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Reviewed, UniProtKB/Swiss-Prot Q9H2F9 (CCD68_HUMAN)

Last modified November 24, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Coiled-coil domain-containing protein 68
Alternative name(s):
    Cutaneous T-cell lymphoma-associated antigen se57-1
    CTCL tumor antigen se57-1
Gene names
Name: CCDC68
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Tissue specificity

Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL). Ref.1 Ref.4

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Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Gene Ontology (GO)
None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Coiled-coil domain-containing protein 68
PRO_0000264611

Regions

Coiled coil101 – 305205 Potential

Natural variations

Natural variant2491V → A: dbSNP rs34751112. Ref.2
VAR_050762

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Sequences

Sequence LengthMass (Da)Tools
Q9H2F9-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 2D7C0DFAC964A815

FASTA33538,869
        10         20         30         40         50         60 
MTTVTVTTEI PPRDKMEDNS ALYESTSAHI IEETEYVKKI RTTLQKIRTQ MFKDEIRHDS 

        70         80         90        100        110        120 
TNHKLDAKHC GNLQQGSDSE MDPSCCSLDL LMKKIKGKDL QLLEMNKENE VLKIKLQASR 

       130        140        150        160        170        180 
EAGAAALRNV AQRLFENYQT QSEEVRKKQE DSKQLLQVNK LEKEQKLKQH VENLNQVAEK 

       190        200        210        220        230        240 
LEEKHSQITE LENLVQRMEK EKRTLLERKL SLENKLLQLK SSATYGKSCQ DLQREISILQ 

       250        260        270        280        290        300 
EQISHLQFVI HSQHQNLRSV IQEMEGLKNN LKEQDKRIEN LREKVNILEA QNKELKTQVA 

       310        320        330 
LSSETPRTKV SKAVSTSELK TEGVSPYLML IRLRK

« Hide

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References

« Hide 'large scale' references
[1]"Serological detection of cutaneous T-cell lymphoma-associated antigens."
Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.
Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed: 11149944] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-249.
Tissue: Trachea.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer."
Gerhardt A., Usener D., Keese M., Sturm J., Schadendorf D., Eichmueller S.
Cancer Lett. 208:197-206(2004) [PubMed: 15142679] [Abstract]
Cited for: TISSUE SPECIFICITY.

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Cross-references

Sequence databases

AF273051 mRNA. Translation: AAG34911.1.
AK313793 mRNA. Translation: BAG36530.1.
BC029508 mRNA. Translation: AAH29508.1.
IPIIPI00018854.
RefSeqNP_001137301.1.
NP_079490.1.
UniGeneHs.120790

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ9H2F9.

Genome annotation databases

EnsemblENST00000337363; ENSP00000337209; ENSG00000166510; Homo sapiens. [Genome view]
ENST00000423029; ENSP00000404628; ENSG00000166510; Homo sapiens. [Genome view]
ENST00000432185; ENSP00000413406; ENSG00000166510; Homo sapiens. [Genome view]
GeneID80323.
KEGGhsa:80323.
UCSCuc002lfs.1. human.

Organism-specific databases

CTD80323.
GeneCardsGC18M050720.
H-InvDBHIX0014461.
HGNCHGNC:24350. CCDC68.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9H2F9.
OMAVIQEMEG
OrthoDBEOG980MH5

Gene expression databases

ArrayExpressQ9H2F9.
BgeeQ9H2F9.
CleanExHS_CCDC68.
GenevestigatorQ9H2F9.
GermOnlineENSG00000166510. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio70843.

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Entry information

Entry nameCCD68_HUMAN
AccessionPrimary (citable) accession number: Q9H2F9
Secondary accession number(s): B2R9I3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 18: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents