##gff-version 3 Q9H2D6 UniProtKB Chain 1 2365 . . . ID=PRO_0000072433;Note=TRIO and F-actin-binding protein Q9H2D6 UniProtKB Domain 1778 1887 . . . Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 Q9H2D6 UniProtKB Region 48 1106 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Region 1168 1554 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Region 1593 1667 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Region 1679 1751 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Region 1889 2017 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Region 2174 2194 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Coiled coil 2062 2247 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9H2D6 UniProtKB Coiled coil 2281 2361 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9H2D6 UniProtKB Compositional bias 120 154 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 234 649 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 662 723 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 736 902 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 914 932 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 942 995 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1191 1209 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1260 1274 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1302 1316 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1327 1355 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1488 1507 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1519 1534 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1594 1608 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1641 1667 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1682 1698 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1724 1738 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1891 1915 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1946 1960 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Compositional bias 1964 1994 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H2D6 UniProtKB Modified residue 1796 1796 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9H2D6 UniProtKB Modified residue 1930 1930 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99KW3 Q9H2D6 UniProtKB Modified residue 1949 1949 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Q9H2D6 UniProtKB Modified residue 1955 1955 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19369195,PMID:20068231,PMID:23186163 Q9H2D6 UniProtKB Alternative sequence 1 1772 . . . ID=VSP_017711;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 Q9H2D6 UniProtKB Alternative sequence 1 172 . . . ID=VSP_017712;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 Q9H2D6 UniProtKB Alternative sequence 1 61 . . . ID=VSP_047498;Note=In isoform 6 and isoform 7. MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPE->MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAMT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9H2D6 UniProtKB Alternative sequence 62 1774 . . . ID=VSP_047499;Note=In isoform 6 and isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9H2D6 UniProtKB Alternative sequence 1317 2365 . . . ID=VSP_017713;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385457;Dbxref=PMID:16385457 Q9H2D6 UniProtKB Alternative sequence 1317 1355 . . . ID=VSP_017714;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 Q9H2D6 UniProtKB Alternative sequence 1729 1774 . . . ID=VSP_017715;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 Q9H2D6 UniProtKB Alternative sequence 1773 1774 . . . ID=VSP_017716;Note=In isoform 1. RR->MT;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11148140,ECO:0000303|PubMed:15489334;Dbxref=PMID:11148140,PMID:15489334 Q9H2D6 UniProtKB Alternative sequence 1794 1806 . . . ID=VSP_017717;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16385458;Dbxref=PMID:16385458 Q9H2D6 UniProtKB Alternative sequence 2109 2144 . . . ID=VSP_047500;Note=In isoform 6. EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK->LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9H2D6 UniProtKB Alternative sequence 2145 2365 . . . ID=VSP_047501;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9H2D6 UniProtKB Natural variant 217 217 . . . ID=VAR_059725;Note=S->N;Dbxref=dbSNP:rs12628603 Q9H2D6 UniProtKB Natural variant 493 493 . . . ID=VAR_059726;Note=S->N;Dbxref=dbSNP:rs4821700 Q9H2D6 UniProtKB Natural variant 817 817 . . . ID=VAR_061708;Note=T->S;Dbxref=dbSNP:rs41302575 Q9H2D6 UniProtKB Natural variant 863 863 . . . ID=VAR_051412;Note=N->K;Dbxref=dbSNP:rs9610841 Q9H2D6 UniProtKB Natural variant 1019 1019 . . . ID=VAR_025719;Note=In DFNB28. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16385458;Dbxref=dbSNP:rs549095193,PMID:16385458 Q9H2D6 UniProtKB Natural variant 1187 1187 . . . ID=VAR_059727;Note=F->L;Dbxref=dbSNP:rs5756795 Q9H2D6 UniProtKB Natural variant 1300 1300 . . . ID=VAR_059728;Note=H->R;Dbxref=dbSNP:rs739138 Q9H2D6 UniProtKB Natural variant 1372 1372 . . . ID=VAR_051413;Note=E->D;Dbxref=dbSNP:rs8140207 Q9H2D6 UniProtKB Natural variant 1377 1377 . . . ID=VAR_051414;Note=W->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11258795,ECO:0000269|PubMed:16385458;Dbxref=dbSNP:rs8140958,PMID:11258795,PMID:16385458 Q9H2D6 UniProtKB Sequence conflict 713 719 . . . Note=RTTQQEN->KSTFGCL;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 1421 1421 . . . Note=R->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 1689 1689 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 1896 1896 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 1904 1904 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 2114 2114 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 2141 2141 . . . Note=Q->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 2274 2274 . . . Note=S->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 2283 2283 . . . Note=E->EHLYPQ;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Sequence conflict 2359 2359 . . . Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H2D6 UniProtKB Region 324 348 . . . Note=Essentiel for its aggregation;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28438837;Dbxref=PMID:28438837 Q9H2D6 UniProtKB Modified residue 221 221 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24692559;Dbxref=PMID:24692559 Q9H2D6 UniProtKB Modified residue 457 457 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22820163;Dbxref=PMID:22820163 Q9H2D6 UniProtKB Mutagenesis 221 221 . . . Note=Does not affect interaction with TERF1. Remains associated with TERF1 at the telomere in late prometaphase cells. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28438837;Dbxref=PMID:28438837 Q9H2D6 UniProtKB Mutagenesis 221 221 . . . Note=Abolishes interaction with TERF1. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28438837;Dbxref=PMID:28438837 Q9H2D6 UniProtKB Mutagenesis 457 457 . . . Note=Prevents the localization of TERF1 to the centrosome. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28438837;Dbxref=PMID:28438837 Q9H2D6 UniProtKB Mutagenesis 457 457 . . . Note=Does not affect interaction with TERF1. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28438837;Dbxref=PMID:28438837