
1160 1170 1180 1190 1200
EKCHLLVEHE TQKLKELDEE HSQELKEWRE KLRPRKKTLE EEFARKLQEQ
1210 1220 1230
EVFFKMTGES ECLNPSTQSR ISKFYPIPSL HSTGS
Length:1,235
Mass (Da):142,695
Last modified:March 1, 2001 - v1
Checksum:i53A43E7CA29B0ED3
GO
Isoform 2 (identifier: Q9H2G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-959: Missing.

Show »
Length:1,204
Mass (Da):138,996
Checksum:i2CA08AF0591C9AD6
GO

Sequence cautioni

The sequence AAH47762 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 611.IKR:
The sequence AAH47885 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 422.IKR:
The sequence AAH64804 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 614.IKR:
The sequence BAA13195 differs from that shown. Reason: Frameshift at position 1172.IKR:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5N → S in BAA13195 (PubMed:9039502).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041080405Q → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041081552C → Y1 PublicationCorresponds to variant dbSNP:rs805657Ensembl.1
Natural variantiVAR_041082604E → Q in an ovarian serous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs190220654Ensembl.1
Natural variantiVAR_041083658A → G1 PublicationCorresponds to variant dbSNP:rs56400929Ensembl.1
Natural variantiVAR_051666666G → E. Corresponds to variant dbSNP:rs7071400Ensembl.1
Natural variantiVAR_041084679I → T1 PublicationCorresponds to variant dbSNP:rs34326537Ensembl.1
Natural variantiVAR_041085683K → N1 PublicationCorresponds to variant dbSNP:rs35389916Ensembl.1
Natural variantiVAR_041086697T → I1 PublicationCorresponds to variant dbSNP:rs3740469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018100929 – 959Missing in isoform 2. IBD:Add BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002804 mRNA. Translation: BAA19655.1.
AF273048 mRNA. Translation: AAG34908.1.
D86959 mRNA. Translation: BAA13195.2. Sequence problems.
AL360170 Genomic DNA. No translation available.
AL138761 Genomic DNA. No translation available.
CH471066 Genomic DNA. Translation: EAW49615.1.
CH471066 Genomic DNA. Translation: EAW49616.1.
CH471066 Genomic DNA. Translation: EAW49617.1.
CH471066 Genomic DNA. Translation: EAW49618.1.
BC047762 mRNA. Translation: AAH47762.1. Sequence problems.
BC047885 mRNA. Translation: AAH47885.1. Sequence problems.
BC064804 mRNA. Translation: AAH64804.1. Sequence problems.
BC111565 mRNA. Translation: AAI11566.1.
CCDSiCCDS7553.1. [Q9H2G2-1]
CCDS76334.1. [Q9H2G2-2]
RefSeqiNP_001291672.1. NM_001304743.1. [Q9H2G2-2]
NP_055535.2. NM_014720.3. [Q9H2G2-1]
UniGeneiHs.591922.

Genome annotation databases

EnsembliENST00000335753; ENSP00000336824; ENSG00000065613. [Q9H2G2-2]
ENST00000369755; ENSP00000358770; ENSG00000065613. [Q9H2G2-1]
GeneIDi9748.
KEGGihsa:9748.
UCSCiuc001kxo.2. human. [Q9H2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSLK_HUMAN
AccessioniPrimary (citable) accession number: Q9H2G2
Secondary accession number(s): D3DRA0
, D3DRA1, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families