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Protein
Submitted name:

CTCL tumor antigen se37-2

Gene

UBE3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei820Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported, TransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CTCL tumor antigen se37-2Imported
Submitted name:
Ubiquitin protein ligase E3A (Human papilloma virus E6-associated protein, Angelman syndrome), isoform CRA_bImported
Submitted name:
cDNA FLJ77551, highly similar to Homo sapiens ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A), transcript variant 1, mRNAImported
Gene namesi
Name:UBE3AImported
ORF Names:hCG_18679Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000114062.17

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37144

PTM / Processingi

Proteomic databases

MaxQBiQ9H2G0

Expressioni

Gene expression databases

BgeeiENSG00000114062

Structurei

3D structure databases

SMRiQ9H2G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini524 – 852HECTInterPro annotationAdd BLAST329

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili141 – 161Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0941 Eukaryota
COG5021 LUCA
HOVERGENiHBG059326

Family and domain databases

CDDicd00078 HECTc, 1 hit
InterProiView protein in InterPro
IPR032353 AZUL
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR017134 UBE3A
PfamiView protein in Pfam
PF16558 AZUL, 1 hit
PF00632 HECT, 1 hit
PIRSFiPIRSF037201 Ubiquitin-protein_ligase_E6-AP, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H2G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM DNNAAAIKAL
60 70 80 90 100
ELYKINAKLC DPHPSKKGAS SAYLENSKGA PNNSCSEIKM NKKGARIDFK
110 120 130 140 150
DVTYLTEEKV YEILELCRER EDYSPLIRVI GRVFSSAEAL VQSFRKVKQH
160 170 180 190 200
TKEELKSLQA KDEDKDEDEK EKAACSAAAM EEDSEASSSR IGDSSQGDNN
210 220 230 240 250
LQKLGPDDVS VDIDAIRRVY TRLLSNEKIE TAFLNALVYL SPNVECDLTY
260 270 280 290 300
HNVYSRDPNY LNLFIIVMEN RNLHSPEYLE MALPLFCKAM SKLPLAAQGK
310 320 330 340 350
LIRLWSKYNA DQIRRMMETF QQLITYKVIS NEFNSRNLVN DDDAIVAASK
360 370 380 390 400
CLKMVYYANV VGGEVDTNHN EEDDEEPIPE SSELTLQELL GEERRNKKGP
410 420 430 440 450
RVDPLETELG VKTLDCRKPL IPFEEFINEP LNEVLEMDKD YTFFKVETEN
460 470 480 490 500
KFSFMTCPFI LNAVTKNLGL YYDNRIRMYS ERRITVLYSL VQGQQLNPYL
510 520 530 540 550
RLKVRRDHII DDALVRLEMI AMENPADLKK QLYVEFEGEQ GVDEGGVSKE
560 570 580 590 600
FFQLVVEEIF NPDIGMFTYD ESTKLFWFNP SSFETEGQFT LIGIVLGLAI
610 620 630 640 650
YNNCILDVHF PMVVYRKLMG KKGTFRDLGD SHPVLYQSLK DLLEYEGNVE
660 670 680 690 700
DDMMITFQIS QTDLFGNPMM YDLKENGDKI PITNENRKEF VNLYSDYILN
710 720 730 740 750
KSVEKQFKAF RRGFHMVTNE SPLKYLFRPE EIELLICGSR NLDFQALEET
760 770 780 790 800
TEYDGGYTRD SVLIREFWEI VHSFTDEQKR LFLQFTTGTD RAPVGGLGKL
810 820 830 840 850
KMIIAKNGPD TERLPTSHTC FNVLLLPEYS SKEKLKERLL KAITYAKGFG

ML
Length:852
Mass (Da):97,968
Last modified:March 1, 2001 - v1
Checksum:i3C061DA8D216055A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273050 mRNA Translation: AAG34910.1
AK291405 mRNA Translation: BAF84094.1
CH471151 Genomic DNA Translation: EAW57643.1
CH471151 Genomic DNA Translation: EAW57644.1
RefSeqiNP_570853.1, NM_130838.1
XP_005268324.1, XM_005268267.4
XP_005268325.1, XM_005268268.4
XP_005268326.1, XM_005268269.4
XP_005268327.1, XM_005268270.4
XP_005268328.1, XM_005268271.4
XP_006720738.1, XM_006720675.3
XP_006720739.1, XM_006720676.3
XP_016878040.1, XM_017022551.1
XP_016878041.1, XM_017022552.1
XP_016878042.1, XM_017022553.1
XP_016878043.1, XM_017022554.1
XP_016878044.1, XM_017022555.1
UniGeneiHs.598862

Genome annotation databases

GeneIDi7337
UCSCiuc001zat.4 human

Similar proteinsi

Entry informationi

Entry nameiQ9H2G0_HUMAN
AccessioniPrimary (citable) accession number: Q9H2G0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.