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Q9H2F9 (CCD68_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 68
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se57-1
Short name=CTCL-associated antigen se57-1
Gene names
Name:CCDC68
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL). Ref.1 Ref.4

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Coiled-coil domain-containing protein 68
PRO_0000264611

Regions

Coiled coil101 – 305205 Potential

Natural variations

Natural variant2491V → A. Ref.2
Corresponds to variant rs34751112 [ dbSNP | Ensembl ].
VAR_050762

Sequences

Sequence LengthMass (Da)Tools
Q9H2F9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 2D7C0DFAC964A815

FASTA33538,869
        10         20         30         40         50         60 
MTTVTVTTEI PPRDKMEDNS ALYESTSAHI IEETEYVKKI RTTLQKIRTQ MFKDEIRHDS 

        70         80         90        100        110        120 
TNHKLDAKHC GNLQQGSDSE MDPSCCSLDL LMKKIKGKDL QLLEMNKENE VLKIKLQASR 

       130        140        150        160        170        180 
EAGAAALRNV AQRLFENYQT QSEEVRKKQE DSKQLLQVNK LEKEQKLKQH VENLNQVAEK 

       190        200        210        220        230        240 
LEEKHSQITE LENLVQRMEK EKRTLLERKL SLENKLLQLK SSATYGKSCQ DLQREISILQ 

       250        260        270        280        290        300 
EQISHLQFVI HSQHQNLRSV IQEMEGLKNN LKEQDKRIEN LREKVNILEA QNKELKTQVA 

       310        320        330 
LSSETPRTKV SKAVSTSELK TEGVSPYLML IRLRK

« Hide

References

« Hide 'large scale' references
[1]"Serological detection of cutaneous T-cell lymphoma-associated antigens."
Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.
Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed: 11149944] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-249.
Tissue: Trachea.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer."
Gerhardt A., Usener D., Keese M., Sturm J., Schadendorf D., Eichmueller S.
Cancer Lett. 208:197-206(2004) [PubMed: 15142679] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF273051 mRNA. Translation: AAG34911.1.
AK313793 mRNA. Translation: BAG36530.1.
BC029508 mRNA. Translation: AAH29508.1.
IPIIPI00018854.
RefSeqNP_001137301.1. NM_001143829.1.
NP_079490.1. NM_025214.2.
UniGeneHs.120790.

3D structure databases

ProteinModelPortalQ9H2F9.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9H2F9. 7 interactions.
STRINGQ9H2F9.

PTM databases

PhosphoSiteQ9H2F9.

Polymorphism databases

DMDM74733556.

Proteomic databases

PRIDEQ9H2F9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000337363; ENSP00000337209; ENSG00000166510.
ENST00000423029; ENSP00000404628; ENSG00000166510.
ENST00000432185; ENSP00000413406; ENSG00000166510.
GeneID80323.
KEGGhsa:80323.
UCSCuc002lfs.1. human.

Organism-specific databases

CTD80323.
GeneCardsGC18M052568.
H-InvDBHIX0014461.
HGNCHGNC:24350. CCDC68.
neXtProtNX_Q9H2F9.
PharmGKBPA143485420.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18923.
GeneTreeENSGT00530000063232.
HOGENOMHBG125739.
HOVERGENHBG079562.
InParanoidQ9H2F9.
OMAMNKENEV.
OrthoDBEOG4M65HZ.
PhylomeDBQ9H2F9.

Gene expression databases

ArrayExpressQ9H2F9.
BgeeQ9H2F9.
CleanExHS_CCDC68.
GenevestigatorQ9H2F9.
GermOnlineENSG00000166510. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other

NextBio70843.

Entry information

Entry nameCCD68_HUMAN
AccessionPrimary (citable) accession number: Q9H2F9
Secondary accession number(s): B2R9I3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents