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Protein

Coiled-coil domain-containing protein 68

Gene

CCDC68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 68
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se57-1
Short name:
CTCL-associated antigen se57-1
Gene namesi
Name:CCDC68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:24350. CCDC68.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi80323.
OpenTargetsiENSG00000166510.
PharmGKBiPA143485420.

Polymorphism and mutation databases

BioMutaiCCDC68.
DMDMi74733556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646111 – 335Coiled-coil domain-containing protein 68Add BLAST335

Proteomic databases

PaxDbiQ9H2F9.
PRIDEiQ9H2F9.

PTM databases

iPTMnetiQ9H2F9.
PhosphoSitePlusiQ9H2F9.

Expressioni

Tissue specificityi

Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL).2 Publications

Gene expression databases

BgeeiENSG00000166510.
CleanExiHS_CCDC68.
ExpressionAtlasiQ9H2F9. baseline and differential.
GenevisibleiQ9H2F9. HS.

Organism-specific databases

HPAiHPA040865.
HPA048197.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFIP11Q9UBB95EBI-2813327,EBI-1105213

Protein-protein interaction databases

BioGridi123235. 13 interactors.
IntActiQ9H2F9. 10 interactors.
STRINGi9606.ENSP00000337209.

Structurei

3D structure databases

ProteinModelPortaliQ9H2F9.
SMRiQ9H2F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili101 – 305Sequence analysisAdd BLAST205

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGTN. Eukaryota.
ENOG4111MW9. LUCA.
GeneTreeiENSGT00730000111306.
HOGENOMiHOG000234846.
HOVERGENiHBG079562.
InParanoidiQ9H2F9.
OMAiEMDPSCC.
OrthoDBiEOG091G0CI2.
PhylomeDBiQ9H2F9.

Family and domain databases

InterProiIPR026735. Ccdc68.
[Graphical view]
PANTHERiPTHR23171:SF3. PTHR23171:SF3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H2F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVTVTTEI PPRDKMEDNS ALYESTSAHI IEETEYVKKI RTTLQKIRTQ
60 70 80 90 100
MFKDEIRHDS TNHKLDAKHC GNLQQGSDSE MDPSCCSLDL LMKKIKGKDL
110 120 130 140 150
QLLEMNKENE VLKIKLQASR EAGAAALRNV AQRLFENYQT QSEEVRKKQE
160 170 180 190 200
DSKQLLQVNK LEKEQKLKQH VENLNQVAEK LEEKHSQITE LENLVQRMEK
210 220 230 240 250
EKRTLLERKL SLENKLLQLK SSATYGKSCQ DLQREISILQ EQISHLQFVI
260 270 280 290 300
HSQHQNLRSV IQEMEGLKNN LKEQDKRIEN LREKVNILEA QNKELKTQVA
310 320 330
LSSETPRTKV SKAVSTSELK TEGVSPYLML IRLRK
Length:335
Mass (Da):38,869
Last modified:March 1, 2001 - v1
Checksum:i2D7C0DFAC964A815
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050762249V → A.1 PublicationCorresponds to variant rs34751112dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273051 mRNA. Translation: AAG34911.1.
AK313793 mRNA. Translation: BAG36530.1.
BC029508 mRNA. Translation: AAH29508.1.
CCDSiCCDS11959.1.
RefSeqiNP_001137301.1. NM_001143829.1.
NP_079490.1. NM_025214.2.
XP_006722615.1. XM_006722552.3.
XP_011524500.1. XM_011526198.2.
XP_011524501.1. XM_011526199.2.
XP_011524502.1. XM_011526200.2.
XP_011524503.1. XM_011526201.2.
UniGeneiHs.120790.

Genome annotation databases

EnsembliENST00000337363; ENSP00000337209; ENSG00000166510.
ENST00000432185; ENSP00000413406; ENSG00000166510.
ENST00000591504; ENSP00000466690; ENSG00000166510.
GeneIDi80323.
KEGGihsa:80323.
UCSCiuc002lfs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273051 mRNA. Translation: AAG34911.1.
AK313793 mRNA. Translation: BAG36530.1.
BC029508 mRNA. Translation: AAH29508.1.
CCDSiCCDS11959.1.
RefSeqiNP_001137301.1. NM_001143829.1.
NP_079490.1. NM_025214.2.
XP_006722615.1. XM_006722552.3.
XP_011524500.1. XM_011526198.2.
XP_011524501.1. XM_011526199.2.
XP_011524502.1. XM_011526200.2.
XP_011524503.1. XM_011526201.2.
UniGeneiHs.120790.

3D structure databases

ProteinModelPortaliQ9H2F9.
SMRiQ9H2F9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123235. 13 interactors.
IntActiQ9H2F9. 10 interactors.
STRINGi9606.ENSP00000337209.

PTM databases

iPTMnetiQ9H2F9.
PhosphoSitePlusiQ9H2F9.

Polymorphism and mutation databases

BioMutaiCCDC68.
DMDMi74733556.

Proteomic databases

PaxDbiQ9H2F9.
PRIDEiQ9H2F9.

Protocols and materials databases

DNASUi80323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337363; ENSP00000337209; ENSG00000166510.
ENST00000432185; ENSP00000413406; ENSG00000166510.
ENST00000591504; ENSP00000466690; ENSG00000166510.
GeneIDi80323.
KEGGihsa:80323.
UCSCiuc002lfs.4. human.

Organism-specific databases

CTDi80323.
DisGeNETi80323.
GeneCardsiCCDC68.
HGNCiHGNC:24350. CCDC68.
HPAiHPA040865.
HPA048197.
MIMi616909. gene.
neXtProtiNX_Q9H2F9.
OpenTargetsiENSG00000166510.
PharmGKBiPA143485420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGTN. Eukaryota.
ENOG4111MW9. LUCA.
GeneTreeiENSGT00730000111306.
HOGENOMiHOG000234846.
HOVERGENiHBG079562.
InParanoidiQ9H2F9.
OMAiEMDPSCC.
OrthoDBiEOG091G0CI2.
PhylomeDBiQ9H2F9.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166510-MONOMER.

Miscellaneous databases

GenomeRNAii80323.
PROiQ9H2F9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166510.
CleanExiHS_CCDC68.
ExpressionAtlasiQ9H2F9. baseline and differential.
GenevisibleiQ9H2F9. HS.

Family and domain databases

InterProiIPR026735. Ccdc68.
[Graphical view]
PANTHERiPTHR23171:SF3. PTHR23171:SF3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCD68_HUMAN
AccessioniPrimary (citable) accession number: Q9H2F9
Secondary accession number(s): B2R9I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.